YMATCTBO 3A MALMEHTOT Tipea ynorpe6a na nexoT, BHMMaTenHO NpowNTaj ro ynaTeTBOTO! > yeajme 20 ynamcmeomo. Moxe6u ke mpe6a da 20 npowumame noemopHo. » Axo uame dononqumenku npauiersa, o5pameme ce kaj Bawuom dokmop un chapmayesm > Osoj nex Bu e npenuwar Bam nuvno u He mpe6a da um 20 asame Ha Ooyeu sua 6udejku moKe Ga uM Hawimemu Oypu U ako HueHuMe cuMnmoMu ce uoMU kako Baume. > Aro ce jasu cepuosHo HecaxaHo Gejomeo unu ako sa6enexume HecaKaHo Gejemeo koe He e onuwaHo 80 O8a ynamcmeo, eedHau Kaxeme My Ha BaUuom mexap unu (bapmayesm. Budeme den 4. Ynarerporo 2a naynetTor comp: 1. mo npememaeyea CLEXANE 2000 1U(20mgy0.2 mi, 4000 IU (40mgy0.4 mi, pactaop sa vnjextuparne u 2a wmo ce ynompegyea 2, mo mpe6a da aHaeme nped da 20 ynompebume CLEXANE 2000 IU (20mgy'0.2 mi, 4000 IU (40mgV0.4 ml, pacrsop 3a mrjexrapaise 3. Kako da 20 ynompebyeame CLEXANE 2000 IU (20mgy0.2 mi, 4000 IU. (40mg)0.4 mi, pacraop 2a uijemupawe Monn wecaxanu dejomea Uyearse u pox Ha ynompe6a Ha CLEXANE 2000 IU (20mg)/0.2 ml, 4000 1U (40mg)0.4 mi, pacreop 3a wHjeruparse 6. Aononwumennu unbopmayuu os Clexane 2000 IU (20mg)/0.2 ml, pactsop 3a uijexTupatse Bo npeTxoAHO Hanonuer wnpuu. (enoxaparin sodium) Clexane 4000 IU (40mg)/0.4 ml, pactsop 3a unjexrmpatse Bo npeTxonHo Hanonuer wnpHu. (enoxaparin sodium) ‘Axmuena cyncmanuuja: eHoKcanapuh KaTpayn. Clexene 2000 1U/0.2 mi, pacmeop 3 unjexmuparse eo oemxodHo Hantonyem winpuu. Enex npetxoguo Hanonver wna o7 0.2 ml waa 2000 IU (eksusaneHTHo Ha 20 mg ehoxcanapin warpuym). Clexene 4000 IU/0.4 mi, pacmsop 3a uxjexmuparse 60 mpemxodHo Hanonkem wnpuu. Enex npetxoguo Hanonker winpay of 0.4 ml vata 4000 IU (eksHsaneHTHo Ha 40 mg ‘enoxcanapnn narpry) Tlomounu cynemanyuu: Boga sa unjexynn Hocwren Ha ono6pexnero 3a npomer 60 Peny6nuka Makenonnja: CAHOON-ABEHTMIC MaxegoHinja gooen, yn. Myj Mactep 11/1/4, 1000 Cxonje, Peny6nuka Makenonnja Mpoussonuren: + Sanofi Winthrop Indust Boulevard industrielZone Industrielle 76580 Le Trait, France ‘+ Sanofi Winthrop Industrie, 180 rue Jean Jaures, 94702 Maison Alford Cedex, France + CHINOIN Pharmaceutical and Chemical Works Private Co. Lid Csanykkvolgy Site Miskolc, Csanyikvélay H-3510 Hungary 1, LITO MIPETCTABYBA CLEXANE 2000 1U/0.2 ml, 4000 1U/0.4 ml, pacraop 2a mijextupatse M\ 3A LITO CE YTOTPEBYBA ®apmaKorepanestcKa rpyna: aNTMTpOMGOTHYHH MeKOBH, XenapmHcKa rpyma, ATC won: BO1ABO5 Ozoj nex @ aitukoarynanc Koj Kako akTHaHa cyncTaHUMja COApKM eHoKcanapuH HaTpMyM W npwnata Ha nexoauTe Kon ce HapeKysaaT HucKOMOneKynapal xenapuHn (LMWH). Jiekor CLEXANE aenyea Ha nea Hawwii 1) ro cnpevysa sronemyBatbeTo Ha NOCTOeUKHTe KPBHA srpyTuyaaisa 80 BeHUTE NH ‘aprepinre (TpoMGosa), co wo My nowara Ha BaWeTo Teno nonecHo Aa rH pasrpanysa. Ha 080] Haul ce cnpesyea nojasaTa Ha OWTeTYBaHsa 80 OPraHitaMOT. 