BLNBHIVOIGSW V7 asusnay sulovsu “ye ‘oppRayeoypene sor oreo i) smears 2p phpuos wf s6isap0 jas elustony PEALE sTURTEUNIS (yeu AGEIeL 270p eI Tams ‘soncen ajs0 “seusape wiseos ap dq aus ua cmp pdnp ‘osinape syyiers ancud = ‘prvarpesur op [22p “AIpou ssloe9 oan 1 soruremposrtaey s]HOpOH 2=129)9 = -muyep ep sofa sensapomy rans we oie]? iseigo Ydasp si Hfopoorvorodoue SLNVdOd STaLNSINVOIGSW ‘vINSGNSdad ‘SSVOLNSWVOIGSIN. SinoV STULLVOMOLNI ‘SINAINVOIGSIN 3G asnGoud AODOTOLVd SUYyis IS asuaAav 2uloway “€ land poe sag zoetunowenn) (590) os eine ‘puome eaemeantny W (fenenwowle (Cifele clinice a medicementelor acis de aseme- spins Tae , produse de digitlice asupra i oir cave sate nesses 0 enpraveghere sae ba Re RES Tg BET Se TS BE atetetor apa cu att mai mare cp cat doze ras ae Terepeul eet mporsl DL SIDE $0, care DL, 50 = doze leit ta 50 % lowe seit be WS om steam in 50'S ee askance or soso ne1 ‘omsoyrte coz ea =P | ‘aso ajgnvaodsa: jens? op amend woe sossed juauma yo grepaide og vfeazng et fam eicao0u poydio 29 co “x fmuozour Soap a8 panzqpooy 2099-129 9p 3982] IP “si Syumsuen o¢ govjoqmiau simmons meecoy ‘sjupo sowsoe sopmeqmaN nin Team earsuieom sued ong sows “ap “ar RyREONNNYS 8 pom eazpRoE aoa STREP OP sh09-s 9p of ‘pose Bp: syennougl yens 20 =TESuNput snore aute 1S 2uzeybupry “RprEerwoH? 2p “oun gud sorrersnsone ayaa sic. TEPER? mmporg if onousd vensens un no 2oFeED 2 © proauroue> vaLouuiofmini iu 38 slunisqns 2foum ¥9 osu RE, ouonoyemsie “epioneed ‘ormpmments sscadzotomm@ % 280}0} aeoRtOION TENE vusfemus 95: no cweouesypotn aemectonted sojoyesamegipoae ‘emsfoxs oje9 sceo8 cyt Year yénp seyqo — Ss ‘mo “mmdnouss ofp aquamstaed yogtpou imposes idosp me susdoima 2790947 38 (moonenont igasoapat) Syeryoosorsreoupmy HF EmgD oie sp tiem 2[o2op ‘vere sezounjendans “somemns o[crae] * (Boar 2 sme oe suefi00 wlemajyrar nee owe ooe 40um Those EIS sid greproonmsonam 9p ‘uzuoypou ap set qa cosy “ownif soyresoway siuaptans 800 ‘mod toundss no sojaymenseoonime rareto fan qresiaayod “njdaioxo 2p ‘sqsondsjeinae nes siawweeyomesy “or -exypooeturey nes sRouisoormm; TES su upd ‘anfeniod mes misrBioms 9p Tet ‘38 oun gipbrep ‘copwey sust0Ns} BEES? “3p tod srvonieuoorpow squmfsauoruyCateva reacfil Kdlosinerazice provocate de medieamente (Gece la es)See ee Jotannegias yooeeeyot yay eesasverm| oat seg sorweee oes | eee # zocor “Se enerome sens)“ nmemy Soeoes poy a svi asia “sur on symone pusuo ~ someSues eade Br vey -sovowaurompt Spimd sopsyss ea RETA va {818 promotor sito ‘supucpBorrasd ‘owes sonst ‘uray ‘puny — reiouR copou Haisqys ns apnoseve5 ‘syozea © ‘ayporseer ~ 2ynjso oun wiapeaéns gredeoe ‘ammo ‘auygea! nes G8] no monetace tat catdea sp sissouced yane 1 stefpoan sora setar spbSaye0 wip und 28) stg aoqdors syemeosied uy stacey wor vate p ahr op [88 ouop fou de op a 8iopo omnloooyy ‘omy squeal ‘msyosoeur upd osoqatoup ce nino "SIasOe Blows op undp epg uorapoormy Somuuojsuen yovosout nas aanes osen > sfumegns som earesoqK> no “aneEegse BEpoe geyeny gummed eseecy “opssaron viepuine of” 2 Mioidesar aney nes ospee EOP aN eeaderpasd 9 = 89 ¥5 ‘unum SfenEapa! ofaaserp eRe S9TEMe Bftpuoo ey “rows099, 2p aiejeates 1 sopupsaics ezeq ad yezioaud oF aisod ‘mo sy soiGsoye soytfooss ymaery “so}30| = We 28 so[UNTED BEM LICr EY es aomeoIpem ep TORE aureo} Shige oor some ges emo ‘ommgnfomnay yeromto ‘reatepoun sus0ytan fasvodates nays a | 2518:0]8 aesnepe oftiowsy, rose “uis1we8:0 Hip gppdedod o ase grpeoad o zo19usqv ‘no Masqen03 wasezo] Head pen(b0> ses Bsuaaay auLovau “ELe es FOR FIncs[out eect owes eT “rm eats ean ae RE TP, Wea oe eee utes ee ee sf pd toe ee Sra! rer raee > 29 [8 opaseidoo: iuincs © nied yoppods as wisusty japonis ot oeX Afrasteamere TABELUL 200 (coum) ‘msbot state oo Fig, 66 ~ Diese j- arate cunoscnte es foarte ant Eontraindioata. Trebule excluse ir te locel, con “ulfamide, Este nece- 127 126scr ‘espmorpeng Fup op nad uocun ‘RO nes MODES 2p ‘aeadse wopiqtit 10d seisape oqnlono, SLNBWVOIG3W 3a Ssnaoua BOISMOLV TWHyLS “ze sjesisenss esohold eed edopoet = sas "HONE 2p 2zm09 10% omnes ‘ulosoon[s ‘ane s0ui03 pooeee HF 9p vunaT greaced ateo “ymmporoussd “oid jniay 2p SoPBuswespeenag (Gave =20p uy). euosjay “eprmeTo od ormsayrse yexede. raat af erngaa Beon0ud tod syuemmeaipom ap SLD O ainaweoian sa Sit net a Coe asngous Suvinosynoid “evo s51eovolve wows ze * 824 umzusjodar myumsyomsy ayo ~ 2 = sejtoures4 sodorss trmuw eaorToo weeosoid (qaomporre "apr lenis sranme epmIA nGOd yn\qeevoderpm eos “ope aise fezes prascuespaus ramndsp +5 soareoop "purnodiat ows seworeeueorp {23 seoferd copes eaiaseomnoy ee AJSRPES “soHojored ume ays amet meson sp aid 8 oor eer; poses comet soo) emma tenon “enc tera Tee Pow peoreyygie sonore? é ges ypramerence “oosraqnene Toor Sromeseoe soe sores sum omementy ‘ooaord yod a] aura syusuo1pour 7 stpredpouad § mppBupe aye TEIN AopsNUsUD|S (MPAIU ef sooo eI ‘anu op pivot 2p 2189 sep ‘wosrer omy. sp spine) rouiseds edioopme opt sensaey yoSispe-gmiew op aoa (HOMOue (ees “onuooen ejloyat aco Gio givsioayy "eur woo weuto) sfney slujzorvo9 fo poses fnow mip gzsefeefoep of "oma ae em § casio jod eeuouose 2p ‘sopsedsoqnose —— gu 2p rqasosp smash ‘poe sues: ete tm adap "Zor wap 0 pnp Ton DOO STI 9p 2189 Biasoag 1 aed 0 ea001d ays0d (No “oqney Teareymezor> 29 psnp" cnpom otis ais njdimaes codoyeureg migureses pupiosze “gompau ei22180 weno vod awestenpeM Sse Com mpoiays yertee) surmmps siscend cis sqeomss = tuiusd soqammpeg savers 18 teyoBoes (ojos “asso oe no ope “sorpamr rama cud ‘onesd syeepiese som = shewiyoud op ofuinsgar ezvonap 36 eld nd oq "Says op sojaqond rammarnodsty sp umin mse moprouteig “Tye soosd nes euicortomoq ‘CRanDae up wee souayued) remy sjeomaye genre Steamainy “somesousowpa nes soigacte ‘somot stsjaesear som efivoacnay ad ‘wueBups nudase amorgangp pasion yuan “SS Ata “lamxs sod SINSUNSOTy BuNaWvoIaaN 3a_ssndoud InTseNys 31v 30D07OLvd Steyls ‘eee unsbaye aie (8 preacey steoq mp orumax 8 sqemmgins yrecaesbe ‘pouahied eyfyae Hosoron pugetioats Tae poyocnoid "Jordnore: rarcori se produce hemoplobiurie 5 prot at # ‘smal retrompective an dovedit 0 ngouri ucbule flosite si doosto eu prudent, mk se eS Tleciuailor trombeembolice iad mult intrvaal Ginwe doze, to foxcie eepbotbi. emote ime bork cerebs ‘par bemoragil le nivelul i, raroori singerdri ms- bone dal 3.28. STARILE PATOLOSICE ebliefsbuloiicatile ete) oa necro eile favori= RENALE PRODUSE DE tubule. Frecvenje acest accident este seam: MEDICAMENTE fia! aed peute cefotch, Asosires ot tte subsiane nefzotosioe (gatbiotice amino samente ~ enticoagu slicozidiee ele.) seu cu furos crests ‘siraile & supradozare), parcetamolal Gn roidiene, slopurinal, compus! rogucerea inavesoasa, iterul Jina gi tceritina, doaele pesiclint, Istamoxeful, pot provoes, de (Gromul este fa general benign. Uneor pa- ogenia este alorgic#, afectarea rinichisini tind tosoqied de erupf cutanate, febré, 135Date SOEs joie Saas TNS es Seine mopmeo Gramone Spey Sees eee SENG “PRSGH ‘eesuese Wormnagiy on foarte Bf aeonee come qaopsatoam T Seemeeee (Guow> s00) pera“ sasopp sasone “Trenrces see “ony (aise Fa emeao of ed sor ever Peoria | oueend et TNE “G HPpaerms Fepihaay Ta re 2 ipnoI seme Soon Sopenowtee Dhotle [ome ce ymree Baia oy ‘erpesd rod of s1eo sumouteoqpour 2piediayd FE ayemar oyforoed ug ae ages “queimoyS my sireyaaijo sent sxafaai09 ‘9p yueundap se-apupiotep Yorsispe panies{| on | | Sonn ipou sarmnay insu; no qeemog ep soucaeaat oo “S! pvr 2ys20p soy ran apn "papSruOpE (0 ‘ated nes yejorss BELSTUOAS nneod me = Rene snp SiNswwolaay so. (2eeieredoa iter ypoqnem mm varios BOlivesH 3 ‘stents vf ‘ipaiop eg “simsice ee 3 Eines a foeea tests ee fe “Bre Mom ango enjons tod Iep one “K emnedoq wp 29 “awed azmjcojo “snus seayiiep sm rent tn ad “awaoud one ‘onmsetoo smmsy exede 5 et : ‘sdoptnom “termmossq> "Tete hoco meoapeces eae aromas a no aog Te wouromeres mars RroIsuOTESIS op BzMUD “woUSUIOSE OP“ “yoyre ‘soisoyoonce sxe 1 gonlane ‘on united “20304 Up a pg afciowep 3 yee eee eee sundnsasd ¢g -otxoy sores sjupe anuod jozummopad ade 8489 sep ‘porBojounts: pam ‘omonsy "BiDA2s mmoy eevep aust: Foowen aa mAeden ousyouns Uy qiste> a sot0355 BN ‘ne ap yiincuioa "wuozenaitisy “aoa crow “rooeessjounmy “ezoyoojamelse 2s 1g ted stusuresypour SANSWYOIOSNN 30 ty sede aro 219 8 2 "yseorsmp wos 5 “areas ay Ws 200 Sep meme etme pepas [iis ad prescoau 3i¢q "78 s20p 25080}03 36. PES guint e-7 uy — Zo|damp © SmIoe) 9D soipRooiomjus soRo|gNE® AOUN w=}EyPIXOIOIO ‘Wrayan ogg, sised curses gfenascass -ordang ame nutad gone; pom 220 epmoons EAH 9 oa OUNGE sso FajoNMOaNY [RMON 2350 gre “32 moory puz> joe sxete 9p ae ayy ns [yen geo op commer soneusetd eaisoo 8 pf 28a op s20cl ve up mins