HYDROLYSED COLLAGEN REFERENCES

Joint & bone health

(1) Dubourg,G.,(2013).Targeting bone health. The world of food ingredients, February 2013.
(2) Kim, H.K., Kim, M.G. and Leem, K.H. (2013). Osteogenic activity of collagen peptide via ERK/MAPK pathway mediate
(3) Leem, K.H., Lee, S., Jang, A. and Kim, H.K. (2013). Porcine skin gelatin hydrolysate promotes longitudinal bone growt
(4) Kim, H.K., Kim, M.G. and Leem, K.H. (2014). Collagen hydrolysates increased osteogenic gene expressions via a MAP
(5) JunLi Liu, Bing Zhang, ShuJun Song, Ming Ma, ShaoYan Si, YiHu Wang, BingXin Xu, Kai Feng, JiGong Wu and YanChua
(6) Adam, M., Spacek, P., Hulejova, H., Galianova, A. and Blahos, J. (1996). Postmenopausal osteoporosis. Treatment wi
(7) Martin-Bautista, E., Martin-Matillas, M., Martin-Lagos, J.A., Miranda-Leon, M.T., Muñoz-Torres, M., Ruiz-Requena, E
(8) Trč, T. and Bohmová, J. (2011). Efficacy and tolerance of enzymatic hydrolysed collagen (EHC) vs. glucosamine sulph
(9) Benito-Ruiz, P., Camacho-Zambrano, M.M., Carrillo-Arcentales, J.N., Mestanza-Peralta, M.A., Vallejo-Flores, C.A., Va
(10) Clark, K.L., Sebastianelli, W., Flechsenhar, K.R., Aukermann, D.F., Meza, F., Millard, R.L., Deitch, J.R., Sherbondy, P.S
(11) Schunck, M., Schulze, C.H. and Oesser, S. (2006). Disparate efficacy of collagen hydrolysate and glucosamine on the
(12) Knox NutraJoint, (2000). New study shows gelatine supplementation may help improve knee function in people wi
(13) F.Guillerminet, H. Beaupied, V. Fabien-Soulé, D.Tomé, C-L. Benhamou, C. Roux, A. Blais. (2010). Collagen peptides i
(14) T.E. McAlindon, M. Nuite, N.Krishnan, R. Ruthazer, L.L. Price, D. Bursteien, J. Griffith, K. Flechsenhar. (2011). Chang
(15) F.Guillerminet,V. Fabien-Soulé,P.C. Even, D.Tomé, C-L. Benhamou, C. Roux, A. Blais. (2012). Hydrolyzed collagen im
(16) M. Schunck, S. Oesser. (2013). Specific collagen peptides benefit the biosynthesis of matrix molecules of tendons a
(17) J.X. Jiang,S. Yu, Q.R. Huang, X.L Zhang, C.Q. Zhang, J.L Zhou, J. Prawitt .(2014). Collagen peptides improve knee oste

Skin
(1)V. Zague. (2008). A new view concerning the effects of collagen hdyrolysate intake on skin properties. Arch Dermato
(2) V. Zague, V. de Freitas, M. da Cosat Rosa, G. Alvares de Castro, R. G. Jaeger, G. M.Machado-Santelli. 2010. Collagen
(3) Proksch, E., Schunck, M., Zague, V., Segger, D., Degwert, J. and Oesser, S. (2014). Oral intake of specific bioactive col
(4) Choi, S.Y., Ko, E.J., Lee, Y.H., Kim, B.G., Shin, H.J., Seo, D.B., Lee, S.J., Kim, B.J. and Kim, M.N. (2013). Effects of collage
(5) Kantor, I., Donikyan, L.A., Simon, E. And Wollschlaeger, B. (2002). Results of a study evaluating the use of a dietary s
(6) Proksch, E., Segger, D., Degwert, J., Schunck, M., Zague, V. and Oesser, S. (2014). Oral supplementation of specific co
(7) Ohara, H., Ito, K., Iida, H. And Matsumoto, H. (2009). Improvement in the moisture content of the stratum corneum

