Reference guide for Pharmaceutical calculations ‘Krisman Second Edition 7 7 REFERENCE GUIDE FOR PHARMACEUTICAL CALCULATIONS SECOND EDITION 2002 - 2003 MANAN SHROFE www:pharmacyexam.com 1Refetenice guide for Pharmaceutical calculations : Krisman - Second Edition . « This reference guide is not intended a a substitute for the advice Of a physician: Students or readers must consult their physician about nty existing problem. Do not use any information of, this reference guide for any kind of self treathient, Do not administer any dose of mentioned drugs in this reference guide without consulitig your physician. This is onby'a review guide for” preparation of pharmaceutical calculations. ‘The author of this reference guide is not responsible for any kind of misinterpreted, incorrect or misleading information or any typographical errors jn.this guide. Any doubsful or questionable answers should be checked in other available reference sources. 2 All rights reserved. No part of this guide may be reproduced of transmitted in any form or by any means, clectroni- cally photocopying, recording or otherwise, without prior written permission of the publisher. RXEXAMG® is a registered trademark.of Pharmacy Exam of unauthorized use of this trade mark wil be considered a viola hnd Publication ine. Arty ‘of law: [NAPLEX® and FPOBED exam ae federally episod tademark owned by Nationl Asiocation Boar of Pharmacy (NABP).ETCB it ‘be teak oaedy Pay Tn Corin Do evio pldosin no way authried or sponsred by NABP orPTCB, \wwrw.pharmacyexam.comReference guide for Pharmaceutical calculations Sate Second Edition PREFACE Reference guide for Pharmaceutical calculations is a resourceful practice guide for preparation of the NAPLEX®, FPGEE® , California Pharmacy Board Exam and PTCB@ exams, It contains more than 400 calculation problems to prepare students to tackle an actual exam. NAPLEX®, FPGEE®, California Pharmacy Board Exam and PTCB® exams are currently putting more emphasis on calculation problems. 25 % to 30% of NAPLEX®, FPGEE®, California Pharmacy Board Exam and PTCB® exams consist of calculations. Calculations related to LV,, IV. infusion, TPN and dosages are very important in retail and institutional pharmacy settings. This guide will provide complete practice on related calculation problems and help to achieve an exceptional score on the examinations. Best of luck, Manan Shroff www>pharmacyexam.com 3Reference guide for Pharmaceutical calculations Second Edition TABLE OF CONTENTS SECTION - I 1. CALCULATIONS 1 2. ANSWERS 36 SECTION - I 1. PRACTICECALCULATIONS © 72 2. ANSWERS 195 swwwipharmacyekam.com Krisman0.001 milligrams (weight in Ibs / 150) x adult dose ~ (body surface area of child / 173 mm?) x adult dose (age in months / 150) x adult dose = 10° grams = 10° grams i 65 milligrams = 1000 ce ounce (oz) = Wee 16 ounce (02) = 480ce = Lpint 1 pint = 480 cc 1 quart = 960ce = 2pints 1 gallon = .3840ce 8 = Spits = 4quarts 1kg = 22 Ibs 1b = 454 grams 1 teaspoonful = Sec Ltablespoonfil = = 15 1 teacupful 120 ec Density a weight/volume Proof gallon = (gal x % v/v strength) / 50% v/v 9% strength = proof spirit /2 Proof gal = gal x proof spirit) / 100 PV = aRE PV = WMxRxT Equivalent we = molecular weight / number of valence mEq = equivalent weight in mg / 1000 ‘mOsmoV/L. = (Weight of substance [g/L] x no of species x 1000) / mol we] pH = pKa + log (salt/acid) ‘Young (child) = (agein years /age +12) x adult dose FP of blood 052°C Each gm of hydrous dextrose provides = 3.4 calories / kcal Each gm of anhydroys dextrose provides 4 calories / keal Each gm of fat provides 9 calories /keal Each gm of protein/aminoacid provides 4 calories / kcal Each gm of medium chain triglyceride (met)= 8,3 calories / kcal Each gm of glycerol provides 433 calories /Keal Each ec of alcohol provides 5.6 calories / kcal 1 ce of 10% fat emulsion provides 1 co of 20% fat emulsion provides 1.1L ealoties / keal 2.0 calories / keal wwwphamacyexam.com 5Reference guide for Pharmaceutical calculations Krisman 52 Second Edition PRA Tog Galvacid) or Gonizedunionized) (or weak acid) 7 pKw - pKb + log (base/salt) (for weak base) B= 23xC Kax Ho (Van slyke’s buffer capacity equation) vo 0 0.576xC Acceleration gravity (g) t Gas constant (R) I calorie Avogrado’s number K = 2,303 log Co t i i 0.693/K, MIC, R, = Cssx VdxK CssxV, Normality (N): ‘Molarity (M): Molality (m): Ka+ HOF where C = total buffer concentration, H,0* = hydrogen ion concentration where C = total buffer concentration ‘Temperature conversion: (maximum buffer capacity) 980 emi/sec? (0.082 lit atm / mole deg 4.184 x 10" erg 6.0221 x 10 mole" where t,, = half life of drug where K’= rate constant where V, = volume of distribution where M = amount of drug in body where C, = plasma concentration of drug where R, = sate of infusion where Css = steady state plasma concentration where Vd = volume of distribution where K = drug elimination constant where L, = loading dose of drug steady state plasma concentration volume of distribution Itis defined as the presence of riumber of gram equivalent weight of solute in 1000 ml or (IL) sohition.. Ikis defined as the presence of number of moles of solute i 1000 ml or (IL) of solution." Ikis defined asthe preschoe of aun ot moles ot solute in 1000 gm of solvent, 23! 90C) = 5CF)-160 vewwpharmacyexam.comReference guide for Pharmaceutical calculations oKrisindiy Second Edition tains? QUESTIONS eet ‘www-pharmacyexam.comReference guide for Pharmaceutical calculations Second Edition 1, ‘Sulfar 3% Salicylic acid 3% ‘White Petrolatum.. ys. 80 gm Find out the amount of Sulfur required to fill the above prescription? a 12gm b. 24gm c 3.0gm 4 48sm 2. How many grams of Dextrose are re- quired to prepare 5% of 500 ce solution? a 25 em b 25m c 55m wo a Sem * é 3. How much Lidocaine is required to prepare 1 : 1000, 30 cc of solution of Lidocaine? a 10mg b. 0.03 mg c. 30mg 4 300mg 4. How many milligrams are equal to 1/150 ge of Nitroglycerine? a 150 mg ’. 65mg c 55mg da 043mg 5. How much Atropine is required to dis- pense 1 quart of 1 in 100 solution? a 9.6mg db. 1.48gm c 23mg 9600 mg ‘www,pharmacyexam.com 6. Krisinan ts How many ce of 75% alcohol should be mixed with 10% of 1000 ce alcohol to pre~ pare 30% of 500 ce alcohol solution ? 7. 346.16 ce 234.43 cc 153.84 cc 121.12 cc How many grams of Heparin are re- quired to prepare 1 quart of 0.45% solution? 8. 2.16 gm 432m 0.45 gm 45 om ‘Ifaprescription reads “Augmentin 875 mg po bid x 10 days,” how many co of Aug- rientin 250 mg/5 cc are fequired to fill a ten-day supply? Bore a 350 ce 35 ec W5ce See 1£ 250 mg of Cefazolin powder are di- uted with water up to the 250 cc mark, what is the % of drug in the final solution ? ee ee 10. 10% 0.1% 11% 0.01% If 1 teaspoonful of Thioridazine con- centrated solution (30 mg/cc) is diluted up t6 the 480 co mark with plain water, what is the strength of drug in mg/ml in the final solution? spy Img/ee 0.52 mg/ceReference guide for Pharmaceutical calculations Second Edition c. 0.31 mg/ee 4. 0.75 mgiee Ui. If a prescription reads “Diphenhy- dramine 50 mg po hs x 30 days”, what would be the dispensed quantity of drug in ml (12.5 mg /5 cc) for thirty-day supply? a 20ce b. Sec c. — 300ce d. 600 ce 12. Erythromycin 2% 60 ce topical solu- tion contains: a. 2gmerythromycin, b. 2.4 gmerythromycin ¢. 0.6 gmerythromyein a 1.2 gmerythromycin 13. 1f60mgof elementary ion are present in 325 mg of ferrous sulfate, what is the % of elementary iron? a. 20.00% b. 10.25% ce 18.46% ad 9.25% 14, If 60 gm of 1% hydrocortisone are mixed with 80 gm of 2.5% hydrocortisone, what is the % of hydrocortisone in the final mixture? a 2.2% whw b. 1.85% wiw cc. 0.25% wir da 1.75% wiw 45. Ifa prescription reads “100 meg cy- anocobalamin im. every week”, how many ampuls of 1000 meg / cc are required to fill a month supply? ‘www: pharmacyexam.com ‘Krisman, pose ewe 16. If 1000 tablets of Risperdal 1 mg cost $2250 and the mark-up on prescription is 20%, what would be the retail price for 30 tablets? a $150 b. $7 c $500 a $8l 17. How much Clobetasole is present in 60 gm of 0.5% ointment? a 12gm b. 3.0gm c 21gm 4 03gm 18. Ifthe ratio of ionized to unionized spe- cies of drugs is 10° and PKa=2.2, whatis the pH of the solution? a 22 b 08 Ceo a 30 19, _ Ifaprescription reads “Augmentin 875 img by mouth twice a day”, how many cc of Augmentin 400 mg/S cc are required to dis- pense a 10 day supply? a 10.93 ce b. 218.75 ce ce. — 75.00ce 4 — 100.00cc 20, Find out the weight in gm of 500 cc glycerine. [Specific gravity = 1.25 gm/ml]Reference guide for Pharmaceutical calculations Second Edition a 625m b. 50gm ce. 400gm ad 0.25 gm 21. Find out the volume of 5 Ib of glycer- ine. [density = 1.25 gm/ml] a 1816 ce b. 6.25ec ce. 637cc 4d 40ce 22, — Calculate the weight of 500 ce of acid. [density of acid = 2.5 gm/ml] a. 1000 gm bd. 1250gm ce. 500gm 4d 200gm 23. Find out the ratio of ionized to union- ized species of drugs at pH = 7. {pKa = 5] 10 1 100 1000 a b c a 24, If the pH of the solution is 3, what is the concentration of HO" in gm ion /L? a. 0.01 gavion/L, b. 1x10" gm-ion/t, . ©. 