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com

om
r.c
ke
an
tR
SKELETAL MUSCLE
irs
.F
w
w

RELAXANTS
w

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om
r.c
ke
an
tR
irs
.F
w
w
w

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PERIPHERALLY ACTING
Non Depolarizing Neuromuscular Blockers

om
r.c
Isoquinoline Derivatives

ke
an
d-Tubocurarine Kidney 40%
tR
irs > 35
Atracurium Spontaneous 20-35
.F
w

Cisatracurium Mostly spontaneous 25- 44

w
w

Doxacurium Kidney > 35

Mivacurium Plasma ChE2 10-20
Metocurium Kidney 40% >35

Misc
Gallamine
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Steroid Derivatives
Pancuronium Kidney 80%>35

om
Pipecuronium Kidney 60%>35

r.c
ke
Rocuronium Liver 90% 20 – 35
an
tR
Vecuronium Liver 90% 20 – 35
irs
.F
w
w
w

Depolarizing Neuromuscular Blockers

Suxamethonium
Suxethonium
Decamethonium

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CENTRALLY ACTING

Benzodiazepines
Diazepam, clonazepam, Nitrazepam

om
r.c
ke
an
GABA Analogues tR
irs
Baclofen
.F
w

Progabide
w
w

Propanediol Derivatives
Mephenesin
Meprobamate

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Misc Compounds

om
Cyclobenzaprine

r.c
ke
Methocarbamol
an
tR
Orphenadrine
irs
.F

Chlomezanone
w
w
w

Tizanidine
DIRECTLY ACTING
Dantrolene

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om
r.c
ke
an
tR
irs
.F
w
w
w

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NON DEPOLARIZING SKELETAL MUSCLE

RELAXANTS

om
r.c
CHEMISTRY

ke
an
tR
irs

PHARMACOKINETICS
.F
w
w
w

MECHANISM OF ACTION

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THERAPEUTIC USES
1) ENDOTRACHEAL INTUBATION – ROCURONIUM
2) SURGICAL RELAXATION – BALANCED

om
r.c
ANESTHESIA

ke
3) CONTROL OF VENTILATION
an
tR
4) CONVULSIONS – RARE
irs
.F
w

SIDE – EFFECTS
w
w

1) BROCHOSPASM
2) URTICARIA
3) HYPOTENSION

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DEPOLARIZING NMJ BLOCKERS

CHEMISTRY

om
r.c
ke
PHARMACOKINETICS
an
tR
irs
.F

MECHANISM OF ACTION
w
w

PHASE – I BLOCK
w

PHASE – II BLOCK

PHARMACOLOGICAL ACTIONS
SKELETAL MUSCLES
CVS

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SIDE – EFFECTS

1) HYPERKALEMIA

om
2) RAISED INTRA – OCCULAR AND INTRA – GASTRIC

r.c
PRESSURES

ke
an
3) MUSCLE PAIN tR
irs
4) MALIGNANT HYPERTHERMIA
.F

5) PROLONGED APNOEA
w
w
w

THERAPEUTIC USES
1) ENDOTRACHEAL INTUBATION

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CENTALLY ACTING SKELETAL MUSCLE

RELAXANTS

om
DIAZEPAM

r.c
ke
BACLOFEN
an
tR
TIZANIDINE
irs
.F
w
w
w

DIRECTLY ACTING SKELETAL MUSCLE

RELAXANT

DANTROLENE

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