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    Frederic Rust
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    2 views2 pages

    Mutations Key

    Uploaded by

    Frederic Rust

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
    Flag for inappropriate content
    of 2
    tone: Yon Date: Peta . ‘There are several types of mutation: DELETION (a base is lost) INSERTION (an extra base is inserted) Deletion and insertion may cause what's called a FRAMESHIFT, meaning the reading “frame” ‘changes, changing the amino acid sequence. SUBSTITUTION (one base is substituted for another) Ifa substitution changes the amino acid, i's called a MISSENSE mutation. Ifa substitution does not change the amino acid, It’s called SILENT mutation. {fa substitution changes the amino acid to @ “stop,” it's called a NONSENSE mutation, Part 4: Transcribing and Translating Mutated DNA. Directions: Complete the boxes below using your knowledge of complementary base pairing and the codon chart in your notes. Classily each as either a deletion, insertion, or substitution AND as either frameshift, missense, silent or nonsense (hint: deletion or insertion will always be frameshif}) ‘Original DNA Sequence: TACACCTTGGCGACGACT MRNA Sequence AV GIL GARE. & CUGLUSA BAR GS G tat SA __ Amino Acld Sequence: Va.) eu ARO Aca Cus Stoo “ — ~ Mutated DNA Sequence #1 TAC ATC TTGGCGACGACT What's the mRNA sequence? ALU ARG ARG CGC VECUL &A (Circle the change) What will be the amino acid sequence? Cut ShroR Will there likely be major effects? 8!» What kind of mutation is this? Seo ARS yn ges ADD SEN Mutated DNA Sequence #2; TA CIGACCTTGGCGACGACT What's the mRNA sequence? AY SACU Gi APNE Gy GLU fala Circle the change) What will be the amino acid sequence? Ad. Lew Glu aiid Pro Leu, Leu ‘Will there likely be major effects? 0X ‘What kind of mutation is thiS? \nkueMon miasengne Wiutated DNA Sequence#3, TA CACC TTIAGCGACGACT What's the mRNA sequence?_(\U QUAY eo __(Cirele the change) What will be the amino acid sequence? 4 tr Beg hy, Will there likely be major effects? \%_ rena kind of mut Sos ede en Shen Wulated DNA Sequence#4) = TACACCTTGGCGACINACT What's the mRNA sequence? AY HV GH BAG CQL Y OF (Circle the change) ‘What will be the amino acid sequence?

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