2) npeperTuaHo, 3a Aa ce cnpeun cbopmuparseTo Ha KDsHM srpyTuyBatba BO KPBHHTe cagos, CLEXANE ce npumenysa sa ‘= TpeTMaH Ha KDBHH srpyT4ysaiea npvcyTHN BO BaWaTa Kos ‘+ 3a.ga cnpeun cosqasaise Ha KpaHi arpyTuyBalba Bo cnegHuTe cuTyauMu ~npen w no xupypulka vtTepBeHuja (onepaLnia), ~ ako uMate axyTHa GonecT v cTe co orpannyera nogarOKHOCT, + ako ware HeCTaGnnia axruia nekTopnc (rpanka Gonke-cocroj6a Kora BaulleTo cue He no5Hea ZosonHo KpB), = no cpues yaap (Mmoxapaujanex wkcpapi) = 9a cnpeysaibe Ha cosmasaibe Ha KOBHM srpy\OUM BO anapaToT sa Aujanusa (10) ce xopucmu kaj nauuenmu co meuiku ByOpexHu owmemyeatea). 2. WTO TPEBA MA 3HAETE MPEA DA TO YNOTPEBUTE CLEXANE 2000 1U (20mg) /0.2 ml, w 4000 IU (40mg)/0.4 mi, pactsop 3a MujeKTapatse CLEXANE, pactaop a mnjexrupatbe HE CMEE aa ce ynotpeGysa eo cneanmre onyyan: + ako cre anepravnu (npeuyacrauTenHi) Ha eHoKcanapuy HaTpMy nw Ha BAO koja oa nomouiTe cyncTanunn Ha nexoT. ShauM Ha aneprncka peaKunja ce: uci, npoSneM npH ronraise wna OTeNHaTO AMWIEIL®, OTEKyBaILE Ha YCHITE, TpnoTo nut jasnKor. + ako cre aneprmuia (npesyscreuTentn) Ha xenapnl wnu Ha apyrure HuickoMonexynapHi xenapyi Kako Haaponapny, THHsanapMH wn aanrenapnl; ‘+ ako nperxonHo (a0 vamukaTuTe 100 neva) cTe uMane peaxyyia Ha xenapiH oBpaHa co CepHOsHO HaManysatbe Ha SpojoT Ha TPOMBOUNTH (KpBHA nnoMKA ou urpaar sHaMajwia ynora Bo srpyT4ysaibero Ha KpBTA) HapeeH XenapMH mayunpaxe TpoMGouMToneHiia wn ako Bo BaulaTa Kos amare NDMcyTHA axTHTena npoTHa eHoxcanapil‘+ ako mmare Teulko KpBapetse ni Hekoja cocTojGa Koja e BoOKopHaNHHA 3a Tojaga Ha Kpaapetbe (KaKO 4p Ha KenyAHMK, AKO BO GAVCKO MMHaTO BM & npasena onepauiia Ha MS00KOT vin OxOTO), BKAYYATENHO h HEORAMHEWEH xemoparvsien vioyn (lMoso4eH yAap co KDBaperse), ‘+ axo ro ynoTpeSysare meKoT 3a TPeTMaH Ha KDaHM arpyTuyaatba 80 BAWATa KDE a ‘Tpe6a Aa npmawTe chitanka nnn envaypanva axecTesiia wnn na Bn ce Hanpasi nywGanka nyHiunja Bo cnepHuTe 24 Yaca, Npeaynpeaysarsa w mepxa Ha npernasnnsoct CLEXANE He Tpe6a na ce samenysa co apyru neKosi Kon npwnafaar Ha rpynara Ha uckomonekynapin xenapmnn, Oave neKoen He Aenyaaar Ha YenocHO CT HaNNH HuTy naK wMaaT VcTa akTMBHOCT M Hain Ka ynoTpeba. Vicbopmupajre ro BaumoT noKTop nn cbapmauesT npeA Aa To ynorpebnNTe neKoT ao: ‘+ nperxonHo cTe umane cepnosio Hamanysatbe Ha OpojoT Ha TpoMGoUNTH (xpeHi rnnosny) nospsaHo co ynotpe6ara Ka xenapi, + ao TpeGa ga npnwuTe cnvtanka nn envigypanka alecTeswia Mnn Aa BM ce Hanpaan nymOanva nyskuuja (avqeTe en onepaunn w aHecTeTHun): TpeOa na ce nownTysa BpeMeHcKOT npocTop nowety npnmeHaTa Ha CLEXANE oBve npoueayon. ‘aXO uae BEWITAYKA CpLIEB 3aNHCTOK, aro umaTe enaoKapanTvc (aHcbexunja Ha BHaTpewHaTa OBBHBKa Ha CTPUETO), ‘ako umare weTopyja Ha racTpHueH yAYeD (4np Ha KenyAHAK), HeonamHa cre wane MosONeH yap, KO wMaTe BNCOK KPBEH NPHTHCOK, ware anjaGeTec nnn npoSnemm co KpsHiTe canosn Ha OKOTO Kako nocneanua Ha anjaer (coctojGa noaHara KaKo aMjabeToKa peTuHonaTHja), + ako Heogamna cre vane cnepauuija Ha MOsOKOT Hn O4HTE, * ako cTe