0.05 gm-ion/L, 4. 10° gmion/L. 25. Whatis the pH of a solution having a ratio of ionized to unionized species of drugs of Lx 106 )PKa=7] weww.pharmacyexam.com es Krisman, 26. How many 500 mg tablets of erythro- mycin are required to prepare 240 ce of 2% solution of erythromycin? a3 ies GO) a 10 27. How many milligrams are equal to 1 150 grains? a 065mg b 121mg c 043mg a4 156mg 28. How many 975 mg tablets of aspirin are required to prepare 100 tablets of 1 grain? a 6 tablets b. 10 tablets cS tablets d. 3 tablets 29, 163 capsules of 150 mg of Clindamy- cin are added to 150 ce of 1% Cleocin topical solution, what is the % of Clindamycin in the final mixture ? a 15% b 13% ce 11% da 0.9% 30. The adult dose of a drug is 500 mg. What is the dose for a2 year old child? fuse young rule] a 71.42 mg b. 101.53 mg ce. .25.46mg a 3118 mg 10 } iReference guide for Pharmaceutical calculations: Second Edition 31. eeoe 32. 35. pup oe ‘The adult dose of a drug is 750 mg, what is the dose for child weighing 20 Ibs? 100 mg 250mg 500 mg 425 mg If adropperis calibrated to deliver 325 mg of iron sulfate in 0.6 cc and an adult dose of drug is 325 mg, what is the dose of a drug in ce for a 15 month old infant? 12ce 0.3cc 0.06 ce. 0.01 ce Tf an adult dose of a drug is 100 mg, ‘what would be the dose for a child having a ‘body surface area of 20 mm? ? a: 5.51 mg bd -12.32 mg c. 20.60mg a 11.56mg 34, Howmany milligrams arin 10 grains ‘of aspirin? 81mg 60 mg, . 325mg 4 650mg If a normal dose of a drug is 10 mg/ g/day, how many 250 mg/100cc ready-infu- ‘Sion bags are required to fill the above order? [Patient's weight is 156 Ibs.] 1 bag 2bags 3 bags S bags www:pharmacyexam.com 36. Krisman If the prescription calls for “50 micro- grams of a drug three times daily for 10 days”, how many 1/100 grain tablets are required to fill the above order ? a Stablets b. 3 tablets ce. Ltablet dG tablets 37. Ifaprescription reads “Lanoxin 0.125 mg by mouth every day”, how many ce of Lan- oxin 50 megice are required to dispense a 30 day supply? a 7560. bv. —-50ce & — 100ce 4 240ce 38. Ifa prescription reads to dissolve 2 gm of guaifenesin in 100 ce of water, how many agains of guaifenesin are present in I tesspoon- ful of solution? a 1.53 grains bd. 2.61 grains c. 3.15 grains 44.20 grains 39. If 100 mg of Lactin is equal to 4500 units, how many milligrams are required to obtain 1 unit? a 2.22mg b. 002mg ce. 325mg a 450mg 40. Ifa prescription reads “Ampicillin 50 mg by mouth twice a day” for a 7 year old child, how many ce (125 mg/5 ce) are required to dispense a7 day supply of the drug? iReference guide for Pharmaceutical calculations Second Edition 150 ee 240-ce 28 ce 56 ce Rese 41. Whatis the dose of a drug fora person having 110 m? body surface area? The aver- age adult dose of the drug is 750 mg. a 1089mg b. 625mg c. 531mg a4 477mg 42. How many grams of a drug are re- quired to prepare 240 ce of 10% solution? a 12m b 36m 48gm 4 24gm 43. How many grams of sodium chloride are required to make 750 ce of 0.9% normal saline solution? a 135m b. 250m e675 gm a 12.25 gm 44. How many grams of dextrose are present in 500 ce of D,,W solution? a 50 grams >’. 125 grams c. 75 grams 4. 25 grams 45. How much Lidocaine is required to prepare 30 ce of 1:1000 solution? a 30mg bd. 0.03mg www-pharmacyexam.com Krisman ce 0,003 mg 4 300mg 46. How much Povidone-lodine is re- quired to prepare 1000 ce of 1 in 750 solu- tion? a 133. gm b. 3.12 gm e125 gm 4 0.95 gm 47. How many grams of dextrose are needed to prepare SL of 1 in 250 solution? a 7Sem b. 20m c. 80gm a4 Slgm 48. Whatis the % of boric acid in 1 in 20 solution? a 05% be 25% 5.0% d 15% 49, To dispense 5% of 250 cc solution of thioridazine, how many cc of 30 mg/ce are required? a -225¢c bv. :153¢e c Silee a 417 ce : 50. If 20 cc ofisperdal 1mg/oc are diluted ‘with water up o 240 ce mark-what would be the strength of drug in mg /ml? a. -2,2:mglee : b. Lmg/ec i cc. 0.1 mg fee aes? 0.08 mg/ee 2Reference guide for Pharmaceutical calculations Second Edition 51. How much 70% alcohol is required to prepare 750 ce of 20% alcohol? a. SOLO cc b. 335.16 ec ce. 2142806 a 428.12 cc 52. How much Atropine is required to pro- pare 3 quarts of 1 in 500 solution? a 221 gin b.-5.76gm c. 3.47 gm a 248m 53. How much Povidone-Iodine is re- quired to prepare 300 ce 10% solution? a 50gm b | Sem 10g 4 25gm 54, In what proportion should 5% of sali- cylic acid be mixed with 1000 grams of 1% salicylic acid to prepare 500 grams of 3% sali- cylic acid? a’ 250gm bv. 490m © 125 gm. ad 375 gm 55. How much atropine is required to pre- pare 240cc in such way that when 1 teaspoon- fal of the solution is diluted to 1 pint gives it 1 in 500 solution? a 225m b. 46.08 gm e 35.15 gm 4 2535 gm ‘wow.pharmacyexam.com 56. How many ampuls of compazine 5mg/ 2 cc ar required to prepare 2 quarts of 0.1% solution? a 125 b. 256 e384 a 4a 57. How many grams of 0.25% triamei- nolone ointment can be made from 2 grams of an active ingredient? a. 200gm b. 500gm c- 600'gm 4 800gm 58, How much sodium bicarbonate pow- det is required to prepare 240 ce of 0.10 N solution of sodium bicarbonate? = 84 em/mole) How many cc of concentrated HCL acid are required to prepare 500 ce of 0.05 N acid solution ? (molecular weight = 36.5 gm/mole, purity of HCl =37 % w/v, density = 1.2 gm/ce) a 10.11 ce b -3.35¢c ce. 2.05cc a 421c0 60. 1£60 grams of 2% hydrocortisone are mixed with 80 grams of 1% hydrocortisone, what would be the % of hydrocortisone w/w in final mixture? 13Reference guide for Pharmaceutical calculations Second Edition a, 321% b. | 142% c 421% a 5.76% G1. If 1 quart of 30% alcohol is mixed with 3 pints of 40% alcohol, what would be % of alcohol in w/v in the final mixture? 36.08% 42.18% 15.23% 8.15% Bese 62. In what proportion should 3% acetic, acid and 1% acetic acid be mixed to prepare 200 ce of 2.5% acetic acid? a. 150. and 50c¢ b. 100 and 100 ce ce. TS ccand 125 ec ad 175.cc and 25 ce 63, How many grams of 60% w/w HCl acid should be added to 500 gm of 40% w/w HICI acid to prepare 400 gm of 55% w/w HCL 250 gm 300 gm 100 gm 150 gm 64. How many cc of purified water should be added to 45% alcohol to prepare 750 cc (25% alcohol? a 125 ce bd. 222ce ©. 4:3338.¢c a 451cc 65, How many cc of D,,W solution should be mixed with D,W solution to get 700 ce of DW solution? www.pharmacyexam.com «Krisman a ice b. — 15lee e 5560 da 175ce 66. How much taxable alcohol is present in 1 quart of alcohol usp? a 1.25 gallons b. 2.31 gallons c. 0.56 gallons a 0.479 gallons 67. How many proof gallons are present in 1 pint 50% wiv alcohol? 0.10 gallons 0.51 gallons 2.30 gallons 0.125 gallons epee 68. How much diluted alcohol USP can be prepared from 1 pint of 0.5 proof gallon? 2 035 gallons b. . 3.25 gallons c. . 0.51 gallons 4. 4.21 gallons 69, How many proof gallons“are present in2 pints 10% alcohol? ; a 0.25 b. 0.05 ce. 0.45 ad 051 70. How much 95% alcobol can be pre- pared from 1 pint of alcohol labeled as 1/2 proof gallon? a 0.263 4 | iReference guide for Pharmaceutical calculations Second Edition b. 0.153 ce. 0.287 ad 0.351 71. How much boric acid is required to dispense 240 cc of a saturated solution? [solubility of boric acid is 1 gm/12 cc} a 20gms b. 10 gms e 1gm a 15 gms 72. A 250,000 IU vial of Abbokinase is reconstituted with 5 cc of sterile water for jection. If2 cc of this resultant solution is ine jected into 500 ce of 5% dextrose solution, ‘what is the final concentration of solution in units/ml? a 100 units/eo b. — 200units/ee cc. 350 units/ee a. 1250 units/oe 73. A prescription calls for Valproic acid 600mg by mouth three times a day for 10 days, how many cc of 250 mg/5 cc are required to fill the above prescription? a 120cce b 240 ce c 360ce a 480ce 74, — Bach tablet of Ibert contains 525 mg of ferrous sulfate, what is the % of elemen- tary iron in each tablet? (elementral iron = 105 a 10% b. 5% c. 15% 4. 20% {www pharmacyeram.com Krisman 75, Each ccof Ibert-500 liquid provide 25 mg of elementary iron, how many cc of Ibert- 500 are required to fill 105 mg of elementary iron? a 11200 b. 15¢c e 1Bee ad lee 76. The recommended dose of Nembutal sodium in pediatric patients is 4 mg/im/kg . How many ampuls of Nembutal Na (100 mg/ 2.c0) are required in a child weighing 50 Ibs? Be gP eae 77. Albuterol sulfate inhalation solution is available as 0.083% w/v. How many milli- grams of albuterol are required to prepare a 2.5 cc unit dose vial? a. 0.083 mg b, 2g ce. . 