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  • CDK4/6 Inhibitors Administration Checklist: Ribociclib

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    Nicole
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    This document provides checklists for administering CDK4/6 inhibitors ribociclib, abemaciclib, and palbociclib. The checklists include performing reviews of current medications for drug interactions, obtaining baseline blood counts and liver/kidney function tests, monitoring for side effects like diarrhea and assessing adherence. Patients should be educated on expected adverse reactions and when to contact their provider.

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    CDK46_Inhibitors_Administration_Checklist

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    This document provides checklists for administering CDK4/6 inhibitors ribociclib, abemaciclib, and palbociclib. The checklists include performing reviews of current medications for drug interactions, obtaining baseline blood counts and liver/kidney function tests, monitoring for side effects like diarrhea and assessing adherence. Patients should be educated on expected adverse reactions and when to contact their provider.

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    © All Rights Reserved
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    9 views1 page

    CDK4/6 Inhibitors Administration Checklist: Ribociclib

    Uploaded by

    Nicole
    This document provides checklists for administering CDK4/6 inhibitors ribociclib, abemaciclib, and palbociclib. The checklists include performing reviews of current medications for drug interactions, obtaining baseline blood counts and liver/kidney function tests, monitoring for side effects like diarrhea and assessing adherence. Patients should be educated on expected adverse reactions and when to contact their provider.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
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    of 1

    CDK4/6 Inhibitors Administration Checklist

    Ribociclib
    o Perform comprehensive review of current
    medications.
    • Any CYP3A4 inducers or inhibitors?
    • Any medications that can prolong QTc
    interval?

    Abemaciclib Palbociclib
    o Obtain complete blood count (CBC).
    • Prior to treatment
    • Every 2 weeks for the first 2 months
    • At the beginning of the subsequent 4
    cycles
    o Perform comprehensive review of current o Perform comprehensive review of current o Monitor electrolytes at the beginning of
    medications. medications. each cycle for 6 cycles
    • Any CYP3A4 inducers or inhibitors? • Any CYP3A4 inducers or inhibitors? o Obtain baseline electrocardiogram (ECG).
    o Obtain complete blood count (CBC). • Prior to first treatment
    o Obtain complete blood count (CBC).
    • Prior to first treatment • Day 14 of the first cycle
    • Prior to first treatment
    • Every 2 weeks for the first 2 months • At the beginning of the second cycle
    • At the beginning of each cycle
    • Monthly for the next 2 months
    • Day 15 of the first 2 cycles o Perform liver function test (LFT).
    o Perform liver function test (LFT).
    • Prior to treatment
    • Prior to treatment o Evaluate for esophagitis or inability to
    • Every 2 weeks for the first 2 months
    • Every 2 weeks for the first 2 months swallow pills.
    • At the beginning of the subsequent 4
    • Monthly for the next 2 months
    o Evaluate for pregnancy. cycles
    o Evaluate for esophagitis or inability to
    swallow pills. o Assess risk for adherence. o Evaluate for esophagitis or inability to
    o Evaluate for pregnancy. swallow pills.
    o Patient education: expected adverse
    o Assess risk for adherence. o Evaluate for pregnancy.
    reactions and when to notify your
    o Instruct patient at the first sign of loose o Assess risk for adherence.
    healthcare provider
    stool to initiate antidiarrheal therapy.
    o Patient education: expected adverse
    o Patient education: expected adverse
    reactions and when to notify your
    reactions and when to notify your
    healthcare provider
    healthcare provider

    If clinically indicated, tests might not follow exact schedule. (Eli Lilly and Company, 2017; Novartis, 2017; Pfizer Inc., 2017)

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