noctapo nue (Ham G5 ronuHn), ocoGeHo ako cTe Ha sospacr Han 75 roam, # ao umare Hapywiena cbyskunja Ha GyOpesute, + ako umate Hapyweva cbyHkunja Ha UpxNOT ApO6, + ako mmate mana nu ronema Tenecka TexnHa, + mmaTe BucoKO HMgo Ha KannyM BO xpaTa (08a Moe Ma ce npoBepM co maGoparopvcka ananusa Ha KpsTa), + ako ynotpe6yaaTe neKosM KOM Bnijaar Bps npoYeCoT Ha srpyTuyBalbe Ha KpETA (euaere nen Ynorpe6a Ha apyru nexoay), pea noveTok co TpeTMaHOT M 3a BpEMe Ha NekyBaILETO IMHOry © BAXHO PerymapHO fa ce npaeat anannan m TecTosM 3a npoBepKa Ha GpojoT Ha TPOMGOUMTH M HMBOTO wa Kanwyt Bo sauiara xpe, ‘AKO HeKoe 00 mpemxodHo HasedeHume npedynpedyeara ce oduecysa Ha Bac ‘uncbopmupaime 20 Bawiiom doxmop. eua He e npawexinuao. Ynorpe6a wa apyru nexoau Sapann prsvKoT on Kpeaperse ceKore MHcbopminpalre ro BawnoT AOKTOp aKo semaTe HeKo] of crenHuITe nexoBtt * Baptbapis - ce KopHcT” 3a paspenyearse Ha KpsTa+ acnupni (nosHat m Kako ayerancanmynnma wucneuHa unm ACA), KnonAgporen Uni BPYTH NeKOBM KOH ro cnpeYyBaar sTpyTHyBaHseTO Ha KOSTA (BHAeTe BO AEN 3 3a Tlpomena wa atrnkoarynaHTaure nkOBH"), ‘RexeTpaH KaKo nbjexuvja (nex KO) ce KOpMCTU GO MHTeHSMBHa Hera), BynpocbeH, qvinorbeHiaK, KeToponak nM ApyrA NeKOBM nosHaTH KAKO HecTepowgHn axTuMHcpnaNaTopHH neKoan (HCAMM) Kom ce KopucTaT 2a ‘Tpetwan Ha Sonka n oToUM npm apTpuTAc (BocnanenMe Ha arnoGoaure) v Apyra cocroj6u + MpeannsanoH, meKcaMeTaIoK nM ApyrM NeKoBN KOU ce _ynoTpeSyBaaT 80 Tepanijara a acrwa, peswaTovneH apTpHTHC M Apyra cocTOj6i, ‘* nekosu 3a Kon € nosHaTo Aleka ro sroneMyBaq HMBOTO Ha KANHyM BO KpaTa KAKO KannyMosn con, TaGneri 32 MoKpelbe, HEKON MeKOBK 3a TpeTMaH Ha CpueSM Hapyuyeaiba Onepauyja w anecretuun Avo Tpe6a fa BM ce HanpaBH cnuHanHa nyHKUMja ANH onepauvja npM Koja ce: Npumenysa ennaypanta wnu cnvHanHa avectesnja, ucpopMupajre ro BawnoT Aokrop eka cre Ha Tepannja co CLEXANE. Bugete gen ‘He ro ynorpe6yeajre neKor’. Mrcbopmupajte ro BauMoT AOKTap aKo ware HeKakos npoOneM co BaUMOT pGeT wn ako HexoraUl BH € npaseHa onepalinia Ha pOeToT. Be monume da 20 uncbopmupame Bawuom Goxmop unu cbapmauiesm aKo sevame nu ako 60 HeodamHa cme 3eMane Koj SuNo Opye nek, Gypu u OHUE KOU He Ce Ha dokmoperu peyenm. Bo coznacHocm co moa, Bawuom doKmop Ke 20 nounazcdu Bauiuom mpemman. YnorpeGa co xpava m nujanoun He © npumernnso Bpemenocr m noete Bpemenocm ‘Axo cTe Gpemexa, ce comMesaTe jexa cre GpeneHa unn nnaxupare 6pemenocr, pea Aa novHeTe Aa ro ynoTpe6yBare NeKoT, mucbopmwpaire ro BaLuMoT LOKTOp nu chapwayest, ‘AKO cTe Gpemena u Mare BeWTaYKn Cpe SanNCTOK, MOXe Aa CTe WINOKeHH Ha MOBMCOK puSMK OA NOjaBa Ha KPBHH srpyTUysaiba VW Tpeba Aa noBapare coBeT of ‘oxtop. Aoese ‘Ako fouTe nu nnanupare Aa AowTe, npeA Aa NovHeTe Aa ro seMare NeKoT TpeSa Aa noGapare coset of BaumMOT AOKTOP. Cosemysaime ce co Bauuom doxmop unu dbapwauyeam nped da sememe KaKoe uno sex. Bnujanne eps cnoco6Hocta 3a Bozerbe MH pakyBaibe co MaWlMHK Clexane Hema anujakve Bp3 cnocoSHocTa 3a Bo3eHe Mt ynpaBysaibe CO MaWMHi, Ce npenopayyea BauuvoT nekap aa Sonn esinenuvia 2a Tprosckara mMapKe ut Gpojor a cepwja Ha nexor Koj wTo ro ynorpeGyeae. 