Sports nutrition
(1) Melvin W. 2005. Dietary Supplements and Sports Performance: Amino Acids. Journal of the International Society of
(2) Newholme.E and Co. 1992. Physical and mental fatigue: Metabolic mechanisms and importance of plasma amino ac
(3) Matsumoto Keitaro and Co. 2008. Branched-Chain Amino acid supplementation increases the lactate threshold duri
(4) Mittleman KD and Co. 1998. Branched-chain amino acids prolong exercise during heat stress in men and women. M
(5) Louard RJ and Co. 1990. Effect of infused branched-chain-amino acids on muscle and whole-body amino acid metab
(6) Blomstrand E and Co. 2006. Branched-chain-amino acids activate key enzymes in protein synthesis after physical ex
(7) Kimball SR and Co. 2006. Signaling pathways and molecular mechanisms through which branched-chain amino acids
(8) Williams M.H. 2005. Nutrition for health, Fitness & Sports. Boston: McGraw-Hill
(9) Kim S.K and Co. 2001. Purification and characterization of antioxydative peptides from bovine skin. Journal of Bioch
(10) Kjaer M and Co. 2005. Metabolic activity and collagen turnover in human tendon in response to physical activity. J
(11) Langberg H and Co. 1999. Type I collagen synthesis and degradation in peritendinuous tissue after exercise determ
(12) Miller B.F and Co. 2005. Coordinated collagen and muscle protein synthesis in human patella tendon and quadrice
(13) Clark, K.L. and Co. 2008. 24-Week study on the use of collagen hydrolysate as a dietary supplement in athletes wit
(14) Castell LM and Co. 1996. European Journal of Applied Physiology.73: 488-490
(15) Krieger W James and Co.2006. Effects of variation in protein and carbohydrate intake on body mass and compositi
(16) Layman K Donald and Co.2007. Dietary protein and exercise have additive effects on body composition during wei
(17) Faipoux R and Co. 2008. Proteins activate satiety-related neuronal pathways in the brainstem and hypothalamus o
(18) Pupovac J and Co. 2002. Dietary peptides induce satiety via cholecystokinin-A and peripheral pioid receptors in rat
(19) Veldhorst M A.B and Co. 2009. A breakfast with alpha-lactalbumin, gelatin, or gelatin+TRP lowers energy intake at
(20) Hochstenbach-Waelen Ananda and Co. 2009. Single-Protein Casein and Gelatin Diets affect energy expenditure sim
(21) Manninen AH. 2004. Protein hydrolysates in sports and exercise. Journal of sports science and medicine.3/ 60-63
(22) Van Loon Luc JC and Co. 2000. Plasma insulin responses after ingestion of different amino acid or protein mixtures
(23) Van Loon Luc JC and Co. 2000. Ingestion of protein hydrolysate and amino acid-carbohydrate mixtures increases p
(24) Houston Mark C. 2002. The role of vascular biology, nutrition and nutraceuticals in the prevention and treatment o
(25 Herregods Griet. 2011. Activity andpurification of ACE inhibitor peptides from animal by-products: in vitro and in vi
(26) Herregods Griet and Co. 2011. Angiotensin I-converting enzyme inhibitor activity of gelatin hydrolysates and identi
ERK/MAPK pathway mediated boosting of collagen synthesis and its therapeutic efficacy in osteoporotic bone by back-scattered electr
otes longitudinal bone growth in adolescent rats. Journal of Medicinal Food, Vol. 16, Iss. 5, 447-453.
gene expressions via a MAPK signaling pathway in MG-63 human osteoblasts. Food & Function, Vol. 5, Iss. 3, 573-578.
ng, JiGong Wu and YanChuan Guo. (2014). Bovine collagen peptides compounds promote the proliferation and differentiation of MC3
osteoporosis. Treatment with calcitonin and a diet rich in collagen peptides. Casopis Lékaru Ceských, Vol. 135, Iss. 3, 74-78.
-Torres, M., Ruiz-Requena, E., Rivero, M., Quer, J., Puigdueta, I., and Campoy, C. (2011). A nutritional intervention study with hydrolyze
(EHC) vs. glucosamine sulphate (GS) in the treatment of knee osteoarthritis (KOA). International Orthopaedics, Vol. 35, Iss. 3, 341-348
M.A., Vallejo-Flores, C.A., Vargas-López, S.V., Villacís-Tamayo, R.A. and Zurita-Gavilanes, L.A. (2009). A randomized controlled trial on t
, Deitch, J.R., Sherbondy, P.S., and Albert, A. (2008). 24-Week study on the use of collagen hydrolysate as a dietary supplement in athl
ysate and glucosamine on the extracellular matrix metabolism of articular chondrocytes. Osteoarthritis and Cartilage, Vol. 14, Suppl. 11
e knee function in people with mild osetoarthritis. Partner in motion.
s. (2010). Collagen peptides improve bone metabolism and biomechanical parameters in ovariectomized mice: an in vitro and in vivo s
. Flechsenhar. (2011). Change in knee ostearthirtis cartilage detected by delayed gadolinium enhanced magnetic resonance imaging fo
012). Hydrolyzed collagen improves bone status and prevents bone loss in ovariectomized C3H/HeN mice. Osteoporosis International
atrix molecules of tendons and ligaments. Journal of the International Society of Sports Nutrition 10 (Suppl 1).
n peptides improve knee osteoarthritis in elderly women. Agro Food Industry Hi Tech 25 (2): 19-23.

in properties. Arch Dermatol Res.

