BJU International / Volume 105, Issue 2 / p.

225-228

The use of Butea superba (Roxb.) compared to sildenafil for treating

erectile dysfunction

Jeff R. Cortés-González,Jorge A. Arratia-Maqueo,Lauro S. Gómez-Guerra,

Anders R. Holmberg

First published: 05 January 2010

https://doi.org/10.1111/j.1464-410X.2009.08748.x
Citations: 9

 Jeff R. Cortés-González, University Hospital ‘Dr Jose E. Gonzalez’, UANL – Urology

Service, Avenue Madero y Gonzalitos s/n Col. Mitras, Centro Monterrey, nl 64460, Mexico.

e-mail: jrcor77@yahoo.com, jeff.cortes-gonzalez@ki.se

Abstract
Study Type – Therapy (case control) Level of Evidence  3b

OBJECTIVE
To evaluate the effect of an extract of Butea superba (Roxb.) (BS) compared
to sildenafil for treating erectile dysfunction (ED).

PATIENTS AND METHODS

An open label study was carried out among 32 men with organic ED to
evaluate the response on the International Index of Erectile Function 5 (IIEF-
5) to BS, a ‘natural health’ product (100  mg), compared to 50  mg of
sildenafil (a phosphodiesterase-5 inhibitor). After a 1-week wash-out,
responders to BS received either 100  mg starch or 100  mg of another
batch of BS (double-blind).

RESULTS
Of the patients in the BS group, 27 (84%) responded positively, compared
with 26 (81%) in the sildenafil group. When assessing the score alone, 12
(38%) had a better score after taking BS, compared to seven (22%) after
sildenafil, and eight (25%) had the same score. The results were surprising
and could not be repeated in the double-blind part of the study, where no
effect of BS was recorded.
CONCLUSIONS
A ‘natural’ health product containing BS was more effective than sildenafil in
the first part of the study, but in the second, using another batch of BS, the
positive result could not be repeated and no effect was recorded. The
conclusion is that the first preparation of BS was most likely blended with a
phosphodiesterase-5 inhibitor, later confirmed by the supplier of BS (a
natural health products company) after their own analysis.

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9

A. Anand Ganapathy, V.M. Hari Priya, Alaganandam Kumaran, Medicinal plants as a

potential source of Phosphodiesterase-5 inhibitors: A review, Journal of
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Crossref

Valerie Jia-En Sin, Ganesh Srinivasan Anand, Hwee-Ling Koh, Botanical Medicine
and Natural Products Used for Erectile Dysfunction, Sexual Medicine Reviews,
10.1016/j.sxmr.2020.10.005, (2020).
Crossref

Luke Fortney, Erectile Dysfunction, Integrative Medicine, 10.1016/B978-0-323-

35868-2.00063-3, (623-629.e2), (2018).
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Francesca Borrelli, Cristiano Colalto, Domenico V. Delfino, Marcello Iriti, Angelo A.

Izzo, Herbal Dietary Supplements for Erectile Dysfunction: A Systematic Review and
Meta-Analysis, Drugs, 10.1007/s40265-018-0897-3, 78, 6, (643-673), (2018).
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Eric Yarnell, Herbs for Erectile Dysfunction, Alternative and Complementary

Therapies, 10.1089/act.2015.29029.eya, 21, 6, (276-283), (2015).
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