3. KAKO BA CE YMOTPEBYBA CLEXANE 2000 (20mg) IU (20 mg)/0.2 ml, w 4000 IU (40 mg)/0.4 ml, pacraop 2a nxjekrupatbeCexoraw ynorpeBysajre ro meKoT ToMHO OHaKa Kako WITO eM npenopavan BaLMoT Aoxrop mnw cbapmayesr. Aro He cTe CUrypHN Kako Aa ro ynoTpebysaTe neKoT o6parere ce sa coper Kaj SaLuMOT AOKTOp un cbapwayes’. + Slexot CLEXANE ce annuumpa npeky uijeKuuja v obmuHO Ke BH ro Rage BaWMoT ZoKTop Wn MennuNHcka cecTpa. «Kora ke ja HanyusTuTe Gonkuyara, Moxe Aa MMa noTpe6a aa nponomKuTe a ro ynorpe6ysare nexoT. Bo BaKos cny4aj MoKe ke TpeOa cami Aa cH ro annvunpare (BajeTe ru micTpyxuminre 3a ynoTpeba HaBeneHn ncony) CLEXANE ce aasa KaKo norkoxkHa (cySxyTaH) mjeruuja, CLEXANE mome ja ce ynorpeGysa u Kako vHTpaBeHcKa (80 Seva) MHjeruuja Mo oppenes THnoBH Wa cpueB yAaP ina no onepauuja + CLEXANE moxe ga ce anniuvpa 80 WesKaTa (aprepicKata nunuja) on eucTeMor sa pujannisa, Ha noweroK og TpeTMaHOT. He cmeete fa ro vajexrupare neKor mytpamyckyno (80 Mycxyn). Dosmparse + Hosara uw spewerpacisero Ha TperMavor ri oppenyea BaUumoT AoKTOp eps ‘cosa Ha Tepanvoxaa wnanKauia. + Axo wave HapyweHa dyHiutja Ha GyOpeauTe BawmoT AoKTop Moxe na eM penvwe nomana josa on nexor. 1. Tpetman na Kpeun srpyTuysatea MpMcyTHH Bo BawiaTa Kpa + BooSyvaenara qosa usnecysa 150 IU (7.5 mg) Ha CeKo) kanorpaw Tenecha Texuna, egHaul Ha AeH unm 100IU (1 mg) Ha cexo) KAnorpam Tenecha Texnna, asa nati Ha AeK.BaumOT AoKTop ke oAny\N KOnKy AONrO TpeBa Aa ro ynorpe6yaare nexor. 2. Mpesenunia na coznae: BHM SIpYTUYBalba BO CeAHMTe cHTyaUN Onepayuja unu nepuod na ozpanuyena nodewkHocm sapadu Gonecm + Bosara koja ke Tpe6a Aa ja npumare fe sasncn of pHanKor 3a nojasa Ha KpaHo arpyrysaive. Ke ev Gygar annnynpann 2.000 IU (20mg) una 4 000 IU (40 mg) CLEXANE, cexoj nex * Axo Tpe6a fa Bn ce Hanpasn onepauinia, npsaTa wnjexuuja CLEXANE Ke av Guae manera 2 vaca npea uni 12 vaca no xnpypwikara HHTepBeHUMja * Ako ware orpauveka NogsitKHocT Kako nocneaMlia Ha 6onecr, BoobuMaeHaTa osa Ke Bu vstecysa 4 000 IU (40 mg) CLEXANE, cexo| nex + Bawmot gokrop Ke ognysn konky Aonro Tpe6a sa ro ynoTpeBysare exo. To cpuee yap (muoKapéujanen uncbapumn) CLEXANE woxe qa ce ynorpe6ysa npn Aga paanmuHu TwnoBK Ha cpueB yaap STEMI (mnokapanjanen wncbapkr co enesauyja Ha ST cermenTor) wn NSTEMI (mmokapawjaneH wicbapkr 623 enesaunja Ha ST cermesror). Hlosara on neKoT Koja Ke TpeGa ga ja npumure ke sasvcn on BawaTa sospacr uw TanoT Ha Cp\es yap Kojusro cre ro wnrane. NSTEMI muokapouianen uxcbapam: * Boo6vwaewara Aosa vsHecysa 100 IU (1 mg) Ha Kunorpam TenecHa TexnHa, Ha cexou 12 vaca, * Baumor AokTop Ke BM Mpenopava fa semaTe MW ACnUpHH (ayeTHncannunn4a kvcenuta).