Classifications

White lesions Premalignant (precancerous) lesions

I- Hereditary and developmental 1 - Idiopathic leukoplakia

2 - Erythroplakia
1- Leukoedema 3 - sublingual keratosis
2- White sponge nevus 4 - Candidal leukoplakia
3- Hereditary benign intraepithelial dyskeratosis (HBID) 5 - white lesions associated with smokeless tobacco
4- Follicular keratosis 6 - solar (actinic) cheilitis
5- Fordyce's granules 7 - syphilitic leukoplakia (3ry stage)

II- Reactive Premalignant (precancerous) conditions

1- Frictional ( simple – focal ) hyperkeratosis
1 - Oral submucous fibrosis
2- Nicotinic stomatitis
2 - Kelly-Paterson syndrome (Plummer-Vinson syndrome)
3- Mucosal burns
3 - Lichen Planus
4- White lesions associated with smokeless tobacco
4 - Discoid lupus Erythromatosus
5- Solar cheilitis 5 - Xeroderma pigmentosa
6- Actinic cheilosis 6 - Dyskeratosis Congenita
III- Immune mediated

1- Lichen Planus Benign Tumors of Connective Tissue

2- Discoid lupus erythematosus
3- Psoriasis - Tumors of fibrous connective tissue:
1- fibroma
IV- Infectious 2- Benign fibrous histiocytoma
3- Myxoma
1- Candidiasis >> fungal infection
2- Hairy leukoplakia >> viral infection
- Tumors of fat cells >> Lipoma
3- Syphilitic mucous patch >> 2nd stage >> Bacterial
infection
- Tumors of lymphatic vessels >> Lymphangioma
4- Parulis (Gum boil) >> bacterial and Fungal infection - Tumors of blood vessels >> Hemangioma
- Tumors of bone >> Osteoma
- Tumors of cartilage >> Chondroma
V- Idiopathic - Tumors of smooth muscles >> Leiomyoma
- Tumors of striated muscles >> Rhabdomyoma
1- Hairy tongue - Tumors of nerve tissue:
2- Geographic tongue 1 - Schwannoma >> Schwan cells of nerve
3- Idiopathic leukoplakia 2- Neurofibroma
VI – Neoplastic

1- Benign: - Squamous cell papilloma

2- Malignant: - Squamous cell carcinoma
- Verrucous carcinoma

1 M.A
Malignant tumors of connective tissue (sarcoma)
- Malignant Tumors of fibrous connective tissue:
1- fibroma sarcoma
2- malignant fibrous histiocytoma
- Malignant tumors of Endothelial cell >> Kaposi
sarcoma
- Malignant Tumors of fat cells >> Lipo sarcoma
- Malignant Tumors of lymphatic vessels >> Lymphoma 4- Odonto ameloblastoma >> with inductive change
- Malignant Tumors of bone >> Osteosarcoma
- Malignant Tumors of cartilage >> Chondrosarcoma
- Malignant Tumors of smooth muscles >>
Leiomyosarcoma
- Malignant Tumors of striated muscles >>
Rhabdomyosarcoma
- Malignant Tumors of nerve tissue >> Neurogenic
sarcoma
Benign odontogenic Tumors
I-1 Tumors of Odontogenic epithelium without
odontogenic Ectomesenchyme
(According to 2005 WHO classification)
1- Ameloblastoma
2- squamous odontogenic tumor
3- Calcifying epithelium odontogenic tumor
4- adenomatoid odontogenic tumor
5- keratocystic odontogenic tumor (odontogenic
kerato cyst)
I-2 Tumors of Odontogenic epithelium without
odontogenic Ectomesenchyme
(According to 2007 WHO classification)
1- Ameloblastoma
2- squamous odontogenic tumor
3- Calcifying epithelium odontogenic tumor (CEOT II- Infection
– Pindborg Tumor)
4- adenomatoid odontogenic tumor (AOT)
2 M.A
II- Tumors of odontogenic epithelium with odontogenic
ectomesenchyme with or without dental hard tissue
formation (According to 2005 WHO classification)
1- Ameloblastic fibroma >> with dental hard tissue
formation
2- Ameloblastic fibro-dentinoma >> with dentin
formation
3- Ameloblastic fibro-odontoma >> with enamel and
dentin formation
occurrence
5- Calcifying cystic odontogenic tumor
6- Odontogenic ghost cell tumor
7- Odontoma: - complex odontoma
- Compound odontoma
III- Tumors of odontogenic ectomesenchyme with or
without including odontogenic epithelium (According
to 2005 WHO classification)
1- Odontogenic fibroma
2- Odontogenic myxoma
3- Cementoblastoma (True Cementoma)
Salivary gland diseases
I- Developmental:
- atresia
- aplasia
- aberrancy
II- Reactive (non-infectious):
- Mucous extravasation phenomenon
- Mucous retention cyst
- Ranula
- Necrotizing sialometaplasia
- Radiation – induced salivary gland pathology
- Mumps >> viral infection >> paramyxovirus
- Sialadenitis >> bacterial infection
IV- Metabolic
V- Associated with an immune defect
- Benign lymphoepithelial lesion (Mikulicz's disease)
- Sjogren's syndrome
Salivary gland Tumors

