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- Aspatate oxidase

- Oxidation
- Ornithine decarboxylase
- decarboxylation

- Putrescine-N-methyltrasferase
- Quinolinate syntase - Methylation
- S-adenosyl methionine catalyed
- 1. Condensation 2. cyclization

- N-methyl-putescine oxidase
Nicotinic acid mononucleotide - deamination
adenyl tranferase

Quinolinate
phosphorribosyl NAD synthase
tranferase - non-enzymatically
NAD CYCLE - spontaneously cyclize

phosphoribosyl pyrophosphate Nicotinamide adenine


dinucleotide

Reduction : Hydrogen added decarboxylation

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