+ Bawnor goxrop ke onnywn Konky Aonro TpeGa na ro ynorpe6ysare nexor. STEM) muokapdujanen uncbapkm Kaj nauuenmu va sospacm 00 75 2odunu + Ke ev Gre aanena noverHa Aosa oA 3.000 IU (30mg) CLEXANE npexy njexyyia go BeHa, + Bo vcTo speme Ke npmmure CLEXANE npexy noTkoxHa (cyOkyraa) UHjeKunia, Boobuwaenara gosa e 1001U (1 mg) wa Kinorpaw TenecHa TexMHa, Ha ceKon 12 aca, ‘+ Bauwor goxrop Ke BM npenopava qa semate w acnupwl (aueTuncanHuAnHa Kucera). ‘+ Baumor gokrop ke oanysm Konky Aonro TpeGa fa ro ynorpe6yaare nevor. STEMI wuoxapdujanen umbapim Kaj nayueHmu Wa eospacm 06 75 20dunu unu nosoke: + Boobiaena gosa e 75 IU (0.75 mg) Ha xnnorpam TenecHa Texmla, Ha CeKon 12 vaca + Marcnmanvara qosa Koja Tpe6a qa ja npumme npeky npaure ABE UHjelynn @ 7500 IU (75 mg). « Baumor goKrop ke oanysm Konky Aonro TpeGa fa ro ynorpe6yaare nexor. Onepaunja nosara kaxo nepkyTana KopoHapHa vTepseHuria (PCI) Bo sasncHoct og Toa Kora cre ja npawwne nocnepHara Aosa og nexot CLEXANE BaAWIMOT QOKTOp Moxe Aa oAnyNM npeg PCI Aa ev Aane AononHuTenHa Ao2a OA SIeKOT Npexy MHTpaBeHcKa MajexuMja (20 ReHA), 3._Cnpeuyeawe wa cosnasaibe Na KPBHM srpyT¥ysaiba Bo cucTemoT 2a awianwsa BooomaeHa gosa e 1001U (1mg) Ha kanorpam TenecHa TexvWa. Mpy xemoanjanuza nexor CLEXANE TpeGa fa ce mjextipa aupexrio Bo aprepnoKara Tinkija Ha NoYeTOKOT Ha QujannsaTa, OBaa Aosa OGWWHO © AoBonHa 3a ANjanvsza CO Tpaeise on 4 vaca. [loxonky e noTpeSHo, sauMOT ZOKTOp Moxe Aa oAnyYN na naZe Roronaarenka Aza on SOIU fo 1001U (0.5 Ao 1mg) Ha kunorpam TenecHa Texwna. Ywempyruu 3a ynompe6a Ha_npemxodvo Hanoniemume winpuueeu Uinpayesnre Tpe6a npasunko Aa ce ynotpeGysaat co yen Aa ce HaManH pHaHKoT (0g Nojapa Ha Gonka W MOAMHKN Ha MecTOTO Ha viKjeKTupaise. Mopa fa ce cnenaT UHicTpyKyunTe 3a ynoTpeGa Ha NpeTxoAHO HanonHeTHOT WINPHL. + Mogrotoska Ha mecToTo sa mnjexTuparse Tpea a ro wnjekrmpare nevor Hamwire ra pauere w ucywere rn, NpeSpawere ro (Ho Hemojre Ra ro TpweTe) co ankoxon penot of KoMaTa Kage WTO Ke ja annnunpare wnjenunjara, Porvpajre ro MecTO Ha wijexTupaise M Cexoja njexunja annuunpajre ja 80 pasnien men og a6noMeHor. ‘+ Ororpanere ro saurTuTHoTo Kanave of wrnara,Ha apeor of nrnata Moxe a ce nojasn kanka of nekoT, Bo Bakos cnyvaj npeg Aa To annuynpare neKor oTcTpaHeTe ja KaNKaTa CO HeMHO Tankaie Ha LINPHYOT M urnara Tpe6a a e HacoweHa Hagony © AnnnKaywja Ha mijexunjara: MperxoqHo WanonveT#oT wnpmy e cnpeMeH 2a ynorpe6a. He TpeGa fa co VCTUCHYBa BosaYX OR WNPMYOT NPeA AABAHETO Ha MKjeKujaTa. Hajqo6po e neKoT Aa My ce Aasa Ha NaLMeHTOT BO NeNeuKA NoNOxOA, BO NOTKOKHOTO TKMBO Ha alTeponatepankvot M nocTeponatepankioT CTOMaNeH sHg, anTepHaTHBHO Ha fesara W Ha geckata cTpaHa, Llenara fonKnka Ha umata TpeOa fa ce BHece BepTHKaNHO BO KOxaTa, NOA NPAs Aron, CO HeXKHO NpYTUcKaibe NOMeFy NaneLOT Nokasaneuor. He ja BHeCysajte MrnaTa BO KoKaTa HakoceHo. KoxkaTa He TpeOa Aa ce ocnoGoan ce AomeKa WenocHo He ce 3aBpuIn MHjeKTAparseTO. + Beguau orctpanere ro uinpiyoT Bo