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949469

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FAIXXX10.1177/1071100720949469Foot & Ankle InternationalErden et al

Article

Foot & Ankle International®

Outcome of Corticosteroid Injections,


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© The Author(s) 2020
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Extracorporeal Shock Wave Therapy, and sagepub.com/journals-permissions
DOI: 10.1177/1071100720949469
https://doi.org/10.1177/1071100720949469

Radiofrequency Thermal Lesioning for journals.sagepub.com/home/fai

Chronic Plantar Fasciitis

Tunay Erden, MD1 , Berkin Toker, MD1, Omer Cengiz, MD2, Bugra Ince, MD3,
Seyda Asci, PhD4, and Ali Toprak, PhD5

Abstract
Background: Chronic heel pain with plantar fasciitis is relatively common and can affect adults of all ages regardless of an
active or sedentary lifestyle. The purpose of the present study was to evaluate the effectiveness of corticosteroid injection
(CSI), extracorporeal shock wave therapy (ESWT), and radiofrequency thermal lesioning (RTL) treatments in chronic
plantar heel pain that has been unresponsive to other conservative treatments.
Methods: We retrospectively analyzed the results of 217 patients treated with CSI (n = 73), ESWT (n = 75), and RTL
(n = 69). The treatment efficacy and pain intensity, as measured using the visual analog scale, were recorded and compared
at the 6-month follow-up.
Results: Pain intensity decreased significantly in all patients. However, it decreased significantly more in the CSI and RTL
groups than in the ESWT group (P < .001). Age, sex, body mass index, calcaneal spur presence, and symptom duration
were similar among 3 groups (P > .05). No complications were noted after the CSI, ESWT, or RTL sessions.
Conclusion: CSI, ESWT, and RTL successfully treated chronic plantar heel pain that did not respond to other conservative
treatments; however, CSI and RTL yielded better therapeutic outcomes.
Level of Evidence: Level III, retrospective comparative study.

Keywords: corticosteroid injection, extracorporeal shock wave therapy, calcaneus, heel pain, plantar fasciitis,
radiofrequency

Introduction (excessive pronation of the foot); and certain extrinsic


factors, such as previous injury to the heel, improper shoe
Chronic heel pain associated with plantar fasciitis (PF) is fit, and improper running pattern.1,5
one of the most common clinical entities encountered by
foot and ankle specialists and affects adults of all ages with
1
either an active or sedentary lifestyle.9 Within their lifetime, Department of Orthopaedics and Traumatology, Acıbadem Fulya
10% of the general population is expected to present to Hospital, Istanbul, Turkey
2
Department of Orthopaedics and Traumatology, Istanbul Kartal Dr.
orthopedic surgeons with heel pain due to degenerative Lutfi Kirdar Education and Research Hospital, Istanbul, Turkey
changes in the plantar fascia.19,20 PF results from the cumu- 3
Department of Physiotherapy and Rehabilitation, Faculty of Medicine,
lative effect of recurrent microinjuries and chronic damage Bezmialem Vakif University, Istanbul, Turkey
4
in the plantar aponeurosis at the insertion of the plantar fas- Vocational School of Health Services, Gelisim University, Istanbul,
cia on the medial process of the calcaneal tuberosity.7 Turkey
5
Department of Biostatistics and Medical Informatics, Faculty of
Severe pain in the medial tubercle of the calcaneus during Medicine, Bezmialem Vakif University, Istanbul, Turkey
weightbearing in the morning that decreases in intensity
during standing is the main symptom of PF.30,33 The main Corresponding Author:
Tunay Erden, MD, Department of Orthopaedics and Traumatology,
predisposing risk factors include an older age; certain ana- Acıbadem Fulya Hospital Sports Medicine Center, Dikilitaş, Hakkı Yeten
tomic risk factors, such as leg length discrepancy, high body Cd. No. 23, Istanbul, 34349, Turkey.
mass index (BMI), thick plantar fascia, and pes planus Email: doktorerden@hotmail.com
2 Foot & Ankle International 00(0)

Table 1.  Inclusion and Exclusion Criteria for the Study.