163mg ad 312mg 78. A prescription for Alomide reads as follows: Alomide 0.1% eye drop sig: 2 gtts ou qid x 30days, How many milligrams of Alomide are present in per day dose of the drug? (J drop=0.1ec) a 16mg b, .23mg ce 4tmg a 0.15mg 15Reference guide for Pharmaceutical calculations Second Edition 79. . Aquasol (Vitamin A) is available as '50,0001.U//ec. How many milligrams of vitamin A are present in 5 cc? [ 11.U. =0.3 meg of. vitamin] 75mg 150 mg 37.5 mg 22.2 mg pose 80. . How many milligrams of Lidocaine are present in 30 cc of 2% Lidocaine viscous solution? a 1000 mg b. 600mg cc. 2000mg ad 60mg 81. How many cc of Megace (40 mg/ec) oral solution are required to dispense a'800 mg dose? a 0ce b. 120cc c 20ce 4 60cc 82. If 2 grams of Videx pediatric powder are reconstituted with 200 cc of purified wa- ter, and 10 cc of this resultant solution are mixed with 200 ce of Maalox plus, what would be the strength of videx in mg/ec? a 10mg/ee dD. 0.05 mg/ee e — Smgfee ad 0.5 mglee 83. Ifa prescription for Cefzil reads “500 mg by mouth four times a day”, how many ce of Cefzil oral suspension (125 mg/5 cc) are required to fill a 7-day supply ? ‘www pharmacyexam.com » Krisman_ a 20 cc b. 80ee c 100 cc 4 560 84. How many ce of Niferex liquid (100 mg elementary iron/5 cc) are required to pro- vide 325 mg of ferrous sulfate? [20% elemen- tary iron is present in ferrous sulfate} a 3.25 ce b. 16.25ce c 819¢C 4. 923e¢ 85. In what proportion should 5% HCL acid be mixed with 20% of concentrated HCL to prepare 500 cc of 8% HCI? a 400ce b.— 100ce. c — 250ce ad 320cc 86. 1 gmofRocephin (mixed with 250 ce 0.9% NaCl) is administered via slow IV. in- fusion over 24 hours. If the LY. set delivers 20 drops/cc, what would be the rate of flow in drops/min? or vb. 347 ‘ 5.13 a& 421 87. If adult dose of heparin is‘5000 units, ‘what is the dose of drug in 2 patient havingia 123mm? body surface areagasiai 2 ss Ba a, 1212.30 units b. 2523.20 units f c. 3554.90 units gd $432.10 unitsReference guide for Pharmaceutical calculations Second Edition 88... Howmany milligrams of Lidocaine are present in 5 ce of 1% Lidocaine solution? a 125mg bmg c, 100mg a4 50mg 89. A prescription reads for Hurnulin N as follows; “10 U SQ in am and 20U SQin pm.” How many days will one vial of Humulin N (10 U/ cc, 10 cc) Last? a 15 days b. —_2.0days c. 4.25 days d 3.33 days 90. . How many grams of Acetic acid are required to prepare 250cc of 7% w/v solution ? a 7.0gm »’. 10.2 gm e175 em a 145gm 91. How many grams of Hydrocortisone are present in 60 grams of 0.05% Hydrocorti- sone cream? a 120mg >. 30mg c 60mg 4 90mg 92. The recommended adult dose of Mezlocillin is 250 meg/kg/day. How many milligrams of drug are required in patients weighing 155 Ibs? a 17.61 mg b. 1.13 mg ce. 21.410mg a 15.17mg ‘wwwipharmacyexam.com Krismai, 93. _ Howmany gramsofPovidone Iodine aé required to prepare 480 ce of 10 in 100 solu- tion? a 48gm ’. 30m c 16 gm a Bem 94, In what proportion should 5% dextrose solution be mixed with 25% dextrose solution to prepare 500 cc 18% dextrose solution? a. 305.55 ec b. 194.440 c. 275.12¢e a 333.15 ce 95, How many cc of Hydrochloric acid are required to prepare 750 cc of 0.25 NHC1? [density of HCL = 1.2 gm/ml, molecular weight = 36.5 gm/mole, purity of HC = 37% wh] a 10.12c€ b 23.20 ce ce 1541 cc d. 5.80 ce 96. Aluminium (AI*) has a géam atomic weight of 27. What is it’s mEq weight? 2 pegs eau 97. How many meq of Nat are present in 0.9% 250 ce normal saline solution? [Na* = 23, Cr =35.5] a. 23.12 meq b. 15.17 meq ce. 53.15meq ad 38.46meq iwe guide for Pharmaceutical calculations Edition 982-2Howmany meq of K* are present in 750 mg of aKCl capsule? [K*=39, Cl =35.5] a. 11.11 meq b. 13.21 meq ec. 10.06 meq a 14.71 meq 99. ‘How many meq of Mg’? are present in 50 cc of 20% magnesium sulfate solution? {molecular weight = 246 em] 101.52 meq a b. 41.25 meq c. 31.56 meq - & — 81.30meq 100. How many grams of CaCl, are re- quired to prepare a 480 ce solution that coh- tains 200 meq of Ca'?? [mw CaCl, = 111 gm mole] 212em 314gm 415 gm 1.1 gm pose 101. How many milliequivaients of Al+3 are present in aluminium chloride? [106.5 gm/ mole} : a 21.2meq ’. 46.7 meq c. 35.5meq a 80.9meq 102. How many milliequivalents of ferrous sulfate are present in 325 mg of ferrous sul: fate? [MW = 151.85 gm/mole] a 5.6meq b. 4.28 meq ce — 7.50meq 4 10.12 meq www>pharmacyexam.com Krisman 103, Howmany milliequivalentsof sodium are present in 50% 200cc of sodium bicarbonate solution? [MW = 84 gm/mole] a 1190.47 meq b. 960.52 meq ce. 321.15 meq 655.23 meq 104. How much KCl is required to prepare 1 quart of syrup that contains 5 meq of K* in each teaspoonful’? [MW = 74.5 gm/mole} a 71.52gm b. 101.23 gm ce. 231.20gm 4 89.90 gm 105. How many milliequivalents of Na‘ are present in a 10% 1 quart NaPO, solution? [molecular weight = 164 gm/mole] a. 1012.23 meq b, 1756.31 meq 960.23 meq a 480.15 meq 106. How many milliequivalents of Li* are present in a 300 mg capsule of Li,CO,? [MW = 74 gm/mole] a 10.1. meq b. 4.23 meq c. 8.10 meq a 5.98meq 107. Mr. X has the following chart fot his daily blood pressure: 4 Day Blood prinmmHg Jan 180 SreSect Jan 2 160 Jan3 170 18Reference guide for Phaimaceutical calculations ‘Second Edition Jan4 175 Jan 5 160 Jan 6 183 Jan7 187 ao oe 108. 110. All. ‘What is the mean blood pressure in mm Hg 2 175 182.11 165.12 173.57 If the probability of success in a Null hypothesis is 0.6, what would be the probabil- . ity of failure? a 03 vb 09 c 06 eee 04 109, What is the degree of freedom in a 2X3 contingency table in a Chi-Square test? boas ‘Whatis the “mode” or “median” of the following values? 120, 135, 140, 118, 175, 105, 115, 190 135 118 127.5 115 How many grams of cocoabutter are re- ured to dispense 12 suppositories of tannic acid each weighing 2 gm, and containing 400 mg of tannic acid? [DV of tannic acid= 0.9} = www pharmacyexam.com Krisman 21.23 gm 18.67 gm M.12gm 13.25 gm ae oP 112, How many grams of base are required to dispense 20 suppositories of boric acid each, ‘weighing 2.gm and containing 500 mg of boric acid? (DV of boric acid = 1.5] 33.34 gm 30,00 gm 40.00 gm 21.00 gm ee oe 113. follows: Prednisone 60 mg po qdx2days, Prednisone 50 mg po qd x 2 days, Prednisone 40 mg po qd x 2 days, Prednisone 30 mg po qd x 2 days, Prednisone 20 mg po qd x 2-days, Prednisone 10 mg po qd x 2 days, then DIC. ‘How many tablets of prednisone 10 mg are required to fill the above prescription? a 42 b 31 eeeaa ad 60 114, ‘A tapering dose for prednisone is as If the concentration of reactant M is half in a reaction that is third order in M, by ‘what factor will the rate of reaction change? a. U8 times b. U4times ce. times ad 4times 19Reference guide for Pharmacentical calculations Second Edition 115. What is the rate of constant after 90 minuies f the initial concentration of a drugis 500 mgfcc, and SO mgfce after 90 minutes? [first order kinetic] a. 0.051 min? b. 0,025 mint ce. 0.33 mint d. 0.86 min? 116. Whatis the half-life of a drug that has a rate of constant of 0.067 days"? [first order Kinetic] a 21.12 days b. 3.15 days a ce. 10.34days @ 35.13 days 117. Whatis the rate of constatof heparin in first order kinetic if 500 units/ec of hepatih remain in a solution after 10 days? © 7° Giitial concentration of heparin was"5000 ‘units/cc} - a 0.56 days" b. 1.23 days e 232days 2 sayy 4 023days: 118. How long will it take to decompose Janoxin to one half of its original concentra: tion? [Rate of constant K = 0.023 min'] a. 40.45 minutes b. 50,60 minutes c. 75,80 minutes 4. 30.13 minutes 119. If the concentration of reactant A is double in areaction thatis second order inA, by ‘what factor will the rate of reaction change? www-pharmacyexam.com Krisman a 2times b. 16 times c 4 times d 1/2 times 120, What is the half-life of a drug that is in second order if the initial concentration of ‘the drug was 0.002M? [Rate of constant K = 7 litet/mote min] a 50.15 minutes b. . 13.65 minutes c 42.12 minutes Be a. 71.42 mimutes 121. How long will it take to decompose radioactive radium to 10% from its initial con- centration of 100%? [K = 3x 10+ per month] 1.23 x 10° months 3.12 x 10° months 4.15 x 10° months 0.76 x 10* months pose 122, How long will it take to decompose ethyl acetate to half of its original value? The initial concentration of dug was 0.01M and 0.001M after 40 minutes. : a 132.10 minutes 2 >. 