CoonBeTeH KOHTejHep 9a oTcTpaHysaike Ha TaKos THN Ha oTnaAeH Marepujan taeHeynorpeSenara xonwama of nekoT unk ommaqHvoT MaeTpyjan Tpe6a qa ce OTCTpaHM Bo cornacHOcT co BaKe4KHTe NOV, Npomena Ha antuxoarynantHara Tepanuja + Mpomena 08 CLEXANE Ha aHmuxoazynaHmu nosHamu Kako aHmaeonucmu a eumamue K (np. eaprbapur) Bawor goxrop ie By Kaxe 2a HanpasuTe TecTOsH 3a ucnTysaibe Ha INR M cnopeA, PeaynraruTe of oBve axanitan Ke Be COBETYBa Kora € COOABETHO Aa ja npeKHeTe ‘Tepanjara co CLEXANE. + Mpebpnarse 08 akmukoazynanmu nasHamu Kako aHmagonucmu Ha aumaMuH K (np. eepcbapur) Ha CLEXANE Mpexneve fa ro 3emaTe akTaroHNCTOT Ha aitTanua K. BauloT ZoKrop Ke 8h Kae a HanpasvTe TecTosn 3a venuTysatse Ha INR M cnopen pesynrarirre of oBuE aHanuah Ke Be coBetyBa Kora @ cOORBeTHO Aa ja npeKnHeTe Tepanvjara co CLEXANE. + Mpowena 03 CLEXANE Ha dupexma nepopanka (npexy ycma) anmukoaeynakmua mepanuja MipexneTe aa ro seMate CLEXANE. Mownere co npuwewa Wa AupeKTHvoT Mepopane akrikoarynaxT 0-2 vaca npea BoobuMaeHoTO Bpeme sa HapeaHaTa ‘mjenuuja w nloroa npononxere ja HopwtanHo Bawara Tepanuja. + Moepnarse 08 aupexmna nepopania (npery ycma) axmuxcaeynakmua mepanuja wa CLEXANE pexniere co ynoTpe6a Ha ampektHara nepopana Tepanuja. He ja nounysajre ‘Tepanujara co CLEXANE foneka He wawunaT 12 vaca no NocneaHara A03a on Avpextiara nepopania Tepanvia, Ynorpe6a kaj qeua w anonecuentH He e ucnnrana Ges6eaocTa n ecbyKacHocra on ynorpeba wa CLEXANE xaj qeua nu anonecyenra, Ako ce zene nogeke CLEXANE of Konky wTo ¢ norpeSHo AKO cTe gene noronema KonwwmHa Of NeKOT UHqopMupajTe ro BAWMOT AoKTOP, MeauuHcka CecTpa win cbapMa\esT AYP M AKO HeMaTe cMnToMM. AKO AeTe CcnyajHo ro mxjexripa un nporonta BaUiMOT nex Tpeba BepHaW ga ro OnHeCeTe BO Ha\6nvckaTa sapasctsexa ycranopa, ‘Ako cte sa6opasune pa semere CLEXANE ‘Ako Te saG0pasvine na ja semeTe BawaTa gosa setere ja sepHaul Kora Ke ce cere 3a nponycror. He sewajTe asojHa qosa sa qa ja HanlomectuTe osara Koja usTo cre ja nponyurune. Bonete Genexnnk 3a a He saGopasnre Aa ro npuMuTe nexor. ‘Axo npecranere fa ro ynorpe6yaare CLEXANE On ronewa eaxnocr e Aa ce npyApxysare Ao noenopawrTe 2a apeMeTpaeiLe Ha TpeTMaHoT Ko] BM rH ABN BaWuMOT ROKTOP Guaején BO cnpOTUBHO, HoKONI cam oanysure fa ja npewihere sawara Tepanija Moxe a cTe VenOKeHH Wa pUBMK Of, nojapa a srpyTaysarbe Ha Kpara. Ako uMame HeKoU npawiatoa 3a ymompeOama Ha CLEXANE KoHeynmupajme 20 Bawuom doxmop, dbapmaysem unui Meduyuncxa cecmpa,4, MOH HECAKAHM DEJCTBA Kako w cire cnwHi neKosh (Kon ro HaanysaaT arpyrwyearsero Ha Kp—ETa), CLEXANE woxe Aa RoBene AC mojasa Ha KpBapelbe Ke Moxe a ro sarpost 2xwoTOT Ka nauyeHToT, Bo HexoM crywaM KpaapelseTo MOxe Aa He e BMAnHEO ‘Axo Bit Ce jaBh Gino KaKsO KPBapere KOE He sanupa chowTaHo Wnn HoKONKy saenexaTe shay Ha uspascHO ¥peapetse (ackny\MTeNHa cnaGocT, saMop, Sneauno, sprornaeuya, masoGonka unn HecGjacHeTa nojaga wa oTok) Tpe6a BegHaul Aa