1N.furane-2-carbaldehyde furfural), neo ween col (Iyt-dimethylethy aleshol), He om ne. P. 2medhytbutar-2-ol, Q pentan-2-01, et R pentan-1-l (pentano), wel S. hexan-I-ol (hexanal), om ee, T. hepa, wow U. hen? BONN V.nexan3o10 Ethanol (96 per cent)! rs Alcohol (96 per cent) (Ph. Eur, monograph 1317) rer DEFINITION Content — ethanol (C:H140; M, 46.07): 95.1 per cent VIV (62.6 per cent mim) to 96.9 per cent VV. (95.2 per cent mim) at 20 °C, calculated from the relative density using the alcoholimetric tables (5.5); "Tir mnap har undergone Pharmacia harmonanon ‘See chur 58 Phamaopoa hameraon. 96 per cent) 1-967 ‘sCHARACTERS Appearance ‘Colouress, clear, volatile, flammable liquid, hygroscopic Solubility ‘Miscible with water and with methylene chloride Te bums with a blue, smokeless fame. bp About 78°C. IDENTIFICATION Firs idensication: A, B. Stcond identification: A, CD. A, Relative density (see Test) B. Infrared absorption spectrophotometry (2.2.24) Comparison Ph, Bur. rference specrum of ahanol (96 per com) OC. Mix 0.1 mL with 1 mL of a 10 g/L solution of porasium permanganate R end 0.2 ml- of dite sufaric acid R in a test- fube. Cover immediately witha fiker paper moistened with a freshly prepared solution containing 0.1 g of sodium rivopmaside Rand 0.5 ¢ of piperazine hydrate Rin 5 mL of ‘oater R. After a few rnutes, an intense blue colour spears ‘on the paper and becomes paler after 10-15 min. D.To05 mL add 5 mL of water R, 2 mL of dice sodiom hydroxide solution R, then siowiy add 2 mL of 0.05 M iodie. [A yellow precipitate is formed within 30 min.¢ ‘TESTS Appearance Its clear (2.2.1) and colourless (2.2.2, Method 1D when ‘compared with water R. Dilute 1.0 mito 20 mL with ‘waer R. After standing for 5 min, the dilution remains clear (2.2.1) when compared with water R Acidity or alkalinity ‘To 20 mL. add 20 ml. of carbon diwidefree water R and 0.1 ml of phonaiphthaln rolaion R. The solution is colourless, Add 1.0 mL of 0.01 M sodium hiroxde ‘The solution is pink (30 ppm, expressed as acetic acid) Relative density (2.25) 10.805 t0 0.812, Absorbance (2.225) “Maximum 0.40 at 240 am, 0.30 between 250 nm and 260 nm, and 0.10 berween 270 nim and 340 nm. ‘The spectrum shows a steadily descending curve with no observable peaks or shoulders Examine between 235 nm and 340 nm, in 2.5 cm cel using ‘water Ras the compensation liquid. ‘Volatile impurities Gas chromatography (2.2.25). Test soluion (a) The substance to be examined. Test sluion (b) Add 150 uL of ¢-merhytpentan-2-f R to 500.0 ml. of the substance to be examined Reference solution (4) Dilute 100 uL of ambydrous medhanol R 10 50.0 ml withthe substance to be examined. Dilute '5.0 ml of the solution to 50.0 mL with the substance ro be cxamined. Reference solution (2) Dilute 50 yl of anleydrous methanol R and 50 uL of ataldelyde R to 50.0 mL with the substance to be examined. Dilute 100 of the solution to 10.0 mi. ‘with the substance to be examined. Reference soluon (c) Dilute 150 yi. of acetal R t0 50.0-mL withthe substance to be examined. Dilute 100 4. f the Solution to 10.0 ml with the substance to be examined.1-968 Ethanol (96 per cent) Reference solution (4) Dilute 100 ui. of Benzene R to 100.0 mL. with the substance to be examined. Dilute 100 uL. on 10 30.0 mL. with the substance to be Calin: — matra: Fused silica; = Size: = 30 m, © = 0.32 mm; = stationary pha: ply{(cyancpropy) (phe dimedh) siloxane B (Bim thickness 1'8 jim), Carrier g08 hel for chromatography R. beatae oe Spicrono 120 Tempera i TS a Dini Fie ii, Injection System stability Reference solution (b) reolion: miniraum. 