Active ingredient in marijuana THC

Initially causes _____ followed by _________ euphoria;depression

ADHD drug found in chinese

Ephedrine
supplements and weight loss products

ADHD drugs/methamphetamines are powerful ________ CNS

stimulants
increased levels of serotonin, norepeinhrpeine, dopamine

increased levels of? increaed catecholamine levels

Sympathomimetics sigsn = hyperthermia

GI upset
ADHD drugs signs death due to DIC

serotonin syndrome

Activated charcoal

Phenothaizines (ace, chloropromazine)

ADHD drug treatment phenobarb

metho for sedation/tremoring

cyproheptadine for CNS effects

vomiting

diarrhea and nausea

Clinical signs of grape toxicity PU/PD

oliguria/anuria

hyperthermia

Clinical signs of kipper who agitation

tachycardia

ingested vyvance mydriasis

hypertension

dpression/recumbency

Common clinical signs of ataxia, mydriasis, glazed eye

resp depression

marijuana toxicity in dogs vomiting

urinary incontinence

casts
evidence of tubular damage glucose
in the urine

Those who present quickly/asymptomatically after ingestion = prognosis

good

Grapes/raisin prognosis azotemia - guarded, consider dialysis

if no azotemia by 3 days post-ingestion, unlikely to have toxicity

 acute kidney injury
Grape toxicity results in ?
clinical signs within 48 hours of ingestion

when do clinical signs show? most signs in 6-24 hours

48 hours
How long should IV fluids be
given with grapes/raisin toxicity monitor for azotemia, casts, UOP

vomiting
How to treat acute ingestion of
grapes activated charcoal

increased BUN and creatinine

75
indicates __% nephron loss

Isosthenuria indicates _________ %

66
nephron loss

creates a lipid sink to draw toxin

IV intralipid therapy for marijuana
into blood from tissues

good with accurate diagnosis and

Marijuana prognosis
good supportive care

Decontaminate if not yet neurologically affected

activated charcoal q6-8h

Marijuana therapy IV fluids

intralipid if severe

most respond well

Prognosis for ADHD toxicity uncontrollable seizures, DIC, or myoglobinuria are

poor prognostic factors

Sudden arrhythmias a concern

baclofen
with this toxin
 CV monitoring and support --> watch for arrythmias

IV fluids
therapy for ADHD toxicity keep in dark place

cooling measures

induced vomiting with apomorphine

therapy for grape toxicity for
alexis cerenia to stop vomiting
Grapes/raisins

chocolate

onions/garlic

Toxic foods sugar free (xylitol)

raw bread

macademia nuts

avocadoes

lisdexafetamine
vyvance is ___________
CNS stimulant for ADHD

Dehydration
What can be seen on presentation azotemia
hyperphosphatemia
of grape toxicity? hypermagnesemia
hyperkalemia

human med for nacrolepsy

What is Vyvance?
ingestion of human meds is #1 toxicity reported

Why should benzodiazepines be diazepam/midazolam

avoided when ADHD drugs are
ingested? increased agitation