60.8 minutes 23.20 minutes ‘ 4 12.15 minntes 123. The radioactive iodine has a'degraded constant of 0.016 year*, How long will it take to decompose to 10% of its initial coticentra tion? [Assume the initial concentration 100%] : a -25.56years. - © b. 32.20 years 143.93 years d 15x 10° years 20 | | | | |Reference guide for Pharmaceutical calculations Second Edition 124, Whatis the apparent volume of distibu- tion of 0.25 mg lanoxin ifthe plasma concentra- tion of the dragiss 0.10 nanogram/ml? a 3.2x10"L bo -25x10L ce 12x10L ad 4x10L 125, Ifthe LV. dose of a drug is 25 mg/L.V. kg, what would be the plasma concentration of drug in a patient weighing 156 Ibs? An ap- parent volume of distribution of drug is 0.5 L/ kg. a. 0.049 mg/ml b. 1.25 mg/ml cc. 2.36 ing/ml 4.28 mg/ml 126. What is the plasma concentration of a drug after 12 hours if the elimination half-life of the drugis 3.62 hours? The initial plasma con- centration of the drug was SOmg/ec. a Smgjee b, 2S mglec c — 40mg/ee a 50:mgfee 127. What is the rate of infusion of pheny- toin ina patient that requires steady state plasma concentration of 20 meg/ml ? ‘The elimination half-life of phenytoin is 4 hours and an apparent volume of distribution is ISL. a 4085 mg/hr b. 51.975 mg/hr ce 70.19mgfar 4 123,20 mgfhr = 128. Whatwouldbe the loading dose ofa drug to achieve 2 20 meg/ml steady state plasma www.pharmacyexam.com Krismaii concentration ? The apparent volume of distribu- tion is 4.5L. 8 é 129, The rate of infusion of Rocephin is 20 mmg/hr. How long will it take to infuse 500 mg 1100 ce Rocephin? a. 10 hrs, b. 20 brs ce Shs a 2Shrs 130; If the total body clearance in a patient is 2100 cc/hr, and hepatic clearance is about 300 cefhr, what is the status of renal function? a. Excellent b. . Normal c. Moderately impaired Severely impaired 131. How many milligrams of sodium chlo- tide are required to prepare 250 cc of 1% bo- ric acid solution to isotonic with eye tears? FP of 1% boric acid = -0.29°C FP of 1% sodium chloride = - 0.58°C FP of blood = -0.52°C 250mg 325mg 991 mg 1221 mg apse 132. How many grams of sodium chloride are required to prepare 100 cc of water iso- tonic with blood? FP of 1% sodium chloride =-0.58°C 21Reference guide for Pharmaceutical calculations Second Edition a 045gm bv. 2.3gm c 14gm 4 09am 133, How many grams of sodium chloride are required to prepare a 1 in 100 solution of cocaine isotonic with blood? FP of 1% sodium chloride =-0.58°C FP of 1% cocaine = - 0.09C a 0.74 gm db. 035m e 150gm a 3.57gm 134, How many grams of boric acid are re- quired to prepare a 300 ce 1% procaine hy- drochloride solution isotonic with tears ?° FP of 1% boric acid = -0.29° C FP of 1% procaine = - 0.122°C a 110gm b& 4.1lgm c 2.21 gm 4 151gm 135. Whatis the maximum buffer capacity of bicarbonate buffer with a total concentra- tion of 0.075 mole/liter? a 0.015 b. 0.210 c. 0.043 da 0.145 136. What is the pH of a solution contain- ing 0.01 moles of acetic acid and 0.1 mole of sodium acetate per liter of solution? [Pka = 4.15] a 3.15 be 41S ‘woerphamacyexam.com Krisman, e 245 a 5.15 137. What is the molar ratio of salt/acid re- quired to prepare a buffer having pi =5 and pKa =4.00? a 10:1 b. 50:1 ce 10:1 pen ee sa 138. What s the pH of the solution contain- ing 0.5 molés of ephedrine and 0.05 moles of ephedrine HCI per liter of solution? [ PKb = 4.56] a 5.65 b 7.56 c 8.90 d 10.44 139, The ratio of ionized to unionized ace- tic acid in a solution is 100:1. What is the pH of a solution having pKa 5.5? paar) bea e 45 a 75 140. What is the % of hydrocortisone in.a mixture of 15 gm of 0.1%, 60 gram of 0.25% and 80 gram of 0.5% whw hydrocortisone?. | a 0.36% ww b. 0.50% wiw . c. 1.25% whw a a.Reference guide for Pharmaceutical calculations Second Edition c. 1:500 d 12500 142. What is the pH of a solution having a hydrogen ion concentration of 10° moles/lit? pegse AVE 5 143. An adult LV. dose of Neupogen is 20 meg/kg/week. How many milligrams will a 150 Tb patient receive weekly? a 2.210mg b. 3.120mg cs. 1.363 mg d4.152mg 144, How many ce of 0.75% sodium hy- pochlorite stock solution are required to pre- pare 1 quart of 1 in 500 solution? a :128ee b. Bi2ec ce — 256ce ad Alec 145. If | gm of Cefazolin is reconstituted with 12.5 cc of SWEI, and the resultant solu- tion is inserted into 50 ce of 0.9% sodium chlo- tide, what would be the final concentration of, drug in mg/ml? a. 12mg/ec b. 10 mgiee 16 mgfee a 20mglee 146. 1f2.ce of (5000 units/10ee) Heparin are inserted into 100ce of DSW solution, how many units of drug are present in each ml of solution? www pharmacyexam.com Kristiaii a 10 unitsice bv. 1Sumits/ee ce. 4Sunits/ee d 98 units/ee 147, Ifan.V. admixture contains 1000 mg/ 250 cc of drug and should be infused within a 5 hour period, what would be the flow rate in drops/min? [LV. set delivers 20 drops/cc] a. 10 drops/min b. 17 drops/inin a 35 drops/min_ 4.21 drops/min 148. If 250 mg/500 ce theophylline solu- tion are given in a patient over a 6 hour pe- riod. By 100cc infusion every hour, what ‘would be the strength of theophylline in meg/ ml? a 250mgice bd. 750megice c. > $00mog/oc 4. 340meg/ce 149. 250 mg/500 cc Rocephine solution should be administered to a patient weighing 155 Ibs. The recommended adult dose of drug is 1.5 meg/kg/min. What would be ate of flow in ml/min? a 1.23 ml/min b. 4.21 ml/min ec 0.211 ml/min a& (0,590 m/min 150. If 20 ce of 10% KC! injection are added to 250cc of normal saline solution, what would be the concentration of KCI in meq/ ce? [mw of KCl = 74.5 gnv/mole] a L2meglee b. 0.650 meg/ce ce. 0.423 meq/ee a 0.099 meq/ce 23Reference guide for Pharmaceutical calculations Second Edition 151. Howmany milliequivalents of sodium are present in 480 cc of 20% sodium bicarbonate solution? [muy sodium bicarbonate =84 gm/mole] a 960.65 meq b 425.35 meq c. 686,66 meq 4 1142.85 meq 152, 120 ce of KCI solution (4 meqfec) are diluted with water up to the 250.ce mark, what would be the concentration of drug in mg/ec’? (mw of KCl = 74.5 gm/mole] a 12.23 mg/ec b. 42.25 mg/co c. 23.84 mgfoo a 63.15 mglee 153. Ifaprescription calls to dispense 120ce of KCI in such a way that 1 teaspoonful of solution contains 10 meq of drug, how many grams of KCl are required to prepare the above prescription?[mw of KC1=74.5 am/mole} a 12.25 gm b. 21.15 gm » ce 13.20gm d. 17.88 gm 154, How many cc of Povidone are required to prepare 5 Ib of 10% povidone iodine oint- ment? [density of povidone = 2gm/ec} a 3.20 b. 15.6 ce ce — 10.1ce do 22,7 ce 15S. 1°5000mg oftriamcinolone powder are mixed with 1 Ibof 1 triamcinolone cream, what isthe % of triamcinolone inthe final mixture ? ww.pharmacyexam.com Krisman a 125% ww b. 3.56% wiw ce. (2.19 whw da 42% ww 156. How many cc of Hydrochloric acid are required to prepare 1 gallon of 2.5% hydro- chloric acid? [the purity of HCI acid = 35% w/w, the spe- cific pravity of HCI = 1.25 gm/ml] a 102.11 ee b. 303.15cc ce 219.42cc a 151.15 ce 157. What is the % of elementary iron in 325 mg of anhydrous ferrous sulfate? [iron = 65 mg] a 10% 7 b. 35% ce. 45% da 20% 158. In what proportion should water be mixed with 7.5% acetic acid solution to pre- pare 1 gallon of 0.5% acetic acid? a. 1220¢c b. 2568.ce c.. 1091ec d. 3584cc 159. Ifthe prescription for Cipro reads 500 mg by mouth three times a day, how many days will a bottle of Cipro (10%,100 cc) last? 2.34 days 3.21 days 4.25 days 6.66 days ao geP 24Reference guide for Pharmaceutical calculations Second Edition 160. How many cc of 2% erythromycin topi- cal solution are requised to prepare 480cc of 0.25% topical solution? a 6Dec bd. — 120ce c 30ce da 45ce 161, In what proportion should 3% acetic acid be mixed with water to prepare a 0.5% 1000 ce acetic acid solution? a 166.66 cc b. 108.51 ce c 323.15 ce ad 421.16 ce 162. 178 tablets of 150 mg of amitriptyline are added in 240 ce cherry syrup, how much drug will present in 5 cc of solution? a 50mg b. 25mg c. 15mg 4 125mg 163. How much hydrocortisone powder is required to prepare 240 gm of 1% hydrocorti- sone ? a 12gm b. 3.6 gm. c 24gm a 48gm 164. 3 gms of sodium thiosulfate powder are mixed with 120 gm of aquaphore. What is the % of sodium thiosulfate in a final mix- ture? a Swi b. -2.5% wiw c 125% ww a 10%wiw www-pharmacyexam.com Krismaii 165. If 60 grams of 1% triamcinolone aré mixed with 60 grams of aquaphore ointment , what isthe % of triamcinolone in the final mix- ture? a 0.5% why b. 15% whe c — 3.0% whw da 4.5% wiw 166. 1 cc of atropine (0.4 mg/ec) is mixed with 49 cc of ocean nasal mist, what is the concentration of atropine in mg/ml? Smoglee 0.1 meg/ee 10.5meg/ce 20.1 megiee ae oe 167. To prepare 60 gm of 2.5% xylocaine ointment, how many cc of xylocaine 10% are required? a 10ce. b See ce 25ec d See 168. The prescription for magic mouth reads as follows: aa 60ce Hydramine elixir. Alamag oral susp. Nystatin oral susp. ‘Lidocaine viscous Total. sssencee How many ce of lidocaine viscous solution are required to compound the above prescrip- a 120ce b.— 180ce ce — 60ce ad 90ec 25Reference guide for Pharmaceutical calculations‘ Second Edition 169. If 13 capsuled of Dicloxaeiltin, gach weighing 500 mg, are added to 500 cc of Alamag suspension, how many milligrams of drug are present in 5 cc of the final solution? a 13mg b. 26mg c 65mg ad 52mg 170. 8 cc of 10% Povidone-lodine solution are diluted up to the 1000 ce mark with p fied water. What would be the concentration of Povidone-Iodine in mg/ec? a 1.2mg/ec : b,-24mg/ec c. 3.2 mgfoe 4. 08 mg/ee 171. 