Total No. of Questions : 8] [1] [Total No.

of Printed Pages : 2

Roll No ..................................

MPY-PP(D)
M.Pharmacy III Semester
Examination, December 2020
Toxicology
(Elective)
Time : Three Hours
Maximum Marks : 70
Note : i) Attempt any five questions.
ii) All questions carry equal marks.

1. Describe Patch-Clamp technique. Add short note on

application of patch clamp technique.

2. Explain principle of toxicology and biochemical and genetic

basis of toxicity. Write note on carcinogenesis.

3. Discuss acute, sub acute and chronic toxicity studies according

to OECD guidelines.

4. Elaborate on documentation and protocol preparation,

reporting and monitoring of safety pharmacology study.

5. What do you understand by abnormal action of drugs.

Emphasize on hypersensitivity, tachyphylaxis, idiosyncrasy
and addition.

6. Describe in details CPCSEA, OECD and WHO guideline in

reference to toxicology.

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7. Give details of cellular and sub cellular toxicity and immune

response.

8. Write short notes on (any two)

a) ICH guideline
b) Heavy metal poisoning
c) Adverse drug reaction

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MPY-PP(D) PTO