What are the long-term complications /sequelae?

Graves’s eye disease is a problem that develops in in people with over active thyroid caused by Grave’s
disease. Grave’s diseases is a most common form of hyperthyroidism. Hyperthyroidism often takes well
over a year or longer to treat effectively, and patient’s thyroid hormone levels, symptoms and mood
often fluctuate uncomfortably. Thyroid dysfunctions are well recognized, for example the effects of
hyperthyroidism in pulse rate or blood pressure and effects of hyperthyroidism on lipids. There is now
an increasing evidence for long term morbidity and mortality associated with thyroid dysfunction. This
includes an increase likelihood of cardiovascular mortality in subjects with previous thyrotoxicosis
treated with iodine and osteoporotic fracture of the femur in those with previous thyrotoxicosis. Sub
clinical or mild thyroid dysfunction may also be associated with evidence of increased risk of atrial
fibrillation.