many human diseases are caused by

defective genes and improper protein

functioning genes within our DNA provide

the blueprint for the production of

proteins specific gene defects or

mutations can result in reduced or

inability to produce a functional

protein or production of a protein with

altered function gene transfer using add

no associated virus or AAV vectors can

target specific cells to correct

disease-causing improper protein

function once inside the target cell

therapeutic genes within the AAV can

correct defective or missing protein

function to achieve this a a V genetic

material is replaced with a therapeutic

gene to restore natural function of the

disrupted proteins a protein shell

called a capsid in cases the genetic

material and helps target delivery to

certain cells once within the target

cells the capsid is shed inside the

nucleus to release its vector genome the

vector genome does not integrate into

the nuclear DNA but instead forms an

episome episomes are not passed on to

future generations of cells thereby

ensuring that the effect of the gene

transfer is not passed on using the

body's natural machinery this allows

stable and long-term expression of the

therapeutic molecule

AAV based vector delivery systems can be

administered by intravenous drip or

direct injection to target tissues a AVS

are ideal vectors for gene transfer as

they are non pathogenic and capable of

transducing both dividing and quiescent

cells the different components of a av

based gene transfer can be switched to

address different therapeutic targets

and diseases and several studies and

clinical trials have indicated that

there is activity in different disease

models gene transfer offers the

potential of long term and potentially

curative benefit to patients with

genetic or acquired diseases by

correcting defective or missing protein

function through a single administration

yoona cure is committed to developing

innovative and cost-effective single

treatment gene therapies with

potentially curative results

in the oceans we have one service water

and we have cold water in the deep ocean

that temperature differential and with

the gigantic thermal mass that's

available in the ocean you can generate

huge huge quantities of electricity the

potential is immense Makai is wonderful

because we've got a core group of really

passionate engineers who are interested

in tackling the tough challenges in

energy especially to benefit mankind

being able to provide more than 100% the

total energy needs of the planet and be

able to do it with no carbon imprint is

a worthwhile goal our relationship with

hne I has been magnificent they share

our dream and our goal they understand

the engineering challenges and the

practical difficulties are moving

forward and the fact that it it's a long

road so it's been a good partnership an

excellent you purchase most of the

equipment on day one and then the energy

is free ootek energy is just sunlight

about 70% of the sunlight coming into

the earth lands on the ocean most of

that is captured in the surface layers

of the ocean

are in the form of heat that's beautiful

because we can extract that energy 24/7

and use that power anytime we want

totally eliminating the need for an

energy storage system and the beauty

about that type of energy base load

power is that you can actually start to

replace conventional power plants our

focus in this project originally was not

to produce power it was actually

designed and built so that we could

study one critical component in the

system which is the heat exchangers so

from this point we can see the nail ha

pumping station this is where we

received water from deep ocean water is

pumped both cold and warm water along

these two pipe lines and the warm

surface seawater comes right here goes

up to the top and this is where we split

it into all three different heat

exchangers where water pours down

through the heat exchangers heat

exchangers are really the key components

to otech and we've got three different

slots for heat exchangers here and the

reason for that is this is a research

facility we need the flexibility to be

able to transfer heat exchangers in and

out to be able to swap them out easily

and test different versions of the same

unit because ultimately what we're

looking for is a high performance low

cost and long-lasting heat exchangers

heat exchanger is a fancy name but

really all it's doing is separating two

different fluids from mixing separating

the ammonia from the seawater so now

we're at the top of the heat exchangers

that are called evaporative what's

coming out is high pressure ammonia

vapor so the warm seawater has gone into

the heat exchanger and heat it up that

ammonia it's boiled it so now it becomes

really high pressure steam how you boil

a fluid with warm seawater it's at room

temperature so how does it boil anything

and the answer to that is you pick a

fluid that has a low boiling point so in

our case we use a refrigerant and it can

actually boil and become very hot

pressure

at room temperature you take a low

temperature heat source creates a high

pressure that propels through a pipe and

comes into the turbine case right here

spins the turbine and that rotational

motion is ultimately what power is the

plant that turbine is connected to a

generator over here and that's where we

get the power this is what's connected

to the grid after the vapor leaves the

turbine we need to convert it back into

a liquid and so we do that in the

condensers vapor comes down through this

pipe inside this chamber where there's

hundreds of little tubes inside this big

tube and the cold sea water passes

through these little tubes and on the

outside of them

the ammonia senses the cold and then

it's converted into a liquid and drips

down to the bottom or it continues the

cycle the waters around Hawaii are very

stable in terms of temperature and that

allows us to extract a very steady

source of power year-round it's utility

grade electricity so it doesn't need an

inverter it doesn't need to be filtered

in any way it's very high quality power

the fuel is free and in fact our price

of electricity free otech is going to go

down as our technology improves

you