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MI LEEY I RMAKNKEFFDALEE I AE SAKNDETLRNELAKVLDD I LKTDPSDPEAFRK I VAEHQEFWDEHDPS LMEFNEGRFFGKSRKQYLKSDDFLNSTDPTYNFQKLHQF

SS01496 .............................................................................................................. 0
SS01308 MILEEYIRMAKNKEFFDALEEIAESAKNDETLRNELAKVLDDILKTDPSDPEAFRKIVAEHQEFWDEHDPSLMEFNEGRFFGKSRKQYLKSDDFLNSTDPTYNFQKLHQF 110
SS01517 .............................................................................................................. 0
SS01616 .............................................................................................................. 0
SS01528 .............................................................................................................. 0
SS01438 .............................................................................................................. 0
consensus

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AAEQRVKLGLEKSDTDTLVA I LKNNPEECRAY I E SKKPGLGNF S EGNVHGWLKEEYTPT I PPKA I NKSTGVL SDEA I KD I KEDAGD
MPSRRNGQSRT
LL L
P PL LWSTGT Q
T L
L KG I NPS EN P
LKRLRM A I
T
D Q
I EDHKAFMS
SS01496 .............................................................................................................. 0
SS01308 AAEQRVKLGLEKSDTDTLVAILKNNPEECRAYIESKKPGLGNFSEGNVHGWLKEEYTPTIPPKAINKSTGVLSDEAIKRIKEQARDLLLLKLINSSGNTQLLKDLRDAMS 220
SS01517 .............................................................................................................. 0
SS01616 ..........................................................................................................MFQI 4
SS01528 ...........................................................................MPSDRNGDSGTLLPLPGLWPTETTPLIERHKAATI 35
SS01438 .............................................................................................................. 0
consensus

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H L
LP NYS L LY
KE FMRF I R
GDEAE I AANA
K
LP T
S
L FK
TSTNQV I
KL L I GS
GFTAEGEDE
D RV
SRFR HKM
MSN
G
TTMT MPNP VRY P Q
QE I VEE F
KLDFA
F
T M L
L E
L
S L
RVTP
S
L AG
E RVEV NVEVE RGTDTLMQS GVNAL
PSW T
L
I SK I L RVTTA
K E
P
KVSNS SYVRV SQTPYYVRVV V SQRS Q GE I SPRSYV PAK I Y I
L I KL LQK I L PR LGFTP I K I SQP I I NKSGSWS LTNS SWQNNL
I I K D NN I D SMHEH I GD HHL EP FKNG
F
LGK I
R
L
HKKG
NR N
Q
NPS SPSYQ
NH
P LKQVL
AK
T Q
L
EKLDEKF FTRE
Y S LWYTYW
P I V
I
Q TVR
SQT
VS
L I R T QP
F I EQL S
F EDAEAEHADFA I H I AAEGAFAE FAFAFAA I DGFAAHFGPHF E I ERGHDD I DAAFDE SDC I AAEDADAAFQNAALDERYLQAVL
EE F L EEDL
VGSA
EL
YQ
VGS
I NFN

SS01496 ..............................MPDRAQVIIRIVPGGGTKTLQQIINQLEYLSRKGKLELQRSARHLDIPVPPDQIRELAQSWVTEAG...IYDE....... 70
SS01308 KPEAERAANALGFPTEGNGVLFLSREVVDALEERVEKLEQEAAKRGFDSYVQSLSHNALLAKKNGLESTTAAGFKNSLDEPYKTYLPESEWERAQG...VLGARYLQAVL 327
SS01517 .........................MREEKEEDVMYVALHESEGRPHAHFAPSLGVSDPYVAVFLSWVETAGIFDRSSSQSVKAKIIQALLYIVSF...AGSA....... 75
SS01616 GEHNMILIYKLTLTKLTEDELKKDFATIPSWATHLDLSNNRLGETSNEELIRVFAKIPGWISHIKLRFNNLGQKNGKDLAKAFAKIPISVTTLDLGSNQLG......... 105
SS01528 LDHFYSFLRKLSLPASLIQSLFSNTFFIMEFFKLIELDNPVIEGVAIS..MFALGTTGSFISTVSPHVTKERHSPHPRVNQFLSDCLYIFDFEIRLQEEVNQN....... 136
SS01438 .....................MKTQRIIHPNIDIRKFPEVNTDFSMTDISMGDLHANALLFLNILVRQGIIAISPENYAKFAEIYTLPELQADYWGTEAPVFS....... 82
consensus * * * * * * * * * * *

