Rh Blood Group Summary
Rh Blood Group Antigens
Biochemical composition
Gene products
Current Genetic theory
Fisher- Race theory
Wiener Theory
Rosenfield/ Numeric terminology
ISBT : standard numeric
Genetic loci
Weak D
Compound antigens
G antigen
Rhnull phenotype
Rh Blood Group Antibodies
Antibody production
Immunoglobulin class
In vitro reactions
Enhancement
Complement binding
Clinical significance
Dosage
Polypeptides with no carbohydrates residues
16 amino acids that traverse the membrane
12 times
Two genes, RHD and RHCE; alleles include
RHCE, RHCe, RHcE, RHce
Three genes; alleles include D/d, C/c, E/e
One gene; alleles include Ro , R1 , R2 ,Rz, r, r’,
r”, ry
Numeric—D= Rh1, C= Rh2, E=Rh3, c= Rh4,
e=Rh5
Rh blood group system is 004; each antigen is
on the red blood cell.
Chromosome 1
D antigen that can be detected only by IAT
ce or f, Ce or Rh7, CE or Rh22, and cE or Rh27
Present whenever the D or C antigen is on
the red blood cell
Results from an amorph gene or RHAG
regulator gene; no Rh antigens, abnormal red
blood cell membrane
Red blood cell stimulation through
transfusion or pregnancy
IgG; usually IgG1 and IgG3
Binds at 370 C; agglutination observed using
IAT
LISS, proteolytic enzymes, albumin and PEG
no
Yes; can cause delayed transfusion reactions
and HDFN
Yes, stronger reactions with homozygous
expression