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Objective. The objective of this study was to produce a standardized medical risk-related history (MRRH) in order to
identify the medically compromised patient (MCP) attending the general dental practitioner for treatment, to develop
such a history (EMRRH), and to validate it in dental practices in 10 European countries.
Study design. The Dutch MRRH, adapted to allow for legal and cultural differences of the participating countries was
introduced. After consensus and repeated testing, the questionnaire was validated. In this last phase, 1000 patients
older than 18 attending dental practices were selected, 100 per country; 994 medical histories were suitable for
statistical analysis. Validation was carried out by a physician accustomed to making preoperative assessments,
including the ASA risk classification.
Results. Mean specificity per country was 99.1 and per EMRRH item was 99.0. Mean sensitivity per country was 93.2
and per item was 93.7. Cohen’s kappa for the countries involved was 0.81 to 0.98 and for subsequent questions was
0.81 to 0.97.
Conclusion. The EMRRH was found to be valid in the detection of medically compromised patients in 10 European
countries. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:597-605)
597
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598 Abraham-Inpijn et al. May 2008
condition than when the patient came in, it is the Table I. The modified ASA physical classification sys-
responsibility of the dentist to acquire the skills neces- tem for dentistry12
sary to identify patients with medical problems that Class Physical status Therapy modifications
would put them at risk during dental treatment. The I Healthy patient None
participating academic medical and dental centers were II Patient with mild to moderate Possible stress reduction and
concerned that in some countries, not only in Europe, systemic disease not other modification as
dentists may not be sufficiently trained to detect and interfering with daily life indicated
III Patient with severe systemic Possible strict modifications;
manage such medical problems.8-11 A preventive in- disease that limits activity stress reduction and
strument is needed to ensure the medical safety of but is not incapacitating medical consultation are
patients in dental practices in Europe. This patient- priorities
administered European Medical Risk Related History IV Patient with severe systemic Minimal emergency care in
(EMRRH; provided at the end of this article) was de- disease that limits activity office; hospitalize for
and is a constant threat to stressful elective treatment;
signed to register medical pathology that can interfere life medical consultation urged
with dental treatment, to indicate the degree of medical V Moribund patient not Treatment in the hospital is
risk involved, and to recommend measures to be taken by expected to survive 24 limited to life support only
the physician and/or the dental practitioner.12-15 hours with or without an
Such an instrument, the Medical Risk Related His- operation
tory (MRRH-98), was part of an inventory study in the
Netherlands. Over a period of 1 year, the number of
medical calamities were recorded in 2 types of general
dental practices. One type used the MRRH-98 system Each center followed the terms of the Declaration of
(reference group), while the control group made use of Helsinki and in addition evaluated the EMRRH in the
various other kinds of history-taking methods. Calam- local cultural and legal context. All legal and cultural
ities due to medical problems dealt were found only in aspects were taken in to account resulting in an
the control group.7 EMRRH acceptable to all participating centers and
This article reports on the prevalence of medical countries. Written informed consent, which covered all
problems in European countries, the need for a ques- information provided to the dentist and to the partici-
tionnaire such as the Medical Risk-Related History pating institutes, was obtained before accepting respon-
(adjusted to meet local ethical and legal norms), and its dents into the study. It was made clear to patients that
validation in the participating countries. The results of declining to participate in the study would not affect
this study across 10 European countries are presented their dental treatment. A power analysis of a pilot study
here. was used to determine the group sizes.
