CAUSES FOR ELEVATED LACTATE

Shock Pharmacological agents*

 Distributive Linezolid

 Cardiogenic   Nucleoside reverse transcriptase inhibitors

 Hypovolemic Metformin

 Obstructive Epinephrine

Post-cardiac arrest  Propofol

Regional tissue ischemia Acetaminophen

 Mesenteric ischemia Beta2 agonists

 Limb ischemia   Theophylline

 Burns

 Trauma Anaerobic muscle activity

 Compartment syndrome  Seizures

 Necrotizing soft tissue infections   Heavy exercise

Diabetic ketoacidosis  Excessive work of breathing

Drugs/toxins Thiamine deficiency

 Alcohols Malignancy

 Cocaine Liver failure

 Carbon monoxide mitochondrial disease

 Cyanide