PREDISPOSING FACTOR PATHOPHYSIOLOGY PRECIPITATING FACTOR

Age, gender, heredity, race, Environment, drugs, infection,

hormones, history UNKNOWN lifestyle
ETIOLOGY

Female producing estrogen 1st generation familial possession Influencing agents in the body
of influencing SLE DNA

Increase level of estrogen Similar activity/structure to

Genetic relational DNA passes down to
our own systemic cell
ext generation

Unknown cause of estrogen

influencing immune response Human leukocyte antigen class 1 &2 in
of the human leukocyte system chromosome 6 possesses multiple
genes influencing in inheriting SLE
in chromosome 6

Occurrence of SLE
activation

Fewer or defective tangible body Defect in mechanism of

macrophages in the body immune complex
Human leukocyte antigen class 1
&2 in chromosome 6 posses clearance
multiple genes influenced in
inheriting SLE
Defective clearance of early
apoptotic cell Apoptic chromatin and
Release of danger signs nuclei attach to dendrite
Secondary necrosis of cell
Endocytose of antigen material by Defective B cell activation by
dendritic cell autoantigen
Release of nuclear fragments as
potential auto antigens
Presented to T cells Hyperactivity of defective B cell

Impaired membrane integrity of

dendrite cell
Activation of defective T cell Production of self and non-self
antibodies and B memory cells

Induced maturation of dendritic

cell Production of defective T
Negative abnormal B cell
cells contribution to already deficient
immune system

SYSTEMIC LUPUS
ERYTHEMATOSUS