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A patient-administered Medical Risk Related History

questionnaire (EMRRH) for use in 10 European countries


(multicenter trial)
Luzi Abraham-Inpijn, MD, PhDa, Gordon Russell, MB.FDSRCSb, Didi A. Abraham, MScc,
Nils Bäckman, DDSd, Erika Baum, MD, PhDe, Philip Bullón-Fernández, DDS, PhD, MDf,
Dominique Declerck, DDS, PhDg, Jean-Christophe Fricain, DDS, PhDh,
Marie Georgelin, DDSi, Karl O. Karlsson, DDSj,
Philip J. Lamey, BSc, BDS, MBChB, DDS, FDS, RCPS, FFD, RCSIk,
Iris Link-Tsatsouli, MD, PhDl, Orsolya Rigo, DDSm Amsterdam, The Netherlands, Cork,
Ireland, Nijmegen, The Netherlands, Umea, Sweden, Marburg, Germany, Sevilla, Spain,
Leuven, Belgium, Bordeaux II, France, Reykjavik, Iceland, Belfast, N. Ireland, Thessaloniki,
Greece, and Budapest, Hungary
ACADEMIC MEDICAL CENTRE, UNIVERSITY COLLEGE CORK, UNIVERSITY NIJMEGEN, NATIONAL
BOARD OF HEALTH AND WELFARE, KLINIKUM PHILIPPS, UNIVERSIDAD DE SEVILLA, CATHOLIC
UNIVERSITY LEUVEN, UNIVERSITÉ VICTOR SEGALEN, FACULTY OF DENTISTRY REYKJAVIK,
DEPARTMENT OF ORAL MEDICINE BELFAST, UNIVERSITY OF THESSALONIKI, AND SEMMELWEIS
UNIVERSITY

Objective. The objective of this study was to produce a standardized medical risk-related history (MRRH) in order to
identify the medically compromised patient (MCP) attending the general dental practitioner for treatment, to develop
such a history (EMRRH), and to validate it in dental practices in 10 European countries.
Study design. The Dutch MRRH, adapted to allow for legal and cultural differences of the participating countries was
introduced. After consensus and repeated testing, the questionnaire was validated. In this last phase, 1000 patients
older than 18 attending dental practices were selected, 100 per country; 994 medical histories were suitable for
statistical analysis. Validation was carried out by a physician accustomed to making preoperative assessments,
including the ASA risk classification.
Results. Mean specificity per country was 99.1 and per EMRRH item was 99.0. Mean sensitivity per country was 93.2
and per item was 93.7. Cohen’s kappa for the countries involved was 0.81 to 0.98 and for subsequent questions was
0.81 to 0.97.
Conclusion. The EMRRH was found to be valid in the detection of medically compromised patients in 10 European
countries. (Oral Surg Oral Med Oral Pathol Oral Radiol Endod 2008;105:597-605)

The continuing increase in life expectancy has added to


the number of ageing patients at medical risk during
The project organizers express their appreciation for the grant from dental treatment.1 Previous reports confirm that medi-
the Aja Ramakers Koning Foundation. Financial support was pro- cal emergencies do occur in medically compromised
vided by Stichting Aja Ramakers Koning, Amsterdam, the Nether-
lands. patients attending general dental practice.2-7 Since no
a
Emeritus Professor, Department of Internal Medicine, Academic patient should leave the dental office in worse physical
Medical Centre, University of Amsterdam, The Netherlands.
b
Emeritus Professor of Dental Surgery, University College, Cork,
j
Ireland. Staff member, Faculty of Dentistry, University of Iceland, Reykja-
c
Staff member, Department of Preventive and Community Dentistry, vik, Iceland.
k
College of Dental Science, University Nijmegen, The Netherlands. Professor and Chairman, Department of Oral Medicine, Queen’s
d
Staff member, National Board of Health and Welfare, Umea, Sweden. University, Belfast, N. Ireland.
e l
Staff member, Klinikum Philipps, Marburg, Germany. Staff member, Department of Oral Medicine and Oral Pathology,
f
Professor and Chairman, Catedratico de Estomatologia, Facultad de University of Thessaloniki, Greece.
m
Odontologia, Universidad de Sevilla, Spain. Staff member, Dental Faculty, Semmelweis University, Budapest,
g
Staff member, Department of Preventive Dentistry and Special Care Hungary.
Dentistry, Catholic University Leuven, Belgium. Received for publication Aug 18, 2006; returned for revision Aug 11,
h
Professor and Chairman, Faculté d’Ontologie, Université Victor 2007; accepted for publication Sep 28, 2007.
Segalen, Bordeaux II, France. 1079-2104/$ - see front matter
i
Staff member, Faculté d’Ontologie, Université Victor Segalen, Bor- © 2008 Mosby, Inc. All rights reserved.
deaux II, France. doi:10.1016/j.tripleo.2007.09.032

