J. Microbiol. Biotechnol. (2007), 17(6), 879-890
JOURNAL
MicroBioLocy
BioTECtINoLoGY
The Reverse Proteomics for Identification of Tumor Antigens
LEE, SANG-YULL!' an DOOIL JEOUNG**
‘Department of Biohemistry, School of Medicine, Pusan National University, Busan 609-739, Korea
“Schoo! of Biologie! Sciences, College of Natural
Received: February 21, 2007
‘Accepted: March 28, 2007
Abstract The idcntification of tumor antigens is essential
for the development of anticancer therapeutic vaccines and
clinical diagnosis of cancer. SEREX (serological analysis of
recombinant cDNA expression libraties) has been used to
identify such tumor antigens by screening sera of patients
witk CDNA expression libraries. SEREX-defined antigens
provide markers for the diagnosis of cancers. Potential diagnostic
values of these SEREX-