METHODS Questionnaire
Dentists and patients Following an inventory study of calamities in the
Medical and dental experts in 10 European countries dental chair, which was carried out in the Netherlands,
agreed to undertake the preliminary work, such as the MRRH-98 was upgraded and adjusted to meet the
detailing the legal and ethical norms of medical history legal and ethical norms in the participating countries.
taking in their own country, and researching the prev- That EMRRH questionnaire included the ASA risk-
alence of diseases that could interfere with dental treat- score system developed by the American Society of
ment. Anesthesiologists in the early 1940s to assess the risk
These experts were asked to instruct cooperating that general anesthesia poses to patients.16,17 That sys-
general practitioners in the use of the EMRRH. Both tem was modified to assess the risk to patients of dental
the dentists and their patients were provided with writ- treatment carried out under local anesthesia (Table I).18
ten instructions in the appropriate language, outlining The questionnaire consists of a number of “yes or
the reasons behind the EMRRH and how it was to be no” questions designed to detect diseases of the cardio-
used. vascular system, the pulmonary system, and so forth.
In each country the respondents consisted of 100 The main questions are in bold type. A negative reply
individuals, all of them patients who had come in for to the main question signifies that the patient is not
dental treatment. Only those older than 18 were asked suffering from this type of disease or condition, and is
to participate, in accordance with the terms of the recorded as ASA risk I. A positive reply is recorded as
Declaration of Helsinki. The study was approved by the an ASA II risk and alerts the dentist to the presence of
medical ethics committee of the University of Amster- disease. Each main question is followed by 2 or more
dam and marginally tested by the participating centers. subquestions printed in standard type. These subques-
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Volume 105, Number 5 Abraham-Inpijn et al. 599
Table II. An example of the application of the ASA Table III. Characteristics of the patients in the partic-
classification in the European Medical Risk Related ipating countries
History Mean age of Age range,
Question Yes No ASA score* Country % Male patients, y y
Do you experience chest pain upon 0 0 II Belgium 62 51.4 18-78
exertion (angina pectoris)? If so, France 54 45.3 18-82
Are your activities restricted? 0 0 III Germany 45 43.3 18-79
Have the complaints increased recently? 0 0 IV Greece 36 57.7 18-83
Do you have chest pain at rest? 0 0 IV Hungary 36 46.0 19-81
Iceland 43 49.1 19-86
Positive response; ASA II; patients answer the subquestions. Ireland 22 57.0 21-83
Positive response to 1 or more subquestions places patient in ASA III Spain 32 51.9 18-83
or IV. Sweden 43 66.5 55-83
*Each item is subdivided into a main or bold question and one or The Netherlands 45 41.0 19-76
more subquestions. Negative response; ASA I; patients disregard the
subquestions.
Table VI. Cohen’s kappa for the participating countries and disease entities
Cohen’s kappa/ Cohen’s kappa/ Cohen’s Kappa/
Country country Disease disease Disease disease
Belgium 0.91 Chest pain 0.93 Allergy 0.85
France 0.81 Heart attack 0.93 Diabetes 0.95
Germany 0.89 Heart murmer 0.92 Thyroid disease 0.95
Greece 0.89 Palpitations 0.91 Liver disease 0.79
Hungary 0.97 Hypertension 0.86 Malignancy 0.90
Iceland 0.91 Bleeding 0.81 Hypervent. not known
tendency
Ireland 0.88 Epilepsy 0.97 Fainting not known
Spain 0.98 Asthma 0.94 Antibiotic not known
prophylaxis
Sweden 0.95 Lung disease 0.90 Medication 0.93
The Netherlands 0.88 Heart failure 0.87 Kidney disease 0.90
Table VII. The distribution of the ASA risk score in % the mean age of patients was 50.9, as compared with
in the participating countries 42.9 in 1998. That increase is reflected in more medi-
Country ASA I ASA II ASA III ASA IV Mean age cally compromised patients with a higher ASA risk
Belgium 35 40 14 11 51.4 score.13 The decrease in the mean percentage of ASA
France 29 53 10 08 45.3 risk score I from 57 to 28 was spectacular. A compen-
Germany 38 48 09 05 43.3 satory increase in the ASA II percentage score was
Greece 22 52 18 08 57.7
Iceland 52 39 07 02 49.1
recorded, from 26 to 47, while the ASA III percentage
N.Ireland 23 48 17 12 57.0 score increased from 11 to 16 and the ASA IV score
Hungary 28 43 12 17 46.0 from 7 to 9.
