RC) aes Laue OL) ‘AT yeasld woman cams othe ofc abu. type 2alabels mus. She was dapnosed wen bees 8 months ape. Lise ‘moaacaten was italy aad, but he patent had no SQMfeant geem rrovenert One rant ago, te pat was Stated cn meora, tovhich sh has boen adherent none, se as Been experiencing dominaldeconfo nd antes stbuted othe taapy. She has no ter medical cenitors Bils28 igi Prysicalexanasensurverataie. Labora tess show henoxiein AIC is 8%, Aer fuer CdecurienmatomsnsSeconined and gybaneispezrted. Compared tomeflomin the new herapy = mot sl to iceac he ako in othe lowing? ewe pancreas Feral stunt ‘Syren hpeaheeria| rama denen o! ial6 ar) ‘AT yeasld woman cams othe ofc abu. type 2alabels mus. She was dapnosed wen bees 8 months ape. Lise ‘moaacaten was italy aad, but he patent had no SQMfeant geem rrovenert One rant ago, te pat was Stated cn meora, tovhich sh has boen adherent none, se as Been experiencing dominaldeconfo nd antes stbuted othe taapy. She has no ter medical cenitors Bils28 igi Prysicalexanasensurverataie. Labora tess show henoxiein AIC is 8%, Aer fuer CdecurienmatomsnsSeconined and gybaneispezrted. Compared tomeflomin the new herapy = mot sl to iceac he ako in othe lowing? A Acs paceatis 6%) B. Rena eystincion © Simetarat hpeaheemia (28) 1D. Vea decency (0%) ‘vavovagna cana (1%) nee tees Bi terieee pletion Noninsuln artabeic agents for tpe 2 labels melius ae Mechanism of ston ‘Si eects GB ial) Noninsuln arti agents for type 2 betes melas GB ast Neckar of ston ‘Sie fects seertagoques | .an sation by ting cel Ke chan eras + Sutoryeas |" Oa aad + Went asin Megenises Blqwaidee | Strite AMPK & nibtmiochondal lcencopmness, | epaic duceseroduten& | » Canhea ‘= Metcmin | peor aucose wake 1 Lon acids mss ematevansergn equa PRL, sun esstnce a + Werte sain [atP- agonists + Pmcestis eee pee + Wie oss + bride + Stagigtin | Endogenavs OLP-1 ROP eves + Nasooharyrais + Ssraletn e-ucosiiase ie . — = ose + Mit ialPPS inners + Stagitin |; EnibpenousGLP.1 AGP ves + Nasontanrgis + Saracen elucosidane Inniore + Ciara inoeers | start saccharide abecrton 1 oem = Mi [secre innior + Gina ae + Canaginaan |; Rena gheose exreton econ 1 osoanieen «Hyperion /AWex.= sterosre monophosphaieachsled can Kase OPPS ceria peptase4 GIP = geste ebony pokpentde, GLP += lucagcrike pepe Kar = AT senstve potassium, PPAR = pease poet ciated reeory,SGLT2= sou cue coranponar2 Materia ie proteredintal medeaton ler mst pars wih ype 2 dubs du os overall eficacy and ack ol hypoyeomia hen used in rmonaterapy. However mornin can cause boars gastonesinal efi nausea, ates), wih ay Be Sever rough o Wart changin tery ‘Sulorphree ate second agers that ve equrty used ade on rap oa replacement fo matrmn, Sulfonlueas abe [ATP-sensitive potassium chanel on he ances beta cal mentanerducng depdlreaton ad Liye caeum chanel pening, The Inceased Ca infu sults beta cel insulin release ndcpenent cf ood gucoveconceraions. Meares ea rerapinierateinie) sre stor acing ge net uncon nar outers ‘Sutorpbreas corenuet bul sul secretin, even when toed les eves re nora an can herefre cause hypooyeemia bypoghcen eto sulrren can Seinen enrace, aredreais ace nes criniten of sdtors| mate meen Longer aang sulonaras (a, ut) ate mare rons caving rypogyema an stone-actng age (9 ghd) (Chole A) Gucaportkeplpepie (GLP) regulates case by sowing gst enptyngand resign lease, PharmacSee screener Meter ne pretreat inal medeaton termes pats wih ype 2 dabezs da 9s overal eeaty an ack ot hypeyema when used a rmonahespy Honsuer mtn can caus brineeome gstronesinal ete, nauees, ares) wien maybe sver enough evant change ery ‘surphrea are second lin gets hate equrty used ade on rapy oa replacement fo matrmn, Sulfonlueas me ‘ATP-sensitive potassium chanel on he ances beta cal entanerducng depdlreaton ad L-type caeum chanel pening, The Inceased Ca infu sults beta cel insulin release rdepenent cf ood gicoveconceraions. Meglieies ea rerapinierateinie) ‘eset acting ge a erry sero eres. ‘Sutorphreas corenusto shut rel ert, ven when teed crs lve te noma an can