597
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598 Abraham-Inpijn et al. May 2008

condition than when the patient came in, it is the Table I. The modified ASA physical classification sys-
responsibility of the dentist to acquire the skills neces- tem for dentistry12
sary to identify patients with medical problems that Class Physical status Therapy modifications
would put them at risk during dental treatment. The I Healthy patient None
participating academic medical and dental centers were II Patient with mild to moderate Possible stress reduction and
concerned that in some countries, not only in Europe, systemic disease not other modification as
dentists may not be sufficiently trained to detect and interfering with daily life indicated
III Patient with severe systemic Possible strict modifications;
manage such medical problems.8-11 A preventive in- disease that limits activity stress reduction and
strument is needed to ensure the medical safety of but is not incapacitating medical consultation are
patients in dental practices in Europe. This patient- priorities
administered European Medical Risk Related History IV Patient with severe systemic Minimal emergency care in
(EMRRH; provided at the end of this article) was de- disease that limits activity office; hospitalize for
and is a constant threat to stressful elective treatment;
signed to register medical pathology that can interfere life medical consultation urged
with dental treatment, to indicate the degree of medical V Moribund patient not Treatment in the hospital is
risk involved, and to recommend measures to be taken by expected to survive 24 limited to life support only
the physician and/or the dental practitioner.12-15 hours with or without an
Such an instrument, the Medical Risk Related His- operation
tory (MRRH-98), was part of an inventory study in the
Netherlands. Over a period of 1 year, the number of
medical calamities were recorded in 2 types of general
dental practices. One type used the MRRH-98 system Each center followed the terms of the Declaration of
(reference group), while the control group made use of Helsinki and in addition evaluated the EMRRH in the
various other kinds of history-taking methods. Calam- local cultural and legal context. All legal and cultural
ities due to medical problems dealt were found only in aspects were taken in to account resulting in an
the control group.7 EMRRH acceptable to all participating centers and
This article reports on the prevalence of medical countries. Written informed consent, which covered all
problems in European countries, the need for a ques- information provided to the dentist and to the partici-
tionnaire such as the Medical Risk-Related History pating institutes, was obtained before accepting respon-
(adjusted to meet local ethical and legal norms), and its dents into the study. It was made clear to patients that
validation in the participating countries. The results of declining to participate in the study would not affect
this study across 10 European countries are presented their dental treatment. A power analysis of a pilot study
here. was used to determine the group sizes.