japesaany #6 3—SuSRIe MPN “Si Foon, say ap oqoizmns nnd sqescopey injure senspioid nes eaeneranp apd smearaets vod spspRoongoatas te -grsoy ‘Riotesmuien esmado tanp tater ‘re ra sHfos! nw cfovoucway “pyr 7 sad op ey Eages emma (ome 5 ap spas BIE IAN of aed op atieo o Sy8a oor a88. INTOXIGATIILE ACUTE pot produce acccasi reacic. Patogenia este EDICAMENTOASE gies sau toxict. Disgnosticul 8.8.1. CUANTIFICAREA TOXICIT DIGAMENTELOR, toxice, observate 18 in jeolagi, su un caracter gradat cresciad 0 dati oa doze. Observate asupra ‘raRELo sack Princtpalcle react catanate medicamentoase si uncle dintre ipalele react Sunjale care le proveacl REACTILE CUTANATE PRODUSE DE MEDIGAMENTEoreod aeeorasureapant iomsgas eoimore <0 Te Ryu oo 8 Or aamy— Ho amar OE ojso op — youttdno pesy Saou 9 srlomy wy mel? op ame if maton 4 9p roovloey emmy geetea ‘speroommedas lone of sunopea man wamionor Wwo v1 BSvOLNaMIVOIGaN Binoy SuULVOXOIN! ‘zee mmo nf sea8opog 26 ayermsuecrpom (ous 05 ase “Goma eet 32 ono ap sajaeaa “sonnaortases S20} 22 esieutgmmodepoig denwacesd sundopyCTARELUL WOO (caine) aan a mae OF pene 510 sia Ty Enea Sst, = ETS “ee coma cu amepon oo aS VE 20 ae [seeennk Commins BO See ® (Sina oo ia, Tol 8 SS ashen 10 al Ged SVT Ganesh lois Ge Sto aaa Tae EOS Eiioce ae 3050 aoe y= 55 oe a 0 rg Se 3 os SED = 3 gig, ose Tp anes aE © [Mets mete # oc oo mle #0 mek assor om ad syismusdeg “opsmanssh (enesye | anoe glonsgns op bru! plensoon: 6 ((emim apocdsad {0 OR war afos ope eleep ‘wodp eoronoud ys agedso oimnrang "somercovonied = ‘afasunsey ap yrmorpay ~ seensrmer rnsdnsen wf side amo “cad toson STewmameys wp assige eiupade mcut 185 mInoqwos wena TnOpGOD ¥ op Sedo 2p ne EES FEA omscooe goIpe poy sponse ‘undo op sopiuroyen aje amare o[sr spevsoos moa surlgo “Goud | eoistiace Sdapen I sated fzop funfaso series EcRmp empess 2p siaqpa oy Ee o2ore aqnidoae: ae oe afdtmaxe oe HEROD ne eteorcerm wenofpym wnonm 1 5 “ord FETE As0=8tere] compensstor, dind nestere, prin (Ge sxempiz naloxons sa: IG extazonist 2 morfine, dup8 tenminarea curei de de2- 3.5, MEDICAMENTELE $I ALTE SUBSTANTE DOPANTE * muanipolsi menite #8 modifice pro- belo de unin’. sant nodlnin dopant a spo, Medicine, Modern, eras enelog f‘aud 2an ne mes oyind « nest "yeder =p Sens VISUYA IS JTSLNEWVOIGSN ‘y 1 51 02 “a6 si pepe semen “no see Ss icin on Pan, ooo femme = wag i aw oy many Sasa *r otiod Wear aE Oe Uae ed wat ‘Enbsing st sow minenang WY = nde 7 S861 “Wg “Sy os Seg igor eat Ws Seber Seopasper eenmsens | aL so Sgeoe 9p sn] ounce Reet X sagnooma sora, eepany teas nodose somsposne apo = Tae prion apes yu3t rod 9289 ‘008 ap ats Bt ae nee seunquitpes 29 “aanerss wees, drys cupjaushs oe S0np 328 ‘eis onmpea rom 4 ' sopweunapen = PES “ojamiruoaipase vostans $8 opprapanp ‘wpiqiosgo fed yor wee at un "geese soe uns suqpsdodey aud Pesso opunsjoage sjeoy jeu up 1 zou cmsuonodiy “moot Smoineye sOjLmaNRS era ROeeD ¥ tbmes wsquafio wy oy wonewte bamouTD sour wl iojsaeunoam scaoere tod enqnosesorpino opg0q extsp yaVinoswaoiauyo ViDovOLvd NL OOO WiNEVs snilyuevinouava “re smcrlts puptoaep venoedeed 1 ‘gonnadem Tunued Fimeiiodum amar 2 16 Teen rma “erage 2p aqosszoad rordio ope jeuooens tk fonfoana "ence fame ‘mmseyfog © Ruse zamareaqe wt aeyGS ap 1 soyneders, smoyos wes simeMoopest ay IPHLENLOD “SRINSTEIPE ap Top npaui e nes terSojosod eateourpone oT sum snd coertoep ‘aypams ap sinasoun i AOIDO10LVd IWyLS 37aNn NI 300109 WWHWs STL LVINOLYva. Ssreporie de 60-70% if prin wind, afeo~ | sind eparet, mm mare masur8,atuoci cand tmece pria ficat. Decerece el na gf micgorearh este mult bmp. a 25 de ore (al ‘area di condi. impune prudenfa fa egeste ‘Tiopenald,bacbitrc flosit per anes- teaia generald pe Gotoreste durata foarte scurt a efect ‘Sdipos (bogat in gr2simi, pont care an tezieul are sfinitate mare), pe misura re i sdugeli. la iasuicienta cardiac’, alnamic, Sin’ fa candifiie unui miocard bobay, @ hiper 1 pe cid convatle seca calc intravenoas unde se acum ‘anELOL = hfodificést fiiopatotogice la cordiact care pot influenga reactivitatea tisulard la patologics la ore medleamente aia Saoposianed a pet ae Te aaa Tana RSW En Sa [eas SET) Tearias teen gd | soomcce Se: cae a SR [Oa aT ES poise ‘aces Se em See ae ae alae esa ‘Sea erase pe tt ‘Sova ene 7Jodo geass sfaszuase : “pofom jeredoyay seomcesy wad joumo 25 epaal elberoyaeay yivnse vinaiolinsn ny golpoioovmuy arilyawinounva zs "eeRwol? vas sre 8 wgomme m 0 peearzorey 09 abd “apeeny opgar sed gaaqHoR Tue Pzopioe op aiiozur ob 3p otis oy soeayany juns swore sonoumuoredans 21 18 sateeampeion, ei Le ud oom 33 sarensiurpe 041 nalnsxo op reso Sf aironpuos swoon mem efzazai od ounmsjosoies 8 atdo:oe ear Tresioreq ered RSID 29 sereasteipe ‘date varednuonay “consmae ‘aigsdo ypoew: ad ‘ed ep gsitod 25 yeeatoifony sia sjoaies az8 ay Su ‘og sapanoss rages JOpNCOpEoE Sa egos 1 anne yesna94 yur 30‘rape. xu rebate evitate in prezeafa insuficieapt re iscal ecm ages Sears epi Te ae» pial te ‘isin aka Baas weal | {200 000 wu. cuprind Tedusl, dar reporta dine aaularea cafonulsi ‘restora intervalulaé tute doze le 12 ore la 2 compris Gontsindics chimioterapicul. igoxiaa esto glicozidd tonicardiect cere 26 climind reas, nemodiical® fa pro- Sonic de circa 2/3 fi cae ero ua indicewosade + waite: Ba) 2 3 FE a ores | _ ose [am] ina) Raa eae See yeu ejaspa "F sveojpujeruos june nes OTerop FONEIONT OU 9109 spmaemeMpETY ree taza 28 emo sjomsuroypem anead “pay “to (sous =p atlony ty ‘aBoqosud je UNSTES Image ap nes aN esise}2 2p atomny of sofazop eadnae nm tap area ‘suaiSouoa. year ‘peas HssiogseY Ys cope ¥ soaieo yop un vamp] (PNG sem Jowrundssiog sy g8 dig “en wissss-guempom gener giesegnact seupoa Bf s7soi0y 220g “THeyooten ea ‘etaaiegne vam oa sompo:d 25 nn 2p spe ‘one! 208 Tap ‘eprmedasoqsclimind im proporie mare, aeschimbate, oon angles @ ace cm fn cazal vitaminet D spare o insuicienit ‘Modifier ficlopatologice fn tnsuficienfa renal, eare pot influente proprictiile farmacodinarsice 31 toxicolagice ale medicamentelor Teas Enger pares Bescon "la Sein cava Taga vases, | aloe esc igs aoa cry Tita Sac, Fanoa ls mae Se) wlocasea, ania] as Ze eco ‘uncon pata al Fae aanme Oa naa aaa ae a mas | 184 sudt eficactatea oft dorsle mici, foaomencle de Glen Risoul eresout de hiperkaliemis fc si Remoragile Is ecidul SESE cvteren spiroolasaci, temter- salle sunt mal feovere fa fas Roja gf alr, churetiee care wefia por renal fice antes 8.3, PARTICULARITATILE ficient rene FARMACOLOGICE IN ets esa de seni de potas. Sut” AFECTIUNILE TRACTULUL curasizaat depolerizent, peal DIGESTIV pecuroolinesteraze (6 stutis parcalart sto oon madion rmentelor aniee pore rnici, care WbOHe up Setccle mercurnle (pot provoce necrozé na (poate saetoxilurs renal "Prantl intestinal accelerat tm ente- = ucts acute Gisiatens’ sbeobfia. Feno- ‘eutfes datoait acfonl lor de ssldsre & penal poste # semnificativ cliaic penta venti Oi, rene, de creslere & uedicaientle pofia ligosolubile — butl- Catabolism! prota. epelamint, propaatsint, ncostigsmint rane Sentt ets grind tot- Ge cee gf tm mod normal se absorb I cua simone pour cle organe. Aste, miiat § itegal, De asemcnss, forméle Sosteatle clotoxice ia enitiotcle emise : Sheondice qi la acidul eucraic sont mai de : reparatele Recreate le wemic, fenoteizele 22 Teplice provoact axcod s doorle obi ‘omprimate are 0 biodixponibil- Sais i inegall, se absoasbe mai "enultranalt. gastro saa vapid “Siniroamele obseruceive 1a nivel 85 185sat euseou reese geesaou 3 2289 {018} sp 25E ed ‘syerteueonpens armifoe YOSEF seus wot sod TONES eho rOLvasH arnniloaay 30100100 vHEVS sulyuvinouava Ys 109 wifojorasoydms preaueste 16 weap sp wuss qos mise JQneE yaeaaqorey aro wou 3p 729 38 aod ~ pt ans ep sniea0x9 mon zane op IMOEUEIS © pelafzove at ee ‘sraseeid od gomaae)$ orodacen@ oy ~Wppols sp panto Wie o YATE ATSOSTP TOTOpat induce 0 si de enzime microzomale hepatice, metabo ‘cporaea hepat eee oe oregte Fssul tox Cpurets fa proporils mare de clue Acat, 2 flitua de cele eu tropism toxic be rival prin conjugee le aivelal cet ee deficiert in insuficieals Tape xiv Ccateva medicaments care pot provoce ress toxice lo epael | areeebad seston Stecanismnl gesstora Tria seco jaa Gotennoe Tie Bie aaa ane gga NST SSIS He oe agi Wpoicala wie [ad wee est gon a Go Som ID ‘Fiona ornate jipaciaide coos —_‘[opones bape ea fades asniag ESAT [ipa Ses GuREOTES) O jaa teince plasmstice. Coneceativ concentrais fanguiai creste gi, pemim dozele mari, cee ml tice pot avea reper fi se Axeaz’ In propo matice, Erect sie acs fxts malt grelungit ‘Preduisooul tnde ot reallzeze aivelust ‘msi mel insnfichene parece, hipoalbaminemie ~ Sefece eB creased pro ust peo este Sing; eceste amibitice tind 3B se