logo TIV
VSQ
QK
SSGTQNLKDALNAKDANAL I TELKKPALLGPHDY I DA
WTG
SY
S LQ
KN W QQ
GD
S
EQTTTN
K
VQY
M
ERL
GIN
PK
M
LT
VT LK
VL I PN
EEKF E FNFDN I F EHLKNK
I R
S IT
LKTT
K N
TSQN
N
R
LG I E LM
KT
AEDDDEDAEAAADF I AE FADN I KDETNLKALDALKALDGAKNLDKFKEVLGKLG I TPADWVKDADFDDDAAFA
K
FQ
LYK
E SW
LG
R
KVQ I E
I
SS01496 ....................................SQSDDDRQQDLTTHIIVSFP............................................AGTDQTAAYE 100
SS01308 SSGTQNLKDALNAKDANALITELKKPALLGPHDYIDKAVTEENLGSLKKNMMKSFINNIKDETNLKALDALKALDGAKNLDKFKEVLGKLGITPADWVKDTDLKDMKQWA 437
SS01517 ...................................VTIELGWRFGDTAVGLLNKVFN...........................................KIFKTDVSFG 107
SS01616 .....................................KKSGEELANAFAGIPTSVTR...........................................LILSQNELYK 135
SS01528 ...................................QEIWFYFNDDQLKEDFKKEITD............................................INELRETLK 167
SS01438 ....................................AENKQERLEEIKKQYNALIAQ..........................................IKIINTKKLIR 114
consensus * * * * * *

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SS01496
RSR
LLGDWELAE
TT Q TYT
D I VG
PVPM
R
NN V
LTV
I HRK
E SKF GG
SYS
L IP F G L
I GS A ALY G T
TVTYSV
SQ L
Y
LV
SK
DGS I LKHHQ
NS G
T
G I R
Y
P
T
M Q
AAEE FALDAFA I AF L FADEGEGC I DD
C
NF V
Y
L
R
I
G
LRL K
YY
LS
K
GAD
V
T
HLAVVTS LRHLMN
Q
KQN
P I
E
E
H
E QH
L
I
NKP
H
W
TKWPNRVNSVTV
P K V
R
RTL
N Q
E GH
LI YQ
WRV STL
SHVSKR GG
I NNLMARMYST
D
N
L
H
E
HG I HFNPQEKKTKG DL LKLRG I KPQ
W
LNR
KQN
I
FPH
AKACDEDAEAF EA I EACEE F FDAAEKD I EEHHLNE LAF
G
A L
PFH
VS T
I NN
SG
S
I
RY
EV
AT
IKIQ
LV
S
K
QM
A
L E
TSI N
Q
VSY
Q
G
LKL S S VWLN
PRLHSPVSNNSN
A I H L AFRG
V V
VVVYTSRY
S
QQ
I D I RNNN I RLKFHK
A I YDAFPKA I FAGAFMEEE F LKDAAAN

ASREWAAEM.....FGSGYGGGRYNYLTAYHVDRDHPHLHVVVNRRELLGHGWLKISRRHPQLN......YDGLRKKMAEISLRHG.IVLDATSRAERGIA.........
G
LA
V NI P
VAKS I TVLNPS
S