Inclusion criteria Exclusion criteria


1. ≥18 and <65 years of age   1. History of trauma or calcaneal fracture
2. Heel pain present for at least 6 months   2. Osteoarthritis, diabetes mellitus, pregnancy
3. ≥5 of the VAS present at the first steps taken in   3. Pain related to peripheral neuropathy or ischemia
the morning   4. Inability to tolerate injections to the heel region
4. Previously attempted at least 2 of the following   5. Allergy to local anesthetics or steroids
conservative measures:   6. Open wounds on the study foot
 Arch supports   7. Local or systemic infection on the date when the procedure was to be
 Physical therapy performed
 Home stretching   8. Previous use of steroidal injection to the heel, previous use of ESWT,
 Oral anti-inflammatories previous use of RTL
 Night splint   9. History of surgical intervention to the heel or any functional limitation of
 Taping/strapping the affected foot
10. Chronic heart disease; neurologic, hepatic, and/or metabolic disease; or
dermatologic infections
11. Seronegative spondyloarthropathy

Abbreviations: ESWT, extracorporeal shock wave therapy; RTL, radiofrequency thermal lesioning; VAS, visual analog scale.

PF is typically a self-limiting condition, and none of the for CPF between 2016 and 2019. Eighty-seven patients who
current treatment modalities have shown superiority when did not attend regular follow-ups or did not meet the inclu-
used alone.36 Based on the natural course of the disease, sion criteria were excluded from the study (21 patients from
nonsurgical treatments are usually administered, including group 1, 36 patients from group 2, and 30 patients from
rest, cold and warm water compression, plantar stretching group 3), and the results of the remaining 217 patients were
exercises, braces and orthoses, nonsteroidal anti-inflamma- reviewed. All of the patients had heel pain that had been
tory drugs (NSAIDs), corticosteroid injections (CSIs), present for at least 6 months and did not respond to multiple
platelet-rich plasma (PRP) injections, botulinum toxin conservative treatments. The full inclusion and exclusion
injections, transcutaneous electrical nerve stimulation, criteria are presented in Table 1. The follow-up examina-
cryotherapy, radiofrequency thermal lesioning (RTL), and tions were performed by 2 physicians and examination
extracorporeal shock wave therapy (ESWT).3,7,19,36 results were recorded. All patient results were investigated
Nonsurgical management of PF is successful in approxi- via the electronic records system. The patients who met the
mately 90% of patients.3,18 Surgical procedures, including inclusion criteria were divided into CSI (group 1; n = 73),
the removal or release of the fascia and removal of bone ESWT (group 2; n = 75), and RTL (group 3; n = 69)
spurs, are indicated if conservative treatment fails after 6 groups. The patients were distributed to the groups accord-
months to 1 year.7,36,40 ing to their first day of arrival in the hospital. Patients arriv-
There is no definitive treatment for PF; therefore, physi- ing on Monday and Tuesday were added to group 1, those
cians and patients choose a treatment based on their own arriving on Wednesday and Thursday were added to group
experiences and interests. Of the 30 nonoperative treat- 2, and those arriving on Friday and Saturday were added to
ments recommended for patients with PF, CSI, ESWT, and group 3. The patients in the groups were also evaluated by
RTL have been compared in a few studies, but no studies their age, sex, BMI, and symptom duration. All the patients
have compared the 3 methods as the primary treatments for underwent lateral and axial radiographs to rule out the pres-
chronic plantar fasciitis (CPF). ence of any possible lesions, such as osteomyelitis, tumors,
The purpose of the present study was to evaluate the or fractures. All patients underwent clinical evaluations at
effectiveness of CSI, ESWT, and RTL treatments on chronic baseline and at 1, 3, and 6 months after treatment. The
plantar heel pain that has been unresponsive to other con- severity of the pain before and after the CSI, ESWT, and
servative treatments. Our hypothesis was that in the treat- RTL during the last 24 hours at rest, at the first step in the
ment of chronic plantar heel pain, treatment with CSI would morning, and during daily activities at the area of the plan-
be more successful than the RTL and ESWT treatment tar fascia origin on the medial tubercle was recorded using
methods. a visual analog scale (VAS), ranging from 0 to 10, with 0
indicating no pain and 10 indicating severe pain.
Of the 217 patients, 184 (84.79%) were female and 33
Methods
(15.21%) were male. The right foot of 140 patients (64.5%)
After we received institutional review board approval, we and the left foot of 77 patients (35.5%) were affected. There
retrospectively analyzed the results of 304 patients treated were 73 patients in the CSI group (group 1), 75 in the ESWT
Erden et al 3