Spain 04 65 22 09 51.9 Other studies in the Netherlands and Belgium
Sweden 30 41 26 03 66.5
Netherlands 46 35 14 05 41.0
show the same reduction in the proportion of healthy
Total 28 47 16 09 50.9 patients (ASA score I from 78% to 57%) when the
mean age difference is 10 years. In one study carried
out in the Netherlands, which included 29,424 pa-
tients (mean age 37.1), the ASA risk scores were
The sensitivity score in the Netherlands (93) was ASA score II 12.7%; ASA III 5.7%, and ASA IV
lower than expected, due to language incompetence: 3.6%. In a Belgian study (mean age 47) those scores
some 41% of the residents of Amsterdam were born were 25%, 11%, and 7%.1,22 In a Spanish study with
outside the Netherlands. the EMRRH, a significant difference was found
Because of the low prevalence of diseases in the (Mann-Whitney test P ⬍ .0005) between the average
dental population studied in 1998, it was decided to age of the medically compromised patients (49.39
include dental practices in this study that were thought years; SD 19.61) and the group of patients without
to have a higher mean age. Thus, in the present study, risk-related histories (31.20 years; SD 18.97).23
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602 Abraham-Inpijn et al. May 2008
The results of the EMRRH trial are good and com- any of the participating patients who used the ques-
pare favorably with the specificity (98.9%) and the tionnaire during a 1-year study involving dental
sensitivity (84.8%) found in Fenton and McCartan’s practices in the Netherlands. This compared favor-
validation study of a self-administered patient health ably with a control population of dentists working
questionnaire in a dental practice.24 Other research, with other questionnaires used to record medical
such as the PARS study (prognosis and assessment of calamities.
risk scale) have been subjected to neither validation nor
reliability tests.25 CONCLUSIONS
Any medical risk that is missed could be of impor- The EMRRH has proved to be a useful tool in the
tance for the dental treatment. During a 3-day work- detection of medically compromised patients in 10
shop, all the false-positive and false-negative answers European countries. Its value lies in overcoming the
were analyzed. False-negative replies for allergy were disparity between the various methods of medical
due mainly to the patient’s failure to recognize the history taking in use throughout Europe, including
significance of allergy to pollen. In the same way, the problems associated with the mobility of dental
patients on anticoagulant therapy sometimes failed to manpower within Europe. It can be helpful to pro-
mention bleeding tendencies. Similar omissions were vide clinical data necessary to plan health and dental
detected with respect to the use of medication. The list care. In this respect, a digitalized format of the
of medication taken by the patient proved to be an EMRRH, including the modified ASA risk score and
important check. preventive measures per item, has been developed in
The false-positive answers could easily be detected the Netherlands.
by a brief verification of the positive answers only.
False-positive replies to allergy were due mainly to the This study, which extended over many years, would
side effects of medication. False positive answers for have been impossible without the support of a
hypertension often had to do with the fact that at some number of researchers in the fields of Dentistry and
time in the past the patient had been told that his or her Medicine. We thank, in alphabetical order, Prof. Dr.
blood pressure was elevated. During the follow-up val- J. Banoczy, Prof. Dr. A. Holm, Dr. S. H. Olafsson,
idation visit, the blood pressure level was found to be Dr. Ir. J. Oosting, Prof. Dr. med. H. Spranger, and
Prof. Dr. F. Vinckier.
within normal limits. During the workshop, questions
We are grateful for the help and encouragement
with false answers were reworded to reduce the inci-
provided by Dr. J.L.M. van den Heuvel (chief dental
dence of false replies (Appendix). officer of the ministry of Health, Welfare and Sport in
The lowest medication rate was recorded in the Neth- The Netherlands).
erlands, due to the restrictive management of prescrip-
tion drugs. This is in contrast to the situation in Hun- REFERENCES
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counter. medically compromised patient in dentistry by means of the
The Cohen’s kappa of the individual countries Medical Risk Related History (MRRH). Prev Med
1998;27:530-5.
showed close agreement. Per item it ranged from 0.79
2. Steward CM, Lado EA. Preparation for office emergencies;
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holic liver cirrhosis was often the bottleneck, because Gen Dent 1988;36:211-4.
