Diketahui:

DB0 = 200mg
BB = 80kg
t = 6jam
Cp = 1,5 mg/100ml
Vd = 10% BB

Ditanya: total obat pada t 6 jam dan t½ obat?

Jawab:
Vd = 10g/100 x 80000g
Vd = 8000ml atau 8L
8000ml = Db / 1,4mg/100ml
Db = 8000ml x 1,5mg/100ml
Db = 200mg

Log Db = -kt / 2,303 + log Db0

Log 120 = -k x 6 / 2,303 + log 200
2,0791 = -k x 6 / 2,303 + 2,3010
k x 6 / 2,303 = 2,3010 - 2,0791
k = 0,0851 jam-1

t½ = 0,693 / 0,0851 = 8,14 jam