I 1 2

II
1 2 3 4 5 6 7 8

P
III
1 2 3 5 6 7 8 9 10

III1 and III3 was diagnosed to have a neurological disorder characterized by mental
retardation and microcephaly.

Question
1. State the most likely mode of inheritance giving reason 9 marks
Answer: autosomal recessive  presence of parental consanguinity, horizontal
transmission

2. What is the probability that II3 is a carrier 4 marks

Answer: 1

3. State the probability that III5 will be affected by the condition 4 marks
Answer: 1 in 4 (0.25)