Table 2.  Characteristics of the 217 Patients in the CSI, ESWT, and RTL Groups.

Group 1 (CSI) Group 2 (ESWT) Group 3 (RTL)


Sex, M/F 11:62 9:66 13:56
Age, y
 Mean ± SD 45 ± 9.1 43 ± 9.6 41 ± 10.1
 Range 27-65 26-62 29-65
Affected foot, right/left 46:27 56:19 38:31
BMI, kg/m2 29.1 ± 2.4 29.7 ± 3.0 30.4 ± 2.9
Symptom duration, mo
 Mean ± SD 8.1 ± 1.5 7.8 ± 1.0 8.6 ± 1.6
 Range 6-10 7-11 6-11
Presence of plantar spur (%) 58.9 48.0 57.9

Abbreviations: CSI, corticosteroid injection; ESWT, extracorporeal shock wave therapy; RTL, radiofrequency thermal lesioning.

group (group 2), and 69 in the RTL group (group 3). There were instructed to practice stretching exercises and wear
were no significant differences in age, sex, BMI, symptom silicone heel cups following ESWT.
duration (month), or side of involvement across the groups
(all P > .05) (Table 2). The relationships between BMI and
Radiofrequency Thermal Lesioning
age and VAS score changes were evaluated with the
Spearman test, and no statistically significant differences The NeuroTherm NT1100 device (NeuroTherm, Wilmington,
were detected (P = .24, P = .32, and P =.52 and P = .24, P MA) was used during each session. For RTL, we applied the
= .55, and P = .41 for groups 1, 2, and 3, respectively). same technique employed by Arslan et al.2 The plantar fascia
The radiographic evaluations showed calcaneal spurs in was palpated with the patient in the prone position, and the
43 patients (58.9%) in group 1, 36 patients (48%) in group painful and tender region was marked by a skin marker.
2, and 40 patients (57.9%) in group 3. No statistically sig- Under sterile conditions, 0.5 mL of lidocaine was adminis-
nificant differences were found between sex and spur exis- tered at the entry points of the cannula, and a 22-gauge radio-
tence or VAS score changes (P = .38, P = .83, and P = .98 frequency (RF) cannula was inserted into the plantar heel
and P = .82, P = .18, and P = .19 for groups 1, 2, and 3, at an angle of 120 degrees. Initially, a low voltage, such as
respectively). 1 V, was used, and the occurrence of any type of stimula-
tion, movement of the toes, or fasciculation was noted.
When an involuntary foot or toe contraction was recorded,
Corticosteroid Injection the probes were removed and repositioned to the heel to
For the CSIs, 1 mL of methyl prednisolone acetate (40 mg) prevent neurological injuries. To find the appropriate posi-
and 1 mL of lidocaine 2% were injected into the site of max- tion, we initially used a frequency of 50 Hz and voltage of
imal tenderness at the inferomedial calcaneal tuberosity.20 0 V and gradually increased the voltage until the patient
Care was taken so that the skin, subcutaneous tissue, and/or experienced a tingling sensation; at this point, we began to
fat pad were not injected. The procedure was performed by reduce the voltage. A tingling sensation at a voltage of
a single orthopedic surgeon (B.T.). All patients were <0.5 V indicated that the probe was close to a sensory
instructed to practice stretching exercises and wear silicone nerve. The settings of the machine were then fixed, and
heel cups following the CSI. after a temperature of 90 °C was reached, 90-second ther-
mal ablation was performed. This process was applied to 1
to 3 different points of pain, with consideration of the
Extracorporeal Shock Wave Therapy potential variations in neural anatomy. At the end of the
ESWT (Masterpuls MP100; Storz Medical, Tägerwillen, procedure, the heel area was covered with sterile bandages.
Switzerland) was administered once a week for 3 weeks; The procedure was performed by a single orthopedic sur-
2000 impulses were administered to the plantar heel region geon (T.E.). All patients were instructed to apply ice packs
with a frequency of 15 Hz and pressure of 1.8 bar.23 After for 3 days, practice stretching exercises, and wear silicone
each patient lay down in a comfortable position, the area of heel cups following RTL.
maximum tenderness was marked with a skin marker, and
the procedure was performed by a single physical therapy Statistical Analysis.  The statistical analyses were performed
and rehabilitation specialist (B.I.). No anesthetics or narcot- using IBM SPSS Statistics for Windows version 22 (IBM
ics were used during the treatment protocol. All patients Corp, Armonk, NY). First, a Kolmogorov-Smirnov test was
4 Foot & Ankle International 00(0)

