Professional Documents
Culture Documents
Fats will enter the Ingestion of carcinogens in the Inherited mutated genes
Signals the duodenum intestine (nitrosamines,
gallbladder to polycyclic hydrocarbones, iso
secrete nile ↑ Bile secretions in the cyclic amines)
intestine
↑ Survival of the
mutated cell
ADENOCARCINOMA IN THE
SIGMOID
Tumors E
Hypo function
become goblet cell
ulcerated due
to continuous Epithelial
passage of lining of the
colon tends Inflammation noccicepto
Tumors tend to to bleed of the r send
bleed due to due to epithelial signals to
ulcerating mass continouos lining the brain
iritation Brain interprets the
and signals coming
Metastasis to the Continuous PALLOR (september
BLOOD IN THE STOOL
↑ O2 (1 years PTA) from nocciceptors FATIGUE
other epithelial but slow loss Easy
16,2010) demand Bone marrow release
cells of the of blood over moreTrigger
platelet for tiring of
ABD PAIN (7/10) – (sept. 7
different organ a long period tissuethe
by repair the cells PTA)
ANEMIA TACHYPNEA SEPTEMBER
body of time MALAISE (1 EASY ↑ CO2 in respirato
↓ O27,2010
on
year PTA) FATIGABILI the lungs count
ry center (SEPT.
↑ platelet – 504x10) – sept.
TY (1 year of the cells
13,2010 07,2010)
PTA) brain
Liver Hypo function of Nephron
metastasis the hepatocytes damage
Elevated
CEA Ploriferation of
Glycogen restore in Protein breaks F ↑ hydrogen
(325ng/mL) adenocarcinoma
hepatocytes and into amino acids ion
– september in the liver
15,2010 does not released
C
Amino acids
Heart is Invasion of the Some H bind Some H bind
Gluconeogenesis does not convert into keto
being hepatoctes and with CO3 = with HCO3 =
occur acids and
affected angiogenesis of HCO3 H2CO3
ammonia
due to the Glucose does not release Ammonia
adenocarcinoma in to the blood Unable to excrete H
combined with ↑ H in the
the arteries of the by the kidney
CO2 by the lungs
HYPOGLYCEMIA- 60mg/dL (september process of Unable to
Na retention
17,2010) oxydative synthesize to Respirator
and water
y center in
reabsorption
↑BV ↓ Glucose in the body tends to use H back to the brain
cell the excess fats Accumulation of triggers
peritubular
HPN in portal vein ammonia in the
↓ ATP spaces
blood
production MODERATE Fat METABOLIC
metabolism ACIDOSIS H combined HYPERVENTILATIO
Excess fluid
↓ Perfusion of Accumulation Unable
with NH3toto N (september 17,
pulls into the ↓ Energy of ASCITES occurs
(september 17,2010)
hepatocytes with of fluid in the secrete
become 2010)
peritoneal the cell (SEPTEMB
portal peritoneum ↑ fatty acids NH4NH4due to
spaceblood ER 15,
kidney
2010)
Compensatory mech is FATIGUE malfunction
NH4 cannot go
activated by shifting fluid (september
↓ Cardiac output back into
Heart tends 17,2010)
intravenously to H justspace
peritubular
to reserve
extracellularly andrepeat
remainthe
in the
the Water will
cycle
remaining reabsorbe
Catecholamines
Blood RAASblood d back in
Release of release
volume in
vessels in (compensati Ccirculating ADH
↓ systemic F
↓ opening and (compensation)
the on)the blood
(compensatio
blood
↑ O2 ↑ preload, ↓ supply in
proximal closure of
volume
circulation the
peripheral demand SV, andheartHR valve ↑ SVR
organs of peripheral
Damage Inability of
of the the kidney to
glomeruli secrete urea,
hydrogen
ions,crea,uric
Inability to acid
filter
macromole Acummulation
cules like of creatinine
protein in the blood
OLIGURIA
(<50ml/shift)
↓ blood volume – sept 16. PROTEINURIA ↑ creatinine
in the 2010 (+1) – sept. level
peripheral area 13,2010 (153.1umo/
L) – sept.
16.2010)
HYPOTENSI ↓ O2↓ of
ON (80/60) Temperature
the cell
– sept. of the cell WEAK THREADY
17,2010 PULSE(SEPT.
COLD
17,2010)
CLAMMY SKIN
↓ Cellular
(sept.17,2010 Trigger
TACHYCARDIA –
metabolism thus
by142bpm
the (SEPT.
decreased) production ↓ CO2 in
TACHYPNEA
respirato
17,2010)
of heat by the cell (37cpm)
the lungs ry center
of the (SEPT. 17,2010)
brain
Review of system
Cardiovascular system
• Tachycardia – compensatory mechanism due to reservation of the remaining blood into the proximal organ
• Weak thready pulse – decreased pressure to the peripheral area due to decreased blood flow/volume and vasoconstriction
• Altered bowel movement (diarrhea/constipation) – due to obstruction, abnormal function of the colon, altered function of the goblet
cells, ↓ absorption of water
• Abdominal spasm – due to obstruction of the mass, accumulation of fecal materials, water, gas in the colon
• Moderate ascites – due to plasma pulling in the blood and secrete it into the abdominal space
• Blood in the stool – due to ulceration of mass and contiuous passing of stool; thus irritating the ulcerated mass that cause bleeding
• Abdominal pain – due to inflammation of the colon caused by invading cancer cells or ulcerated mass
Metabolism
• Hypoglycemia – glycogen stores in the hepatocytes thus glucogenolysis is not occur; decreased production of glucose by the liver that
result in decreased glucose in the blood
• Metabolic acidosis – inability of the kidney to secrete hydrogen and toxic materials; use of fatty acids by the body to use as a source of
energy
Renal system
• Oliguria – compensatory mechanism of the body increasing reabsorption of water and retention of sodium by the kidney
• ↑BUN – inability of the kidney to excrete the creatinine due to altered function of the kidney
• Metabolic acidosis - inability of the kidney to secrete hydrogen and toxic materials; use of fatty acids by the body to use as a source of
energy
Integumentary system
• Cold clammy skin – compensatory mechanism of the body by decreasing blood in the peripheral area to reserve the remaining blood
volume to the proximal organ of the heart; thus decreasing O2 supply to the cells; thus decreased workload of the cell that leads to
decreaed temperature
• Hypothermia - compensatory mechanism of the body by decreasing blood in the peripheral area to reserve the remaining blood volume
to the proximal organ of the heart; thus decreasing O2 supply to the cells; thus decreased workload of the cell that leads to decreaed
temperature
Respiratory system
• Tachynea – compensatory mechanism of the body due to metabolic acidosis; thus exhaling the hydrogen in the body in form of carbonic
acid
• Hyperventilation – of the body due to metabolic acidosis; thus exhaling the hydrogen in the body in form of carbonic acid
General
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