LEUKEMIA 4.

CHRONIC LYMPHOCYTIC LEUKEMIA

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}A group of malignant disorders affecting the }
blood and blood-forming tissues of the bone
marrow, lymph system, and spleen.
Clinical Manifestations

1.Anemia
2.Thrombocytopenia
Bone Marrow 3.Leukopenia
4.Chloromas
Types: 5.Gum infiltration
a.Red marrow- consisting mainly of myeloid 6.Hepatosplenomegaly
tissue (RBC, platelets, most WBC) 7.Bone pain
b.Yellow marrow- fat cells and some WBC 8.Anorexia
develop in YM 9.Petechiae

NORMAL BLOOD CELLS

1. WBC
Granulocytes
Agranulocytes

2. RBC

3. Platelets

CHARACTERISTICS
}Replacement if BM with malignant, immature
WBC
}Appearance of abnormal, immature WBCs in
peripheral circulation
}General infiltration of cells into liver, spleen &
LNs throughout the body

ETIOLOGY:
L
E
U
K
E
M
I
A

Classifications of Leukemia:
1. ACUTE LYMPHOCYTIC LEUKEMIA
}Mostly lymphoblast present in BM
}
2. ACUTE MYELOGENOUS LEUKEMIA
}
}

3. CHRONIC MYELOGENOUS LEUKEMIA

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}