1.5 between the 1 peak (acetaldehyde) and the 2° peak (methanol) Lise — matharol in the chromatograin obtained with test solution (a): noc more than half the area of the corresponding peak in the chromatogram obtained with reference solution (8) (200 ppm VV); = aetaldhyde ~ acetal: maienima 10 ppm VV, expressed as acetaldehyde CClcalate the sum of the contents of acetaldehyde and acetal in parts per million VV using the following expression Lede , 30xCs , 4405 yds * Cr — Ce * 1183 A ses fhe poo eto antalya in the hmatopram Sieinel eth stanton @, A {Uc the ps de to socal ia be beomatopam ‘Sheine wt een sto o let ofthe pa duo snal he chromato abrained seh te ton 0, a ‘ode ass of sera ‘boson: maximum 2 ppm VIV. Calculate the content of benzene in parts per milion VV ‘using the following expression: 2Be Br-Bs TT becisen Gh 1B, = mencdtho peut dort bent i the cvomamgam bined (Fah ene tte If necessary, the identity of benzene can be confirmed using another suitable chromatographic system (stationary phase with a diferent polarity) total of other puro in the chromatogram obtained with test solution (B) not more than the area of the peak due 2019 to 4-methylpentan-2-ol in the chromatogram obtained wth test solution (b) (300 ppm), — civegard limit 0.03 times the area of the peak due (0 “{methylpentan-2-ol in the chromatogram obtained with test solution (6) (9 ppm). Residue on evaporation Maximum 25 ppm mV Evaporate 100 ml.to dryness on a water-bath and dry at 100-105 °C for I h. The residue weighs a maximum of 25 mg. STORAGE. Protected from light OIMPURITIES A. L-diethonyethane (acetal B. acetaldehyde, ° propan-2-one (acetone), D. benzene, E. cyclohexane, F methanol, G. butan-2-one (methyl ethyl ketone), wc or, H, 4-methylpentan-2-one (methyl isobutyl ketone), 1. propan-I-ol (propanol), 4. propan-2-ol (isopropyl aleohe!),a 2019 He Aon K butan-I-ol (butanol), We Ag, Lbuten-2-0l, os Hee M. 2-methylpropan-I-ol (isobutanal), or IN, furane-2-carbaldchyde (furfural), 56,00 eon, 0. 2methylpropan-2-l (,I-dimethyethy! alcoho, et eX, a" P. 2emethylbutan-2-ol on wean Q. pentan-201, ee R pentan-L-l (pentano), nen S.texan-L-l (hexanoD, we~—~ow Ts heptan-2-, new, U.hexan-2-1, A Ay V.hesan-so10 oa nee Dilute Ethanols Dilute Ethanols DEFINITION The official Dilute Ethanols contain 90, 80, 70, 60, 50, 45, 25 and 20% viv respectively of ethanol. They may be prepared as described below, the final adjustment of volume bbeing made at the same temperature, 20", as that at which the Ethanol (96 per cent) is measured, NOTE On mixing ethanol and water, contraction of volume and se of womperatare occur TESTS Acidity or alkalinity; Appearance; Volatile impurities; Residue on evaporation Comply with the requirements stated under Ethanol (6 per cent ETHANOL (90 PER CENT) ‘Alcohol (90 per cent); Rectified Spirit Dilute 934 ml of Ethanol (96 per cent) to 1000 mal with Purified Water Content of ethanol 80.6 10 90.5% wh Apparent density 826.4 to 829.4 kg m®, Appendix V G. ETHANOL (80 PER CENT) ‘leah (80 percent) Dilute 831 ml of Ethanol (96 per cent) 10 1000 mi with Purified Water. Content of ethanol 79.5 10. 80.3% vw. Apparent density 857.4 to 859.6 kg m®, Appendix V G. ETHANOL (10 PER CENT) ‘Alcohol (70 percent) Dilute 727 ml of Ethanol (96 percent) t0 1000 ml with Purified Water. Content of ethanol 69.5 10 70.4% wh. Apparent density {883.5 to 885.8 kg m”, Appendix V G. ETHANOL (60 PER CENT) ‘Alco! (60 per cent) Dilute 623 ml of Ethanol (96 percent) to 1000 mal with Purified Water, Content of ethanol 59.710 60.2% ww Apparent density 907.60 908.7 kgm", Appendix VG. ETHANOL (50 PER CENT) ‘Alcohol (50 per cent) Dilute 519 ml of Ethanol (96 per cent) to 1000 ml with Puried Water Content of ethanol 49.6 t0 50.2% ww Apparent density 928.6 to 929.8 kg mr, Appendix V G. ETHANOL (4S PER CENT) ‘Alcohol (45 per cent) ‘Dilute 468 ml of Ethanol (96 per cent) to 1000 ma with Puntied Water