METHODS Questionnaire
Dentists and patients Following an inventory study of calamities in the
Medical and dental experts in 10 European countries dental chair, which was carried out in the Netherlands,
agreed to undertake the preliminary work, such as the MRRH-98 was upgraded and adjusted to meet the
detailing the legal and ethical norms of medical history legal and ethical norms in the participating countries.
taking in their own country, and researching the prev- That EMRRH questionnaire included the ASA risk-
alence of diseases that could interfere with dental treat- score system developed by the American Society of
ment. Anesthesiologists in the early 1940s to assess the risk
These experts were asked to instruct cooperating that general anesthesia poses to patients.16,17 That sys-
general practitioners in the use of the EMRRH. Both tem was modified to assess the risk to patients of dental
the dentists and their patients were provided with writ- treatment carried out under local anesthesia (Table I).18
ten instructions in the appropriate language, outlining The questionnaire consists of a number of “yes or
the reasons behind the EMRRH and how it was to be no” questions designed to detect diseases of the cardio-
used. vascular system, the pulmonary system, and so forth.
In each country the respondents consisted of 100 The main questions are in bold type. A negative reply
individuals, all of them patients who had come in for to the main question signifies that the patient is not
dental treatment. Only those older than 18 were asked suffering from this type of disease or condition, and is
to participate, in accordance with the terms of the recorded as ASA risk I. A positive reply is recorded as
Declaration of Helsinki. The study was approved by the an ASA II risk and alerts the dentist to the presence of
medical ethics committee of the University of Amster- disease. Each main question is followed by 2 or more
dam and marginally tested by the participating centers. subquestions printed in standard type. These subques-
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Volume 105, Number 5 Abraham-Inpijn et al. 599

Table II. An example of the application of the ASA Table III. Characteristics of the patients in the partic-
classification in the European Medical Risk Related ipating countries
History Mean age of Age range,
Question Yes No ASA score* Country % Male patients, y y
Do you experience chest pain upon 0 0 II Belgium 62 51.4 18-78
exertion (angina pectoris)? If so, France 54 45.3 18-82
Are your activities restricted? 0 0 III Germany 45 43.3 18-79
Have the complaints increased recently? 0 0 IV Greece 36 57.7 18-83
Do you have chest pain at rest? 0 0 IV Hungary 36 46.0 19-81
Iceland 43 49.1 19-86
Positive response; ASA II; patients answer the subquestions. Ireland 22 57.0 21-83
Positive response to 1 or more subquestions places patient in ASA III Spain 32 51.9 18-83
or IV. Sweden 43 66.5 55-83
*Each item is subdivided into a main or bold question and one or The Netherlands 45 41.0 19-76
more subquestions. Negative response; ASA I; patients disregard the
subquestions.

tions are answered only when the main question is RESULTS


answered positively. Dentists and patients
The subquestions are graded to indicate the increas- An overview of the countries involved, the number
ing severity of the disease. A positive answer to the first of patients in each country, and their gender is found in
subquestion of a principal question gives rise to a score Table III. The patient population was 41.8% male and
of ASA III and subsequent positive replies to subques- 58.2% female. The mean age was 50.9 years (range 18
tions of the same principal question result in a score of to 86).
ASA IV. Therapy modifications are suggested for each Of the participating dentists, 78% were very satisfied
rating of II or higher. Scores of ASA III and IV include with the results because a great deal of information had
a recommendation to seek medical consultation. The been obtained in a relatively short time. Patients
ASA V category is not included in the EMRRH, as a seemed to appreciate the dentist’s concern for their
patient in this condition would be too ill to visit a dental general health.
practice. Scoring is not cumulative. Table II contains
an example of the ASA scoring of a question of the Questionnaire
EMRRH. Of the 1000 pairs of questionnaires (the patient-
administered questionnaire and the recorded verbal his-
Registration and statistics tory), a total of 995 medical histories were available for
All the participating centers followed the standard- statistical analysis. According to a power analysis, the
ized procedure described in 1992 and 1997.12,20 Each patient population consisting of 994 patients was ac-
patient was asked to complete the EMRRH question- ceptable for statistical purposes.
naire. Afterwards the answers were checked by the On the basis of the results of an inquiry among
dentist in order to ensure that there were no errors or participating dentists, the patient-administered ques-
omissions. At a second session the patient met with a tionnaire proved to be easy to use in the general dental
physician experienced in pre-assessment control, who practice. Because it is standardized, it takes only 2
took a traditional verbal medical history and who re- minutes to administer in the case of a healthy individual
corded his or her findings. A third independent re- and no more than 10 minutes in the case of a patient
searcher compared the 2 forms for each patient, the with reading difficulties and/or complicated health
patient-administered questionnaire and the recorded problems.
verbal history. In this comparison the findings of the
pre-assessment physician were taken as the ”gold stan- Registration and statistics
dard.” No relation was found between the prevalence of
Both the sensitivity and the specificity of the ques- systemic diseases and the mean age per country. In the
tionnaire were assessed, per country and per EMRRH 10 countries represented, the overall prevalence of dis-
item. Cohen’s kappa, a measure of agreement between ease entities within the dental population studied, ex-
observers that includes an adjustment for chance agree- pressed as percentages, varied from 0.07 (The Nether-
ment, was likewise calculated. Additional comments lands) to 0.19 (Spain). The mean prevalence per disease
made by the participating general practitioners were varied from 0.02 for epilepsy and kidney disease to
summarized. 0.27 for hypertension. The prevalence per item was
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600 Abraham-Inpijn et al. May 2008