aow 189sempeceminy uspo area so “arspennys emp ASVOLNANVOIGAIN yumm sn op aundsp aro ‘yasspour a aTNALLOWHALNI “9. apew. XLVE (esos) 6.4, INCOMPATIBILITATILE En eS Bin mead = oe mane Sails, etude, baie, opie, pecomecral, aperimentate, do Ia anime 62:1, INTERACTIUNILE ASUPRA ; PROCESULUI DE ABSORSTIEser Hb. 1 eosroose ‘sj orm sowon por eee snefnfsoaoyfas Sermspauayip 29 FeO 2 warensiunnpe gorD eenoegE yronfom o] eNO “epee sue usp i a om ‘9p tmusse03d sssam03p ssmussnoo ses nereld 2 poupe poe ‘mes wary goronaid ‘serapHSe bs FamnfarD jaoderparg wamnoiypout aja iodswp ato od ayu=uR-neagd ia domenil eandfovascular efit, protongind efestl 1o- vovizeerh dieses Deplasarea de pe procebels plasmatice 1e rea proce de epurare « glicozid ‘seeea, aioiaistare de ch suprevegherce bi = Geren dozel de digoxin ‘hind. dlspost Se edminstenat Gmp fedelungst. ABELL XLV 1 fi relevante lini, datorite deplasieit Weuntlsde Legare Usulard, cn eresterca SF sperices riseul toxle 6.2. INTERACTIUNILE ASUPRA METABOLIZARIL MEDICAMENTELOR smedicementoese Ia nive-ABELL 1 censhmatice, care fea eflesciati Citeva exemple de pot f releyante prin s ABELOL LE ‘modifiearea ellmingrit eracjunl eredicementonse prig fnare, care pot ft Felevante fai Trine eed caine aaa Tim imide come Faxon Teves ant, ae, rei fae Se = oo Sr SS aaariae ager a Meadconante care se eiinarss | Matconante 2 corel 7 Be sige wa YC, Tin iofueantsiok, prcke- Feaivi n ca 6.24. INTERACTIUNILE ASUPRA EXCAETIE! URINARE cl, seo sae ene = pen: ‘3 peotra un pH al ail is § qi pevie 30%, fad pial este 5 Dicicamcatele sab seide se elimintez g0190701Z140WOLYNY aVaLSIS HONN IM3AIN 7 'BOIWWNIGOOVNY sunsilovesini zee Suposeo oo 1p jnaipou eaqensisp seo 3c soyodsmen, isueacar yfejooe gezsquoyq 20200099 “ona, oe enn a oo wn pug “um ayy ty 38 rots Wap nto 1rtowfoe omo shansgns 7 ¥ narsoosy uvinosion, ‘sommumsrggue ated (earEe ynexdoad bd euqeuad “ouy 98 sortssuapeeg sim aja = “qordone INU ase oqo, ma oaja page Bune “eH spied npr 2] fajstes 2p atfoony ay 2p und Z soj20 © negeig “sseoxzmadesie9 aside ‘opeetsqns agrseds pracrqeodeyre ty 200 ontoe of Be Bag “erence otuviigoownuvs Niguo 3a 3svoLNaNyoiaH ‘sTINniLoveaLNI “ee veqmorcey zema sofoqg@t espos ep seeogmoia ep eases “MSDE "JARS BELO} qe EmeQU sea) op& {TABELIL UT (ona) cc. eazd PaS trot sb. ae oct inh, coutioue AV 6 inamie, fim oe miowich re. sma (ia mipsatens) ©) fh Se Suess is 1 2 taco, ato SS, pelcoenis cu poet vse ru tamstpene | 3 teerd 902 oi eee | RISE SH cp von 29 sated “yogoou Ie apis J “Sows Seatpost aaa | soni 2 pear #00 a Gao | seats op seemed 2 | nn a taaeHE z Gmina 1 Tae‘TsRB10. Ut (conse) ot ext (1) — ab, metab pea denis + cone, usm, oatamani i Sa See cme [cre cm net = eosin 7 ios tence 1 Been i ett eat fe Brees + eater te geet ope wee Scar SEE Se pte te este: vee 4 depeimante exarie coca te. depetaast conte CE ectmal statin 4 SHEETS sake oe sais SRE hase, encngiae cafes isaore smemen 2 Toman vet Sa ae)ABELL 11 contanee) {ABELL it (one) Pesan taempuase onl, onacopat peed Flssee Shae eae oni =) Pr ins geann ts pe ee i be ies. eee 2 poke, Si wclhetenine Qa Boca, bose Shaped anion sera seme ace(spore 9) Spas oe A ‘Gounod 1 aaaABELUL LI (onus) | __TABELL 1 (eons) 4 op oi mou tose at scp ye esate 4 FS Sesto, 1 Hoe mate a tim so) J a chic Flac saan: pest (4 meats) sa okra ce Pe scezonSp 8b semen aot eq ‘aed a0 ‘Gener aa aaasavE‘= de exemplu ond ‘cetarool $40 i snalgesic, de sau peoira ant (nl #e eoomandé ef administra sk s2 Ta eel pia o orf Saints eau 3 ore = dap mast. Ta € 64. INTERACTIUNILE MEDICAMENTE-BAUTURI ALCOOLICE $I MEDICAMENTE-ALIMENTE sau produse latte, care sant bogate 2 sbiorb: 6.4.1, INTERACTIUNILE MEDICAMENTE-BAUTURI ALCOOLICE 042, INTERACTIUNLE dacine gt exoxacins). Absorb flerdl me MEDIGAMENTE-ALIMENTE dlcamentos este micgoratt de eftre uncle ‘componente aie alimeatelor ~ tanin, ca Gin, protine ia exses. Levadopa se ab- Souike mai pois cind ae adsiaistesat cu o diets boss In protene, espectiy feni- feleclat, eauinoseld cu care fot fa com- 5 veghere telor fn stomac Gimp de 2-3 ore face w fgusttiniestinale) tsi, dupa a1, evi- mm 220ewe wane ‘ans “ups ‘mesa imazapig TO -aBan wy Rog {eae Seay oh we Samumojsten ye o suse sojsuemopem © pojuents > EEDI|NUD U8 apoguion op dopereanrd oncassey opemisueoipP Poimnize wg rooyyduy sumo sioongat tod ayucmsye wy emtfoes aprguimny “im mid teipRes eaptoN® Fier nega fue) 2p "oiy solace e'ytum Hud semanas papofom See “im [wut safes swod = song 8 suo, “ade no ~ eos mem TRY Te se eerie. boned gas oa 8 oom) pp extnemnie, uumct soxper Genemane. atc: ors RGINOONpIT yeweARICS oF ‘sengigo od wpsnguioa wud) mgd | goer pamitoe jnaiey Tenojeesn G0 9p svow says semeu> © to oR amp Hpvttord nw snenuayo aay jg Mis nkreemopea tommy SOUS Oia) (as 3 sponimesé sp suxy op atu peHoaied emmeune opment 2p sine. 3 uy atefoq yt OF-og ap aise ayenzn ejszop mraad smnailge wyfenusou0> “(pr fajendaid need a1 ¢) suensiemupe 9 op alan ine erfeqeosoo Freee 222), fad ot pny “quid ido oduan sjetocl SonweRos Tsa0e FHT ado sys no varenormacide praersOHeS rape wp ames OZ Wop ome Ta oj ‘onuneso dopa oe 2e0 aieoup “puase sumaporoual iemmudoud aycut de miocard, daci na exist contain ica Asocieree ex trombolitice intrave~ toe Gajectate fa primele ore ale infarct ff semaclor de isehemie pe electocandio- i Numlnl erizelor Rony een J angine de piept Se adminis. ‘tesa ra, fncepind en doze mist ~ 10 mg Ge 3 onl - gi ecosednd progresiv pind la pana Asecierea cu alte categorit de medies- Insufiioge renslt, wade ta inmficicaye carne 3 te feo 6 periosdi eupriash tou 3 sia miocerdic este att ria ciminuares Cuyului sanguin hepatic. Bradicardin marcedi (cub SO/minu) gi blo feotl ps (ele beta edrenergice la bolnevi on infarct ABELL LX Baar | Foros licence. In conde tratamentahe cro- tear inijal fic, beta blocentsle pot provoce suodifi- met cu 50 mg oral de 1 or/s, eresoind tatea profil lipproteinslor plasmatice Ja 100 mg de 2 ori Soa | Nope a3 338 335aap ea: apn pce emeongy apm as Joyal» aeaeny com opie aR © TRIE tp PEE gy 4 seen sors rane, ope gern mE tegen ne aia sues AV p> le TS sasha ena satis Fae > ace eee ajo etek Jor i Smpiedie& spasmul arterial corona exgommezing, Ia angina cro- isthe Coles. Mosioa anak” Mii satpenense™, 338We 1 2 sonst eooosanes, Wf eam Au ogy og (umedessa enstamps wom 188 oy gaHBHE no weUeg Ym yopsedsores wmgue UP weoqpay as, “a coojamzaso|s impo sotacooise resoupaco i pcs ped sump a selon dase some ‘HUB “(coussenoy peesooley 26 POE “puood ‘pioyes uoqes uadioonoug “pcndoion) yogareder> 4 “Sem ‘aaqajeo yum oymanoayy yest 300 nibeoy “yimuodas ong [esas frau of satay sprzanp manos ~ 5 J T ad meanttpete ~ se — armory a : 2 Sion ] z i 2 a || tora “I Son | SS [mee | Se | cay | eam PIE Jopreues os suNoy] SpoMESIpM OPH aye TwUPEHM SAL snot trav i | sap ~ gopedeg aremjoqnam ted psinds ‘mmenoag, Aes i sincol) “isopan cuomoNsy SIV G55) noKEHOHD our ‘aurea 2 gosnig sosido Edn ‘oses yuHBus 9 Haro BL NCIS musmoue “Tmuetreoypem ypHyenvos no symtosied v| OPN y 200d Qa “ase appr sil guseaoy sezop oso1ou “greaynmnf sise NE Yenyuneed "pow‘Verapamil re 0 biodispont sdmiaistriit sugar. Dozele necesare rapetgl Dov fetiyile farmacocinetice ale principalelor blocante ale canalelor calciuiui Verspanil | _Dildazen $50 > % Ta 30 3 ‘pai, Fal 5 Prope + 15 noverapani} larespand (0%wee ‘ toms ARRON ope ea ms ret op) op sod jeu axfors pmsseen 5p UU anar stop no swords ee 2 nuyigo ne-s oxsar> yoauiean =p TEP omen mado oy pmedezma 2p yee REDE facto wy Yoeojtind Mesteenay 2p yet ‘9pm | ps usage oem sept yan sara soy Jeeeriop oe en cepap 3e= Seen aofann 209 ppmmcoe STOP snueAsp ED soeyEUED LOPE 2p asGeNNENUENRA MFT BANE toox aareeR| * fn angina vasospastici. primente ale nimi, 10.4, ALTE ANTIANGINOASE Amiodarona (aniedarone, canilor, bergice. ‘Farmacocizetics emiodaronei este e+ yacterizald printr-on rronzit fim i o acumulare Gepsa IWorul dine eport gt eliminare 40 siabi- legte dupi cicea o hint de uacament. Tim pl de fnjomatatve ese de 25-52 alle (cu * Capt Asta 346 _. 