is 

Jane a teacher? No, she is not. She is a doctor. 

are you American? No, I am not. I am Australian.
are John and Paul at home? No, they are not. They are at the
university.
Is the book on the table? No, it is not. Itis on the chair.
Is your father from Madrid? No, he is not. He is from
Barcelona.

1. Your brother's a doctor. (frase negativa)

Your brother isn't a doctor.
2. Teachers are on holiday in August. (frase interrogativa)
Are teachers on holiday in august?
3. It's late. (frase interrogativa)
is it late?
4. You're from Denmark. (frase negativa)
You are not from Denmark.
5. They're my friends. (frase negativa)
They are not my friends.
6. I'm late for class. (frase interrogativa)
am i late for class?
7. You're at home this weekend. (frase interrogativa)
are you at home this weekend?
8. This seat's free. (frase interrogativa)
Is this seat free?
9. She's married. (frase negativa)
she is not married.
10. Mary's happy here. (frase negativa)
Mary is not happy here.