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op mig 0925609 Isis asters (GUIDELINES 2 A 24-step guide on how to design, conduct, and successfully publish a systematic review and meta-analysis in medical research “oulat Muka! Mijas? Jelena tite Sanne Verhoog-Julla Bohs! -Wichor Brame Rajiv Chowdhury!» Oscar. Franco! Asract ‘Tanorm evened pict in heath ce, gins al plc eqire acute ene, colton, sd inepraton ot all nae evidence ie comprehensive, agg, and ae-efica manne, Approaches o evades Syne sich cafly cme tema reviews an mtinalyes ae eset ols enmaize se i. Unionantly eal systema reviews taly stots he ality can ary sana ine welcomed cerdene sats pial vies a compen se af sep, ne ble omling ces. Sept guide on Bow how oreo or aprise systematic eviews hc ack sidan on howto sytbesiz viene ec. T iia the el anf development of vse ses, we provide clea conc, 4p gue on oo peor tere ‘eve ands of observational ses and cna ls We esi each tp tas with cones ea Pied provide eierant eerensrsf er sides The 24-tep side (1) simpli the made of condcing "emate rviw, )provies alice rfssonl an resarcher wth mthodlolely sod on emt ‘yea evo nd metas and (3) ion enance the ty of eine eidece snes it Ts i ‘hl helps eases toeter understand he compe of he races apase th quality polished sysemaicevews, {dete compen and se) idee om mel Mee Keywords 24 Sp Sysemiirvew Met-amlyi Gidlin- viene synths Introduction “Tn practi of evidence-based medicine egies upto dine syaeies of exiting evidence Systema reviews find metansiecs ought to te rigrogs and tanepa. ‘nant prove emprcly deriv aners faced ‘esearch questions. The puSicaon of stmati reviews Gera ma aly isso exponent in reset de ‘Mes! an they hve sadly migrated othe op of he Pyramid of what i conaered gon evden Nevertoess, Tenn eeu at ae senstv Yo isan errs To provide secure answers a iit potent pital ey ‘areca preparation nd organ Several ran infor sich the Cote sllaboation ands 1993) have atemped to regulate and improve the quality [Here we provides concise, 2p ede on howto Performa systematic review and mcteranay Amand scope ‘We son a concise snd comprehensive pace puide nd checklist with 24 sep that an lp biomed revearchors onda systematic review and mea analy Sg 1) Tis guide (1) sinpies the metodolony af 2 sysoratic review (2) rovides tol o cont mth ‘dolgicall sound systeratic eviews and taal, ‘nd (ican enhance the quality of existing evidence Sates eft. Tis pude can Be sey avons pla niga systematic eview,mbster one that sly mt rave oe iclods a quanta element however ell Professions nd researchers ho ae fair with Raie Ibid of researc ang ae abe oer Pe tas {cal principe sed beth serch ay Bott ost ance provides oe detailed information and examples for les experience esarches. @ oom o-~--0.- set = oo Step-by-step guidethe 24 steps Sup 1 Define eeech question ‘To dfne x rescirch eston, ft etalk in tal he primary and secondary the dy ching pose {al ef modes). The more cleat a esarch uetion ‘he aim ofthe research projet te more it wil xis wing the sare stategy. wheter Toesed oe bos hd conducting the satematc even. Dowling 3 sod ‘eserh seston and defining thet of the regres ‘anning the Wrst 10 Wenify gape nthe eld The utes of nematic eviews on Simla esearch ques yew lose gap anda alae, Some reser de ho develo api ew pubic appear equ ‘nw and mur cron stemaie eview the viene ‘ormananine vine network met ayes ne wom {uo apres be ined [7] Ava esearch ‘ust scsi emerges am existing aoe and ‘herrea may ite deftion mi ale ofthe research qieton, Thos nla PUCOWS), ed a ‘2 STEP CUOE ‘viens bast clinical practice [8 PEO [9] and SPICE {10} orquiatve sear questo: ad SPIDER i} haw wo detinea rare pesion Step2:Esablsh the tam wal rgnit an sorted eam i sess. Many Seps sich he Irate seach revision proces and ‘quay assent eu doable chsas ndpendet reviewers, anda thie ineyenden viewer if ede to sae disagreements that ay arise ding the stl) inclusion proses. Chome crf oleae and exerts tha yor are planing ocelot: you shold eva thr cotptence inthe ld unity 12. The am stds (ea rain of medial infoation specials) undesired nematic meus syne ings and petra met ‘Scand koomine the ar er imeiaon The emp ly ofthe question eng adds and the expected net ‘of eerences lo wil gue i the sizeof the eam. The Sine the nb of his ois wil dle he parts patio of ndpeadet reviewers Experts so be a {howd acts ten ues otha oe goup experts Fenot nei inietial For example reve ens th ar toodminat ty lina ome exert ae more Ul 10 ald yccoeceived options oad To he oi ote ss Price lower ality review (1) ial eam canna function wahoo ac ede The eer ot by fn th fessor orth os sane er he ea Te eae ornate pet akescar tat 09 eto ‘etlloed, hep ll team member ifort tae ther tation al phase of he rs. Step 3: etn the search seategy tps 3,4 and are nein paral) A compeeensve such forms the foundation fay 95- tena view nd cosets of ring speci vee eee eee {he fall 100 reeenses he maxim numberof ro ces that s posible odo aa frm Gage Scat "wom Gooale Scola but most oa thes 200 ete ces have 1 be aie from Gooele Schl (1) Ise ‘be wor nodes sym eidence on clncl als, (Cote ier i esommcn obo seu oa relrenses nv he been oa! i eno reashe he (Coctrae Iary [ PaytNFO an CINAHL databases sould be serch the sea question aed oe eld of psychiatry psyniogy andor wang allied oh, Reser ao stow tt CINAHL ta ine of qlitatve rescarh str tant in Pb ‘hereto if sommend oth serch of those toy ‘ype aswell Cena to search quality nd reed ity Fhe incon af arian on each specs [1], Ont arp has established a metod hat describes in Jeti a {Sstep process to del asystemati seach sag) 16) In appa w2 we rs ov tae earns or searching datas Example Seow’ for an exale ofthe Seah see for “which evalbaed he msecaon Pete pyoes=ons ‘emtaton followed with ela nemolorc det oad lucene homcosti,and bkaf ype ? ables i alt ‘nomen. A Tera search wie done eine ive letonic “habe MEDLINE vt Ori, Ene com, Web of Se ‘ce Coe Collin, Cocti CENTRAL va Wiad Goose Scholae Thi example eects the comple of search satay an resents syanes rhe ret sia aes ‘top Dena selection teri cstonincsion) Selstion criteria idem erat evince dering the ‘ererng pen. The etn ceria ge thereover, Save ine mi abn anemeeneasy Sn incorpo snc that on nl “isin cle of pbs and apical cao: cha series of esd poplao sth psoas. See ee ce roses nd mi writen clit wl sti nmi Ize mistakes during scteaing. A Samp chess ca be founda wd, -zample M-analses that inside nerveton std is ofen pot estimates randomized cone als (RCTS) Wat ue sana ret coal aro. Foe ‘eunpk trol ara may eit paceo or aonb Stnc, or theme teamentu fe inert a Patt Tower dose. acetone al mt aa {TCTs we ease he association of plant-based ther pes with tenopusa sympoms To maintain come) nd hea ofthe dc of interes reas witht "placed or conta ne eed Hee als that ‘compared noaocmonal hrs with estoge or tee edict hat eke ces ru (17 Step 5: Design data coleton om ey opin astra rovcw the extraction ofr hen ds fom pimary stds nd om i al subject) wing andariaed daa exten Dua re alleen (1) general chart the ay ach Invesgsor ume’, year of th sy, nd fang were, (2) characteris othe sn poption ta my ne eso a ei (3) expo otro, Wich ‘an ince ancximent tho, eitrbain in he ny Population, and dosage when dseribing das, 4 ont ome, 3) metods sc the pe of tatiana a won we a Factors ied or, an (0) el oh ‘sears of sotto, atid anal, a stb tf ests aprement Designing the data exact om ‘fen nets rm pitino nt ee ths inte etd tte ala, Ava fee pie hone allow oman of the da xricton orm c- Ing MicosottAsceswEtcel Quali REDCap. Googe FoeayStoes SRDI (Sysemalic Rviek Dat postr pera ghee) 5} Fate tae tha owe ed forreence ening ithe Coven (ipsfwcovsdence aad Dales or sere ‘ecumyean be ao wd daa een tol ade WS eee camp ofa ty protein w6 Resisting the evi tccnteniel to aod sap a serps ef {o provide spun. Tere a plato fre tron tne mot fen na are Prope Coen {ek uVPROSPERO) oseiens nah sci cae, nd Cochrane (nips cochrane on cohrne i) forrevews epg inirentons Irons ho oe ‘sor view a Prosper at gion W2 tap 7 Run the src statin maple tbat As mentone in tp 5, Morte seach should actade ss froin ditabre: Exe, MEDLINE, Web of ‘Science. and Gale Soir Each tabs as so ay ot wnting a sear ran. tap 8 Colca ferences nd abstain sn fle Collect lof he esac rls of sep 7a nN ther oo sch at Caden (ronnie ils (ww dstitiererco). or Rayyan (yan Serna aval. we ane wing ‘elected rferenes fom databe in an Endo le, "tpn the vefrences fom ht datas in fat ‘ned by EN. Tesco on ep atone from the majo datas nt EndNote ace pied nw ‘Step Eminat upicter evi eat sai rn ah ey hpi rears wl rede the reviewer wero when srcening ties and asc, Due tothe betergenconn ‘ate of alsin ahve: e-dpiaon ex be ca ‘ersame ad imecomsming. Oo gro hs paid 3 tnahod tnng EndNote ise et aca Je-upeaie TIO) Thee a oer software avslae er dedupicuon, uty hive nt Ben thr nal fr sccurey Example Desi ition om boo prom de-p ‘aon wing EndNote can be fu chewher [1 ang sbarat an be eens simltansoel june he relrano th ube he tie ound tobe esa. sac ms one inte pat whem serene was done ‘on pape In this phase, rerences te selects based on Telco eri pied othe ile an abst td ‘src, and has oly te tile the Fefereace should Be Inc forthe next step. Ath phase tint Dees tokesprack ote reason fr exclusion [19], Vato st ar apliatons sch as Rayan. Covi nd Disil ‘ae aah forte ie and brat secon pase [20-22], We do not rcommnd the axe of Eee or his pose becanse Is complicated and trne-

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