300 mg de 3 os, apol cfs 200-400 mgs + ecaptarea; de 26 at se edutiaisteazB, ca ant- anginos, pe cal oral, primele 8 le cite 4, 5 alle to fiecare siptimiad. Este indi- cath fn angina or tail Bt gf ponevea la soar, Lion Fipiisetal de tratament rispuasal Ta efor diminceank. Blectl Yor Sniagoniem compedty cu ionii de ealeiu ‘trougsler netezi vascular. Bfi- acitetca in angise pootorla este mode fi, Se administeacd ora, ote 60 mg de ‘Porili Ge Sncepe on doze mai miei). RRedsfle adverse sunt fae: fbn it 5 Ga 3 prize). fa flee infarc terspentics To angina tits conehi- dovedité ou eeritudibe ‘Se sdminiseazé oral, cite 150 mg de ania de dared & vee ease pot f allatste miedicameatos. injecteati intravenos Tents pundsmaoal ae prope easagre- clic 40 mg de 2-8 onl stu pesfure, 400 meta ibsoarbe bine din Re fn lest gi elimi-aalat cee ede mkamitajre intrevenoast rapidi posto fi canzk de wep ote ge admiaisteadd orl, doza obig- Bpotensione arterial jie adverse sunt rare, S-au seat~ MEDIGAMENTE ANTIANGINOASE INREGISTRATE IN ROMANIA Tho Mack (Mack, Germanis), spray 125 mgldoa8, cpr. 20 mg, 49 me, 60 mg (reterd) ° nonis (Oren, Fiend), ops. 20 23. Cord, Corait opr ret 40 mg Pec Romanie, Dexsoo, Ise, Isosorb retard Zéravje, Yugoslavia), voagyes 10 mg, 20 mg, ope net 40 mg. opt. 20 7 Peo round (Pbarwacia, ‘TBesorbld (Aatibitice, Roms), cpt ‘oe ee 2 mg 10 me. 20 mg. ee "Gencve,, — Issorbid dnivar (Laburmed, Romizis), 8 ‘pr. 10 3g. Cts Chemical, see), Isosorbide dinate (EIPICO, Esp), pe. 5 mg, 10 mgbre 32 002 Se og may ade “eusep, silo “(ersancig “VaWS) euourps03 Sa 092 ado Cemmmey “Tame Rucwmponey Peosoponey oorepoguy ssvoursacunie ary wz fe 5 go ort 0 3 oF "any '3do pam “woWD) pundion, ae og Buoy as Cepmmey unpang nny) faery AO “de Bug sto (emeuoy OC % or stern ~ anew pesinay, —VARED Pre apiog “ding i wb emntan “o8—) xepepico Mi go og tr ado ha Gy ate ermal) pie more mepy my ema ERISOAY LoTINT Ceomy weusnt inp wong buon, 8 do “(epaiy “uumpry) sidiecnoug "Bar 0g wo (id Sly) wore donot = sw ot Sm of % ado “(enepso8ing “aljsep2) sma 3 Bm pg var sd Xda “(ermopooeyg “poOTeTY) uaRiPIY “Geant uexeg) ys or eudieoay aaron Ba ¢ Jar ad “memes aay Su gf “Bu g alo WHS) Pevies opis oc db “RRL GET 8 Mppe AD OF eRHOS ‘8a of Bar € x “Oyng “naRE) armuoye Padeopury ImimP[ JopeUED ye UEDA“ 1 gf 5 sg ado Yerepeon ‘pouteoy) ve Bar OF ‘(ommmoy! samaoy) Bu 08 “roy “9 ‘wonmnaowaugd aeiv) emmoypir FYB { =u “Sa 08 “Foy at OF TS ake (OBEY "eSOET-ISD rove Proueadons fur do por ‘soporg) a on 2 opt “tm op abs eh “aso lone mare ‘ ogg “no “(elanig ‘suoy ouaqneg se0y) son97= . 210th Su | ado “efong “opmng) wlowepuny 3a of do “ormmmusg “gary OF ave ‘don orery “But og do 0 ‘EARMEEY 19) JD uoK gpptomeary epemeaoy soiRrouespe-eeg 2ques0ng, Bu og “3d “emu “wmegg se) Buoqoney Ba 02 slo “omopmey“eydas2y) uo ouuaen a {ups (emp “pemyy) werogjaty Sat $2 8 ‘Gepap ‘eam pseu ‘0 gz vat ‘Mo rope sp Saade ‘aR reg re 1/8 ¢ of sb "(oremaing “eges0p) sat xo ‘Bu op Bug ido “eos “wox0) US 09 ‘Op ‘02 puoreuoyy fax gp “Bar gz ido “(renmand ‘suea 28g 21900) sooty owoyy “aa ors alo “Bu op iD 2840) sedep on owe oON OHO sumo pigionony iw ado emguoy ‘poman) apomuoy, Str gp "tng do (rtm, ‘suc eq 22900) pris sooKoyy 3 oF iP eas std) ev 9004)BIBLIOGRAFIE SELECTIVA Tin, Now Yor, 196 Rudurrd J. ~ Phen 35080s stesso someon pale 5 em pf 84 mo eeepc some W sue sme SP ES Sap Ma ~ aE fA cogs gonsuseyd wfens20u09, eed oad of Form wu aod a SN ers ojdeosiosu too nd conte aiounsucdouucig ~ (20 24 bit qicmnl [Bie (OTROS PABST inepco) epeateo esnay myo plea sp yosoise oxduraxe op ‘sfansqas 2p eareyeges wid YVNOWINd ININVLOVAHNS ‘ATELNWHOLOSdXS IS FTSAISMLILNY “8b65 agin. Volumal aparent de dis- kg fer titagul de ang de 3-4 ori. Poste 6 carl mat ‘nibd marin, care este robeil respon sill de efeciul analgesic pot provoca broahospa Uitonith elibeaci dei ful deprimant central. Lat ‘mai mari de 03 mglkg a spimorphine, codstnne, iyrocadone, d- ‘od rin sioteas, 20 propria asemingioae codeine. Riel Scgendenje! este ceva mal mare pentru Dozele wile eant de 25 Decele mazi pat proveca ussciuuce gun, pam bas Go cha, cpl ea administrarca de - ate. * Sireagd gi somacleage. Nu provoacé Pentosiverina (pentoxyerine,carbeto- practic dependeayt at fenal (tevopropoxyphens), Tarudit cu mstadona, are de opioide. Are progriett gl ese slab bronbodiatetoae. Se administeezh or racic scfuae 50 mg dimineas sh seara. La copii s© pol ‘pentty ceime- injroduee supozitoare coafiuéad 20 mg, espe 8 mg i cl sugar (ou se ads-- Sind de 40 mg de 2-3 ris (Comprimste ikea la drste mai aici de 4 Juni). sau capsule retard ated att deprimit inhibin componea- fea, pentru preparatle retard, 50mg rift; dozele recoman congestie nezal, diaee, erupii utanate, 1) dorer-retard, poseladine), un compue de sintexB fi Firudize ou opicidele gi eathistaminicele, 48.2. EXPECTORANTELE Expectorantele sunt substanje care fo- vorizeard expostoraia, crescénd cantaces Ore c-e frets Ao a an-o-on anu Hs = tr ‘ip, 105 ~ Suc cml» wer meicanet eiveas (si wnepoinyie) ores 2p pepe aud se] sacessjodsa ap pau? pseooe TE Co-s0'0 =p e2op af ‘quo of sepydea ‘symm ref un we etppoy ‘qumylod =p aL} gas f20 2 3p) 219 9 samoay af BSE QE =p wise ouopendsor sfeamgasm my 1 propwe =p oud unm sjozoq, eaeys aise gonnadeis aERs w NUS aMGaN HOME sp LAE vereyoeays “omesoadr> ruled aiLEyIp -oID Hosp wf eR wy ~ gleoeTmOME ‘9 eponeov ous‘ tn op ST etn we ato a emer dung oiase® ploerqown no p> Tes ben op @ Sahaape ye p> ION ‘eed woosost ted aroun op SHARS "BIE §-> 2p BO OOE 9P PEE 17E sda docs ty sfepueeioaal 2220p “f2 1 36 BLOT 9p BIRO Soup sp aouop~ mie soy 2 au ee Sys mtg nes pinged sanasrapy us plead onme vo genase? alot + ep weneo y yod aueicyadas vo sysop syeuly “porbuougoryou oyfecoecindy 0 amyf case wo expe sizaneus oqoqued putoyey fsnonar mmmcen © owe 4p sarERU Nevesopoodee wtizodaos wayere i fn, SLNYINWISOLguORS SIINVUOLOaaa “Tze “iu 3 voseoyipnmy to "pseoonas apenas dcp movant sudeeo weap ouHl? od es minstonmeiuscodmes wp io mp rike ‘jruse vouaslaws no “aorbuougoryai 40 fat nes qe “Buco syeedaad op area aur uA, ‘aoe feusip aud jnimona "sm ‘2p jynxoyss konpa 785} oFoupyy op lund “eyeey sep ges ho} “somo Emaydej — prog8et. 9p md ‘uueyp = suansrat md ReETIERS “NCI 18 sou Oy grBoq amIpRY wafer OnE) ~eyooigrongbaye Sg © “IEEE HP “aus no ‘ogsqoj Ts efamiooadig j obey REFAROBOTPEE BOSGE 38) HOS| \ i de evcal serie de compustolci gi trembexins . ‘Benzoe, 6 rigin& cxtrash din. Sorax wen de acid benzo, este 9 cleorsint onfindad fo principal ei atop foi legitad - § = 8 ~ fol ms fF fregmentale de mucoproteind {i Bronbopulmacare, cronice obs jredemisent an ‘foes pe care le fluidic Hi core 48.2.2.1. Mucolticete saa mucoraglawoarele ac- file de ageguva macromolecuelor p foghicidie care formesth scbeletal ma- cusulti, 2 ‘consecutiv. ‘oguraree expect ‘ip. 106 Deacon ponents ner neta, le MEAN PEM ele ucts cic Catena) Mesva (mistabron, mistabronco, muco- e sedi, posi parapetanohl Doz sat pin gruparea prin grupares sulfonic® pe Pe jh enpectoneze (ea fia de wzen). Do ingicatilor ca te peste prof oragice produsd de ‘eofesfamica. Ea se Gali. Deesle recomandate sunt de 0.75 8 de 3 onla. Provosct uncon greafd ea wotliald » antiner ‘is Seeasd indicaje se edministeazt ioe GH C008 Nat AS ~ Cty Hig 85” by f-g-cHs 7 f Acotstird “ereO acu Cy iy Oy te Brass ‘Amie (i. 107 = Svcs chic # ner epee moss sisors orp “rojas wapendeo © $f yoga ‘arcsquoaq Te f0q ins 2p sndaraa en “(rupu2ame: ‘jexoiquio) yajoxoaquy rime “Yoong nideisx> =p) oad m0 stoma To FEPSNSTREPE = PED oacty ‘ao ‘opjottoqutzersp PEE 9p omomet TapuoTEn md poy qUmmaeby swtompdogon ania uyNownd ThiNviovauns ‘est ‘2.08 H meeTEoR: “yEneaT gt afijes o-meIp ifotamse ap eammsTanape sos 2995 ade no ows run exlseap Ra 2p sojvodea wamejeya: gpeeamooar 2g ‘soieoso awvowmdequoig mniore aay ‘yen aotfoouy selsa® BOUIP ‘8 geal‘Surfacantal est indicat pentrt wrata~ menue curaniv si profilasia sbrdromatat EDICAMENTE ANTITUSIVE §I EXPECTORANTE INREGISTRATE IN ROMANIA lefedanc ‘Golmonsin (Biofem, Ros int 5 Coseind Casein phosphate Medimger, Unga, cpr. 15 38 318 respiruoric. La nc Pedneipale racic adverst soit Tussomag. Codsinmopfen (CT Asznci- Brow 11% (fos inon (Bockrnger Ing, Germenis), ‘Brag, gl, iat. 8 mg/6 ral tibotice, Romania) Dextrometorfa akindss (Pour, sirop 01%, 8 mg Brombexin (Lab. Domenii, Roma! i confirma radiologic tnecetied. Doza vasist8 cu pre- brombirat-(Biofsem, Ro: Bromhexin (Lab. Helecr, Masistra, ‘Labormed, Romasie) epr. & mg . Romtais), _Bromhesin Fablbere List, Germanit) — med, Rominit), 6 mI Frans), gelle 12 mg * Bromhexin 8, 10 BC (Berlinchemie, ‘Germeais), sol iat 8 mglS tl, 10 mal5 mi ‘8 (Phare Meusebsch, momar greatete micd gi esie ermoalatl ta uncle ‘ceiliceind (CC-200 (exal Pharma, Germenis), ops 200 mg, cpr. ef. 200 mg Acesplelsein 100, 260 yon CT (CT ‘Aerasimitel, Gorm Zn GION Glens, Yugosla- op 125 sig! ‘Cong Toner Pharma, Germ fale sep 100 mg, 200 9, 0 mgr pr rel 600 me Gueifencana anbroxol “Heed (Bicfera, Romine), sol int “Ambon Speier, rein, 10 goo mk stop 2 9100 oo i? coed ‘Trecid (Sicomed, Rominis), opr. Codetnt foxes Cabormed, Remisie) cor. 13 1S Cocina fesforic& (Lab. Magistee st ‘Sintoferm, Romisia), epe. 15 mg Caden’ fesforc8-EEL (Bicesl, Roma aia), cpr. 15 mg Farmacod (Formacom, Romtiia), 1s mg Fouls de codeind (Laurmed, Romtais), cpr 15 mE Say 30 mgs aYOLLVINLSVILNY WIivoIdal “31 YAUOSTaS 31vuDoneiaSp Heese Sp spuidep summa ep pucsesey oud cpmedo inden rene oyeqmtg STANINVLIA “82le sat bine euporiate in doze jee, Supradozarea poste ‘severe fo oszal vitamiaelor ipo- valburart soluble. 