I- Benign Tumors of salivary gland

A- Pleomorphic adenoma
B- Monomorphic adenomas
- Papillary cyst adenoma lymphomatosum
- Canalicular adenoma
- Basal cell adenoma
- Sebaceous adenoma
- Myoepithelioma
- Oncocytoma

II- Malignant tumors of salivary gland

- Mucoepidermoid carcinoma
- Acinic cell carcinoma
- Adenoid cystic carcinoma
- Salivary duct carcinoma
- Carcinoma arising in pleomorphic adenoma
- Adenocarcinomas
- Sebaceous carcinoma
- Oncocystic carcinoma

III- Non – epithelial tumors of salivary gland

- Hemangioma
- Lymphomas
- Sarcomas

IV- Metastatic Tumors

3 M.A

Oral squamous cell carcinoma
Squamous cell papilloma
Odontogenic Tumors
Ameloblastoma
Unicystic ameloblastoma
Peripheral ameloblastoma
Mucous extravasation Phenomenon
Mucous retention cyst
Pleomorphic adenoma
Warthin’s tumor
(Papillary cyst adenoma
lymphomatosum)
Mucoepidermoid Carcinoma
Source of salivary gland tissue in the
bone
Adenoid Cystic Carcinoma
1 M.A
Histogenesis & Pathogenesis & Origin
Malignant tumor of squamous epithelium arising from the prickle cell
Benign neoplasm originating from surface epithelium
Group of tumor originating from tooth forming tissue
Tooth formation results from an interaction between odontogenic epithelium
and odontogenic ectomesenchyme
1- Enamel organ or its remnants (Reduced enamel epithelium)
2- Dental lamina or its remnants (Epithelial rests of Serres).
3- Epithelial root sheath of Hertwig's or its remnants (Epithelial rests of
Malassez)
4- the Basal layer of surface epithelium.
5- Epithelial lining of odontogenic cysts as dentigerous cyst
Dentigerous cyst
- epithelial rest of serres (remnant of dental lamina )
- or basal layer of surface epithelium
- Mechanical trauma to the minor salivary gland duct , resulting in its
transecting following there is extravasated mucous into the surrounding C.T.
leading to Secondary inflammatory reaction consisting initially Neutrophils
followed by macrophages
- A granulation tissue formed a wall around the mucin pool giving a pseudo cyst
- Obstruction of salivary flow and accumulation of mucin within the dilated duct
itself
- Salivary duct stone may obtain blockage of the salivary flow
- NO history of trauma
reserve cell in the intercalated duct and myoepithelial cell
- Papillary cyst adenoma lymphomatosum is thought to arise within lymph
nodes as a result of entrapment of salivary gland elements early in
development
- Intra oral lesions may arise in an area of reactive lymphoid hyperplasia
secondary to chronic inflammation
arise from reserve cells in the interlobular and interlobular segments of the
salivary duct system
1- embryonic entrapment of salivary gland tissue in the bone
2- if in maxilla >> arise from the gland of sinus lining
3- or from odontogenic epithelium that lined dentigerous cyst due to mucous
secreting cells in odontogenic epithelium of dentigerous cyst
- Arising from intercalated duct
- Myoepithelial cell