2capsules of chloramphenicol 500mg are added to 30 grams of fluocinonide cream. ‘What is the % of chloramphenicol in wiv? a 2.52% b. 4.12% 5.63% ad 3.33% 172, 8 capsules of clindamycin each weigh- ing 150 mg are added to 60 cc cetaphil cleanser, What would be the concentration of drug in mg/ec? a 12 mg/ec. b. Omgiee 35 mglee a 20mglee 173. To prepare 60 gm of 2% Clindamycin topical gel, how many capsules of Clindamy- cin each weighing 150 mg are required? a 2caps bd. Bcaps ‘www pharmacyexam.com Krisman ce caps a Acaps 174, To prepare 1000ce of 0.25% of Dakin solution, how many cc of 5% sodium hy- pochlorite are required? a 100 cc b.50ce co 60cc ad ' 40ce 175. To prepare 1 mg/5 ce (120 cc) solu- tion of Trilafon, how many ce of Trilafon (img/ce) are required? a Wee one 35.60 e. Weo a 0c 176. 2c of Vancomycin injection (250 mg/ cc) are added to 8 ce of isoptotears. What is the final concentration of drug in mg/cc? a. 75 mglee b. 25 mgfec ce. 50mg/ee a 80mglee 177. Anadministration of 1.5 gm/kg/day of amino acid via peripheral infusion normally achieves optimal fat metabolism and spares protein catabolism. What would be the dose of amino acid in grams for 155 Ib patient? a 23.45 gm b 190.60 gm_ c 89.65gm ad 105.68 gm 178. Howlong willit take to administer 2500 ccof TPN solution with arate of 60ml/ke/day in patient weighing 140 Ibs?Reference guide for Pharmacentical calculations Second Edition a 15.71 hours b. 22.24 hours c. 10.86 hours d. 9.75 hours 179. How many éalosies are provided by 500 ce of D,,W solution? a, ‘145 calories b. 510 calories ce. 325 calories 4252 calories 180. How many total calories are provided by 1000 ce of 5% dextrose and 5% alcohol? a. 131 calories b. 450 calories c, 253 calories 4. 75 calories 181. The maximum recommended rate of infusion of dextrose solution is 0.1gm/kg/br. How many hours will it take to infuse 1000 co of D,,W solution in a patient weighing 155 bs ? a. 10.15 hours b. 30.12 hours c. 42,58 hours 4.7.15 hours 182. 2.4 liters of 5% alcohol solution are administered to a patient with a rate of 0.33ce! min, How many hours will it take to finish the whole infusion? a 121.21 hours b. 90.15 hours c 45,65 hours 4. 75.67 hours 183. Refersing tothe ahove question, ethanol ismetabolized at arate of 20 cc/hr. Will it make. the above patient sedate? ‘www pharmacyexam,com ‘Krisman “Yes No Cannot say 4 Cannot be caloulated ere 184, What is the volume of dextrose solu- tion required to prepare a peripheral parenteral nutrition for Mr.Shroff that provides 1100 nonprotein calories and 30 gm of amino ac~ ids? The formulation should provide 45% of nonprotein caloties as fat and have a maxi- mum dextrose concentration of 12.5%. a $76.15 ce b. — 823.18cc ce. — 1423.52ce gd. 390.63 ce 185. How many cc of amino acid solution are required to prepare a 3% amino acid solu- tion containing 30 grams of amino acids? a 500ce b. — 1000ee c — 250ce dd 355¢ce 186. Using the Harris Benedict's equation, whats the Basal Energy Expenditure for Mrs. Shahel? es ‘Age = 35 years, W = 1201bs, H = 5*2” BEE,,..,= 655.10+9.56xW+ 1.85xH ~4.86xA = weightinkg heightinem ageinyears a 1100.11 calories b. 986.5 calories c. 1304.03 calories d. 825.05 calories 21Reference guide for Pharmaceutical calculations ‘Second Edition 187. What would be the total calories provided by a TPN mixture containing 1200 ce of DSW, 1000 ce of 10% amino acids, 100 ce of 5% alcohol and 300 cc of 20% fat emulsion ? a 575 calories b.. 250 calories ©. 680 calories d. 1172 calories 188. Ifa prescription for TPN calls for pro- viding 55% of 1500 nonprotein calories as a dextrose, how many ce of D,,W are required? a 451.52.ce b. -323.32c¢ ce. 808.82 cc 616.15 ce 189, If a prescription reads to compound TPN that provides 45% of the 2000 nonpro- tein calories as fat and the remaining 55% as, dextrose, how many ce of 20% fat solution are required? a 1000ce b.-250ce c — 750ce d 500ce 190. How many ce of 5% amino acid solu- tion are required to provide 2gm/kg/day ina patient weighing 165Ibs? a 1500ce b. 500ee c 3000 ce 4 2000ce 191. How many calories are provided by 250 coofS% glycerol? a. 101.S2calories b. —-75.82calories www pharmacyexam.com ‘Krisman c. 53.75 calories d 41.11 calories 192. How much calories are provided by 500 cc of 20% lipid solution? a 500 calories b. 750 calories ce. 475 calories d. 900 calories 193, A prescription reads “Alphagan 0.2% drop, 1 drop od gid x 10 days”. How many milligrams of Alphagan are present in each drop of solution? (1 drop =0.1cc) a 12mg b-24mg c 02mg 4. 0,002 mg 194, How much Timolol is present in 10 cc of 0.5% Timolol opthalamic solution? a 500mg b 05mg c 5gm a4 50mg 195, Ifa prescription for Haldol decanoate Teads “75 mg im. twice a week x 4 months”, how many vials of haldol decanoate (100 mg/ co, 1 ec) are required to fill the above order ? a 2Avials b. 12 vials c. 10vials 50 vials ot son gates 28 | | |Reference guide for Pharmaceutical calculations Second Edition ce. 80calories d. 90 calories 197. In what proportion should 2% acetic acid be mixed with 10% acetic acid solution to prepare 500 co of 5% acetic acid solution?” a 102.12 ce b. 204.15 ce c. 312.50ce 4. 405.90 ce 198. A tapering dose for prednisone is as follows: “40 mg po qdx | day then taper 10 mg everyday until D/C”. How many tablets of 5 mg are required to fill the above order? 10 tablets, 5 tablets 20 tablets 15 tablets ao oe 199. How many milliequivalents of sodiumbi- carbonate are present in 50 ce of 50% so- dium bicarbonate? [mw = 84 gm/mole] 131.15 meq 204.25 meq 302.10 meq 297.61 meq pe re 200. Whatis the half-life of a drug in a day, if the degraded constant of the drug is 9.9 x 10° days? [first order kinetic} a 3Sdays b. 60 days: © 70 days d 105 days 201. How many grams of Ainoxicillin are present in 200 cc (250mg/5 cc) of Amoxicillin sotution? www.pharmacyexem.com ‘Krisman a Sgm b. 1Sgm c. 10 gm. a 20gm 202. A prescription calls for Demerol, “75 mg IVP q6h pr pain x 7days”. How many vials of Demerol (100 mg/cc) are required to fill the above order 7 a. 10 vials b. — Lyials c. 15 vials d > 21 vials 203. Which of the following are correct DEA numbers for Dr. Sheghi, Rama? a. . BS4312567 b. AR3252181 c. —_ BR4530895 d. 482332764 204, How long will ittake toinfuse 250 cc of D,,W solution ina patient with a flow rate of 0.5 celsecond? a. 2.50 minutes b. .60 minutes c. 8.33 minutes 4. 10.12 minutes 205. If an adult recommended dose of a drug is 5 mg/kg/day, how many milligrams of the drag will a patient receive every 4 hours? [patient weight = 110 Ibs} 55.12 mg 101.23 mg, 41.66 mg 24.84 mg pose 29Reference guide for Pharmaceutical calculations Second Edition 206. How many calories are provided by 500 cc DW, 300 cc 3% amino acid and 500 ce of 10% lipid solution? 123 calories 205 calories 401 calories 571 calories ae gp 207. How many milliequivalents of Kr are present in 400 cc of 20% solution of KCI? (mw of KCl = 74.5 gm/mole) a 576,80 meq b. 432.11 meq c. — 808.16meq 4 1073.82 meq 208, What is the ratio of ionized to union- ized drugs at pH = 6? [PKa= 4] eoge 209. A drug with a weak base property has aPKb value of 85. Whatis the ratio of unionized toionized drugs at PH=6.5? a. 100:1 bho cy lO a&. 1:100 210. A Viracept powder (144 gm) prescrip- tion is written as follows: “1250 mg by mouth twice a day”, How many scoops (each 50 mg) are required per day? 100 scoops : 5 scoops 50 scoops 25 scoops ee oP wvvepharmacyexam.com Krisman 211. Referring tothe above question, how long vwillit take to finish the whole bottle of drugs? a 23.1 days b. 14.5 days c. 33.5 days 4 57.6days 212. fan .V. order is prescribed to admin- ister 0.2 mg/kg/day of theophylline, how many, milligrams will patient receive per day? {patient weight = 120 Tbs} a7 123mg bd. 856mg c 421mg ad 109mg 213. How many capsules each of 750 mg KCl are required to prepare a 10% 180 cc so- lution of the drug ? (aw of KCI= 74.5 gm/mole) a 10 b 15 Gaal a 24 2114,. How long will it take to decompose the drug to 50 mg/ce? The initial concentra- tion ofthe drug was 500 me/ee with a half life of 9.9 x 10 minutes. a 0.15 minutes b. 1.29 minutes c. 0.329 minutes 4. 0.809:minutes i { iReference guide for Pharmaceutical calculations Second Edition a 10mg b 15mg ce 25mg a 55mg 216. Ifthe sensitivity of the balance is 4 mg, ‘what's the minimum permissible quantity hat can ‘be weighed on a balance? [an error of +5 is per- missile] a 80mg b. 100mg ce 150mg d& 250mg 217. If the sensitivity of balance is 3 mg, what is the minimum permissible quantity that can be weighed on a balance when an error of + 1is acceptable? a, 300mg bd. 250mg ce. 75mg a. 50mg 218. ifabalance hasa sensitivity of 3mg, what isthe % error allowed? [minimum weighable quantity is 150 mg] a 41% db. -£2% c £5% a #10 219. In essay of ethyl nitrite spirit, nitric oxide gas is liberated from a spirit and col- lected ina gas burette that occupies a volume of 50.ce at a temperature of 25°C and a pressure of 710mm Hg. What is the volume of gas at °C and 760 mm Hg? [assume that gas behaves ideally] a 101.23 ce b. 42.79 ec www-pharmacyexam.com Krisinan ce 2.15ec ad 80.85 ce 220. Calculate the value of the molar gas con- stantR at STP. The volume of gas found is 22.4 Titers at 1 mole of an ideal gas. a. - 0,064 atm lit mole K° b. 0.152 atm lit/ mole Ke c. 0,082 atm lit/ mole K° 4. 