28.1, VITAMINELE HIDROSOLUBILE 590 ‘prin urn, fa majoritte sub (SST id£59 ‘epend:y MPI Belesop isd ye mogeios men satop coe se ft jay yoqeeut soma easrmso} x{ “oy Mp ommq qivege es Og SouIUTCNA syeicore yopie © of gf easyduos ap sess sua FOREHD EMIERG Fed Ad neee ne notng ‘ow, poo oon S Ty sunauedooy nooo" ottoy 9 : Nooo ho-to-u-z16- Bano he : y Fanca - = x spuumunaony ST Oy ee te eg ce nolD-=¥ rumpus HOT ‘On ewvagooy : i oAo® nt s. fe ho rhonipaprip tio -oto-sol Ql oo WO HO. Ho 9 Sg vores TsEZoU men eHeonrINg BEd yeotdicw ap aqrosge 2 Syfers capsionl uy ys0q wrinneur) 7 oot ep rant as o ated Sar ‘mupHd neous no ndaxoa fapendne 8g aojemqueys. Indus a WNINLIN) vNIXOGIuid “eT ez ‘rvousaenuy nes amenosnusenH: geoyoge & ‘usadscomplensl B. Efi vareiturile de 3 ites piridoxinei este metabolizat Ya cea mei mare parte, ala de ire formiad wn derivat N-metilt, pentra ‘Gousle foarte mast epurares se face pre- trie asocierea de preparat= coali- st minerale echilibrate. ,- Dack spunsul au este adecvat se reco- sandé asocierea de tiamind,riboflevink gi Piridoxind Sn doze farmecclosice. de eguld, bine super dinitrate prelungit fast pravoce nlburdri newrolog! jomene de nevi hares coenzimelor corespunzdtoare, fe s7ti Geosrece este bine suportatl Acid meamvtsaau plerdend Winare cxecsive sicctinie. provosel frecveat congest fcidulei nicotine (pelagrd secundart). In def opt Gfuaminel poate éeclanga un sindrom de chiar {a dozele relativ entry coresterea defcitulsi ‘genetics carscerizale P ul ‘gekmald 4 unor enzime Saree perferict 2 dopes, micgorandi-t © Rcacitalea fn parkinsonism. roamelor de milabsortgic $i le 28.1.5. BIOTINA $I ACIDUL PAN- hipertiroiieni, Je prezenta TOTENIC carcino, fa aminoscidurit $i 28.1.4, ACIDUL NICOTINIC $1 NICO- TINAMIDA (VITAMINA PP) saga “Anumite medicaments ~ ikoniezido, cieloserina, Rdralazirele, penicilaina — Sdniniate timp fodelungat, pot B cauxa ‘Acidul nicotinie ftconte ‘ fname, iacin fese.apreciat In 0,1-0,3 mg, centtats ‘coprnad fa aliments ‘Biotin serveste dropt coenzimi ta .procesele de carboxdare (a piruvatll st Einar forme asl de CoA), avdnd un rol fe manifestt print erupiic ct pe piclea eapust la luring (nooale orle pot Fenomene de bipoviaminows Bg, d= obi- forisnt ix metabolismil glicidic si flips In mod esters. completcard nevaln de vitamind PP fo- = 60 mg de aminoacid -exflintvs,alpecic,gloitatofied biper- 2, an0- ile pentru respirala. ti ‘doulor obigeuite acidul nicotinic ‘Nicotinamide cate mai avantajoast‘ad ony 28 vores “CY gL ep ampE un ar ce Hj apundsaian 20 ¥220) BHA OF -pRqwarE AHOFTEII? 0“ CHIMION.A (0 wnuwrwin) oIgHOOSY TNMIOV “STE 9 geetieapias Smo roe aca “asoese yoda ¥ nnaed og op Sad | | | | | yeaa [apEE ase sed “ogee vo 38 gioqungesca pag} ns “genar 2722 jode ‘yursepd uy aysarBaad 2pe2s 100K : eosa ais afouny sop ¥ RoMod ZO}\ ek a acesior fonoment 20 ext cunos- acid fe, Eat produs gt de bacteie n> ek. festaale, de asemence este probebil si- vAeidulaseorbic ests de reguld bine Drgeniem. Forneszi fn fesutun Dosele excesive, edministrate pot faveriaa formarea de cal Drie mrirea exorefiel de oxe- ul presungit est sopti= oe minore de elor, Inodital trifosfasal eliberat din fos- fnortolal nemmbrener fune{ioxese fe cotnpoxiia ipoproteinelor plasmstice gi Ire iano ele proveie Ff alcool ou deficit de folet. 28.1.7. INOZITOLUL $1 CARNITINA Sina; scfoneard do ase Se eesiere peatre difeie tpur de cesta. ina, ca face parte din aceeagh servine indeosebi ia metsbel Imitocoudri, unde Dolizai. Carnitine favorizeeat, ben, mcabolizaren serch 3 pte Togitetat allmeatar ~ sport este de cinea 1 g/t provine din vegetale, unde fe gtsesle sub fonmk de hewaforfat sau dstiva, Tn confi HO on Ho: on idglor rege vileza procesulut de fosfoilare oxi Seiden (oryy-or-gr-cs-c00 be Levocarniing i evoosmiinel 698 +. 28.2, VITAMINELE LIPOSOLUBILE ‘Aceasth grupk cupsinde vitamincle Ay Indebongat, fate, indeoeebi tn feat. Accasta explicd condi de carenis, sinptomele (oper aarala (Guph ‘works digestive — grea, vom, durest uvinale, diets; Ia dozele mer posts fa um misos earacteile al compli rea produstlui racemic produce une- exalt Rretinot =~ CHZOH > retinal fe— CHO fod retinaie = 2 COOH ratinoin) ‘lg. 146 ~ Sunotace chimied a vieminelos A TVitanion K site prevent fn esptoil “Madicaa bamonatct 68ny puymmnds souioads une emit TE a ayoAaap se ‘ito sowdeoeu joruniod on REWER ROTO Tinea ¢ =p emoep ty oe dead of isno¥s: ase fa Seong] "F2rao2=p sousep oF eR "uy. eae HOUOH! 25 TeouR 5 aprcitess oyuce Umis sso189 wLid 2300 9s aise Seanpou Asem [ eeeuey Ser site ote oh, gets | “b> % Pan | stein —) — pats if 5 “Herne ots omg ap Imoehar Fes sfmaxe 5 sa © snodap '8/8" coe #8 oot nm ssuudeo “uem enteoza® Sd up eine cp 2 POND PICOMfulsed, fibroze chistic8, cl bstrciia bilan ete, Cio turd procesul de éepe joue febrile $ in be fagh de wansformdrle experimental prt Ge proteint ansportoare ‘Fenomencle clinice ale hipovitami- * gozei apar atunel cid concentra plas- 5 ue! fervor x hiperkaratou! foliculard. Tra Tamental ov preparate de vitamin A tnis- 1-2 tile; lextnile oou- ate incep sf regreseze dup6 sasoxidante itamine A favorkzeout procesele ima de apérare cninfeyions’. Cereals prezintd © absorbie ws frisimilor, espectiv @ testa. In hipoviterinozs Sack doze de 100 000 ui. GO mg) sa ‘dmministerea orld ete 200 000 wiles timp de 2 alle. La nevoie, © poate 1 tan 1-2 siptimdsi fa sindromul de bsorbfie este descori necesar® su rmentarea 4 25 000-50 000 wii. fe revomandd iajetares intemiscolaré a” digi decaf slimext asain co mal- 28.22. VITAMINA D $1 COMPUSIL stares ral» 200 00 ui inuoIT i tants in econom ero, caleifedicl, ‘um analog de yal Cy-Cyo dia ine B a} mucleulut tu fommazea de colecalciferol ‘precursor, conju fn ormesté prin ira- (@ usitate international Supradozarea vitamiet A determin 0005 ug colecalifeeD. Is fenomene toxlce de hiperviamincet Ria- Refioadn de cregere, ca si in timpul sere ul ese mate clad se adminisueezk ailic, ili gal elptiit este, nesesel Wo spot fexogen misi mare in jural « 400 wit fo condiile unet expuneri insufictente 1s sosre este de aemenca nevole de un ples de vitumind din afar, care depigets can- ‘| ou bige . Ja gravide, pot ff cautl de malformatt coagenitale, Retlaolii de sinterd pow tn rise tevatogen mare. *Capielel -edioaya demote"soe oe sind pmowioy 2 ssopouamy my green jem 2p so sa eomemnioy “Gury ejooe "HQ OL emmNOfem oy “coe 36 GQ BENE sofor auras, -o590 Up valremgond bud 1 “pups ‘20yx0) slajsuce a "4D 2y Sf cess fone my sony oe vomeed ape © 2p HeFot EDS Que ous 24 ups my aayOMR OEE -nifoe ne menaiogouy 8 oomue sfonee + 1 Foduowfou! & 3] RUaRES ao GPE eH apodep op 16 sieojnons omioy me “wojny sone 20 Hfadinue sun oUNND eam ~ oer “Fat ones ya. Joun ezdnse pare = Lied ao oe ae emer i ; catsmauned [ox on ane ato op ae ‘wep asi man sips oy “ut a | “UsRTeSIO Wy Cf WSOPE spyiounys v8 jumsTOMEM — GFT By a cua ee ee a vee © seufeeu efgweqe Sons =| | epenend owing | [sees 1 2Bos rover © neue: eesunHe aqua ~ —q———— | 4) oaneemtionse ULsisi 9 me at we ta ton dsfisit al mers, Sngroserea | seavs prin suplimentares = 400 = ergocal ec a hipov D se sdministeaz® scldere aan seks reece clayoncesll foi | Si foes sais. | snea méregic produceres ymalacie defectul de calci- cone OI Te gimslea TD alice Stel Oo vai leat gi avind un ct ll este un analog al sitaminel D foarte eficase pe Tizarea eaiulat din oo jgneit. Min Jor impane aiociarea de preparate de tale $i fo fede Tactat, glo- Sonat sau carbouat de calcio i fosfat oi le nopializsca clcilsl g Fostauivt ia see. Io rabitizmel i osteo ‘isleta din cadmul sindroemelor de ralab- “ebje intestueld ee amiaisceazh infil 3p0 000 wi vitamin’ Diet eBtva zie, 02 ind apoi doza, pe misore rezalvisih €3- en nee gu alfe-caltdl. ‘Bxgocaleiferolal (ergocaletfer cefero. vaamind Dy, davitanon D, de Semendd witanina D 20 000-80 000 0d SE ia osteodistotis din insficengs renal Eloaicd se adminiveaz8 oral dihidrosahis. feral 250-150 ip, caltfedio! 