Table IV. Results per disease in the participating countries*


False False
Question negative positive Sensitivity Specificity Prevalence
1. Angina pectoris 4 8 96 99 0.11
2. Myocardial infarction 3 2 93 100 0.06
3. Heart murmurs 3 4 97 99 0.07
4. Heart palpitations 9 12 94 99 0.14
5. Heart failure 7 3 95 99 0.06
6. Hypertension 31 18 85 97 0.27
7. Bleeding tendency 5 9 91 99 0.05
8. Epilepsy 0 1 100 100 0.02
9. Asthma 1 6 98 99 0.09
10. Lung disease 4 7 90 99 0.10
11. Allergy 19 19 85 98 0.21
12. Diabetes mellitus 3 4 97 100 0.08
13. Thyroid condition 4 1 92 100 0.07
14. Liver disease 8 2 89 100 0.03
15. Kidney disease 2 2 94 100 0.02
16. Malignancies 2 8 99 99 0.04
17. Infectious disease 3 1 92 100 0.02
18. Hyperventilation 2 6 97 98 0.10
19. Fainting 1 5 95 99 0.06
20. Antibiotics 5 8 94 98 0.10
21. Medication 23 7 95 98 0.54
*Number of questions for each disease is 995 except for infectious disease and antibiotics (n ⫽ 783); for hyperventilation and fainting (n ⫽ 789).

highest for medication at 0.54 (range 0.39 to 0.86). A DISCUSSION


review of the results, including the false-positive and An essential element in this study was the proper
negative, answers is found in Tables IV and V. clinical evaluation of the EMRRH questionnaire. The
The mean specificity of the EMRRH per country, verbal history is considered the gold standard since the
expressed as percentage, was 99.1 (range 98 to 100). physicians administering the verbal medical history are
Because fainting, hyperventilation, and the need for accustomed to conducting preoperative assessments,
antibiotic prophylaxis before dental treatment are not setting the ASA-risk scores. They had no access to
part of the original ASA risk assessment for general other medical records and no medical examination was
anesthesia; these items were not included in the pre- included, since the aim was not to diagnose new ill-
assessment interview in France, Sweden, and Northern nesses, but to register what the patient already knew. As
Ireland. When these 3 countries were included, the the study aims to reflect the everyday dental practice
mean percentage was 99.0. The mean specificity per with regard to elective treatment in the countries in-
item was 99.0 (range 97 to 100), regardless of inclusion volved, we thought it unwise to select a group of
or exclusion of the above items. respondents on the basis of (hospital) records being
The mean sensitivity of the EMRRH per country, available biasing the external reliability of the study.
expressed as percentage, was 93.5 (range 87 to 98) The participants of the study modified the score in
when the 3 countries mentioned were excluded, and 1979 and often described an adapted ASA classification
93.2 (range 85 to 98) with inclusion of these countries. system for use in dentistry with treatments under local
Mean sensitivity per disease expressed as percentage anesthesia.18,19
was 93.5 (range 85 to 100) when infections, hyperven- On self-registration it is important that the patient is
tilation, fainting, and antibiotic prophylaxis were ex- willing to cooperate, that language competence is ade-
cluded. When these 4 items were included, the percent- quate, and that the dentist verifies the completeness of the
age was 93.7 and the range was 85 to 100. answers.20,21 There were difficulties in Greece and in
Cohen’s kappa per country ranged from 0.81 France; the sensitivity scores were poor at 87 and 85. In
(France) to 0.98 (Spain). Per item, the Cohen’s kappa Greece this was due to literacy. The solution was to have
ranged from 0.79 for liver disease to 0.97 for epilepsy family members help with filling in the questionnaire. In
(Table VI). France there exists a lack of familiarity with question-
Table VII shows the distribution of the ASA naires. The process therefore was more time-consuming
scores and the mean age of patients in the countries then in other countries. After verification, the subject
involved. coverage was 100%.
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Volume 105, Number 5 Abraham-Inpijn et al. 601