0.76 atm|lit/ mole K* 221. What is the volume of 3 moles of an ideal gas at 20° C and 740 mm He? IR = 0.08205 lit atm/ mole deg] 25.151, 35.10L 74.07L 52.10L, Be oP 222. If 0.5 gm of methylacetate in the va- por state occupies 500 ce af'a pressure of 780 mm Hg and temperature of 120° C, what is the molecular weight of methylacetate? a.» 20.15 gm/mole b. 31.41 gm/mole c. 1050 gm/mole 4 5.60.gm/mole 223. 1f50 gms of ferrous sulfate are diluted with water up to 1000 cc, what would be the molarity of the solution? [mw of FeSO, = 151.90 gm/mole] a 05M b. 12M c. 0331M ad 21M 224, Whatis the % mole fraction of ferrous sulfate in a solution containing 25 grams of ferrous sulfate in 1000 gm of water? [mw of FeSO, = 151.9 gm/mole, mw of HO =18gm/mole} 31Reference guide for Pharmaceutical calculations Second Edition a 752% db. 23.11% c 0.29% a | 99.71% 225. 1f0.2M solution of acetic acid dissoci- ates in 1.2.x 10* moles each of hydrogen and acetate ions at 25°C, what is the dissociation constant Ka for acetic acid? a 12x10¢ b. 24x 108 ce 72x10" d 35x 10% 226. The ionization constant Kb for a mor- phine base is 3 x 10% at 25°C. What is the hy- droxylion concentration of a3 x 10*M aque- ous solution of morphine? a. 9x10" moles/lit b. 3x 10% moles/lit c. 1x10? moles/lit d_ , 9x10*molesit 227. Aduantity of hydrochloric acid (0.1 M) ‘isadded to increase the H' ion concentration from. 1x 10" to 1 x 107 moles/liter. What is the new ‘hydroxyl concentration? a. 1x10*molestliter b. 1x10" molesfliter ce. 1x10 moles/lter @ 1x10” molesfiter 228. Ammonia has a Kb of 1.5 x 10% at 25° C. What is the Ka for its conjugated acid NH4* at the same temperature? a 12x10¢ b.085x10" ce 066x108 a. 034x104 worw.pharmacyexam.com, Krisman 229, Themeasured solubility ofsilver chloride ‘in water at 25° Cis 1 x 10+ moles/liter. Whatis the solubility product ofthis salt? a 1x 10" been 108 G, 1x 107 dixie 230. What is the solubility of silver chro- ‘mate in moles/lter in an aqueous solution con- taining 0.08 M of silver nitrate? The solubil- ity of silver chromate (Ag,CrO,) in water is 8 x 10% [KSP=2x 10] 105.56 x 10 moles / liter, 85.23 x 10* moles / liter 43.56 x 10 moles / liter 312.5 x 10" moles / liter ao oP 231. When boric acid is distributed between water and methylalcohol, the concentration in water and methylalcohol were found to be 0.06 molesfiiter and 0,03 moles/liter. What is the distribution coefficient? a lors b. 20r05 c. 40r2 d 150r3 232. 10 gmof aspirin powder is dissolved im 100 cc of solution. The solubility of aspirin, at 25°Cis 0.33 gm/100 ce. The first order rate constant for aspirin degradation is 5 x 10$sec- ‘ond. What is the zero order rate constant? a. b $ c 1.30 x 10%. a@ 142x104: i 233. Theinitial concentration ofadrag decom- posing according to first order kineiis 10? units! ml. When the concenitration of drug falls below 32Reference guide for Pharmaceutical calculations Second Edition 10° units/ce, it should be removed from the ‘market. What would be the expiration date for this product? (K = 2.303 x 10" hour! } a. 20x 10° hours b. 40x10? hours ce. $x 10? hours a 40hours 234, A sample of methylspirit rose to a eight of S cm at25°C in a capillary tube hay- ing an inside radius of 0.05 cm. What is the surface tension of methylspirit at 25°C ? Den- sity of methyl spisit is 1.5 m/em. 121.56 201.11 183.93 305.12 ap oP 235. If a droplet of oleic acid is placed on water having a surface tension of 72.8 dynés! em at 20° C and an interfacial tension of 30 dynes/om. Will the oleic acid spread on wa- ter? Surface tension of oleic acid at 20°C:= 35 dynes/cm. a 105 b. 201 cc 355 da 128 236, An O/W emulsion containing turpen- tine oil with a specific gravity of 0.45 is dis- persedin aqueous phase having specific gravity of 1.05. Ifthe ol particles have an average diam- eter of 10 micrometers and the viscosity of external phase is 0.25 dynes/om®, What is the velocity of creaming in cm/day? [g= 981 om/sec*] a 24x10" b.-13 x 108 wwwpharmacyexam.com Krisman c 23x10 ad 31x10" 237. How many milliosmols per 100 ce ate present in 500 ce D,.W solution ? [mw of dextrose = 180 gm/mole] a 138.88 be 1388.88 e. 456.23 ad 520.15 238. What is the osmolarity of 500 cc of 25% sodium bicarbonate solution ? [mw = 84 gm/mole} a $952.38 b. 2763.18 c. 7032.11 4. 1809.09 239. How many milliosmols per liter of CaCl, are representated by 50 ce of 20% CaCl, solution? a $405.4 b. 1232.11 c. 2516.15 a 3315.23 240. In what proportion should 3% 200cc boric acid solution be mixed with 8% boric acid solution to prepare a5% 100 ce boric acid solution? a —-:100ce b. 60ce c. 40ce ad 50ce 241, How many milliequivalents of Nat ions are present in a 50% 50 ce solution of sodium bicarbonate? [mw of NaHCO, = 84 gm/mole} 33Reference guide for Pharmaceutical calculations Second Edition a 105.32 b. 325.16 ce. 297.61 a 40119 242. One teaspoonful of chlorpromazine concentrated solution (30 mg/cc) is diluted up to 240 ce with distilled water; 10 cc ofthis resultant solution are diluted up to 1000 ce with distilled water, What would be the concentration of drug jinmegfoe inthe final solution? a 625 esse 62's) e625 d 0.00625 243. Calculate the osmolarity of 200 cc of 0.9% sodium chloride solution. a 805.11 b 307.69 e. 420.11 a 105.21 244, How many milliosmols/L are represen- tated by 30 ce of 10% KCl solistion? a 1232.11 Db. 980.05 c. 2684.56 a 1411.23 245. An LV. order for250mg/100 ce should be administered via LV. infusion overa 12 hour period. Ifthe LV. set delivers 20 drops/cc, what Would be the flow rate in drops/min’? a 128 b. 15.60 c 8.90 427 www.pharmacyexam.com Krisman 246. 20ccof 10%KCI sotution, 50.ccof 25% ‘NaHCO3 solution and 30 cc of 20% CaC2 are mixed with 5% 1000 cc dextrose sdlution. The infosion should be administered over Shouts. What isthe flow rate in drops/min ?[L. set delivers = 10 drops/cc] a 13.19 b 14.05 c 18.01 d 22.91 247. How long will it take to infuse 500 cc of DSW solution if the flow rate of the solu- tion is 20 drops/min? [LV. set delivers 20 drops/ec] a 1.Shours b. 10.11 hours c. 5,60 hours ad 8.33 hours 248. Calculate the flow rate in drops/min to infuse 300 cc of clindamycin solution over a4 hour period. [LV. set delivers 15 drops/ec] a 20.12 v8.75 e 75 ad 1630 249. if the normal therapeutic recom- mended dose of metronidazole is 10 mg/ke/ day, how many infusion bags of 250 mg/100 ce are required? [pt weight = 155 Ibs] ° peep wre 250. How much dextrose is required to pre- pare 1 in 100, 50 cc dextrose sofution? 34crpneeenmcanpeenee=e trseoyenr Reference guide for Pharmaceutical calculations Second Edition a 05em b 2gm ce i5gm a4 36gm Ba www.pharmacyexam.com Krismant 35Reference guide for Pharmaceutical calculations Second Edition ANSWERS www>pharmacyexam.com 36Reference guide for Pharmacentical calculations Second Edition 1. (b) 2.4 grams. The amount of sulfur required to fill the above prescription is 80x3 = 2.4 grams. 100 2, (b) 500 ce of 5% Dextrose solution con- tains: 500x5 = 25 grams of dextrose. 100 3. (©) 1: 1000 is generally interpreted as 1 ‘gm in 1000 cc of solution, The amount of Tidocaine in’30 cc of 1:1000 solution can be calculated as follows: = 30x 1000 0.03 gm = 30 milligrams. 4, (d) 1 grain is equal to 65 milligrams, there- fore 1/150 grains are equal to: =1x65.5 150 43 milligrams 5. (d) 1 in 100 solution is interpreted as 1 gm of drug in 100 cc of solution, We want to find ‘outhow much atropine is required to dispense 1 quart (960 cc) of 1 in 100 solution, there- fore: = 960.x1 = 9.6 gm atropine = 9600 mg. 100 6. (c) To solve this type of problem, we need to use the alligation method. So (75%) Ce eo (10%) ‘Total parts 65 (30%) www>pharmacyexam.com ‘Krisinaa ‘To prepare 65 (30%) 20 parts (75%) needed To prepare 500 (30%) ? = 500.20 = 153.84 cc (75%) alcohol 65 If we mixed 153.84 cc of 75% alcohol with 346.16 cc [500 ce - 153.84 ce] of 10% aleo- hol, then we can get 500 ce of 30% alcohol solution. 7. (b) We want fo prepare 1 quart (960 cc) of 0.45% heparin solution, therefore we can say = 960x045 = 100 432m. 4.32 gms of heparin are required. 8. (a) This type of calculation is classified as a dosage calculation and can be calculated as follows: ‘We have a suspension of Augmentin 250 mg/ S.cc and we want to dispense dose of 875 mg, =S.x875 = 17.5cc 250 ‘The patient is taking 875 mg twice a day and therefore: =2x 17.5 co =35 cc per day. Patient is taking drug for 10 days therefore, = 35 x 10 = 350 ce would be the dispensed quantity of drug. 9. (b) 250 mg (0.25 gm) of cefazolin pow- der are diluted with water up to 250 ce mark and we want to find out the % of drug in the final solution. 