50-100 18 De ssrmer ST fhidotabisteroll (cikydretactyaeroh ‘AT 10, coleamlne, tac fein combeterea si arene Cyptia wtamnine D, cae denvolt 1 full GOReS fenomece de hipovitaminodk tm eondipile ‘Srinemyl unor candy fisiobogee d& vie is oneainm, Aceasta fe dX0Te2 hull 3 yg oral sa if nteavenos. Le pends ‘Siminisueact cxpocueiferol sun colecal- {Sterol 20 000-60 000 w/a dsc poland 2 SH ta renal de exeapla fost Hoda renal (unde caleiferolii su pot activa Tunkel "Medionja dermasionic” _ ae preaiath re farce 50 pt ‘Toate preperatele de vitamin D sant te necesnrd adminis- tn doze mari, de 5 oxice fa doze mari, Administ Teagié de vitmiat D ~ 50.000 sal mult ~ la persoanele eu rlspuns a deternisa fenomene de hiper- jak. La copii, doze ilsice de icemiet si elimintsi osaare stat. Celeivl mobilizat 32 poste depune tm ferurar, biosebi fo ti to nefrocleinoz& difuzt sau n¢- He clisice suat: obo- $i. La coll se poste ope reir, Now D.pot prezeata insuficien{t peratroidian, (i biporeloenie i convulsi, Exist posl- carece hipefosfaremia ‘Retile metatatice 28.2.3, VITAMINA E Sub mumele de viterint B 2 pringi compost din grups rozofe ‘mai importa ese rt800 ones plemiges gefue o wiucs ans aemsedeed pono pasties Set 5 ar er tos “seme we cae 78D WeBTOPME HANEY) peony oot fou “elem “opaeay) & (Aor 1 2a os KeeaeD “END OF JY ko ouning “oD auoreEy umercea HO ear og 245 “Su gz “ada ‘enemoto, “emai NOD ‘cormmoy dase) mete> op roueroneg Tr 66 005 s1oy “Cet "yot00 op souairumy tm za cot og “emmy “pemosts) ay oenoA do (emp ‘paces 21a 83 005 “Cepmusy ‘rama "nus ‘poucydo Yougua “3 uous ‘at ‘o1z2e jaszydo2cl) yeWO8 [H}o49}o00, ‘aepory) 9 do “(ome 12 "xo “(euemED -waes) 9 povagosee 4 do eupsiog “urmgfomg) aoe moot Aa Dior Po fo Wo ow auaniosozpiy suena 1 0) S089 fae) ay 4 : 4 05 \erpey“ponnoemanga “ae 9g se -VINYHIOW N] ALVULSIOSEN! ZOINMIVIA SLvEvasuE ba we wd cad30 agit mh nine E forte (iofsrm, Rett), pa. gl 100 mg gel 30 000 vi. Viramind A (Biota, RomAnia), oP BIBLIOGRAFIE SELECTIVA 29. HORMONII SEXUALI $I PREPARATELE, SIMILARE, GONADOTROFINELE, ANTAGONISTII HORMONILOR SEXUAL! Principal estrogen aetoral ~ esradio- ful — se formeszi In ovar, tm folicoll Graf. Are drept precursor testosteronal, fe ergeceior sexoale Pr le seoundsre 29.4, ESTROGENI ‘Acoust gpl enpsinde Rormonl stein} comput dese, cae a PPC ia poniilizarca coleterlului pent sintcca [iGoilol homosal. aly 2 estogeal a _ sstrona fh este ‘nai polin ao8sh ‘Testosterone Estradiol a= Estrgnd ——t Esto we enabatiea™ ‘ru. 151 = Vaow A meta enroute‘yemovdns naeg “2 [> 9p dump [eo cpenstanape “prat 220p 7 prninumcoar nnueg yy Fajueesonso BEIGE op oapaede2 snmroford wn np aieloose ul — yie8 aise ooluefonea HUnpoe war "aon ‘ROMP g7ULO} 25 EA ‘oi ap yonzes nnaed um ‘eonucosten quns ‘aor gopemreyd sien ud aso pimoqoeid ecm sseyd snyonsSoaugy jaan crams eee “suse ap “Inotupr aalojntooe pugziios of Tn wag: renecan weary f opMIORS BEEP syed whup: poss "eunm Ty soa fone sqeesresdasospion pois te eeysospoe epun “sodepe Tate! 2 ej s8 ooBonso Fanecousr ANG Ton 2 1 yppuamdnsoonsoo ango 2p ssnposd tons ta8aRs0 ep form Ynnae terane ise Eoow|d ap ramet waRORde Jape “poy “ums esa oy woop tae Ho 2p oor vans ap Stale atpores safer ¥| gupd epuposas> aerdosd Hy 0 Up ‘uzooyd ango ap sey er snpodl jms ofanse muse made my rey omeiodsy injnmaysis eidnst arse ns SauoOy “ateeuodsy nasetodsy =p aetaoos et Joei2sI109 esis oA24p "Prem toy sniolio sacnou gosanond teele traxsdermice), estrogen conjuzati clinlestadiol 15 psi. Adri P get, de fovea raportal beneiciulisc uebuie eva i avatajos ua smonodependesti. lovosct uneor! remiss im cancerul de acai fniagonisac direc anéroge~ roacd frecant grea, dat ‘atro-progestogene poaic fi caurd d= ert inlenmescrucle nercgulate, Le bir- ‘ovocs sckdcrea bi fstrogeaice ¢ eadometrci, consecuty lipest ovulaie:, Dace sangeraca este ro- find gi periosloast ac recomsndl injec ne veosiune arterield Covers probabil geaeratt de -angiote fmedicamente induc enzimele mado Tizante bepatice, eccslerind inaciverea hormonilo= Estrogenit felon tapeuic cupring Epeoi nofural ~ estradiol ca alts sh ub forme estenfieste prin siatert, eston8, cstropeni aulfoconjugalt din wring fe endos gest in doze musi timp é& 5 "Poloszes de doze mich gi aspires 1. progestogen scale. consigershil ‘align el stamentlel subsist The estrogen. Studil epidemiclogice 2 fiatek de esemenca, © eestee modesth & Sieului de concer mamar. pebtra tra malt de 5 aa), &u thlesest ‘Botrdiolal (esradia, desl, diogyr, csrrafen, oertrogel, sytem, vazifem) sto ing ete peinepslul estogen je over. Adminis jronizatd se sbsorsbe regede gt fn proporie mre oped jemi ales fa ‘provocs malformail 1a ‘enbrelor, D> asemenes, foada de elpar. face es efecn sf fic elt a Fail scurla, Doge gubstimsivd, medic este fie 12 ge oral, fn taburbsle d= men0~ a Hecare lea, esosind, de regoll, un pro at use i) de asemesraseLen xovir (in menopauzi sau la femelle castrate) pentru fatava proparate estrogk nt produse fs we formesnt portind de Ia fnfluenge bormonuini. Mean dopinde. de seoregia progesteronsisi, fa neeput de cle compul galbeo, spol de cre placent. Votan lems cress, 56 ficege consinwtal miometrlui fa sciai colagens deote y omnis eruoMog sounds" jee ‘ones mmostrejeg ofemost: sonpat ¥ an \ sted 8 ginpdownuasod wg gsnnsgns ado ' ‘at v2 "wotonse wn m2 enfrooso wg “sis “oj so (suausisa8aud) [auosaysoB oe ‘fay Sze yin ‘novormore 2q 4 youn tea. 9 1 sonnésar mmnuss rex SPIE Sa “np ste “pie pu s2op tod “prmeONSG Sy aed wees angst 220p indo [Rutsxopes som 1 ssydiedny “RU H{ yrzonstummpe 2g opm koma ap faostl joscepoy — yeHEN(opal ord |Biseouye oun pe anemeye sa 4 Aoyanstoos eaisandop pres70 ‘erasers; afer “GH oneae(d fo) Spas fond anmp sued goog, “esr | quosasce, sosiogein sou gi) oase S geuea riironp FreoAomord (F amqaise - a anpignoud w gomeezones = = - 2 * ws seufoul a 2p jreauep gRse[om ne pues ‘yomnadery oy jmosectand opsed noo + = = os = pos auioaer posto Supe 2p BEGNSES = ade @ # ae | mee | Gem | iafemo | fame sauscisa) | anssgu shane | -rerbac) stone suicide | puueweoper | rue ade EEeen aT ‘enjieysoBoid exioygo © BoIGOIOIg BaTeATO ox nea 129 © peIBo|olg ERRENANOYrit frees To cee, $0 a BT tp cancer endomeil rcuent Se mets dove mast de 5 detent amelirwea tolane. B ore stone andro- cate poste relevant ie}. Este efleace pe cale oraid. Epu fe face prin catabolizare bey A sareiad, pot f torgi wil selesjionate de avort hs ful de progesteron a fost dovedit cu cer- tadive (Grin doziet bormonsle) Hidroniprogesteronal (Iydroxyproges caucerul endometrial, dozele ind de 200-400" mg a uv pe ‘mental famenoreel al prin ineufsienté luleald. Doze recoman- dminiserae pes ire allele 16 gf 29 ale irogesterona (dydrogesterone, dix ‘phastom. gynorest) wn un izomer al ge Sebideoprogestronul tn indicate ginecologice find Zilnie (a 2 prize), tee allele 16 $25, fe ciclslui, eveanal dupa o pregitire cu fcogeni. in avortal babitsal se admi- sreavi 20 mg mls primele 46 hunt poste fi in} ing dat Ju 3 hunk, In cazceral endoroe- 1000, ewadprpetecn Germann Fig. 159 ~ Suotre chiniel« progeseseali gi ¢ unr pogesadte destin die ‘poses. 72Imamnos eénp pope rex wo gjecouiog “HOH STEAMLAIOVULNOO “ese vee sou estto2souosay) {rponseBs0905071 “ejosno THGRIRD Yo9j3 n> JRABSp un ss9 sows praassnmiaiold sowgrundssios peg sIHe =Ie29p HEAP iueiod © am yeizo0.jouaiozmas0/¢ (Gerodusn adnan 38 sqeroutiog axpdovences som wilezadines ‘a peut “onosiny roma op aifaices BW flowizod ‘woqdiow ‘potossra “ous98 9p ugotoep si ORFLMSNTES POU A og losieaemsou gt op smitiny “Frame 2p entmnafoed som ¥ BORED omNNS — ps7 RZ yousnseiny yousyseury ier es oi of 00008 ee HomHO%HO: mel So nome IO es gw 20 _— oe "oe o — sor 6. %atracep for aedorte este 0,16 pet fu efeste endrogenice neplijabils ~ geal, gestoden ~ sunt ms ‘mon, progesttiy 454 estrogen. 29.3.1. ASOGIATII ESTROPROGES- TATIVE CONTRACEPTIVE CContaceptivele care asoclad un esro- tative contracept Ricoied overaii, cu iahibarea decvoleiit fe din femei si éupE 3 cislusl 2.3% din cemuri se produce | amenoree, eae uncor! se micafine pid la aes 5 (estaden 0,075 0g, dlaceiat 2 5 ck Hee Simtaigueask eorect, coma ucoute erik te devcuamcact ceptvele do acest dp sum foare efcace produce singerre de ip menstual; pear 126 tou preparatele care contin doze mici de Je tip 19-0 -balajul poste cuprinde gl compri abo pent allele de pourk 50 ma) si un progeste: ‘Se administiessd foie im cazul contracepBvelar este cousin doze miei de hormoti $i al celor care i. hcemefionnie #0 pet Oatd problems doeurge a faptul poate aves drept comery aegis en Saw thou courengeey bluguiOY UL BIEHEIGENN| o[ei0 aANeISOBoid-onse eanideseNuCD ox aHin nostieate, antecedentele de sareink extra: ‘wombeembolice prezeute f islipemia eterogend, adepomul hepe fc, easicomol de sta si alte carinoeme Dpormoao-dependente te necesard. prod “Medrosiprogesteronul acetate. it ind, petra primutzle pentru urmtosrels fia sczeagl dovk de estrogen Ine ssare de progestaly (de excmpla (6,125 mg levonorgestrel eau 1_mg nor ‘Tretencotul se admiistreazh sph cares Fela ‘Ua tip. pardoular de interven fe couprimate coniiadnd doze mich, care ifaulce aad ailnie, sub form de posi de comprimate, neti scceagt doz levonorgestrel 05 mg — sod contracept area mucusuat cervteal, cu fngrearca ermatozoialr; 29.3.2, FROGESTATIVELE FOLOSITE GA MEDICATIE UNICA IN SCOP CONTRA: cEPTIV 3 ani. Acjoneas res ovulalu fer 29.9.3, ESTROGENI FOLOSIT! OA _ MEDICATIE UNICA TN SCOP CONTRACEPTIV provoust reasyil adverse, ca Ima vastaoe, matt fi ceputal watamentl, fa po fe ece necesard adBugarca th foe de coutracepie suplimenter(prezer- Natl). Deed admiuiswares unei doze tn Uieaie mai mult de 3 ore ge contin tra tamed weual, dart oe se admvgé uaa seagerzle vaginsle nedieg- epic, care Estrogenii aofionsari contraceptiv ‘dete mari von, disconfor ata comporale, loa imediat dupS nage i eogtere in reutale, cefaee, reall gi vom. Se presupane fs endometrlui, EBcactatea este de 99%, rimele 3 7ove sojouerceainsiea > ,vojpyarsoipuy——> ,ugguersaibuy % eeeeeeies omen ES + Jousis9j00 > uoicueuBals —SfiaeiseBG]\ uawmsoapy [EORRiBOR| ( Raw] tnvznoavuy 18 INZDOUANY liZOUsIS “rez ne § "ayo @ op Bu joypousopune —soviet feminin, iloatatea corporal este fenitale Tamia subdez- 2 ual Capebile sf folotessod un precursor sndeo care 25 se comport ce factor Je (anscriticy etermintad eegterea sintezel de ARN gh Uaeor pot i obfiauteaoeleagh fi a vieed, der rezul- ielor hipefizare stanalate defscte ale 5 alte font cane, consumulul exegeret’ st ‘poate realize benef lea : asacat esror i pot aves consecinfe nodorte. Le femel s= produc fenomene de vrlizare, preneate Gore, de testosteron de. 200-300 . prezeaja edenomului de oi de priapism, mai ales la frostal Gi pot case volun, accenméed (ameatalai Adminietazes indelusgaté de- Jerenja de arin). Sercian gi penoeda de {ering diminuares epermalogenezei (=~ contraindica sub gonadot q De androgeni 1h ox ate provoca modifisee ees salnondosd sau! swmaopoxt tte, Fah J0un © REND eens — 95th goon voreysoupcon.s 0 ‘Benne ¢ op Bu 053i | ik 5 ot ‘Spm of Fn ea “ pmurcipey | isolidouc nquod queue pu eunige no ioIoIs r pouedord vaqsoe0 i sake ot Kr E 50° . 2s pasupour erayée uy sf Mame eS =p som uy] PUREE ¢ areOY 8] FOP socos no fode pogamuco “poqdaroo ear 1 “Lp eamdeul ey pmpmoussoson juan 17 nied wouog ur g'¢ soo gzeczrany osorege my pytcag eosin Bae teiBu S06 tode in ‘paSunpad sumtzo 3 NVZTTIMIA sulyisiud se "youorm “Old NULNAd esi wsmaio -3ud {Liso703 5p ores Bm Cop-OGe HERDIOAHcendometriale se vindecd spuclor. Tratamentul 32 200 mag de 2-3 ove, apoi dows so sade svervale stick ep je recomandete shat ee 100-400 > ebule exclasd 29.42, STEAOIZ|I FOLOSITI PRE- Dor lizante ~ provoack dexvel ridie8tor al egusul, msi mult decd dez~ ‘eziulelorceminale gi # prostate Ye qobolan, La om, susese curbe ‘pondered, denvolli musculature sit Favorizeatt suabolismal pretei. on Metanatonan Nandrolond decancat Fig. 157 ~ Saveire cialel » weer secs ansbotcan, 138 cue de peuas de 24 stp Formeajelcr_ sp! Tedicalii priate substanpele SEXUALI Is sceasts groph sunt fncadrate medi ccamute copabile £4 Spledice efctele dix 39‘unsey 9p spastied no gprourco gs atoure ayioeds proemuctone nud giseaoe wp erreurs IINSOOLSALINY “1-962 sprandsezoo fotseds soqpondscas jour 3 spnecmes Seon & ‘pup oad ‘yuobone> )pvamersyy "pansed aise loxgadretionny Ep 2 = Das) Roma = ‘Goteout ae a) ‘seroma eroens = | t | = ome ite ors| ‘esodee eee) pmapewne | stapes be eg ee el 5 2200 8 arensaqupe ap soqe> “qs edna —'pluezioqead juoafaepoad aumffve no pony 1 aateewTamoston 29.5.2. ANTIPROGESTATIVELE cxpfcual, nchisiv penta contacepya post dar axe dezavantajl de a deresla sgonizsres Svinlor saat endomatioze, Ieiomioamele, 782 gesteron $i luco- hing. Evsloarea Ini pent eceste indicat 29.5.3, ANTIANDROGENII fo face antagonigtlor Azilo impiedicale pria antagonism com Jn xivelul receptorlor pectic 00 magi), impindicd denvoltares sexald rcoee, iiogoeaz2 impulsuile sexuale gi emmite deavoltarea somatic normal ‘fecha dont dazele se "gonadoto iv @ aiveloul plesmatic al tet - perimentale dozele mari de ciprotorend 3 hepttoame, m3sre cuiseure wang gysuo> imo ‘prnedonsts Rica epnenaf pruowsoy Bate onepeed Soyensy suum sip eesiga a ‘Finedowour 9p uoum sagosjopeuoy ‘srgOR apsyeo ed “srgodigousry “pan me ‘suomause jf sunono joint Pucun sxyfoopouo$ prgeatsd s asopdas oy vosoday for wo footy ns spujonopouot es sanidaceptoop, STENKOULOGYNOD “}s6z “gmayodiy-omemnodiy corto

injetesad intramuscular gonador ‘se face sub supravegherea unui in folesirea aces ‘poi eu 26 sociind menotropiod tor me sdecvate de ururire biologict 29.6.2. GONADORELINA St ANALOGII AGONISTI susului. Prepaet mente - kripiocur, LRH, lurele TE-AH ~ contin goasdoreliod ob ‘Gonadotrefinee, opus dir gi ces corionlel, pot iceoa thule jlogicé cousth fa contro onadarro csinieant. Esrogenii st reraitd un control tetoafereat urgety Shupea sistenmlui hipotalame hipaa & specifich ab cel Isler gonsdotrofe, er und Cot ‘Gensdotropinele‘ouodoatso op aces posts vines orp gspurimecer seo nt —— Or soy “emmBan, sR) seo Sur ¢ 360 (hong som ‘50 opt "8 oF sau ‘qufabs SADIE) e0085py youse2epy 38 005 ‘aur ot “Ho “eile ‘woldg) avai ‘uaqoe 29 gevansyannpe 2 “essmnege y smoot arom opge sxoqidon “amptgo ap (alsls lalalslale [= ett adeno tt tmcalne ge © dslsl [alalalsle [F ‘Parametatona (goronerharone, der EB : g 3 2 ‘la |apalalela la elite fs wesicie Mise mete = 5 S Fainere a stn opel Se adminis a Sal, fa dead 2 ae de 612 malt gh g : God de tonejace de 2-6. mate Mi eoe a : i 8 3 é ‘ & ] ] g e Falelt |e Pi aa gia |i & \Slile |2lalelaye i alale \elelel2l2 no mee euopras # eaBones ZomgeRD wo; wa evone1d Iw seop na ennjad fem, "BooTps0. wYfeorpeur =p asuposd 30]29 Snonmmpmere nos sieape epzioe, loos - ofoqoyeuisp # sy2ojourmzo zm aaeed seaden! # peng “om pune uo p 90> tf HORE sae co ates oy ome aolsies) sewBojamen gq apm -ruxep) sajrof (6e papzendno “90g 7 Ea[es ge[noefout a Smt ppl pone ay Bien Jenfodiy ae aoncoqion op 2p OS ‘ouey un aise “ELOY es vindauz09 Suios “faydaroo109) wayonoop0, anaiovsooveiaL 18 VHISOULOOUHOD Toe Sap # Huyenospioe aoep 6 oYx hipertensune arterial, Teli, Feaveatewlceraui e Seve mai mic decd! peatru corticotrofina > stu Preparate de ttracosactd retard (cor- srosy depot, ynacten depot) cuprind su8- ‘seetat ea hidroxid : . ‘eute ale solerozei in piel, sinérom jules, unele forme de epilep- ‘ozele recomandste sunt de hipofiaas, ce unmare 2 secre de bicreconizon. Iagcruperse broscl 2 sel poate declanga fenomene de le adverse. slergice sunt posi semlate canusi cae de soe 30.3. MINERALCORTICOIZIL score cdtiva bor ‘racpels) Bind aldosteromal — sri tn metabolisil elecroifilor rncpal, petra Saget one Somicosuprarale. fa a stl subaonnal (alvel plesmeuee me peril mare, mal aes fm feat. Administat m1 ce fm ucleu, unde se fixeaxi de croma- tind i iaaenjeazh. consseutiv proces de rmantcriptie @ ARN, respeciv simexa pro feied, ModiScares ransporalul Tonle meme 9 latea de 142 ore, timp accssarsintezeuncr protsine speci= ‘ier Is nivelul celulelor fata, Favorizarea -reabsorbiei wala a ionilor de sodiu fnue\inutd ce secteia reactivl de eldo- seroa, poste 6 combanuté prin diurer ‘anialdosteronice ~ spironolacton ‘amteren si amilorid.*ue somony # aefoiewane sieereis” a210088D oo To etinks Sesemnonmao noses O18 emg qezoore ssipe cess vesiooy eeuaig Cameos oe f sue fosoipy simua) geprduy weed soo sopneo exdase poop porch aunCe ‘nes Zo]RIosmsoonog ezIMS no TES ojo fda Rosse MIP eyIOSOMTPSG §ZIOoWYOOUNY “yo sora “Bap dose 0p wrecerMn 25 roodeaye (preapeersran ayoquem) sorscopmonezep =P “apoxe oj ‘woloonpasd ol yeseoduo aso oroieopre 9p [mEUEC =pze8 RICANS ‘iro ~ 92 7 afarsomUU Freep © BUI S -proonsctreum da op sedo> sen ¥ aes wENS ~ Eo" FLY ozpeeoipnis vopeonereg ossopry 0 ° ° 6G [yor oY wo Ba ot > 7 H me op ies “OH Hohe oH HotePREPARATE DE GLUCOCORTICI CORTICOTROFINA, MINERAL CORTICOMZI §| ANTICORTIC HREGISTRATE IN FOMANIA Gtueovorticoizi on, Finlande), opr. 4 ig, ac. inj. 250 mg, rol (Mustafa Neves 4 mg, 16 mg Prednol L (Mostafa, Neves 0 mg, 40 mg, 250 mg (odin suc: Hldrocontcone (Hewofeam, Yogoslvi), fac. ig). 