Scribd Logo
Upload

Welcome to Scribd!

  • Kaposi Sarcoma

    Uploaded by

    ZiaKhan
    8 views49 pages
    Kaposi sarcoma is a reactive hyperplasia of blood and lymphatic vessels caused by human herpesvirus 8. It has several subtypes including classic, endemic, AIDS-related, and iatrogenic forms. The AIDS-related subtype is the most aggressive and fatal, typically involving the skin, mucosa, lymph nodes, lungs, and GI tract. Prognosis depends on the ACTG staging system, with stage T1S1 having the best 3-year survival rate. Diagnosis is made through biopsy and histopathological examination showing vascular spaces lined by hyperchromatic endothelial cells. Treatment involves surgery, radiation, chemotherapy or antiretroviral therapy depending on the extent of disease.

    Original Description:

    Kaposi sarcoma

    Original Title

    Kaposi sarcoma

    Copyright

    © © All Rights Reserved

    Available Formats

    PDF, TXT or read online from Scribd

    Did you find this document useful?

    Is this content inappropriate?

    Report this Document
    Kaposi sarcoma is a reactive hyperplasia of blood and lymphatic vessels caused by human herpesvirus 8. It has several subtypes including classic, endemic, AIDS-related, and iatrogenic forms. The AIDS-related subtype is the most aggressive and fatal, typically involving the skin, mucosa, lymph nodes, lungs, and GI tract. Prognosis depends on the ACTG staging system, with stage T1S1 having the best 3-year survival rate. Diagnosis is made through biopsy and histopathological examination showing vascular spaces lined by hyperchromatic endothelial cells. Treatment involves surgery, radiation, chemotherapy or antiretroviral therapy depending on the extent of disease.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    8 views49 pages

    Kaposi Sarcoma

    Uploaded by

    ZiaKhan
    Kaposi sarcoma is a reactive hyperplasia of blood and lymphatic vessels caused by human herpesvirus 8. It has several subtypes including classic, endemic, AIDS-related, and iatrogenic forms. The AIDS-related subtype is the most aggressive and fatal, typically involving the skin, mucosa, lymph nodes, lungs, and GI tract. Prognosis depends on the ACTG staging system, with stage T1S1 having the best 3-year survival rate. Diagnosis is made through biopsy and histopathological examination showing vascular spaces lined by hyperchromatic endothelial cells. Treatment involves surgery, radiation, chemotherapy or antiretroviral therapy depending on the extent of disease.

    Copyright:

    © All Rights Reserved
    Download as PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 49

    KAPOSI SARCOMA

    Rook’s Textbook of Dermatology

    Presenter: Dr Saad Zia


    Chapter overview
    • Basics
    • Classification
    – Epidemiology
    – Clinical features
    • Prognosis
    • Practice questions
    – Pathology
    • Investgations & Management
    Basics
    NOT a sarcoma but REACTIVE HYPERPLASIA
    • Blood vessels
    • Lymphatics
    Basics
    • HHV-8
    • LN involved- Lymphoedema
    • Blue/Dark purple
    • GI / Lungs involved
    Basics-Evolution
    Patch→ plaque → tumor stage
    Classification-subtypes
    • Classic
    • Endemic
    • AIDS related
    • Iatrogenic
    Classic
    • Old age
    • Start with Legs→ Slowly progressive
    • Eastern Europe / Mediterranean
    • Ashkenzi Jews
    Geography
    Geography
    Geography
    Endemic-Africa
    • Children/ young adults
    • Lower limbs
    • EBV associated
    • Lymphadenopathy ± Skin involvement
    • AGGRESSIVE- Fatal→2y
    Iatrogenic
    • Transplant pts
    • CS
    • Ciclosporin
    • Chemo
    AIDS related
    • MSM →40%
    • Head / Neck /Arms/ Trunk
    • Mucosal/Visceral
    • AGGRESSIVE- Fatal→18m without Rx
    • Rx HAART →IRIS
    Visceral involvement
    • Mainly in AIDS related KS
    • Lungs
    • GI→ Massive haemorrhage
    • LN
    IRIS
    IRIS
    IRIS
    PROGNOSIS
    Karanofsky
    Performace status score
    AIDS clinical Trial Gp
    Staging system for KS
    ACTG
    Staging system for KS
    PROGNOSIS→3y survival
    ACTG stage T1S1

    All othe stages


    DD
    • Pyogenic granuloma/Hemangioma
    • Malignant Melanoma
    • CTCL
    • Stasis Eczema
    • Acroangiodermatitis
    Questions
    Questions
    Questions

    Kasabach Meritt Syndrome


    Questions

    Kasabach Meritt Syndrome


    Hemangioma thrombocytopenia syndrome
    CLINICAL SLIDES &
    HISTOLOGY
    HIV related- Face
    HIV related- Face
    KS- Patch stage
    KS- Patch stage
    KS- Nodular/Tumor
    stage
    HIV related- Face
    Vascular spaces-spindle cells
    Vessel lining-Hyperchromatic
    Endothelial cells
    Vascular spaces
    Dissecting collagen
    Vascular spaces-Haemorrhage
    Promontory sign
    Geography
    Promontory sign
    IH-Stains
    • CD 31
    • CD 34
    • Factor VIII
    • D2-40 /podoplanin
    • Latent nucler antigen 1
    – HHV8
    Investigations
    • Labs →WNL
    • Test for HIV
    • Biopsy for HP
    • HHV-8 testing NOT done
    Management
    • Limited Disease
    – Excision /Cryo
    – Imiquimod
    – I/L Inf α2b / Vinblastine
    • Radiotherapy→ 93% pts respond
    • HIV related → HAART/ cART
    • Iatrogenic → correct immunosuppression
    Management
    Advanced /Disseminated Disease
    • Liposomal Dxorubicin
    • Paclitaxel
    • Imanitib
    THANK YOU

    You might also like