Table V. Results per participating countries


False False Questions
Country negative positive Sensitivity Specificity Prevalence (n)
Belgium 7 7 96 99 0.10 1722
France 16 10 85 99 0.09 1802
Germany 24 27 93 98 0.12 2121
Greece 35 17 87 99 0.14 2100
Hungary 9 0 96 100 0.08 2100
Iceland 4 11 98 99 0.08 2100
North. Ireland 18 23 91 98 0.11 2014
Spain 3 1 97 100 0.19 2100
Sweden 15 3 96 100 0.12 1900
The Netherlands 4 19 93 98 0.07 2100

Table VI. Cohen’s kappa for the participating countries and disease entities
Cohen’s kappa/ Cohen’s kappa/ Cohen’s Kappa/
Country country Disease disease Disease disease
Belgium 0.91 Chest pain 0.93 Allergy 0.85
France 0.81 Heart attack 0.93 Diabetes 0.95
Germany 0.89 Heart murmer 0.92 Thyroid disease 0.95
Greece 0.89 Palpitations 0.91 Liver disease 0.79
Hungary 0.97 Hypertension 0.86 Malignancy 0.90
Iceland 0.91 Bleeding 0.81 Hypervent. not known
tendency
Ireland 0.88 Epilepsy 0.97 Fainting not known
Spain 0.98 Asthma 0.94 Antibiotic not known
prophylaxis
Sweden 0.95 Lung disease 0.90 Medication 0.93
The Netherlands 0.88 Heart failure 0.87 Kidney disease 0.90

Table VII. The distribution of the ASA risk score in % the mean age of patients was 50.9, as compared with
in the participating countries 42.9 in 1998. That increase is reflected in more medi-
Country ASA I ASA II ASA III ASA IV Mean age cally compromised patients with a higher ASA risk
Belgium 35 40 14 11 51.4 score.13 The decrease in the mean percentage of ASA
France 29 53 10 08 45.3 risk score I from 57 to 28 was spectacular. A compen-
Germany 38 48 09 05 43.3 satory increase in the ASA II percentage score was
Greece 22 52 18 08 57.7
Iceland 52 39 07 02 49.1
recorded, from 26 to 47, while the ASA III percentage
N.Ireland 23 48 17 12 57.0 score increased from 11 to 16 and the ASA IV score
Hungary 28 43 12 17 46.0 from 7 to 9.
Spain 04 65 22 09 51.9 Other studies in the Netherlands and Belgium
Sweden 30 41 26 03 66.5
Netherlands 46 35 14 05 41.0
show the same reduction in the proportion of healthy
Total 28 47 16 09 50.9 patients (ASA score I from 78% to 57%) when the
mean age difference is 10 years. In one study carried
out in the Netherlands, which included 29,424 pa-
tients (mean age 37.1), the ASA risk scores were
The sensitivity score in the Netherlands (93) was ASA score II 12.7%; ASA III 5.7%, and ASA IV
lower than expected, due to language incompetence: 3.6%. In a Belgian study (mean age 47) those scores
some 41% of the residents of Amsterdam were born were 25%, 11%, and 7%.1,22 In a Spanish study with
outside the Netherlands. the EMRRH, a significant difference was found
Because of the low prevalence of diseases in the (Mann-Whitney test P ⬍ .0005) between the average
dental population studied in 1998, it was decided to age of the medically compromised patients (49.39
include dental practices in this study that were thought years; SD 19.61) and the group of patients without
to have a higher mean age. Thus, in the present study, risk-related histories (31.20 years; SD 18.97).23
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602 Abraham-Inpijn et al. May 2008