100 mp? ml, $00 mg/h mocinat (Siomed, Sg ‘Predation (Vsamed, Sees), ope. Sma rizmeinoion’ ericon (Betlin Chemie, Germanis), Bristol Myers Squib, ie 10 ma ta, 40 ma! ac. i Fludrocorecon ‘Avtonin-H (Metk, Germania), opr. omg ‘Antioorticolzl nid, Rogluten (Sind, 250 mg BIBLIOGRAFIE SELECTIVA rol LK, Hang, eh - Gs ngs aoa Ream. Dit HD. Ae, at : 1, 2 1994, 20, 629. McGowan JE. Je. Chesney PI. “au ce tame gine porate ypopiyirsarentiea, Gian’ 12 Plamncsope cg 2 ie GEE, Grecipan FS ny et 9 iose oowme og anwosdsar tz wp sendaos) 6 V ~ sorpnded nlaey ¢ W! x00 18 O00 9 capoula 9p 3H a ‘neq syn op pelaios sys eo ‘wNTInsNt ininuzavia 1nLNaH as 20 soogo it op sand 6 ypotetonees ded ywomies gman eared oud “uae saad géejo pad o-ney qzesTEIO} amo ~ apisiaud-aid ~ yosmooid sip Hea ey sompgynsip Had gnop wud ow85— HSUoG guns noone Hf eons TANODVONTS “YOILAEVIGLINY WiivoIdaN “Le Fatarodoo 0 yBnepe 2 ape) 2m Silom ono 24 onto “gorsienampetaeq cami) ‘sumpom ‘ajeagind ojsewdand |rTagsun ot metabolice - subunitate Uraufetnia ullzee @ gucoze, peice, hlderen posucl de eneria | eakdaren oviaol potent, crogiarea gucaneo- reed od i eta heroin capa In osue gi slenel] Depp potash isosklar 95 000); 0 leghturt subunit alfa gi Nat, actvarea trozinkinaze. Se produc fosfo- — ‘ie i cascada, cae roglazh fmogia wor | 3 |. protsine gi stimlosca sau inhiba expresia ~~ -genelor peotru agumite enzime (mecenis- Aifess ale Ianpsilor poptidice stu ca alter) discrete ale sedilor de legare de subunitats alfa (M> 135 000) i beta Qe 782ny apedaarvugor proen EgSTSE eusdane RE 2 hace at fetGenH agony 90 Fy op 0 YeaeTupe FS Fane oom eee eeeg uaae 9 tz eho ‘was ae 1 stgormange e) piso [EP Weald eo op amine q FREEADSTOH Y ‘ERe-t ¥) REIOEEN gE HDG EDEN =p auseony eg # sone learns : epied 8 eenog spear ajsunasay mo sfferedios wy Summ purusuy apignzenone, ato taraeet ‘toiod $8 wyaog somsog 2p serecume sa TEE OOL/Sut OPT € fam oy soNeaHs 209 ‘aoadiouou, mugs ~ 208s $F oy ‘yoiod sui8uo ap wourenmes i puna — sagen no yee & wojreadmne Out unt ia) geudaoo aysuadsns oup eoySa] gore 2g “7a egos “alaes ap nioy qne spoooysoure giiqnjos gue ema sep op snfep nora sp cyereay meager Few "as 6 p@uies ay 22ay syeod 29 Ho, sony Sjnuor EOmRset © sep ep HEE, |B B100 Riemp op yf spides rinse eon ns zopeneqep[njonaeo narod mes 2079Sulfamidele antidiabetice exulsele - fonomane neurogllcopenice. ‘Faint obvervajia. cf jasulioa umant, pro- Soacd mai pia deeatinsulinele snimale Tennne do hipoglicemie, ozs ce poste avca unul aige mab tare de reach 98 do sulfonamide, in majoritate Ripoglicemianse si selefiouate de diabet, ‘Aoeste medicamente pot conrola hiper- ria Ie preparatele ,eelati rar. "Se masifestt prin fenomene ‘se obyia sclderi cu 20- ‘jean. Se rocomaadl seesinul de isulind este ‘Sulfamidele antidiabetice actioneazt si prin mecantime exrapancreatice. Acestea int importeate, probabil, mai ales in Coadiile watamscataler prehungtty ead Gul beparing, fenolfaleira micgreanl efos~ Shi icclinet gf fevoriea2¥ hiperlicomis. eq) pot contola, fa eontianare, 81.1.2, ANTIDIABETICELE ORALE Stlfamidele seusibilzesex celalcle In ac. wood fonomene Upodivejice loea- _Aatidiabeticle orale — suifamide st ust compigh de sinter 2 Fcace In ace le, si eovenle la ter. Lipoatofia este insuligele a de temperotura sclzutd a pre 2 predomint la femel, Ese daiontt probe” un este indipeasabilt, 190 71spzamyms 200m ya 9 tangevs "wofaar op anos aa xcon|d somegna| 6 {Otero 2. I MILO Ditton Coprpant Quran Oar) “ Manakin Fig. 168 ~ Seuctra chin a uaorsulfamide anddiabedce find activi doze mari ~ 1 gle pentru proferat oa doza slic ek fi fractional enuitgad explorates ulburéitor ghucidie de astur heparca. Efecal esto de duvatd re. tostabolisauias giueidio tm ineutileaye lan soured ~ 6-8 ore ~ de aceon ete do bopatod tu eau 196 “Ha 304 “aozpeDospIy “oumER|O=aTs ainpasd sooypioo uguaudep voset09ue> Amad soeays y syed jruofeonjDBIBLIOGRAFIE SELECTIVA pc (Sindan, Romina), cpr. 5 me iidia> Fania, Tali i Sindan- Giguidons Ghurenorm CLerpis‘Boebsages, Romt- ni), pe, 30 mg ‘olburamidt Tolbutemld (Aemedice, Sicomed gf Sin- ‘ofa, Roms), epe. 500 mg Biguanide ian (Azmedica gi Sicomed, Romt- yj 20 ui, 10m, @ +P) BIS) ope 00 Glucagon Insuline cu actiune lenta st dura bila Gtucagon Glicogsn (Novo, Danemerca) fs. ij. ime. Glucagon Novo (Nove Danemare), fae inj, 1 mg,508 ‘ssoteced sjeaeomopor © if ruspom roreoumog « oR aumONNS = oct ees cukoponp st psamoperouoa pene oe eee eee 10m r9 Tom umn ioo8) GUS! Ip SRS ‘= sojmuor eiequeoua> opeae vo gptided "hod ‘nigueyapon ‘anodes ‘wd ‘ameotog ooqnoo ap szadeo cise 5 soe aos jmpoy“BuyngeT%asti ~ 960 O19 aberss gusosjou eieal a>. yoymossee INBIGIOWLL INOWUOH “ze YNVIGIOULLLINY viivoidaw IS INaI INOWHOH “Zebdrenergic, fenomen iinportant mai ales entra sparaml cardio-vascular 1 ssjiune important este accea de in- i hibare a secret de sirosofnd hipafiearé = fect supresi, care corespundes mecanis= ru Aziologie de antoreplare s funciiei irons’. rinciplii receptor. ai ;- onnonilr tidia! fae pare die sess flsese tn membrana mitocondriala,acio- trea lor find impostantd probebil pentru jar vaele medicsmente ~ saliciloyh, fen ton, anizoagulanse cumarinice, cofibrat Seplaseazd hormonittroidieal de pe pro- {- aivelul ADNealui, Un al teilea tip ceptori sunt esi eupringi in membranele Celulare: acicnszea lor mireste provesul e caplere « ghicozei gi aminoactzior fn fine elute. A fost deserist gi 0 stimulare di- 808 307p aod Syd stor armed? a) yew wu Jons sussosen fUouoy =p 2220 doo “ona ponpoad ye guy) "Rogosom 2p sh ‘ose napa, atsodne dons 1g e761) ¥ “pomoaey plasma op gE joo wesw ‘sem nnaed ‘ammpaqns dos oy 8010) eq yevafoborm SWORE “BOE imstoo B proouedas oo a ‘saned Sy Qr-s “Font 1 srqmd eprom ‘eugeuponsy 25 ‘wo ‘=plomp pues © amEMAE Hoare uSigo aiaoep = prusypomoder sojmoy modanen 2 pagoasteo aR ‘p yemgye 1 yo nvomsyenoco oye sumos aoqedyo A “OWURIGUUOM Ioee-LA-H EN ® BONE‘wofink este ull gf a bolnavil ou gop Tirolda pulbere este up prepara brut Bfectul nei siagure doze mari se fuse. Jena dup 4 ore oe 32 fermi to crea ugerinke infestcit cu eluperel a pre- eral Prepaatele hormonale droidisne agna- 1 cardtopara ischemicd pot provo- foase ~ se introduce ta tub intragastric sau lotravenes ta dos de 5-10 ug le imervale de 8-12 ors; mu tebuie depiyite 30 hg fm primele 24 ore; dova subst {iv deplind este 100 ug. Liotironina poste fi utlt peat eupresta pe termen scurt © scerejed de rototial, iacusiy le 209) Giagoos eplin efcase. Supradozarea hormo- ideal decent feno _ a0 "32.2, PROTIRELINA $1 TIROTROFINA 30 minute si rev Gdupt aproximativ 3 ore. Stimulare secre : srofink poate & Hmpiedicath de jamie de 4-5 minute. Se sub form de preparate obf- peas dlagnosticul dis profilin’ este marca ‘eoumdsr (bipofiza) sive {$1 trotofisel plasma mu 8 re ironink, de asemence, $1 Sroofi jonee tdiedotronige. Aso: ‘cierea acestor tmedicamente face uncori Seessui cryieres dosel de bonne. (Ca real adverse posts provoca gust retaic, grea, hiperteasiuns erterslf, ue Xoie de trina confuse ~ ia general mi tick Moles exe frtaté din. 2 asi alcopeniee ~ subvaie ee tc nts Sect askport Ia tgetia ene ab gt gosedowetine) gh beat Boert, unde ‘provoucl creslerea producfiei Preparatele farmaceutice s¢ obfin din hi- Gelber de trowofas prolsctns. poses de bowae siesesee dump ‘quyumdgs wast ‘ye enaigo edep arede [nvoayg FPuocnog jojo puyegoe“Temuoa en ¥10p 2p soramivo1. STSNSIGIOUILNY “e-ze soqmeaoys ‘fad mm oe sito puoinguoses pun edi 0 ce 8 op a Semen ge ung sp ede up go tmmeredaig “zeo0| afi yo ade] Ul WF posyoaceyd smug OS oes, n piisaqand 2 43} wip opodat qioeqe 2 cu iy 9p 202uI00 Tay sovowaxd Jojapneon sarezopeidng Rae eee sco “Sjeuomy jaussres pryumeTeo sno year ef gaeonoyise euganot] Ha fortge ep wins alspunoss sisajg ase zeus |S yeesepe oFGat HOH coca i <> <> ae awoged &, Petiemst art Toot «adn tia, Timpul de tnjumbtiie este de 6 ore, tro singurd riz, Beneficiul © evideniank cova mat repede decit peo- Uieidian’ normals; dupt cies se alunge la doza de Sntrefinere de 50-100 mgfa. Durata stamen- sie de 2-3 anh ‘Reaciile adverse sunt cele obigauite poral 2 cel putin fa acest fel se poate realiza xodicwren gag. Ce eft nedot 1a © pro- porjie mici de peosne dig zonels cu sd endemich se denvoltS fenomene de Seri

nas =icos 6 premncor of myusaje samen; 2 pops oqooso Hlosyey ajeur op areoveurojaaasyTrahenet 8 pene, EY Tea 88 8, 198.1.1. PARATIRINA $l CALCITONINA 33. PARATIRINA, CALCITONINA $I ALTE MEDICAMENTE CARE INTERVIN IN REGLAREA CALCIULUI $I IN PROCESELE DE REMANIERE OSOASA, VASOPRESINA SI ALTE MEDICAMENTE FOLOSITE IN DIABETUL INSIPID, SOMATOTROPINA $I MEDICAMENTELE CARE Il MODIFICA SECRETL PROLACTINA $I BROMOCRIPTINA 98:4. MEDICAMENTE CARE cosas do nivel call te. sags INTERVIN IN. REGLAREA CALCIULUI $1 IN PROCESUL DE REMANIERE OSOASA ‘Hormnonul parstivcidien ~ zoratirina ~ mina, wa, bormon,tiaidian, intr~ Paratirina (parathyrin, parathorm) aa porathormonul este hormoual secretat J¢ oufiaut de 84 aminoaciel mast mcle- Aciinca ‘ilad elaivd de circe 9 500. Seoeia este jit mbulare a calcul gt micjorrea res 7 Viena D fi clit eoat expe fn eaptlle “Viele posable respec 2Caeh™ a9ego ns HOWE wp sages ojanemonpem 2 3p docu) 96 magoumeiez] “sme! osioape 21 sfeuemen ayaRasep pagorperdiay 1 monqingouas ‘omonsel 9 (eovase wi) emer tasoEARSO © “enpouot sina poe reese STEOUdaTdSLLNY “LP Peron | fom, apis se sending sexe sate 22 ib ‘sreoqpu aopdayopme pjmomenpam 8 apsleyMds 2p MEH a|EBNG ws00 Inge