Professional Documents
Culture Documents
• Infective endocarditis
• Myocarditis
• Pericarditis
INFECTIVE ENDOCARDITIS - OUTLINE
• Introduction
• Etiology
• Pathophysiology
• Diagnosis
• Treatment
• Complications
• Prognosis
• Prophylaxis
INTRODUCTION: DEFINITION
• IE is a relatively rare but serious disease with high mortality despite the
improvement in diagnosis and therapy
• Estimated annual incidence 3-10/100 000
• The profile of patients and pathogens has changed over time (rheumatic
fever x PM/ICD)
Incidence IE
• Common:
• viridans (alpha) streptococci
• enterococci
• S. aureus
• Other streptococci
• coagulase-negative staphylococci (usually restricted to
prosthetic valves or internal devices)
• Less common or rare:
• HACEK group - (Haemophilus, Actinobacillus, Cardiobacterium, Eikenella, Kingella)
• Gram-negative (e.g., Pseudomonas)
• fungi (e.g., Candida spp.)
• Coxiella burnetii
Valve endothelium injury Pathophysiology
bacteremia
Platelet - fibrin
deposition
Non bacterial
trombotic endocarditis
(NTBE)
Adherence
Local destructive
effects of Antibody response
intracardiac infection to the infecting
organism
Clinical
manifestations
of IE
1. Braunwald’s heart disease : a textbook of cardiovascular medicine / edited by Douglas L. Mann, Douglas P.
Zipes, Peter Libby, Robert O. Bonow, Eugene Braunwald.—10th edition
DIAGNOSIS-
MODIFIED DUKE
CRITERIA
How to diagnose ?
DIAGNOSIS
SYMPTOMS
RISK FACTORS
CLINICAL FEATURES OF ENDOCARDITIS
ROTH’S SPOTS
Janeway
lesions
Conjunctival
petechiae
• Blood culture
• Echocardiography
• ECG test
• Other laboratory test
• Serology
• Chest x-ray
1. Braunwald’s heart disease : a textbook of cardiovascular medicine / edited by Douglas L. Mann, Douglas P. Zipes,
Peter Libby, Robert O. Bonow, Eugene Braunwald.—10th edition
ECHOCARDIOGRAPHY
Blue areas
are bacterial
colonies
• Subacute (alpha-strep)
• duration depends on the isolate’s degree of sensitivity to beta-lactam antibiotics
• Sensitive strains treated with ceftriaxone 2gm IV daily x 2-4 weeks PLUS gentamicin
1mg/kg q12h x 2 weeks
• Acute (Staphylococcus aureus)
• (for MSSA) High-dose semisynthetic penicillin x 4-6 weeks
• (for MRSA) Vancomycin IV dosed to maintain 15-20mcg/ml trough levels x 6 weeks
• Enterococcal endocarditis
• High-dose penicillin or ampicillin PLUS gentamicin 1mg/kg q12h x 6 weeks (for drug
susceptible strains)
For a more detailed discussion, see treatment guidelines from the
UK: Gould et al. J Antimicrob Chemother 2012; 67: 269-289
US: Baddour et al. Circulation 2005; 111: e394-e434
Microorganism Antibiotic Duration class Level Alternative
( weeks) antibiotic
2. 2015 ESC Guideline for the management of Infective Endocarditis. Eur Heart J 2015;Aug 29
3. Rosario V. Freeman and Catherine M. Otto . Hurst the Heart 13th ed
Paravalvular abscess with regurgitation in a patient
with rheumatic disease who presented with fever.
2.Uncontrolled infection
3.Prevention of embolism
2. 2015 ESC Guideline for the management of Infective Endocarditis. Eur Heart J
2015;Aug 29
TREATMENT OF ENDOCARDITIS:
INDICATIONS FOR SURGERY
• Persistent positive blood cultures despite maximal antibiotic therapy
2. 2015 ESC Guideline for the management of Infective Endocarditis. Eur Heart J 2015;Aug 29