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Upper respiratory tract symptoms Any one of: Any one of:
(&/or fever) WITHOUT shortness 1. Respiratory rate > 24 /min 1. Respiratory rate > 30 /min
of breath or hypoxia 2. SpO2 < 93% on room air 2. SpO2 < 90% on room air
^^Higher chances of NIV failure ➢ Tocilizumab (Off-label) may be considered when ALL OF THE BELOW CRITERIA ARE MET
## LMWH: Low Molecular Weight Heparin: if no contraindication or high
o Presence of severe disease (Preferably within 24 to 48 hours of onset of severe disease/ICU admission)
risk of bleeding; UFH: Unfractionated heparin o Significantly raised inflammatory markers (CRP &/or IL-6)
o Not improving despite use of steroids
o No active bacterial/fungal/tubercular infection
o The recommended dose is 4 to 6 mg/kg (usually a dose of 400 mg in a typical 60kg adult) in 100 ml NS over 1 hour (single dose)
o
➢ Convalescent plasma (Off label) may be considered when following criteria are met
o Early moderate disease (Preferably within 7 days of symptom onset)
o Availability of high titre donor plasma (Signal to cutoff ratio (S/O) >3.5 or equivalent depending on the kit being used)
o Usual dose is 200 ml given over a period of 2 or more hours
Department of Medicine, AIIMS (ND)