The results of the EMRRH trial are good and com- any of the participating patients who used the ques-
pare favorably with the specificity (98.9%) and the tionnaire during a 1-year study involving dental
sensitivity (84.8%) found in Fenton and McCartan’s practices in the Netherlands. This compared favor-
validation study of a self-administered patient health ably with a control population of dentists working
questionnaire in a dental practice.24 Other research, with other questionnaires used to record medical
such as the PARS study (prognosis and assessment of calamities.
risk scale) have been subjected to neither validation nor
reliability tests.25 CONCLUSIONS
Any medical risk that is missed could be of impor- The EMRRH has proved to be a useful tool in the
tance for the dental treatment. During a 3-day work- detection of medically compromised patients in 10
shop, all the false-positive and false-negative answers European countries. Its value lies in overcoming the
were analyzed. False-negative replies for allergy were disparity between the various methods of medical
due mainly to the patient’s failure to recognize the history taking in use throughout Europe, including
significance of allergy to pollen. In the same way, the problems associated with the mobility of dental
patients on anticoagulant therapy sometimes failed to manpower within Europe. It can be helpful to pro-
mention bleeding tendencies. Similar omissions were vide clinical data necessary to plan health and dental
detected with respect to the use of medication. The list care. In this respect, a digitalized format of the
of medication taken by the patient proved to be an EMRRH, including the modified ASA risk score and
important check. preventive measures per item, has been developed in
The false-positive answers could easily be detected the Netherlands.
by a brief verification of the positive answers only.
False-positive replies to allergy were due mainly to the This study, which extended over many years, would
side effects of medication. False positive answers for have been impossible without the support of a
hypertension often had to do with the fact that at some number of researchers in the fields of Dentistry and
time in the past the patient had been told that his or her Medicine. We thank, in alphabetical order, Prof. Dr.
blood pressure was elevated. During the follow-up val- J. Banoczy, Prof. Dr. A. Holm, Dr. S. H. Olafsson,
idation visit, the blood pressure level was found to be Dr. Ir. J. Oosting, Prof. Dr. med. H. Spranger, and
Prof. Dr. F. Vinckier.
within normal limits. During the workshop, questions
We are grateful for the help and encouragement
with false answers were reworded to reduce the inci-
provided by Dr. J.L.M. van den Heuvel (chief dental
dence of false replies (Appendix). officer of the ministry of Health, Welfare and Sport in
The lowest medication rate was recorded in the Neth- The Netherlands).
erlands, due to the restrictive management of prescrip-
tion drugs. This is in contrast to the situation in Hun- REFERENCES
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EUROPEAN MEDICAL RISK RELATED HISTORY HEALTH QUESTIONNAIRE

General questions:
Name:
Address: 1. Have you ever experienced medical problems or
Postcode and city: complications during surgery or dental treatment? If so,
Date of birth: Nature of the complications?................................
Occupation: Which dentist?...................................................
Name of medical GP:
Name of specialist: 2. Have you ever had medical problems related to the
use of medication? If so,
Date: Nature of the problems?......................................
Which medication?.............................................
Medical risk based on patient’s history: ASA score Interaction with dental treatment and preventive measures:

1.......................................................................... .............. ....................................................................................................................................


