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J. Microbiol. Biotechnol. (2007), 17(6), 879-890 JOURNAL MicroBioLocy BioTECtINoLoGY The Reverse Proteomics for Identification of Tumor Antigens LEE, SANG-YULL!' an DOOIL JEOUNG** ‘Department of Biohemistry, School of Medicine, Pusan National University, Busan 609-739, Korea “Schoo! of Biologie! Sciences, College of Natural Received: February 21, 2007 ‘Accepted: March 28, 2007 Abstract The idcntification of tumor antigens is essential for the development of anticancer therapeutic vaccines and clinical diagnosis of cancer. SEREX (serological analysis of recombinant cDNA expression libraties) has been used to identify such tumor antigens by screening sera of patients witk CDNA expression libraries. SEREX-defined antigens provide markers for the diagnosis of cancers. Potential diagnostic values of these SEREX-

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