Cell Biology: Cellular organization, division and processes

NPTEL Course outline

Introduction to cell organization, cellular biochemistry, nucleic acids, information flow, cellular
processes, and division

 Introduction to Cell Biology, Cell components, organization and processes - Part I

 Introduction to Cell Biology, Cell components, organization and processes - Part II
 DNA: The genetic material. Part I
 DNA: The genetic material. Part II
 Quiz : Week1 Assignment1

Regulation of the cell cycle.

 Regulation of the cell cycle-Part I
 Regulation of the cell cycle-Part II
 Checkpoints: The DNA damage and DNA replication checkpoints.
 Quiz : Week2 Assignment1

 The Ubiquitin Proteasome system AND S-phase: regulation of entry to S-phase and DNA
replication.
 The Ubiquitin Proteasome system
 S-phase: Regulation of entry into S-phase and DNA Replication.
 Quiz : Week3 Assignment3

 DNA replication; Centrosomes

  DNA replication-Part I.
  DNA Replication-Part II.
  Centrosomes In Development, Evolution And Disease.
  Quiz : Week4 Assignment4

 DNA replication-Part III AND Introduction to Mitosis

 DNA Replication-Part III.
 Mitosis-Part I
 Quiz : WEEK5 ASSIGNMENT5

 Cytokinesis; Cell death, aging and senescence; Introduction to Meiosis.
Cytokinesis
 Aging and Senescence
 Apoptosis Part I
 Apoptosis Part II
 Meiosis Part I
 Quiz : WEEK 6 ASSIGNMENT6

 Meiosis, Nuclear Organization, Chromatin Organization, SMC proteins and chromosome

organization, Cohesin.
 Meiosis Part II
Nuclear organization
Chromatin organization
  SMC proteins and chromosome organization
  SMC proteins and chromosome organization-Real-Time imaging of DNA loop-
extrusion by SMC complexes.
  The cohesin complex and its functions-The mysterious biological function of
chromosome loops
  Quiz : WEEK 7 ASSIGNMENT 7

 Meiosis, Mitosis, Cell diversity: Budding yeast, Plant cell and Stem cells.

Meiosis Part III

 Mitosis-Part II
 The budding yeast, Saccharomyces cerevisiae
 The Plant Cell
 Stem cells Part I Intro-SL
 Stem Cells Using gene-edited stem cells and live imaging to study cell biology
  Nerve cells
  The Cancer Cell
  Quiz : WEEK8 ASSIGNMENT 8

Cell Biology: Cellular organization, division and processes

By Prof. Shikha Laloraya   |   IISc Bangalore
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Learners enrolled: 7807
This course focuses on cell organization, and the molecules and intracellular processes crucial for life and
inheritance. A particular emphasis is on DNA transactions such as chromosome organization, replication,
chromosome segregation, etc. Some examples of key discoveries in the field of cell cycle regulation,
chromatin organization, and the dynamic processes and molecular machines involved in cell division will
be discussed in detail. Other topics include Nuclear organization, Mitosis and Meiosis and cell death. In
addition, cellular diversity will be discussed including selected specialized eukaryotic cells and their
functions, cancer cells-how controls go wrong, and stem cells.
This course includes 2 modules of 10 lectures each. It is intended for graduate students mainly M.Sc.
students (or 1st year Ph.D. students). Final year B.Sc. students may also find it useful.

Course layout
Week 1: Lecture 1- Cell components and organization; macromolecules, membranes, organelles, and processes.
       Lecture 2- DNA: The genetic material; Cell Cycle.
       Lecture 3- Regulation of the Cell Cycle.
Week 2: Lecture 4- S-phase: DNA Replication and its regulation. Repair and recombination.
       Lecture 5- Checkpoints: DNA Damage and DNA Replication checkpoints.
Week 3: Lecture 6- Chromosome reorganization during mitosis; The centrosome duplication cycle.
      Lecture 7- The microtubule cytoskeleton; Spindle organization, assembly and dynamics.
      Lecture 8- Molecular motors; Role of motor proteins in mitosis.
Week 4: Lecture 9- Mitotic checkpoints; Chromosome segregation and cell division.
      Lecture 10- Meiosis
Week 5: Lecture 11- Cell death, aging and senescence.
      Lecture 12- Chromatin organization
      Lecture 13- SMC proteins and chromosome organization
Week 6: Lecture 14- The cohesin complex and its functions.
       Lecture 15- Nuclear organization
Week 7: Lecture 16- Cell diversity and properties of specialized cells.
      Lecture 17- The Cancer Cell
      Lecture 18- Stem cells
Week 8: Lecture 19- Nerve cells
      Lecture 20- The Plant Cell

Books and references

Alberts, et al. Molecular Biology of the Cell.
Lodish, et al. Molecular Cell Biology.

Course certificate
The course is free to enroll and learn from. But if you want a certificate, you have to register and write the proctored exam
conducted by us in person at any of the designated exam centres.
The exam is optional for a fee of Rs 1000/- (Rupees one thousand only).
Date and Time of Exams: 24 April 2021 Morning session 9am to 12 noon; Afternoon Session 2pm to 5pm.
Registration url: Announcements will be made when the registration form is open for registrations.
The online registration form has to be filled and the certification exam fee needs to be paid. More details
will be made available when the exam registration form is published. If there are any changes, it will be
mentioned then.
Please check the form for more details on the cities where the exams will be held, the conditions you
agree to when you fill the form etc.

CRITERIA TO GET A CERTIFICATE

Average assignment score = 25% of average of best 6 assignments out of the total 8 assignments given
in the course.
Exam score = 75% of the proctored certification exam score out of 100

Final score = Average assignment score + Exam score

YOU WILL BE ELIGIBLE FOR A CERTIFICATE ONLY IF AVERAGE ASSIGNMENT SCORE >=10/25
AND EXAM SCORE >= 30/75. If one of the 2 criteria is not met, you will not get the certificate even
if the Final score >= 40/100.

Certificate will have your name, photograph and the score in the final exam with the breakup.It will have
the logos of NPTEL and IISc Bangalore.It will be e-verifiable at nptel.ac.in/noc.

Only the e-certificate will be made available. Hard copies will not be dispatched.

Once again, thanks for your interest in our online courses and certification. Happy learning.

- NPTEL team