ce c6parue Kaj BauMoT AoKToP. To] MoKe Aa OANySH BHUMATeNHO Aa ja cnepu sawara cocTojéa wn qa ro npoNes neKoT Ko) ro ynorpesysare. Mipeanere qa ro semate nexoT CLEXANE 1 senHaul oSparere ce Kaj eauMoT Aoxrop nn MenuUMHcKa cecTpa aKo BM ce jaBar Cuno KaKAM aHayA Ha TeUKa aneprvcka peakunia (Kako OTexHaTO ANWetSe, OTeKyBaIKe Ha yCHUTe, ycrara, rpnoro nu ounre), Vincbopmipajre ro senHau sawmoT AokTop aKo aM ce jaaT 6uNo KaKN aHaUM Ha ‘noknpaibe fa Keko| ypBeH CAR OA KPBHO srpYTHyBaKLe BKnyTENHO! + nojasa Ha Gonkw rp¥esu, YpseHAo,TonnHKa MNK OTeKyBaibe Ha eneH oA ‘AOnHNTe excTpenuTeTu-oBa Ce cumnToMM Ha AnaBoKa BeHcKa TpoMGosa, + egocTatox Ha save, Sonka 80 rpaqiTe, HeCeeCTHYA Mh HoKaUITyBaIGe Ha Kps-o8a ce ciwntoww Ha Genonpodxa enon. ‘Aro 81 ce jasv GoneH vicHN co cosRaBaise Ha TeMHO YpBeHN TOK nog BawiaTa Koa Kon He Ce NosneKysaT nog npuTHCOK BaLUWOT AOKTOP Moxe Aa noGapa a HanpaswTe wcnaTysarba 3a Aa BM TO NpoBepH Opojot Ha TPOMGCUNTH (KpAHH nosey), Bxynen npuxas Ha Hecaxanume eoxmt Muory vecrn HecaKann agjersa (npyjasenin kaj noseke og 1 oA 10 naynexTy): © Kpaapeise + Sronewexo Hitso Ha xenaTankn eHanmn Yectn Hecakann mejcrea (npyjasenn kaj nomanky on 1 on 10 naueHTH) + Tlonecta nojasa Ha moapmikn on BoOGMNaeHO WTO HajsepojaTHo ce AoMxM Ha Wit30K 6pO) Ha TpoMBOYMTA (KpaHW NTO4Kn). Tiojasa Ha posesi nniaka no KoxaTa Ko" Haj4ecTo Ce jaaysaar ao yenoT Kage To e HijekTipan meKor. Koxen noun (ypTuKapia). Tlojasa Ha Gonka unit MonpMlkn Ha MecToTO Ha MMjeKrHpatee. Hawanes Gpoj Ha upsenin KpBH KneTKA Bucok 6poj Ha TpoMGountu, Tnasodonka Tlomanky wecta HecaKann aejersa (npijasenn xa) nowanky og 1 on 100 naunenna): + Harna nojasa Ha Tewka rasoGonka (08a MoKe Aa © 3HaK Ha KpBaperse 80 Mo30KoT) ‘+ Mpeocernmaocr nn oTeKysaie Ha cTOMaKoT (08a Moxe fa © aHaK Ha KpBapeite 80 cTomator}. orem upseHu KOXHi Neswi Co HenpaBuna cbopma co Wnt Ges nnikoav, Vipuraunja wa xoxara (nokania upuTauuia). Moxontysake Ha KoxKaTa Wank GerkuTe of ouNTe 4 noTeMMyBaKe Ha Gojara Ha ypinara (oBa Moxe Aa € SHak Ha OulTeTyBatbe Ha cbyHKuujara Ha LupkHtoT p06).Porkn Hecakann aejcrsa (npiiasenm kaj nowanky of 1 on 1000 naunexTu): + Teun anepruckn peanynn, Cumntomire Bkny4ysaar: ucKn, nojasa Ha oToK nw npOGAeM CO AMUIeIETO, OTOK Ha YCHHTE, NMYETO, proto Uni jasUKor. + Sronemevo HNB0 Ha KanuyM 80 KpaTa. Osa HecakaHo nejcTBO nowecTo ce jasyea Kaj nayneHTn co HapywieHa cbyrKunja Ha OyOepeauTe un anjaber. Baumot foxrop Ke sn Hanpasu vcnuTysaiba 3a a TO Openh HMBOTO Ka kanmyn 80 BawiaTa kps. + SronemeH 6poj Ha eosHocbiina (Tun Ha Senn KpBHA KneTKi) 80 KpeTa, Bawnor Zoxtop ke si HanpasH HcniMTyBaiba 3a a Bn ro ONPERH GpojoT Ha eosnHocpunn a0 xpaTa. + Onafaise Ha kocara + Ocreonoposa (cocToj6a npw Koja e sronemena KpuinusocTa Ha KOcKHTe) 10 Aonrorpajxa npumena Ha neKor. + Uyscrso Ha croKOTKalbe, TanlocT Mn MycKynHa cnaGoct (ocoSeHo Bo onHata nonesiHa og TenoTo) ako en Guna vasenena chunanna nyHKyyja vwnw cre npnwune cnuHanka axecreavia. + WikorTwmenunja (7yGerse Ha KouTpona Bp3 MoKpeHsero nu necbeKauMjara). + Mipneycrso Ha Tepaa Maca nnk jasonuitba Ha MecTOTO Ha MnjeKTuparse. Mpujasyeare na necaxanume dejcmea Axo 3a6enexume nojaea Ha HeKoe HecakaHo dejcmeo, Be monume da 20 Uuxcbopinjpame Bawuom dokrmop, drapwayeem unu weduuuNcKa ceompa. Ova eu exnyyea u wecaKaume dejcmsa KOU He ce Hasedert! 