Professional Documents
Culture Documents
Topical : For oral drug delivery a wider variety of small molecules can be delivered as long as
they have good aqueous and lipophilic solubility. For weak electrolytes we need to consider
when they will have their unionized species. For example, with weak acids they will have higher
absorption in the upper part of the small intestine as they will have a higher ratio of ionized
species. Conversely, weak base will have more absorption in the lower part of the small
intestine for the same reason. The formulation, as we have seen, will dictate how quickly a drug
will dissolve and what will be the RLS for drug absorption.