Table 3.  VAS Scores Before and After Treatment in All Groups.

Pretreatment VAS 1st-mo VAS 3rd-mo VAS 6th-mo VAS P value


Group 1 (CSI) (n = 73) Median (Q1-Q3) 9 (8-10) 2 (1-3) 2 (1-2) 1 (1-2) <.001
Mean ± SD 8.9 ± 1.1 2.2 ± 1.1 1.7 ± 0.7 1.4 ± 0.7
Group 2 (ESWT) (n = 75) Median (Q1-Q3) 9 (8-10) 4 (3-5) 4 (4-5) 5 (4-6) <.001
Mean ± SD 8.8 ± 1.0 3.8 ± 1.1 4.2 ± 0.8 4.9 ± 0.8
Group 3 (RTL) (n = 69) Median (Q1-Q3) 10 (8-10) 3 (2-3) 2 (2-2) 2 (2-2.5) <.001
Mean ± SD 9.2 ± 1.1 2.6 ± 1.1 1.9 ± 0.7 2.1 ± 0.7

Abbreviations: CSI, corticosteroid injection; ESWT, extracorporeal shock wave therapy; RTL, radiofrequency thermal lesioning; Q1, quarter 1; Q3, quarter 3;
VAS, visual analog scale.

used to determine which variables should be included in the


data analysis and whether the data for the variables were
normally distributed, but the data were not normally distrib-
uted. Therefore, nonparametric tests were used. The Freid-
man test was used to analyze multiple variables within
groups, and when statistically significant results were
observed, the Wilcoxon matched-pair signed-rank test was
used to compare the corresponding variables. The Wilcoxon
signed-rank test was used to compare 2 variables within the
same group. The Kruskal-Wallis test was used to compare
continuous variables (age, BMI, symptom duration, and
change) across groups 1, 2, and 3, and when statistically
significant results were observed, Dunn’s post hoc test was
used to compare the corresponding variables. The Mann- Figure 1.  Graphical illustration of the visual analog scale
Whitney U test was used to compare categorical variables (VAS) scores before treatment and at 1, 3, and 6 months after
between 2 groups (sex and spur presence). Relationships treatment in all groups. CSI, corticosteroid injection; ESWT,
among continuous variables (age and BMI) were evaluated extracorporeal shock wave therapy; RTL, radiofrequency
with the Spearman correlation coefficient. The median (Q1 thermal lesioning.
[1st quarter]–Q3 [3rd quarter]), mean ± standard deviation,
frequency, and percentage constituted the descriptive statis- posttreatment and between the first and third months post-
tics. The statistical significance level was set to P < .05. treatment (all P < .001) (Table 3).
The mean VAS score changes are shown in Table 4. The
changes between the pretreatment VAS scores and the scores
Results at other time points (first, third, and sixth months) were com-
The VAS was used to evaluate all groups before the treat- pared across the groups, and significant results were observed