LKV I GK I FM
EHE I HF EEDKYE I TLN

189
SS01308 RARQFELEINRVSSLGSGAHSKLMSTLTKLPVEKQREILAKPQQLRHLMNAYESHVAEHYLGKN......ASGIAELLTENKRLEG.FRAIHNAEVARVLANFKPEITLN 540
SS01517 DSEDWPSKFLG..GIFAGASYITISGLCVFACHRLVKHWNARTSEKKLMEEDHRVVRSTLGGFNNFINAPASSLAQVLFSVKYLSSPWNAVFALSAFVSLTVLN...... 209
SS01616 RTGGELATAFAKIPSSVTHLVLVNNGLGEKNGKELATAFANIPSSVTTLDLALNDLSKIKSTELA...VIFTKIPTSVTQLDLSHNNLNKKSGKNLAKIFANIP...... 236
SS01528 TLVDETYPNHTLAFITQDELEACNNDLPTQQRIYYWKKQPVNTNLTHVFIDIHSHMEGMLGGWPR.....AIIFRYLQAILPFMSGVLSVNHVLQHFIGGEEDMP..... 267
SS01438 LIGDELVDRGVIDYFILKLLQALYDQGADFEILLSNHGIEFVEACELFKENGNKLVAKRLGNIQHG..NSFHALQEAIAAGAISNEEVLNIYHQVYKKHLKIISYS.... 218
consensus * * ** * * * * * * * *
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SS01496
LE
RPAY

DKQVAA I D PF Q
T
E LNVS
RA
Q
NEY
LRR I NTAKNFR LAR
NTS L Y V SV W
PM I L SP I TL
EDA I N I EHNCHS
I
TQATD I Q I L ERK
ML L
I KK
GGN
G
KSKLKAE F I QR
G
S
LYRTW
Q TR
KHK I GE I DDH
C
T
TTR
PSKWK
F
LQYPVVR
I
ED
S EW AR
V
SRVY
N
YNTL
RVK Q
STNLKQFD DSGD
D
PRST
L FKP M
L STKKRAL E SQ
WS FNN S
KNR I GF I KTL C
Q
Q I
T D
PE T
SGSK
R
R
LTL I DK
NP
IM
G
TT
S
RHWQ
LK
KFVN
M
S
YYLDTYYL
TR
R
LP
MK
QY
YN
SM
PH L
AEYNS S SN
WNR L
HGLHQN
NGH I F F I
I EK

AF FDGHGFADAAADEGEGFKAE F I EAKA I EAFDDCE F EDAA I AFAEEAAAQCKHAAEDAE F F L EGAADEAA

IN

.......ERPITYAEHRRLERMQAQKIQFEDTDFDETSPEEDRRDLSQSFDPFRS....DPSTGEPDRATRHDKQPLEQHARFQE.SAGSSIKADARIRVSLES......
S
S TN
T I GQL
Q
Q

PGEG I D
L
I
E
VV
Q
G
IT R V L
SW
KL PAVRVAR
GF L LTPT
ADCKL LNG
L
I
Y
KP
TH
G
GVTF SK
Q
S
G
S
K
E
A I S S
V
S

C
E 281
SS01308 DKQVAAINQALTTANSNPNTYTQATDYKILIDAIKTQSGSVNQKDFYNAFNLNDDGRAFTSSTPRKDEMSKQQQHNQHIYAEYNS.TSNSGNKKLLAVLLSIEKPVTFSK 649
SS01517 .......REAFNELINRAVSWCFGDDHQIKEERHQLTTRFKRARQLQWTSEDRST..FFEPQIPLPEKLKYLWQKAGGQWEIIES.PQSGAEEGTPLLSNASES...... 303
SS01616 ........TSVTNLNLSCNELGKKSGKGLAAAFAKIPTSVTDLNIEDNDLDNRTG...KELAMAFAHIPAFVNTLRLGDNNLGNK.SGEELAEIFAKIPLSVTS...... 328
SS01528 .......LPRYIPMQVFAIAIALFKLSITWERKFKRGEKWWAEFYLRVKLGKSSICEILKICLTSPHNLLALCTYTASMFFFLEKGAIDQILKITCRISTACEH...... 364
SS01438 ......LDPDANEIKVFSHAGIGLNHIRGLARKFKVPYSEESAVDLAKTIDAINKKFAEKASSGEIHTLYTHDMMYRGYAGEHLN....STDEVVAATVWGREYG..... 313
consensus * * * * * * * *

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D I VNRFLRPLKDS ETPQDYADTL FDS
YNEPSN

