66

66) Recent evidence shows that signals from the extracellular matrix (ECM) can regulate
the expression of genes in the cell nucleus. A likely mechanism is that
A) mechanical signals of the ECM can alter the cytoskeleton, which can alter intracellular
signaling.
B) intracellular signals might cause changes in the fibronectin binding to the cell surface.
C) orientation of microtubules to the ECM can change gene activity.
D) integrins that receive signals from the ECM migrate to the nucleus.
E) proteoglycans in the ECM undergo endocytosis and produce intracellular signaling molecules.
A
67
67) Signals between the ECM and the cytoskeleton may be transmitted by
A) fibronectin.
B) proteoglycans.
C) integrins.
D) collagen.
E) middle lamella.
C
68
68) ECM proteins are made by ribosomes in which part of a eukaryotic cell?
A) mitochondria
B) cytoplasm
C) nuclear envelope
D) Golgi apparatus
E) rough ER
E
69
69) What types of proteins are not synthesized in the rough ER?
A) endoplasmic reticulum proteins
B) extracellular matrix proteins
C) secreted proteins
D) mitochondrial proteins
E) plasma membrane proteins
D
70

70) Which of the trees in this figure groups the domains according to similarities in cellular
size and architecture?