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accidenten in de tandartspraktijk. Ned Tijdschr Tandheelknd
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.
General questions:
Name:
Address: 1. Have you ever experienced medical problems or
Postcode and city: complications during surgery or dental treatment? If so,
Date of birth: Nature of the complications?................................
Occupation: Which dentist?...................................................
Name of medical GP:
Name of specialist: 2. Have you ever had medical problems related to the
use of medication? If so,
Date: Nature of the problems?......................................
Which medication?.............................................
Medical risk based on patient’s history: ASA score Interaction with dental treatment and preventive measures:
Updating of patient’s history (oral): date: date: date: date: date: date: date: date: date: date:
1. Have you seen your medical GP or specialist
in the last year? yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no
Nature of the complaints:..............................
.................................................................
CONSENSUS EMRRH Workshop Amsterdam June 2000 enabled by the Aja Ramakers-Koning Foundation (A.R.K.)
ASA yes/no
1 Do you experience chest pain upon exertion 9. Do you suffer from asthma? If so, II 17. Do you suffer from hyperventilation? II
(angina pectoris)? If so, II Do you use any medication and/or inhalers? III
Are your activities restricted? III Is your breathing difficult today? IV 18. Have you ever fainted during dental or medical
Have the complaints increased recently? IV treatment? II
Do you have chest pain at rest? IV
10. Do you have other lung problems or a
2. Have you ever had a heart attack? If so, II persistent cough? If so, II 19. Are you on medication for any reason at
Are your activities restricted? III Are you short of breath after climbing 20 steps? III present, prescribed or otherwise? II
Have you had a heart attack in the last 6 months? IV Are you short of breath getting dressed? IV - for a heart complaint?
- anticoagulants?
3. Do you have a heart murmur, or heart valve - for high blood pressure?
disease, or an artificial heart valve? II 11. Have you ever had an allergic reaction to - aspirin or other painkillers?
Have you had heart or vascular surgery within penicillin, aspirin, latex, dental materials or - for an allergy?
the last six months? II anything else? If so, II - for diabetes?
Do you have a pacemaker? II - Prednisone, corticosteroids (systemic or topical)?
Have you ever had rheumatic heart disease? III Did this require medical or hospital treatment?III - drugs against transplant rejection?
Are your activities restricted? III Was it during a dental visit? IV - drugs against skin, bowel or rheumatic diseases?
What are you allergic to? ........................... - for cancer or blood disease?
4. Do you have heart palpitations without ..................................................................... - penicillin, antibiotics or antimicrobials?
exertion? If so, II - for sleeping disorder, depressive condition or anxiety
Do you have to rest, sit down or lie down during state?
palpitations? III 12. Do you have diabetes? II - have you ever used recreational drugs?
Are you short of breath, or pale or dizzy at these Are you on insulin? If so, II - other medication (prescribed or otherwise)?
times? IV Is your diabetes poorly controlled at present? III .............................................................
.............................................................
5. Do you suffer from heart failure? If so, II
Are you short of breath lying flat? III 13. Do you suffer from thyroid disease? If so, II ............................................................
Do you need two or more than 2 pillows at night Is your thyroid gland underactive? III ............................................................
due to shortness of breath? IV Is your thyroid gland overactive? IV
6. Have you now or in the past had high 20. Do you have to take antibiotics before dental
blood pressure? II 14. Have you now or in the past had liver treatment? II
Write down your last know blood pressure -----/---- disease? II