LECTURE GUIDE ON FREE-LIVING PATHOGENIC AMEBAE

Acanthamoeba spp.
Morphology of Acanthamoeba trophozoites
Diseases caused by Acanthamoeba
Where do this organisms thrive and what is their source of food?
Stages of Acanthamoeba spp. Life cycle
What are the bacteria that have been implicated as possible
reservoir hosts of Acanthamoeba spp?
Mode of entry to the human body
Pathogenesis and Clinical Manifestations
A. Acanthamoeba Keratitis
Symptoms of AK
Diagnosis
Differential diagnosis
Treatment
B. Granulomatous Amebic Encephalitis
Systemic manifestations
Neurologic symptoms
Neurologic findings
Postmortem gross examination of neural tissue
What are the most affected areas of the brain
The clinical manifestations of disease
 Diagnosis
Treatment

Naegleria spp.
Morphology
Forms of trophozoites of Naegleria fowleri
Where do this organisms thrive?
Stages of life cycle
Pathogenesis and Clinical Manifestations
Mechanisms producing a cytopathic effect on host tissues
Signs and symptoms
Characteristic cerebrospinal fluid findings
Postmortem examination of infected brain
Diagnosis
Treatment