ado-Santelli. 2010. Collagen Hydrolysate Intake Increases Skin Collagen Expression and Suppresses Matrix Mettaloproteinase 2 Activity
take of specific bioactive collagen peptides reduces skin wrinkles and increases dermal matrix synthesis. Skin Pharmacol. Physiol., Vol
M.N. (2013). Effects of collagen tripeptide supplement on skin properties: A prospective, randomized, controlled study. Journal of Cosm
luating the use of a dietary supplement formula in the management of age-related skin changes in women with moderate to severe w
upplementation of specific collagen peptides has beneficial effects on human skin physiology: a double-blind, placebo-controlled study
tent of the stratum corneum following 4 weeks of collagen hydrolysate ingestion. Nippon Shokuhin Kagaku Kogaku Kaishi (J. Soc. Food

the International Society of Sports Nutrition. 2: p63-67

portance of plasma amino acids. British Medical Bulletin, 48: 477-95
es the lactate threshold during an incremental exercise test in trained individuals. J Nutr Sci Vitaminol.55.p52-58
tress in men and women. Med Sci Sports Exerc. 30 (1): 83-91
hole-body amino acid metabolism in man. Clin Sci. 79 (5): 457-466
n synthesis after physical exercise. J Nutr. 136 (I): 269S-73S
branched-chain amino acids mediate translational control of protein synthesis. J Nutr. 136 (I): 227S-31S

bovine skin. Journal of Biochemistry and Molecular Biology. Vol 34. 239
sponse to physical activity. J Musculosketet neuronal Interact.5: 41-52
tissue after exercise determined by microdialysis in humans. Journal of Physiology.521: 299-306
patella tendon and quadriceps muscle after exercise. J Physiol.567 (3). 1021-1033
y supplement in athletes with activity-related joint pain. Current Medical Research and Opinions, 24 (5): 1485-1496.

on body mass and composition during energy restriction: a meta-regression. Am J Clin Nutr.83:260.74
ody composition during weight loss in adult women. Journal of Nutrition. 1903-1910
ainstem and hypothalamus of rats. The Journal of Nutrition.1172-1178
pheral pioid receptors in rats. The Journal of Nutrition.132: 2775-2780
TRP lowers energy intake at lunch compared with a breakfast with casein, soy, whey, or why-GMP. Clinical Nutrition. 28. 147-155
affect energy expenditure similarly but substrate balance and appetite differently in adults. Journal of Nutrition. 139.p2285-2292
nce and medicine.3/ 60-63
ino acid or protein mixtures with carbohydrate. Am J Clin Nutr. 72: 96-105
hydrate mixtures increases postexercise plasma insulin responses in men. American Society of Nutritional Sciences. p2508-2513
prevention and treatment of hypertension. The Journal of the American Nutraceutical Association. Suppl 1
y-products: in vitro and in vivo evaluation. PhD thesis. Ghent University, Ghent, Belgium
latin hydrolysates and identification of bioactive peptides. Journal of agricultural and food chemistry. 59 (2): 552-8
c bone by back-scattered electron imaging and microarchitecture analysis. Molecules, Vol. 18, 15474-15489.

, Iss. 3, 573-578.
tion and differentiation of MC3T3-E1 pre-osteoblasts, Vol.9, Iss. 6, 1-6.
Vol. 135, Iss. 3, 74-78.
ntervention study with hydrolyzed collagen in pre-pubertal spanish children: influence on bone modeling biomarkers. Journal of Pediat
paedics, Vol. 35, Iss. 3, 341-348.
randomized controlled trial on the efficacy and safety of a food ingredient, collagen hydrolysate, for improving joint comfort. Internatio
as a dietary supplement in athletes with activity-related joint pain. Current Medical Research and Opinions, Vol. 24, Iss. 5, 1485-1496.
and Cartilage, Vol. 14, Suppl. 114, 199.

ed mice: an in vitro and in vivo study. Bone 46 (3): 827-834.

magnetic resonance imaging following treatment with collagen.hydrolysate: a pilot randomized controlled trial. OARSI - ICRS Volume
ice. Osteoporosis International 23 (7): 1909-1919.

trix Mettaloproteinase 2 Activity

s. Skin Pharmacol. Physiol., Vol 27, Iss. 3, 113-119.
ontrolled study. Journal of Cosmetic and Laser Therapy – online ahead of print.
men with moderate to severe wrinkling of the periorbital area. The Journal of the American Nutraceutical Association, Vol. 5, Iss. 2, 10-
-blind, placebo-controlled study. Skin Pharmacol. Physiol., Vol. 27, Iss. 1, 47-55.
gaku Kogaku Kaishi (J. Soc. Food Sci. Technol.) Vol. 56, Iss. 3, 137-145.

): 1485-1496.
nical Nutrition. 28. 147-155
Nutrition. 139.p2285-2292

nal Sciences. p2508-2513

59 (2): 552-8
ng biomarkers. Journal of Pediatric Endocrinology and Metabolism, Vol. 24, Iss. 3-4,147-153.

proving joint comfort. International Journal of Food Sciences and Nutrition, Vol. 60, Iss. 1, 99-113.
nions, Vol. 24, Iss. 5, 1485-1496.

olled trial. OARSI - ICRS Volume 19, Issue 4.

cal Association, Vol. 5, Iss. 2, 10-19.