Given, dose=100mg F = 0.

85 t(1/2) =8hr
Vd = 400 L Ke = 0.08663 /hr

Discrete dosage segment:

Time %CDR %release at sampling interval Amount in sampling interval
0 0 0 0
1 17.15 17.15 17.15
2 25.45 8.3 8.3
4 42.18 16.73 16.73
6 58.23 16.05 16.05
8 71.52 13.29 13.29
10 83.14 11.62 11.62
12 90.36 7.22 7.22
16 97.33 6.97 6.97
20 100 2.67 2.67
24 100 0 0

Time Blood amount after absorption Total Cp(ng/L)

0
1 17.15 17.15 36.44375
2 15.72691 8.3 24.02691 51.05718
4 13.22519 6.979697 16.73 36.93488 78.48663
6 11.12142 5.869418 14.068715 16.05 47.10956 100.1078
8 9.352308 4.935754 11.830767 13.49688 13.29 52.90571 112.4246
10 7.864612 4.150611 9.9488157 11.3499 11.17592 11.62 56.10986 119.2335
12 6.613567 3.490362 8.3662313 9.544441 9.398141 9.771576 7.22 54.40432 115.6092
16 4.676842 2.46824 5.9162542 6.749435 6.645978 6.910056 5.105687 6.97 45.44249 96.5653
20 3.30727 1.745438 4.1837313 4.772923 4.699762 4.886507 3.610531 4.928897 2.67 34.80506 73.96075
24 2.338765 1.234302 2.9585625 3.375214 3.323478 3.455537 2.553219 3.485513 1.888114 0 24.61271 52.302
28 1.653879 0.872847 2.0921736 2.386813 2.350227 2.443613 1.805531 2.464811 1.335197 0 17.40509 36.98582
32 1.169555 0.617242 1.479499 1.687856 1.661984 1.728023 1.276797 1.743013 0.944196 0 12.30816 26.15485
36 0.827061 0.436488 1.0462408 1.193582 1.175286 1.221986 0.902899 1.232587 0.667697 0 8.703827 18.49563
40 0.584863 0.308666 0.7398584 0.844052 0.831114 0.864138 0.638493 0.871635 0.472167 0 6.154988 13.07935
44 0.413591 0.218276 0.5231974 0.596879 0.58773 0.611083 0.451516 0.616384 0.333897 0 4.352554 9.249177
 48 0.292475 0.154356 0.3699836 0.422088 0.415618 0.432133 0.319293 0.435882 0.236118 0 3.077947 6.540637
52 0.206826 0.109154 0.2616372 0.298483 0.293908 0.305587 0.225791 0.308237 0.166973 0 2.176597 4.625269
56 0.146259 0.077189 0.1850191 0.211075 0.20784 0.216098 0.15967 0.217973 0.118077 0 1.5392 3.2708
60 0.103428 0.054585 0.1308379 0.149264 0.146976 0.152816 0.112912 0.154141 0.083499 0 1.088459 2.312975
64 0.07314 0.0386 0.0925231 0.105553 0.103935 0.108065 0.079847 0.109002 0.059047 0 0.769713 1.635641
Time(hr) Cp(ng/L) dAUC AUC(0-t)
0 0
1 36.44375 18.22188 18.221875 140
2 51.05718 43.75047 61.97234
4 78.48663 129.5438 191.51615 120

6 100.1078 178.5944 370.11058 100

8 112.4246 212.5324 582.64298
10 119.2335 231.6581 814.30108 80

Axis Title
12 115.6092 234.8427 1049.1438 60
16 96.5653 424.349 1473.4928 Column B
20 73.96075 341.0521 1814.5449 40

24 52.302 252.5255 2067.0704 20

28 36.98582 178.5756 2245.646
32 26.15485 126.2813 2371.9274 0
0 10 20 30 40 50 60 70
36 18.49563 89.30096 2461.2283
40 13.07935 63.14996 2524.3783 Axis Title
44 9.249177 44.65705 2569.0353
48 6.540637 31.57963 2600.615 AUC (0 - t) 2657.804
52 4.625269 22.33181 2622.9468 AUC (t-∞) 18.88186
56 3.2708 15.79214 2638.7389
60 2.312975 11.16755 2649.9065 AUC(0-∞) 2676.686 ng.hr/L
64 1.635641 7.897232 2657.8037
Cmax 119.234 ng/L
Tmax 10 hr