Tema 3 Cautare medicala folosind cuvinte medicale in PubMed

Coman Claudiu, seria B , grupa 14

Why Are Women Prone to Restless Legs Syndrome?

Termenii PICO din intrebarea mea sunt:

P:Willis–Ekbom disease
I:periodic limb movement disorder
C:Genetic Predisposition to Disease
O:women

P:A disorder characterized by aching or burning sensations in the lower and rarely the
upper extremities that occur prior to sleep or may awaken the patient from sleep.

I:Excessive periodic leg movements during sleep that cause micro-arousals and
interfere with the maintenance of sleep. This condition induces a state of relative sleep
deprivation which manifests as excessive daytime hypersomnolence. The movements
are characterized by repetitive contractions of the tibialis anterior muscle, extension of
the toe, and intermittent flexion of the hip, knee and ankle.

C:A latent susceptibility to disease at the genetic level, which may be activated under
certain conditions.

O:Human females as cultural, psychological, sociological, political, and economic

entities.

Numarul de rezultate obtinute folosind termenii initiali=647

Numarul de rezultate obtinute folosind termenii verificati in MeSH=35

Restless legs syndrome is a relatively common neurologic disorder considerably more

prevalent in women than in men. It is characterized by an inactivity-induced, mostly
nocturnal, uncomfortable sensation in the legs and an urge to move them to make the
disagreeable sensation disappear. Some known genes contribute to this disorder and
the same genes contribute to an overlapping condition-periodic leg movements that
occur during sleep and result in insomnia. Dopamine and glutamate transmission in the
central nervous system are involved in the pathophysiology, and an iron deficiency has
been shown in region-specific areas of the brain. A review of the literature shows that
pregnant women are at particular risk and that increased parity is a predisposing factor.
Paradoxically, menopause increases the prevalence and severity of symptoms. This
implies a complex role for reproductive hormones. It suggests that changes rather than
absolute levels of estrogen may be responsible for the initiation of symptoms. Both iron
(at relatively low levels in women) and estrogen (at relatively high oscillating levels in
women) influence dopamine and glutamate transmission, which may help to explain
women's vulnerability to this condition. The syndrome is comorbid with several
disorders (such as migraine, depression, and anxiety) to which women are particularly
prone. This implies that the comorbid condition or its treatment, or both, contribute to
the much higher prevalence in women than in men of restless legs syndrome.

Bibilografie:
1.Ferré S., García-Borreguero D., Allen R.P., Earley C.J. New insights into the
neurobiology of restless legs syndrome. Neuroscientist.
2.Gonzalez-Latapi P., Malkani R. Update on restless legs syndrome: From mechanisms
to treatment.
3.Becker P.M., Sharon D. Mood disorders in restless legs syndrome (Willis-Ekbom
disease) J. Clin. Psychiatry.