CURRENT TARGET THERAPY IN

DYSLIPIDEMIA: KEY POINTS OF

MANAGEMENT WITH STATINS

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 STATINS
Beyond Lipid Lowering Effect

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WHAT ARE STATINS?
Originally identified as secondary metabolites of
01 fungi.

Hydroxy-MethylGlutaryl-Coenzyme A (HMG-CoA)
02 reductase inhibitors.

Because serum cholesterol level is strongly

03 associated with coronary heart disease, it has
been generally assumed that
the beneficial effects underlying statin therapy are
entirely due to cholesterol reduction.

04 The newer third-generation synthetic statins, which

include fluvastatin, cerivastatin, the penta-substituted
pyrrole atorvastatin, pitavastatin (NK-104), and
rosuvastatin, are much more potent than the
mevastatin derivatives.
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3 CATEGORIES OF STATINS INTENSITY

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MOA

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ROLE OF STATINS IN
CHOLESTEROL SYNTHESIS
PATHWAY AND ITS
PLEIOTROPIC EFFECTS

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