References:

Avallone, R., Zanoli, P., Corsi, L., Cannazza, G., & Baraldi, M. (1996). Benzodiazepine-like Compounds
and GABA in. Phytotherapy Research, 10, S177-S179.

Bornheim, L. M., Borys, H. K., & Karler, R. (1981). Effect of cannabidiol on cytochrome P-450 and
hexobarbital sleep time. Biochemical Pharmacology, 30(5), 503-507.

Riemann, D., & Perlis, M. L. (2009). The treatments of chronic insomnia: a review of benzodiazepine
receptor agonists and psychological and behavioral therapies. Sleep medicine reviews, 13(3), 205-214.

Poskanzer, K. E., & Yuste, R. (2016). Astrocytes regulate cortical state switching in vivo. Proceedings of
the National Academy of Sciences, 113(19), E2675-E2684.

Rouach, N., Koulakoff, A., Abudara, V., Willecke, K., & Giaume, C. (2008). Astroglial metabolic networks
sustain hippocampal synaptic transmission. Science, 322(5907), 1551-1555.
Prolo, L. M., Takahashi, J. S., & Herzog, E. D. (2005). Circadian rhythm generation and entrainment in
astrocytes. Journal of Neuroscience, 25(2), 404-408.

Saper, C. B., Fuller, P. M., Pedersen, N. P., Lu, J., & Scammell, T. E. (2010). Sleep state switching.
Neuron, 68(6), 1023-1042.

Brancaccio, M., Patton, A. P., Chesham, J. E., Maywood, E. S., & Hastings, M. H. (2017). Astrocytes
control circadian timekeeping in the suprachiasmatic nucleus via glutamatergic signaling. Neuron, 93(6),
1420-1435.

Srivastava, J. K., Shankar, E., & Gupta, S. (2010). Chamomile: a herbal medicine of the past with a bright
future. Molecular medicine reports, 3(6), 895-901.

Palmieri, G., Contaldi, P., & Fogliame, G. (2017). Evaluation of effectiveness and safety of a herbal
compound in primary insomnia symptoms and sleep disturbances not related to medical or psychiatric
causes. Nature and science of sleep, 9, 163.

Volgin, D. V., Lu, J. W., Stettner, G. M., Mann, G. L., Ross, R. J., Morrison, A. R., & Kubin, L. (2014).
Time-and behavioral state-dependent changes in posterior hypothalamic GABAA receptors contribute to
the regulation of sleep. PLoS One, 9(1), e86545.

Nuutinen, T. (2018). Medicinal properties of terpenes found in Cannabis sativa and Humulus lupulus.
European journal of medicinal chemistry.

Aoshima, H., Takeda, K., Okita, Y., Hossain, S. J., Koda, H., & Kiso, Y. (2006). Effects of beer and hop on
ionotropic γ-aminobutyric acid receptors. Journal of agricultural and food chemistry, 54(7), 2514-2519.

Karabín, M., Hudcová, T., Jelínek, L., & Dostálek, P. (2016). Biologically active compounds from hops
and prospects for their use. Comprehensive Reviews in Food Science and Food Safety, 15(3), 542-567.

Saper, C. B., Scammell, T. E., & Lu, J. (2005). Hypothalamic regulation of sleep and circadian rhythms.
Nature, 437(7063), 1257.

Krueger, J. M., Obal Jr, F. E. R. E. N. C., Opp, M., Toth, L., Johannsen, L., & Cady, A. B. (1990).
Somnogenic cytokines and models concerning their effects on sleep. The Yale journal of biology and
medicine, 63(2), 157.

Zanoli, P., & Zavatti, M. (2008). Pharmacognostic and pharmacological profile of Humulus lupulus L.
Journal of ethnopharmacology, 116(3), 383-396.

Möhler, H., Fritschy, J. M., & Rudolph, U. (2002). A new benzodiazepine pharmacology. Journal of
Pharmacology and Experimental Therapeutics, 300(1), 2-8.

Al-Snafi, A. E. (2016). Medical importance of Anthemis nobilis (Chamaemelum nobile)-A review. AJPST,
6(2), 89-95.

Murillo-Rodríguez, E., Palomero-Rivero, M., Millán-Aldaco, D., Mechoulam, R., & Drucker-Colín, R.
(2011). Effects on sleep and dopamine levels of microdialysis perfusion of cannabidiol into the lateral
hypothalamus of rats. Life sciences, 88(11-12), 504-511.
Guan, X., Cravatt, B. F., Ehring, G. R., Hall, J. E., Boger, D. L., Lerner, R. A., & Gilula, N. B. (1997). The
sleep-inducing lipid oleamide deconvolutes gap junction communication and calcium wave transmission
in glial cells. The Journal of cell biology, 139(7), 1785-1792.

Abourashed, E. A., Koetter, U., & Brattström, A. (2004). In vitro binding experiments with a Valerian, hops
and their fixed combination extract (Ze91019) to selected central nervous system receptors.
Phytomedicine, 11(7-8), 633-638.

Sakurai, T. (2007). The neural circuit of orexin (hypocretin): maintaining sleep and wakefulness. Nature
Reviews Neuroscience, 8(3), 171.