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  • Hema 2 - Activity 5 - Yabes

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    Valdez Francis Zaccheau
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    10 views2 pages

    Hema 2 - Activity 5 - Yabes

    Uploaded by

    Valdez Francis Zaccheau

    Copyright:

    © All Rights Reserved
    Download as PDF or read online from Scribd
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    of 2
    Laboratory Manual in CEnical Hematology 2 (MTPC 118) REPORT SHEET Activity No. 5 CLOT RETRACTION TIME Name: Jabes. Sy Leen B. Rating: - Date Performed: March 9, 2ozt Date Submitted: March (2, 2021 __ 4 RESULTS: Name of Patient: Jouilyy Yabes Age/Gender: _26 / female : Clot Retraction Result: Normal Interpretation: Complete _ Retrachon _ Illustrate the final set-up. Result after 2 hours Result after 24 hours Laboratory Manual in Cinial Hematology 2 (TPC 118) REVIEW QUESTIONS: 1. Give the clinical signifi : relokth ae nosing hemor Spas time test and observation inical signticance of clot petty ji it ction time test indicates tha Poet Pas Tirombastheria. and/or Berard ovlee Syxdtone,uhlen tere is a high value for the Clot Reachon Time. In addtion, Clot refraction time that is prol 5 r longed may indicale bleeding disorders like Hemophilia, Yon Uillebrand disease, and deficiency in vomin K. Reduced clot redraction time may be caused by Disseminated Inrowasoulor Coagulation (010), hypofiloring- geremnia, and dysfibrinagenemia. In Giggnosing temonhagio disorders, the clot ae oe adhere on the sides of pecimen tube which makes the clot Na, K-CHay 13, 2019). Clot Reaction Blood Test March 9 202) 2 ae boepesare ve cn enon reece roche laoreet erect Platelets induce clot retraction by releasing multiple Coagulation foclors therein the octiated platelets incorporaled in the clot rearrange Ond contract their infracelilar actin myosin ene The. intracellular actin network is comected to the intemal part of fhe inlegrin allbA3 fibrinogen receptor. following coagulation, the, exlernal part of allb83 wil have. bound fo the fibrin network, the formed clot vill compact on itself and hence reduce, its volume. Lastly, the relracton is driven by the interaction between the Fibrin cuside the celle and the actin-mosin skeleton of te, platelets, which is mediated by ailbB3. clot Relroction.(n.d) ikon March 9, 202) from platelets.se/clo}-rerackay, 3. Briefly discuss fibrinolysis. oe Fibrinolysis is the breakdown of fibrin within blead clots. There are tuo ‘ypes of fibrinolysis, being primary and secondary fibrinolysis. Frmary fibnnolysis Coens naturally ond secondary fibninclysis occurs due to an external cause Such as medicine or a medical disorder Fibrinolysis ic fighlly controlled by the actions of various cofe inhibitors, cane ssmin is the main protein thal activates fo Pasmia is comerted from Plasminogen by tissve plasminggen aasiolor Ciba) Ord urokinase (up A). tPA is syheseed ty endothelial cells whereas uPA is Syttesized ky monocytes, macrophages and urinary epithelium cells. yPA Jower affinity fo Plasminogen thon PA, also uPA does not require fibrin. ars @ cofactor to iiniiale plasmin formotion. Plasimin activates {pA ond uPA creating a positive Redback leop where the activation of plasminogen leads fo more, adlvation of plasminagen. This positive Redback loop ig Crucial as clearing blood clots that have, oie! their purpose, ig ex important. Hokenzie, 6. Cad) brat ie Fibrinclcis? Rebeed Horch 4 202) Foy tne ————_itwans-nedical.ne/ heath shat is~ brinolyére. O

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