LGEDP
TRLV
PL

F I NWGKR I G
LR
LND
N
NK
R L I LG
GT S
K I STF LVR
EDK I P
Q
K K P S
F SPK
VM
ND
YLTT
A
SM
K I MPK
TH L ETQL I TR T YV
YAVT I YNEYVKKQSG
L I KNTNVNL S SNHF LNNV
AATAPPF F I DCAHAELTPTVFNE I KNDLRKQELLDTHAYHD I EAS E I F
G L KF I L E G
R
I RT
LYA
S
A P V L
ALNGTT
V
L ENRNYKSGFPNN
S
TT
PGDKNMG I FTTM
TF ENHGADADKGEA I ALDFAK I
V
S
RP TTVY YN
I GD
DR
L
V
L FVNM
S
K I PPQHQH
EAFADFAMAL
G
P
Q

G
G
I Q S
Q
A S

C
V
S
S V
S
L Q

SS01496 .........................ERSAQPS..................................ASKIPVIGHFGIETSYVAEAS..VRKRSGIFGTSRPVTDVAMH. 329

SS01308 DIVNRFLRPLKDSETPQDYADTLFGENPTNPANKKFKDDLLRELTPTVFNEIKNDLRKQELLDTNPAHVMTAIKALSTELESIKGITGPIRTNADKLKFINDIDPVHLYN 759
SS01517 .........................SRDREWVNKIIKGTIVG.......................MSPSPALVYALVVYEELNHRLGKGIAISAATLTGTGSFALFSVQM 365
SS01616 .......................LDLRYNELGKRNGKELAIA.......................FAKIPSSVTNLNLKFNHLGKITG.EELAMAFANIPTNVDSLVLAN 391
SS01528 ..........................DFNALNPPPLSGCKLP......................VAYSLTAMSTITLIFTQIITDIDRYLQNQNAASGFCEKVTRLFQCL 426
SS01438 ..........................DLIRTSKKFKITFIHG......................HDSYDPEKVEHVTLNNQLGQFQNNVGDLYLYATNGMRAVPTQYLNP 375
consensus * * * * * * * * * * * *

logo P
N
L
T
K
VQ
LK
QGS
R LYTR
K I RQQ
DRFGGNEG
K
V
R
P K
RESTMV
RKDK
A YY
RVYE
L EQL L SNL P
ND PKF
CEADAKAETEADN I EPDDE
KI
S SGT
AK
GL SRDCGLVVDQLRRQVVALEGHLKS LPKEGEFKVV
S LTTT
STQN
LP
IM
RHFMN
R
P
LHGEKKNEW
SPL AVV
KHGF
F
YWRT
VSN
LT
VKL E

L LM A Q
S EV
NVP
LMAQ
PD I AQPT
EVYTL EKLYK
Q
L
Q K Q
A TKM R
T V
Y
W

I D I GFAAGAD I FKA I AQS S FDDGVGS EDLDFYKK I QGKLET I VKEVDVAAKG I I WC

D H
SS01496 .TVKRQQRSKRRNDEE......................................AGPSGANRKGLKAAQVDSEANVGEQ............................... 369
SS01308 PTFQGTARSKAAQMKERYEGLSRDCGLVVDQLRRQVVALEGHLKSLPKEGEFKAAGLTLEQKAEIKKLRTDLEAELSAVREDLDFYKKIQGKLETIVKEVDVAAKGKMHY 869
SS01517 LKALYGEKSKVDKKVEYVS...................................ILMGFFATSPLLYVLMQYALDVPAL..............................W 410
SS01616 NELGAKSGEELAKIFSKIP..................................ASITSLNMGNDWFAVIEKLSQQKMVLS.........................TITHV 442
SS01528 CRRDQNRETNPETLLEDLS...................................SDSRQTTQKHFKVWVAVIAANTLEG..............................C 471
SS01438 DKKIQGSREKDRPDKPNDY..................................VVKIHHTKPSFFKTSNPKITFPDSYKR...........................IWD 424
consensus *** * * *