.......................................................................... ....................................................................................................................................
2.......................................................................... .............. ....................................................................................................................................
.......................................................................... ....................................................................................................................................
3.......................................................................... .............. ....................................................................................................................................
.......................................................................... ....................................................................................................................................
4.......................................................................... .............. .......................................................................................................
..........................................................................

Updating of patient’s history (oral): date: date: date: date: date: date: date: date: date: date:
1. Have you seen your medical GP or specialist
in the last year? yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no
Nature of the complaints:..............................
.................................................................

2. Have there been any changes in your state of


health recently? yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no

3. Has there been any change in your medication


recently? yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no yes/no

CONSENSUS EMRRH Workshop Amsterdam June 2000 enabled by the Aja Ramakers-Koning Foundation (A.R.K.)
ASA yes/no
1 Do you experience chest pain upon exertion 9. Do you suffer from asthma? If so, II 17. Do you suffer from hyperventilation? II
(angina pectoris)? If so, II Do you use any medication and/or inhalers? III
Are your activities restricted? III Is your breathing difficult today? IV 18. Have you ever fainted during dental or medical
Have the complaints increased recently? IV treatment? II
Do you have chest pain at rest? IV
10. Do you have other lung problems or a
2. Have you ever had a heart attack? If so, II persistent cough? If so, II 19. Are you on medication for any reason at
Are your activities restricted? III Are you short of breath after climbing 20 steps? III present, prescribed or otherwise? II
Have you had a heart attack in the last 6 months? IV Are you short of breath getting dressed? IV - for a heart complaint?
- anticoagulants?
3. Do you have a heart murmur, or heart valve - for high blood pressure?
disease, or an artificial heart valve? II 11. Have you ever had an allergic reaction to - aspirin or other painkillers?
Have you had heart or vascular surgery within penicillin, aspirin, latex, dental materials or - for an allergy?
the last six months? II anything else? If so, II - for diabetes?
Do you have a pacemaker? II - Prednisone, corticosteroids (systemic or topical)?
Have you ever had rheumatic heart disease? III Did this require medical or hospital treatment?III - drugs against transplant rejection?
Are your activities restricted? III Was it during a dental visit? IV - drugs against skin, bowel or rheumatic diseases?
What are you allergic to? ........................... - for cancer or blood disease?
4. Do you have heart palpitations without ..................................................................... - penicillin, antibiotics or antimicrobials?
exertion? If so, II - for sleeping disorder, depressive condition or anxiety
Do you have to rest, sit down or lie down during state?
palpitations? III 12. Do you have diabetes? II - have you ever used recreational drugs?
Are you short of breath, or pale or dizzy at these Are you on insulin? If so, II - other medication (prescribed or otherwise)?
times? IV Is your diabetes poorly controlled at present? III .............................................................
.............................................................
5. Do you suffer from heart failure? If so, II
Are you short of breath lying flat? III 13. Do you suffer from thyroid disease? If so, II ............................................................
Do you need two or more than 2 pillows at night Is your thyroid gland underactive? III ............................................................
due to shortness of breath? IV Is your thyroid gland overactive? IV

6. Have you now or in the past had high 20. Do you have to take antibiotics before dental
blood pressure? II 14. Have you now or in the past had liver treatment? II
Write down your last know blood pressure -----/---- disease? II

21. Women only, please, are you pregnant? II


15. Do you have kidney disease? If so, II
7. Do you have a tendency to bleed? If so, II Are you undergoing dialysis? III
Do you bleed for more than one hour following Have you had a kidney transplant? III
injury or surgery?
III
16. Have you ever had or do you have cancer or
Do you suffer from spontaneous bruising? IV leukemia? II
What is the disease?..........................................
Are you receiving drug therapy or have you had III
8. Do you have epilepsy? If so, II a bone marrow transplant for this?
Is your condition getting worse? III
Do you continue to have attacks despite Which medication……………………….
medication? IV Have you ever had X-ray treatment for
a tumor or growth in the head or neck? IV
ASA yes/no ASA yes/no

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