erefre cause hypeplye=mia ypostcena oto sures can te indeed ty exer, misedeats act ess, inion ef adstoral miabec medications Longe ang serra eg, burt) ra more pret cavangrypogyema han stane-actng age 9 gids). (Ghote A) Gcaportke pepe (GLP) relates gcos by Swng aati enptyng ans nes inn lease, Phamacoog (GLP agora) loves lod core nd prone neigh oes, Ane panceatis sa rconmon bt sere aves fleck (notes B) Renal dystncion can occur wth soi sucosecovarsporet 2(SGLT2)mhibtos du excessive osmcic Sass, butts neta carmen aderse fect of slfonveas. However, pressing reralimpaimen can increase the sk of hypeaiceni uc tosufonueas (note D) Meermin can decease absorption tari Br: acing 9B x efconcy longterm use, Sufenreasd not havea sneat cfecton vain Br metboten (hole ) SGLT2 rhb (9, apspican)devresse renal resberpon of cose, lesdingtnmessd ray gicose los dower ond ucose els. Ti excess glucose the ne can increase he isk of rrr Yat nections and vahorapnal caress. They can aso cause hypoenson auetocemote urea ‘Education objective: ‘Suoryresiritit the ATPsertve ptascum came! on he ance beta ca means, nduig depliaton an pe calc ‘ann opening, The nereaoed Cotsen bata ol aun late ndapandar oad glucose cencenstona. Sunes . ialar) GB increased Coo struts belaclingul reese nepenfen iad use cncenatons. egies, epepnie, nee) {7 ton acing ss ne rencontre _sutrphreas corenuet saute wut Sein, ven when toed ss nels te nomalandcan err cause hypoglycemia ypoahcomia oo sufoucas canbe indvodty exrese, sted maak, act ness, ciaten ef addtoral stab medications Longe: sulorvess fa, eure re mor roe causing hyperemia han shoe-cing casa ide) (rete A) ucsgantkepaypepie (GLP) regulates gens by sown gasticemplyng anaincreasng sun ease, Phamacabge ‘GLP gaits (6, nena) overload coe and proce waigtlos. Aue panei isn urconmon bt seas averse eect. (Chote B) Rerlaytuncton can orc wn son ucse coarser 2(SLT2) nnn due a excess osmete des ute nota ‘common adverse eet ot suonyuess. However orexsing renal mpamen can nctease he kof hypgicenia he suo and can inrais he nk otaee sess ata ata (rete D) Mesermin can ceceaseabsrptonc ann ie ang 2B. decency ng tm use, Subyveas do not have Sgcat econ viarin Br metabo (hota) SGLT2 nbs, cpap) decease renal reabsrpon of css eating tinea ray pcs os nove bos (ucsetevels. Te acess glucose te une can wcfease he ik of uray Yat ncn and vaovapnal cardia. Tey can 350 cause hypotension ave to cemote ores Edueatons objective: ‘Sutzryhreas mtb ATP senste plssium carne! on he ances beta cat membane dug ceplrzaten an pe calcu ‘rarel opening. The nereased C2 int ctmstos beta col neu release independert ofbced gens cncenratos, Suenpbreas ‘simulate nsuin section eren when Bes gos ves are roma whe can leads hypoaceri Pamacsoay doce, Diabetes & eats Diabetes retus ialee OE oe EE Asayectavonanienaigtio a enue ett srs anata eke. Tepe ta ‘te ng ant ipsa ped Nea sgn anag yp ase, yp, ‘year a mores. Unione aes acon fied rang en Ses rant Onte mong ogi ero! ume elma. The pes wk ne eran sa see gy Bs oe porte at eprom Gecreine tcf he loi meses Setar se?) aren ‘As.yecldworan i aug oe meant depart teal andi oun ave a temo ck acre Tepe snd twine espa anda np anton lanad. Medal tsa sign er long-tndng pe 2 abet mals byes, hyperemia and migranes. Whe hosptize, th paertrecevesaconbnatn oflng- and sher-acig nein for dates management ‘On he merino sume fain les cose vel 's 2 mgek. The ptetis ava and ale ar says se fetshungy but has noche _ynploms cf hypsicems Concert ue of whchef the lng meteors best xpi ts dng? A Aerastain (5) 5. Doxazosin) ©. Hrechoronizae 16%) . Losaron (#8) Progra (2%) F verapan (2) ‘Sympathetic system neurotransmitters Boke aman er %aren Wi mnerncachrcstr i) Nompeshine BD Anne Car Le Ce Florged hypolrceri can leat ineversble neuro: defts and death, To even ry, cunteregutor stems ace bod cose ‘esperse a ypagyzema va sppaneterervus Stam a:aten fe, ncepnephneepinephene cease) and nese seen ot ‘tueagen corsa ana giant hamone ‘Symptoms of hypagycem nl irto2 general ages: neurogenic aon) and neweyenpeic. ey