logo YY
VT
Y
S SA I
D D NKAH P T
S
AVSR
LAH ATQLPNA
QY
V VP KTWRDVHTAE L R
S L S SV
TNV
IF A S G E
YW R RST G
W
KRRVNTG
I YQ KEVVPSVS
S
L
ST
S SV
K G
AVPRV GSVETR S LPQ VDYDNDV EPVT
Y
P S E LNK
ST
SQVPS TSP LTQV
K I D P
SS S SS GNT S SNQVPS HQV Q SVNS LV T YPPS S
L
Q I R LG SML K L PQL SVP PML E LN R
LTL PR LQ I I I T
Q F LKWK L PQ
KKTKQ
L KHTNL
S S SNS
I RQTQ S
M QR L NR S
P M VVYK V
I FNGF I I TRK I S F
I
G I PKF E LNKI PR LGE STDGHWL LHHRK
I
FNH I LDG I GDKLKLK GKFPNPQL LHKQ I DNKGP I S C
DAGDEGFQEADKA
LK
RKDD
KCG F
GKEEDD I LGAF FAARSAEGTFAGGN I I VEA I AE LHAE I ADAF LDDAEADAF F EAAF FDHPF I C I E LH I I ADECVAK I AE F L LA GSKFE I LQF
SS01496 DTRDDSNKAADPVSASIGTEQPEASPKRPRDRHDGELG..........GRKRARG.......NRRDDGRGGT...................................... 424
SS01308 YYNSEGIKRHPPVSRDQIPPLPNVPNPSLRSSTTATTGSNGRIQEFLVGEKIPEGQIVVVDVSHKTAPKSGAPVETIGRYTQDNNVPDQVTSKKGEISKVPGSKFEILQF 979
SS01517 IFVPFLAIASTAVRSHGAKQLLDATIASWSEVSEEELFR..........KKISQLAEIFPKFSPIAVTKIHGFFSTP..VDNDNDMPEPSDNRLMTLV............ 496
SS01616 VIDYSSAQEHSAKLKLLATVFPNLNKVTFMDIHGNNALAGQNPIEEAKWLKLCGIKNSVPSLLSQALFFVAKNKEHRSIQDYPSLLPKELTDSISSLLKC.......... 542
SS01528 QQGLGIFTSMLSFLAHVTQQSPNAVLKTVAAVFAAGASLS......YWGWLHRQGKDFLTKTAETVNQIKDYLPLSIFSCPSSHDSHEPIVANEAPVNYAPV........ 567
SS01438 SADGDSNITKIKALLKDYTKEDSILGSFWGLIFTLHWGRHHVKSVHQIAQTKYTSVEAILSDLKALKPREGGSLDKRIKFIELQIIAQRCDSPEPQFNLK.......... 524
consensus * * * * * * * * * *

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PTQVPPPNPPSGDPLVEAKVNF SMAMAAD I LAS LDSPPTKDKP I RLRGSNPEELEYLYTALV I LGEKNPKFKFNRDA I EVNSAVFHPDNVKGRLWGF SSNS LYSQVFTNT
SS01496 .............................................................................................................. 424
SS01308 PTQVPPPNPPSGDPLVEAKVNFSMAMAADILASLDSPPTKDKPIRLRGSNPEELEYLYTALVILGEKNPKFKFNRDAIEVNSAVFHPDNVKGRLWGFSSNSLYSQVFTNT 1089
SS01517 .............................................................................................................. 496
SS01616 .............................................................................................................. 542
SS01528 .............................................................................................................. 567
SS01438 .............................................................................................................. 524
consensus
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GLTETQN I I QSK I KHMQQMTDEKF SPQKEREKVDSKVQE I TDKQSKMKKELNPVHKTTERT I EQEGPAPE SPSTGMRK
SS01496 .............................................................................. 424
SS01308 GLTETQNIIQSKIKHMQQMTDEKFSPQKEREKVDSKVQEITDKQSKMKKELNPVHKTTERTIEQEGPAPESPSTGMRK 1167
SS01517 .............................................................................. 496
SS01616 .............................................................................. 542
SS01528 .............................................................................. 567
SS01438 .............................................................................. 524
consensus

X non conserved
X similar
X ≥ 50% conserved