80 exampewnomo ynamemeo. HecaxaHume pearyuur od nexoeume moxe da eu npujacume 60 Hauuorantuom ysHmap 3a dbapmaxosu2unavya npu AzeHuujama 3a nekoeu u meduyunexu cpedcmea (yn.Ce.Kupun u Memoduj 6p.54 Kam 1) unu no femermponcru nam npeky ee6 cmpanama Ha Azenuujama htp:/imalmed. gov mi. Co npujasyearbe Ha HecakaHume dejcmea npudonecyeame da ce Komnnemupaam rrodamouume 2a 6ea6eeHocmea 0d yriompeba ita nexom, 5. YYBAIbE HA CLEXANE 2000 IU (20mg) /0.2 ml, 4000 IU (40mg)/0.4 ml, Pacteop 3a wHjexTaparse Flekom 6a ce wyea Ha Mecma wedocmannu 3a deyal Pox Ha ynorpe6a Jlekom He cies 0a ce ynompebyea no ucmeKom Ha Camymom Ha ynompeda wmo e naseden Ha makyeawemo. Vicmexom Ha Gamymom Ha ynompeba @ do mocnedHuom eH 09 Meceyom wmo e Haseden Ha NaKyeareemo. Hasii Ha wysaibe Ha neKor Jlexor pa ce Wyea 80 opurianloTo nakyBaibe Ha Teuneparypa Ro 25°C. Wnetpyxumu 3a paryearse co ommagnor matepijan Meqmumickn nponssogn He TpeGa fa ce oTcTpaHysaar npexy KaHanwaayvoHara Mpexa wn co gomauiKuoT oTnaa, Mpawajre ro BauwoT capmaueat Kako Aa ro oTcTpanute oTnanHMOT MaTepijan oA MeqMYMHcKTe npomaeo~Y, OBHe Mepk/ Nomeraar aa ce sawTuTuTe ceGecn u Baulara oxonmia 6. ONONHMTENHK VHOOPMALAN Codpxuna na naxyearsemo: Clexane 2000 IU (20mg)/0.2 mi, e pacteop sa ukjeKrupaive u e aocraneH Kako.© 0.2 ml pacrsop 3a mjexrupaise 80 npeTxogHo HanonHeT wnpwy (craxnen) - Kytwja co 2 un 10 wnpmua, Clexane 4000 1U/0.4 mi, e pacreop 3a ubjekripaibe me aocTanen KaKo: © 04 ml pacteop 3a iijekrupatse 80 nperxoaHo HanonHeT wnpay, (ctaxniex) - Kytwja co 2 uni 10 wnpnua. Hawn wa wanasarce Ha neKoT: TlexoT ce npnmenysa camo 80 sapascrseva ycraxosa (3) Darym Ha nocneanata peuauja Ha BHaTpeuIHoTo ynaTcTBO: Mapr, 2018 Bpoj Ha ono6penmeto 2a cTaBatke Ha meKoT Bo NpoMeT: ‘* Clexane®, pacraop 3a uijekrupaise, 2000 1U(20mg)0,2 mi;2 HanonteTa ‘avjexunokn winpanua co nrna x 0,2 mi/kytuja ~ 15-4480/13 og 28.11.2013 ‘+ Clexane®, pacteop 2a unjerruparse, 2000 1U(20mg) /0,2 mi:10 HanondeTa jenunckn uinpanya co urna x 0,2 miikytuja ~ 15-4480/2-13 of 28.11.2013 + Clexane®, pacteop 3a unjertuparse, 4000 IU (40mg) /0,4 ml;2 HanoneTa mnjenunexn uinpnya co wrna x 0,4 mi/kyTuja - 15-4479/13 of 28.11.2013, © Clexane®, pacreop 3a majextuparse, 4000 1U(40mg) /0,4 mi:10 HanonweTa vmjekyncKH winpMua Co urna x 0,4 milkyraja - 15-4479/2-13 on 28.11.2013 3a pyr wicbopmaymn Bo Bpcka co 080] nek, Be Monae KoHTaKTuMpajre ro MocuTenoT Ha opoGpenmeTo sa npoMeT 80 PenyOnika Makegonuja Ha cneaHvoT Tenecbox: 02/ 3239 232