ment and at 1, 3, and 6 months after the treatment, and the (Table 4). There was a significant difference between groups
posttreatment scores were statistically significantly lower 1 and 2 and between groups 2 and 3 in the changes across all
than the pretreatment scores in all groups (Table 3, Figure 1). 3 time points (P < .001 and P < .001, respectively). The
In group 1 (CSI), there was a significant difference between VAS score change was not statistically significantly different
the pretreatment VAS score and posttreatment VAS scores at between groups 1 and 3 because the responses to the treat-
1, 3, and 6 months (all P < .001) (Table 3). In addition, the ment were similar (P = .81). No complications were noted
VAS score was significantly lower in the sixth month after after the CSI, ESWT, or RTL sessions.
the treatment than in the first month (P < .001) (Table 3,
Figure 1). In group 2 (ESWT), for the VAS scores, only the
Discussion
difference between the first and third months after treatment
was not statistically significant (P > .05), while there was a Heel pain attributed to PF is one of the most common foot
significant difference in the other within-group comparisons conditions that occurs, and many treatments have been pro-
(pretreatment vs 1, 3, and 6 months posttreatment, 1 month posed for its management. In this study, the clinical results
vs 6 months posttreatment, and 3 months vs 6 months post- of CSI, ESWT, and RTL, which are the treatment options
treatment; all P < .001) (Table 3). In group 3 (RTL), for the for CPF cases, were compared. The final results of the study
VAS scores, there was a statistically significant difference partially supported our hypothesis because RTL treatment
between pretreatment and the first, third, and sixth months also yielded similar results to CSI. Controversial results
Erden et al 5

Table 4.  Changes in the VAS Score at the First-, Third-, and Sixth-Month Follow-ups.

VAS score reduction

  1st-mo visit 3rd-mo visit 6th-mo visit

CSI ESWT RTL CSI ESWT RTL CSI ESWT RTL


  (n = 73) (n = 75) (n = 69) (n = 73) (n = 75) (n = 69) (n = 73) (n = 75) (n = 69)
Median (Q1-Q3) 7 (6-8) 5 (4-6) 7(6-8) 7 (6-8) 4 (4-5) 7 (6-8) 8 (7-9) 4 (3-5) 7 (6-8)
Mean ± SD 6.7 ± 1.5 5.0 ± 1.5 6.6± 1.5 7.2 ± 1.2 4.5 ± 1.2 7.2 ± 1.2 7.5 ± 1.4 3.8 ± 1.3 7.1 ± 1.1
P value <.001 <.001 <.001

Abbreviations: CSI, corticosteroid injection; ESWT, extracorporeal shock wave therapy; RTL, radiofrequency thermal lesioning; Q1, quarter 1; Q3, quarter 3;
VAS, visual analog scale.

