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he past two decades have seen the highly pathogenic morbillivirus disease, en- frequently results from a change in ecology of
emergence of pathogenic infectious zootic to Asia, was introduced into Africa in host, pathogen, or both (15). Human population
diseases, such as acquired immunode- 1889. The panzootic front traveled 5000 km expansion has driven the emergence of EIDs
ficiency syndrome, multidrug-resistant tuber- in 10 years, reaching the Cape of Good Hope via increasing population density, especially in
culosis, and tick-borne diseases, which rep- by 1897, extirpating more than 90% of Ken- urban areas (dengue, cholera), and encroach-
resent a substantial global threat to human ya’s buffalo population and causing second- ment into wildlife habitat (Ross River virus
health (1). Emergence is associated with a ary effects on predator populations and local disease) (2, 16). This encroachment may have
range of underlying causal factors (1, 2). extinctions of the tsetse fly. Populations of been a key factor in Africa for the global emer-
These include interactions with zoonotic some species remain depleted and the persis- gence of Marburg and Ebola viruses and human
pathogens within a host-parasite continuum tence of rinderpest in eastern Africa contin- immunodeficiency virus (HIV) (2, 17). Pres-
between wildlife, domestic animal, and hu- ues to threaten bovid populations. sures of human encroachment on shrinking
man populations (Fig. 1). In this review, we Pandemics of cholera, influenza, and oth- wildlife habitat also cause increased wildlife
identify a number of EIDs that predominantly er diseases seriously impact human popula- population densities and the emergence of wild-
involve wildlife [(3, 4), Table 1, and Web table tions. Such clear-cut panzootic outbreaks of life EIDs (11–13, 18). The international move-
1 (5)]. We define wildlife EIDs by applying diseases in wildlife are probably rare events, ment of livestock and modern agricultural prac-
criteria similar to those used to define human but a lack of awareness and reporting, partic- tices have led to EIDs such as rinderpest in
EIDs (1, 2) and categorize them according to ularly during the earlier decades of European Africa and bovine spongiform encephalitis
their specific characteristics that are “emerging” expansion, almost certainly belies their true (BSE) in Europe. Similar situations occur in
or novel (Table 2) and to their epizootiology. extent. Historically, wildlife diseases have been wildlife populations managed either in situ or in
considered important only when agriculture or captivity. The extent of in situ management
Wildlife EID, Past and Present human health have been threatened. However, may be substantially underestimated. Recent
Parallels between human and wildlife EIDs because of outbreaks of disease in endangered analysis (19) suggests that 15,000 tons of pea-
extend to early human colonization of the
globe and the dissemination of exotic patho-
gens. In the same way that Spanish conquis- Fig. 1. The host-parasite ecological
tadors introduced smallpox and measles to continuum (here parasites include
viruses and parasitic prokaryotes).
the Americas, the movement of domestic and Most emerging diseases exist
other animals during colonization introduced within a host and parasite contin-
their own suite of pathogens. The African uum between wildlife, domestic
rinderpest panzootic of the late 1880s and animal, and human populations.
1890s is a paradigm for the introduction, Few diseases affect exclusively any
spread, and impact of virulent exotic patho- one group, and the complex rela-
tions between host populations
gens on wildlife populations (4, 6 ). This set the scene for disease emer-
gence. Examples of EIDs that over-
lap these categories are canine dis-
1
Institute of Ecology, University of Georgia, Athens,
temper (domestic animals to wild-
GA 30602, USA. 2Infectious Disease and Pathology
Activity, Division of Viral and Rickettsial Diseases,
life), Lyme disease (wildlife to hu-
National Center for Infectious Diseases, Centers for mans), cat scratch fever (domestic
Disease Control and Prevention, Atlanta, GA 30333, animals to humans) and rabies (all
USA. 3Institute of Zoology, Zoological Society of Lon- three categories). Arrows denote
don, Regent’s Park, London NW1 4RY, UK. 4Australian some of the key factors driving
Animal Health Laboratory, CSIRO, Private Bag 24, disease emergence.
Geelong, Victoria 3220, Australia.
*To whom correspondence should be addressed. E-
mail: daszak@uga.edu
Table 1. Selected emerging* infectious diseases (EIDs) of humans and lying emergence. The expanded table (Web table 1) is available as
Table 1. (continued)