37Reference guide for Pharmaceutical calculations ‘Second Edition = 100x025 = 0.1% 250 10. (c) 1 teaspoonful (5 cc) of Thior- idazine solution (30mg/cc) contains 150 mg of drug. This solution is diluted up to a mark ‘of 480 ce therefore: = 150 = 031 mg/ml 480 IL. (@) ‘We have 12.5mg/Scc Benadryl solution. We want to dispense 4 50 mg dose: = 50x5 = 20ce for I day 125 For 30 day supply: = 20x30 =600ce. 12. (d) Erythromycin 2% topical soli- tion contains = 60x2 100 = 1.2 gmof erythromycin. 13.(€) ‘The % of elementary iron can be found as follows; = 100x60 325 18.46% 14. (b) in 60 gm, 1%: ‘The amount of Hydrocortisone 60 = 0.6 gm of hydrocortisone. 100 Amount of hydrocortisone in 80 gm. 2.5% 80.2.5 = 2 gm hydrocortisone 100 f cortisone in. ixture, wwwpharmacyexam.com Krisman = 100x2, m. 140 (80 gm+ 60 gm) = 1.85% wiw. 15.(c-) — Lampul Pationt is taking 100 meg of the drug LM. ev- exy week, therefore: = 100 = 0.1 cc of drig every week. 1000 of ce requir =0.1x4=04cc The correct answer should be 1 ampul, 16. (d) 1000 tablets of Risperdal Img cost $2250. The % mark up on prescriptions is 20%. ‘Therefore the retail price of 1000 tablets would be: = 1202250 = $2700 100 ** Each $100 cost = $120 retail cost** Price for 30 tablets would be: = 30x2700 = $81 1000 i 17.4) We want to find out the quan- tity of Clobetasole present in 60 grams of 0.5% ointment. = 60x05 = 03 gmof clobetasole. 100 es 7Reference guide for Pharmaceutical calculations Second Edition 18. (c) A pH of the solution can be found by the following formula: pH = pKa + log io unionize = 2.2 + log lO 2.2 +3 52 19. (b) We have 400 mg/5 cc Aug- ‘mentii in stock. We want to find the dispensed quantity for a 10-day supply. = 815x5 = 10.93 ce for each dose 400 ‘The patient i taking a dose twice a day for 10 days therefore : = 10.93x2x10 = 218:75¢c 20. (a) sper Weight in grams = no of ml x = 500ce x 1.25 gm/co = 625 gm 21. (a) Weight = density x volume Volume = weight density = Sx 454 1.25 (Ib =454 gm) 1816 ce glycerine. 22.(b) Weight = density x volume =2.5x500 = 1250 gm of acid. ww w,pharmacyexam.com Krisman, 23.(c) pH = pKa + log salt acid 7 = 5+log salt acid log [saltacid] = 2 salt/acid = 10?, ratio of ionized to unionize drug will be 100. 24.() pH = - log [H,0°] 3 = - Jog [H,0°] log [H,0°] TH,0°} = 10° gmion 25.(d) pH = pKa + log [salt/acid] + log[ 105} 1-6 =i 26. (d) 240 cc 2% Erythromycin so- Jution contains: = 40x 2 = 4.8 gm of Erythromycin 100 ‘The number of 500 mg tablets of Erythromy- = 4800 = 9.6 = 10 tablets. 500 27. (©) 1 grain is equal to 65 mg there- fore: 1/150 grains will contain: = Lx 65 =0.43 mg 150 28. (a) 100 tablets of Lgrain of Aspirin contains: 100% 65 = 6500 mg of Aspirin, 39Reference guide for Pharmaceutical calculations Second Edition ‘Thenumber of 975 mg tablets of Aspirin: = 6500 = 6.66 = 6 tablets 975 29. (b) contains: 1 % 150 ce Cleocin solution = 150x1.= 1.5 gm Clindamycin 100 ‘The addition of 3 capsules each weighing 150 ing will result in: 1.5 gm +045 gm = 1.95 gm % of Clindamycin in final mixture would be: = 195x100 = 13% 150 30. (a) 71.42 mg ‘Young rule = age in year x adult dose age + 12 = 2. x 500 =71.42 mg 4 31. (a) 100mg Clark’s rule = Weight in ibs x adult dose 150 = 20 x 750 = 100mg 150 32.(0) 0.06 ee According to Fried’s rule: = agein months x adult dose 150 15x 225 = 325 mg 150 www.pharmacyexam.com Krisman ‘The dropper is calibrated to deliver 325 mg of Iron sulfate in 0.6 cc, therefore: = 0.6325 = 0.06ce 325 33. (d) 11.56 mg A child dose can be calculated by: = Body surface area of child x adult dose 173 mot = 2x10 173 = 156mg 34.(d) 1 grain is equal to 65 mg, there- fore 10 grains contain = 10x65 = 650 mg of the drug. 35.(c) _ Patient weight is 1561bs, there- fore weight in Kg would be 156 ='70.9 kg. 22 A normal therapeutically,recommended dose of drug is 10mg/kg/day, therefore the dose in the above patient is: = ie 10x 70.9 109 mgReference guide for Pharmaceutical calculations Second Edition = 1x65.x1000 100 = 650 micrograms [1 mg = 1000 meg] A prescription calls for 50 meg of adrug three times a day for 10 days, therefore the number of tablets required to fill the order is: = 50x3x10 = 2.30 = 3 tablets 650 37.(a) A patients taking 125 meg of Lanoxin every day, therefore to fill a 30 day order, = 30x 125 = 3750 meg of Lanoxin. Each ml of Lanoxin elixir provides 50 meg of admug, therefore the number of cc required to fill the entire order is: = 3750 = 75 cc of Lanoxin el 50 38. (a) A prescription reads to dis- solve 2 gm of Guaifenesin in 100 ce of plain water, therefore the amount of drug present in. 1 teaspoonful (5 cc) of solution would be 39. (b) 100mg of Lactaid is equal to 4500 units, there- fore 1 unit is equal to: = 100 = 0.02 mg of Lactaid 4500 40. (c) 2B ce AT year-old child is taking 50 mg Ampicillin by mouth twice a day for 7 days, therefore: www pharmacyexam.com Krisman = 50x2x7 = 700mg of Ampicillin ‘We have 125 mg/5 ce suspension in stock: = 5x00 = 28ce : 125 41.) 477mg An adult dose of drug can be calculated by the following formula: Body surface area x adult dose 173 mm* = 110 x 750 = 476.87 mg-= 477 mg 173 42. (@) contain: 240ce of 10% solution will = 240x110 = 24 gm of drug. 100 43. (c) 6.75 gm sodium chloride ‘The amount of sodium chloride required: = [50x09 = 6.75 gmof sodium chloride 100 44. (b) D,,W. will be interpreted as 25% Dextrose solution. ‘The amount of dextrose present; 00x25 = 125 gm of dextrose. 100 45. (a) 1: 1000 solution isinterpreted as 1 gm of dmg in 1000 cc of solution. 41Reference guide for Pharmaceutical calculations Second Edition = 30x1 =0.03 gm =30 mg of Lidocaine 1000 46. (a) 1.33 gm of Povidone-Iodine. Thea Pe Todi = 1000 = 1.33 gm of povidone iodine 750 47. (b) 20 gm of dextrose tof dextrose requir = 5000x1 = 20 pm of dextrose 250 48.(c) 1 in 20 solution is interpreted as 1 gm of drug in 20 ce solution, =100x1 = 5% boric acid 20 49. (d) An amount of thioridazine re- quired: = 2505 = 125 gmof drug = 12,500 mg "100 tock soluti wii = 12,500 = 416.66 ce = 417 cc 30 50. (d) 20 ce of 1 mg/cc Risperdal so- ution contains 20 mg of drug. Sire in the ut = 20°= 0.08 mg /ee 240 ‘www:pharmacyexam.com Krisman 51.(¢) To solve this problem we can use the ratio-proportion method. V,C, = V,C, V1 = 150x0.2 = 214.3 cc of 70% alcohol 07 52.(b) 1 500solutionis interpreted as 1 gm of drug in 500 ce solution, therefore: = 3x960x 500 5.76 gm of Atropine. 53. (a) 50 grams. = 500x10 = 50 grams of Povidone Iodine 100 54.(a) To solve this problem, we can use the alligation method. 5, 2(S%) ee [ 3 os 2(1%) Total parts 4%) To prepare 4 parts (3%) 2 parts (5%) ‘To prepare 500 gm ? 3 = 5002. = 250 gm of 5% salicylic acid. 4 55. (b) To solve this problemi, we imust first find out the amount of drug present in ‘the final solution. ‘The amount of airopine in 1 pint, Lin 500 sol" 2 3h Ogg ; = 480 x1 '= 0.96 gal of atropine, 500ce guide for Pharmaceutical calculations Second Edition Now, 0.96 gm of drug must be present in 1 teaspoonful of the drug solution, therefore we can say: See (I teaspoonful) contains 0.96 gm 240ce solution requires? = 240.x.0.96 = 46.08 gm of atropine, 5 56. (c) The amount of compazine present in 2 quarts of 0.1% solution = 24960401 = 1.92 gmof drug. 100 ‘Number of ampuls required: = 1920mg = 384 ampuls 5 mg 57.(d) 800 gms ointment. = 100.x2 = 800 gm ointment 0.25 58. (d) ‘The gram equivalent weights of solute in I liter of solution is defined as normality, therefore 1N solution of sodium bi- carbonate will contain 84 gms in 1000 cc. ‘We want to find the quantity of sodium bicarbonate in 240 cc, 0.1 N solution. LN solution contains 84m 0.1 Nsolution contains? =0.1 x84 = 8.4 gms/1000 ce. 240 ce = 240x 8.4 = 2.016 gm of NaHCO, 1000 59. (0) IN solution of HCI will con- tain 36.5 gms per 1000cc, therefore 0.05N solution will contain: ‘veww.pharmacyexam.com Krisman = 0.05. 36.5 = 1.825 gm HCV1000cc 1 '500cc solution will contain = 0.912 gm HCI ‘Wenced 0.912 gm C1 acid and purity of con- centrated HCl is 37% wi, For 37 gm pure HCL 100 gm HCl For0.912gmpureHCl 2 = 1000912 = 2.46 gmHCl 37 Volume of cone. HCl = 2.46 12 2.05 ce HCI 60 (b) 1.42% whw 2% 60 gm HC contains % 80 gm HC contains 140 gm HC contain 1.2 gmHC 0.8 gmHC 2.0 gmHC % of HC in final mixture: = 100x2 = 1.42% wiw 140 61. (a) 36.08% w/v alcohol quart 30% aleohol contains: = 960x30 = 288 cc alcohol 100 = 1440x40 = 576 cc 100 ‘Total amount of alcohol is (576 + 288) in (960 + 1440) therefore % of alcohol in final mix- ture is: = 100x866 = 36.08% alcohol 2400 43jReference guide for Pharmaceutical calculations ‘Second Edition 62.(a) _Tosolvethis problem, weneed tovuse the alligation method. tl 1.50 (3%) So 25 1s Ns stga Total parts 2.00 (2.5%) For 2 parts 2.5 % requires 1.5 parts For 200 ce 2.5% requires 2 = 200x115 2. = 150 ce of 3% acetic acid should be mixed with (200 co-150 cc) 50 ce of 1% acetic acid to prepare 200 cc of 2.5% acetic acid, 63.