have been reported regarding whether ESWT is effective in there was a significant reduction in the VAS score in the
treating PF. first month posttreatment compared with the pretreatment
The effectiveness of ESWT has been reported in some score. However, it was observed that the VAS score
placebo-controlled studies. Haake et al13 reported that decreased less in the ESWT group than in the CSI and RTL
ESWT is ineffective in treating CPF. Speed29 reported no groups.
beneficial effects of ESWT compared with a placebo during CSI at the point of maximal tenderness upon palpation
a 6-month period. Similarly, Buchbinder et al6 found no evi- is an effective treatment for CPF. Although this treatment
dence suggesting that ultrasound-guided ESWT is more seems to be very effective, there are conflicting results
effective than placebo at relieving pain, improving func- regarding the duration of its effects after the injection.
tion, or improving quality of life after 6 and 12 weeks. In Ball et al4 reported significant improvements with CSI in
contrast, there have been many studies showing that the the short and medium term. Similarly, Crawford and
success rate of ESWT in treating CPF is between 48% and Thomson10 reported that CSI can be useful in the short
88% and that it significantly decreases the VAS score.12,17,18,22 term. Ugurlar et al35 reported that CSIs are more effective
It has been suggested that ESWT is safer than CSIs, and the in the first 3 months after treatment than are ESWT, PRP
therapeutic benefits of ESWT start 2 weeks after applica- injections, and prolotherapy. In a systematic review, Uden
tion.22,25,29 In contrast to Buchbinder et al, Theodore et al31 et al34 reported similar results for CSI and the use of cus-
reported better results for ESWT in a placebo-controlled tomized functional foot orthoses for PF. Whittaker et al37
trial. Rompe et al26 observed significant improvements in reported that CSIs are more effective than some other
56% of the patients treated with ESWT and in 16% of the treatments at relieving pain and improving function in
patients treated with a placebo at 12 weeks after the treat- people with plantar heel pain. However, in another study,
ments, and these proportions increased to 88% and 34%, CSIs were not more effective than placebo injections at
respectively, after 1 year. In another study, Melegati et al21 reducing pain or improving function. Kane et al16 reported
divided patients into 2 groups, those with a history of ste- successful results over a long follow-up period after CSI.
roid injections (group A) and those without a history of ste- Tsai et al32 reported that the therapeutic effects of steroid
roid injections (group B). Three sessions of ESWT were injections lasted approximately 1 year. Porter and
applied to both groups. After 2 months, no pain was detected Shadbolt24 compared ESWT with CSI and reported suc-
in 31.6% of the patients in group A and 11.5% of the patients cessful results with both methods. In their studies, the
in group B. At 10 months after EWST, 39.5% of the patients level of pain was lower in the 3rd month after CSIs, but
in group A were pain free, but none of the patients in group the pain level was similar between the 2 groups at the
B were pain free. Yucel et al41 reported an 88% success rate 12th month. Kalaci et al15 reported there are long-term
in the ESWT group in the third month after treatment. Ozan positive effects of CSI. Similarly, Genc et al11 reported
et al23 compared the results of RTL and ESWT in patients that the VAS score continued to decrease at 6 months after
with CPF and reported similar success rates. It was also CSI in their long-term follow-up study. In our study, the
reported that the VAS score continued to decrease in the VAS scores continued to decrease until the sixth month
first, third, and sixth months after treatment in both groups. after treatment in the CSI group, and the VAS score
In a randomized controlled study, Ugurlar et al35 reported decreased more in the CSI group than in the other groups.
that ESWT was successful, especially in the first 6 months RTL acts by dissipating heat from an active electrode
after treatment, but its effectiveness decreased after the first and has been used to treat numerous clinical conditions,
year. In our study, the ESWT group had a similar success including Morton’s neuroma, trigeminal neuralgia, lumbar
rate; although the results worsened after the first month, disc herniation, coronary vascular disease, cardiac
6 Foot & Ankle International 00(0)

arrhythmia, cervical pain syndrome, lateral epicondylitis, Declaration of Conflicting Interests


and essential tremor.28,39 During the percutaneous RTL The author(s) declared no potential conflicts of interest with
procedure, most surgeons use fluoroscopy to confirm the respect to the research, authorship, and/or publication of this arti-
location of the electrode.8,14 However, successful results cle. ICMJE forms for all authors are available online.
have been reported without the use of fluoroscopy.14,28
Similarly, we performed RTL without fluoroscopy to con- Funding
firm the location of the electrode. In an ultrasound-guided The author(s) received no financial support for the research,
percutaneous RTL study for PF, Wu et al38 reported a authorship, and/or publication of this article.
reduction in pain in 83.9% of patients and showed that the
VAS score continued to decrease for 1 year. Sollitto et al27 ORCID iD
performed RTL for resistant PF and reported that 92% of
Tunay Erden, MD, https://orcid.org/0000-0002-0926-5879
the patients experienced a complete resolution of the
symptoms. Cozzarelli et al9 reported a success rate of 89% References
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