(b) To solve this problem, we can use the alligation method, or 15 (60%) ow 58, 40 ss Total parts 20 (55%) For 20 (55%) parts 15 parts (60%) require For 400(55%) 2? = 400x 15. 20 = 300 gm 60% w/w HCI acid is required. 64. (c) 333cc water is required, Se 25 (45%) 25 sh eo 20.(0%) Total parts 45 (25%) www>pharmacyexam.com Krisman For 45 (25%) parts 20 parts of water req For 750 (25%) alcohol. 1 = 150.x 20 45 = 333 ce water. 65. (d) 175 ce of 25% dextrose solu- tion. “Cp 5 (25%) 10, ‘Total parts 20 (10%) For 20(10%) parts 5 parts (25%) require For 700 cc 10% 7 = 0x5 20 = 115 ce of 25% dextrose solution, 66. (d) A quantity of solution that con- tains 1/2 gallon of pure alcohol (absolute) is said to be 1 proof gallon: Alcohol USPiis 95% vi. Taxable alcohol means numbeis of proof gallons. eso 1 gallon = 4 quarts Proof gallon = gallon x % strength ¥ 44 ponies 4 we elueieessReference guide for Pharmaceutical calculations Second Edition = U8 x50 50 = 0.125 gallons. 68. (c) Proof gal = gal x % v/v strength 50% viv fluted al JSP is 49% gal = proof gal x 50% % strength = 05 x 5 49 0.510 gallons. 69. (b) 0.05 proof gal Proof gallons = gal_x_% v/v 50% . = 28x10 = 0.05 proof gallon 50 70. (a) 0.263 gallons Proof gal = gal x_% v/v strength 50% Gal = 50_x proof gal, % VIN = 50 x05 = 0.263 gallons 95 Tl. (a) ‘To prepare saturated solution, 1 gm of boric acid should be dissolved in 12 cc of solution. 240x1= 20 grams of boric acid. 2 www pharmacyexam.com Krisman 72. (b) 200 units/ec ‘The amount of Abbokinase units in 5 cc of reconstituted solution: },000 units/ec 2.ce of this resultant solution are injected into 500 cc of 5% dextrose solution: 100,000 500 = 200 units/ec. 73. (©) 360 ce, ‘The ce of Valproic acid will need to fill 600 mg dose, = 5x600 = 12ce 250 ‘A patient is taking 600 mg three times a day for 10 days, therefore: 74. (d) 20% elementary iron 525 mg of Ferrous sulfate contains 105 mg elementary iron. = 100x105 = 20% 525 75. (d) 21 ce. = 5x105 = 2lec of Tbert-500 liquid. 25 76. (c) The weight of a child in kg 50 = 22.72kg. 22 45Reference guide for Pharmaceutical calculations Second Edition ‘The recommended therapeutic dose in a child is 4 mg/im/kg, therefore: 2.72x4 = 90.9 mg Number of ampuls =90.9 = 0.9 = 1 100 77. (b) 2mg. A nilligram of albuterol sulfate is required to prepare 2.5 cc 0.083% solution, = 2.5x0.083 = 0.002 gm = 2mg 100 78. (a) A patient is taking 2 drops in each eye four times a day, therefore the total number of ml would be 1.6 cc (Ldrop =0.1c¢). ‘Thenumber of mg of Alomide present in daily dose: = 16x01 = 0.0016 gm = L6mg 100 79.(a) 75mg U. in 5 ce. = $x 50,000 =250,0001.U. Each LU. contains 0.3 meg of vitamin-A: = 250,000 x 0.3 meg = 75000 meg =75 mg 80, (b) The amount of Lidocaine present in 30 cc of 2% Lidocaine viscous so- ution is: = 30x2 = 06em 100 = 600 mg. ‘weww>pharmacyexam.com Krisman 81. () ‘The number of ec of Megace oral solution re- quire: = 800 = 20 cc 40 82. (d) 2. gram (2000 mg) of Videx powder are reconstituted with 200 ce of puri- fied water: = 2000 = 10mg /ce 200 10.ccof this resultant solution (10x 10 = 100mg videx) is mixed with 200 cc of Maalox plus: = 100 = 0.5 mgiee. 200 83. (€) —Thenumber of ce of Cefail oral suspension are required to fill one dose are: = S00x5 = 20cc 125 20ce x4.x7 560 cc. 84. (a) The amountofelemeiitary iron present in 325 mg of ferrous ‘sulfate: = 325x20 = 65 rig of elementary iron’ 100 7 ‘The number of ce of Niferex liquid required: od blsoald Blew oirod™ = 5x65 = 3.25.6 of Niferex solution.Reference guide for Pharmaceutical calculations Second Edition 85. (a) ‘Tosolve this problem, we should use the alligation method, x 3 (20%) ao 2.(5%) ‘Total parts 15 (8%) ‘To prepare 15 parts 12 parts To prepare 500 ce a = 50x12 15 = 400 ce of 5% Hydrochloric acid should be mixed with (500 cc-400 ce = 100 cc) 100 ce of 20% Hydrochloric acid to prepare 500 cc ‘of 8% Hydrochloric acid. 86. (b) 1 gm of Rocephin in 250 cc 0.9% NaCl should administer within 24 hours, therefore = 250cc 24x60 min = 0.173 ccfmin. An LY set delivers 20 drops per ce, therefore: For lec 20 drops require For 0.173 cc ? 0.173 x 20 3.47 drops per minute. 87. (c) An adult dose of drug can be calculated by the following formula: = Patient's surface area in mm? x adult dose 173 mm? wwwpharmacyexam.com = 123 x 5000 173 = 3554.9 units of heparin. 88. (d) The milligrams of lidocaine presents in 5 cc of 1% lidocaine solution are: = 5 = 0.05 gm = 50mg 100 89. d) The total amounts of Insulin used by patient per day: = 10+20 = 30units. ‘The number of days the insulin (100 units/10 cc) vial will last: = 100 = 3.33 days, 30 90. (©) ‘The amount of Acetic acid re- quired to prepare 250 ce 7% wit, = 250x7 100 = 175 gmof acetic acid. 91. (b) —Theamount of Hydrocortisone required to prepare 60 gm of 0.05%: = 60x0.05 100 = 0.03 gm of hydrocortisone = 30mg of hydrocortisone. 92. (a) Patient weight in kg = 155 ee = 70.43 kg aTReference guide for Pharmaceutical calculations Second Bdition ‘The recommended adult dose of Mezk 250 moglkg/day. 93. (a) preted as 10 gm of drug in 100 cc of solution, therefore 10 in 100 solution is inter- 480x10 100 = 48 gins of povidone iodine, 94. (b) << (25%) 1 By using the alligation method, ‘Total parts 20 (18%) To prepare 20 parts (18%) 7 parts (5%) ‘To prepare 500 cc (18%)? = 500x7 18 = 194.44 cc of Dextrose 5% solution is re- quired. 95. ©) 1 N HCI solution contains 36.5 gm of HCl acid in 1000 ml solution, therefore 0.25 N solution contains = 025x365 = 9.125 gm of HCV1000 ce 1 ‘The amount of HCl acid in 750 ce solution is: viww:pharmacyeram.com Krisman = 9125x750 = 6.84 gm HCl 1000 ‘The purity of HCI acid is 37% wiw, therefore the total amounts of HCI acid required are: = 100x684 37 = 18.49 gm of HCl acid ‘The number of ce of HCl acid required: = 15.41 cc of HCI acid. 96. (@) Aluminum has a gram atomic weight of 27 and valence of 3: equivalent weight = gram atomic weight number of valence ' oR ' © 5 97. (d) ‘The amount of sodium chlo- tide presents in 250 éc of 0.9% NaClis: . = 250x0.9 = 2.25 gmNat 100 7 ‘Total. equivalents Najzpweight in gm 48 ssi signa Weipa stesReference guide for Pharmaceutical calculations Second Edition mEq of Na* = equivalents x 1000 0.03846 x 1000 = 38.46 meq of Nat 98. (©) An equivalent weight of KCL is Equivalent weight= molecular weight number of valence = 145 = 745em 1 Total equivalents of K* = weightin gm equivalent wt Total equivalents of K* = 0.75. gm 745 gm = 0.0100 equivalents of K* mEqofK* = equivalents x 1000 0.01006 x 1000 = 10.06 meq 99. @) An equivalent weight of MgSO, is: Equivalent weight= molecular weight number of valence = 246 = 123 em 2 Total equivalents of Mg"? = weightin gm equivalent wt 50 ce 20% MgSO, solution will contain = 50320 = 10m MgSO, 100 = 10 = 0.0813 equivalents 123 wwwpharmacyexam.com Krisman mEq of Mg = equivalents x 1000 0.0813 x 1000 = 81.30 meg. 100. (d) An equivalent weight of CaCl, will be: Equivalent weight = molecular weight number of valence = ll = 555em 2 ‘Total meq of Ca’? in 480 ce solution are 200, therefore mEq of Ca? = equivalents x 1000 Equivalents = 200 = 02 1000 ‘Total equivalents of Ca’ = weightin em equivalent wt Weight in gm = total equivalents xeq wt = 02%555 = 11.10 gmof CaCl, 101. (©) The gram atomic weight of Aluminum chloride is 106.5 gm/mole. equivalent weight = gram atomic weight number of valence = 1065 2 = 35.5 gm mEq = eqweightinmg 1000 = 35,500 = 35.5 of Aluminum? 1000 49Reference guide for Pharmaceutical calculations Second Edition 102. (b) equivalent weight = molecular weight number of valence = 1SL85. = 75.92 gm/mole 2 mEq of ferrous"? = weightin mg equivalent weight = 225. = 4.28meq. 75.92 103. (a) The amount of sodium bicar- bonate present in a 50% 200 ce sodium bicar- donate solution would be: = 100 grams Total equivalents of Nat = weight in em equivalent wt = 100 = 1.190 equivalents of Nat 84 mEq of Nat = equivalents x 1000 1.19 x 1000 a = 1190.47 meq. 104. (a) —_Each teaspoonful contains 5 meq of K’, therefore the total meq of K* in 1 quart solution is: = 960x5 5 960 meq of K* mEq of Kt = equivalents x 1000 Equivalents of K"= meq of K* 1000 = 960. = 0.96 equivalents of K* 1000 www.pharmacyexam.com Krisman Equivalents = weight in gram ‘equivalent weight Weight in gm= 0.96 x 74.5 = 71.52 gmof KCL. 105. (b) The amount of Na* present in 10% 1 quart solution of NaPO, = 96010 = 96 gm of NaPO, 100 i Equivalent wt = molecular weight number of valence = 164. = 54.66 gm/mole 3 ‘Total equivalents of Nat = weight in gm equivalent wt = 6 17.56 equivalents. ©. 54.66 mEq ofNat = equivalent x 1000 1.756 x 1000- = 1756.31 meq 106. (©) 8.1 meq. seo Equivalent weight= moleculi Weight -* no of valence =74 = 37 gm/mole 4 : 2 Equivalents of Li -weight in'gmi *** ‘ equivalent weight = 03 = 0.0081 equivalents. 37 savbipe E220, equivalents x 1000 0.0081 x 1000 8.1 meq Pei, HCE Ne 50 = shun wat