4.

2: Therapy Area / HMB – Copy

NOTES CONTENT
URL domain/therapy-area/hmb
Page title Heavy menstrual bleeding
Key message addressed

Meta title Therapy Areas | Heavy menstrual bleeding| Bayer

(20 – 50 characters)
Meta description Discover the heavy menstrual bleeding prevalence and effect of HMB on quality of life, HMB diagnostic
(90 – 150 characters) pathway and treatment algorithm here
HEADER Therapy areas
(Recommended headline length:
20 characters)

Title bar Heavy menstrual bleeding (HMB)

Hero banner

Pre-defined image will be supplied

Breadcrumb navigation Home / therapy-area / hmb

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NOTES CONTENT

Module 1 – HMB prevalence and effect of HMB on QoL

Headline Heavy menstrual bleeding affects 1 in 3 women and can have a major impact on their lives 1,2

Image

Alt text Three women

Body text list
In a survey of 1,627 women who perceived their menstrual flow as above average:* 1

 82% (n=1,334) noticed an effect in their relationships with their partners 1

 80% (n=1,302) experienced an impact on their work performance 1
 68% (n=1,106) avoided participating in social activities1

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Button text More information
Button link (Opens the pop-up)
Pop-up content * Results from a study aiming to gain an understanding of women’s current knowledge, attitudes and
beliefs around HMB. A total of 6,179 women aged 18–55 years old were recruited from 15 countries and
responded to a 52-question online survey.1

HMB – heavy menstrual bleeding

1. Bitzer J, Serrani M and Lahav A. Contraception 2013;4:21–28.

Body text (callout) Encourage an open discussion by asking your patients how their menstrual flow impacts their daily lives †3

Image

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Image copy Her daily life3
• Does she arrange her social activities around her period?
• Does she worry about having bleeding accidents?

Her bleeding3
• Does she pass large blood clots?
• Does she bleed through in less than 2 hours?
• Does she have to change her sanitary wear during the night?

Her health3
• Does she ever feel breathless or light-headed?
Alt text Her daily life, her bleeding and her health

Button text More information

Button link (Opens the pop-up)

Pop-up content † Adapted from the HELP group questionnaire (available at: www.heavymenstrualbleeding.com). The
HELP group is an independent panel of healthcare professionals with an expert interest in HMB. The
foundation and ongoing work of the HELP group is supported by Bayer AG.

HELP – Heavy Menstrual Bleeding Evidence-based Learning for best Practice; HMB – heavy menstrual
bleeding
Abbreviations HMB – heavy menstrual bleeding
References 1. Bitzer J, Serrani M and Lahav A. Contraception 2013;4:21–28.
2. Hurskainen R, Grenman S, Komi I et al. Acta Obstet Gynecol Scand 2007;86(6):749–757.
3. HELP Group. Essentials for the diagnosis and treatment of Heavy Menstrual Bleeding.

Module 2 – HMB diagnostic pathway

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Headline Heavy menstrual bleeding diagnostic pathway helps to address women’s specific needs*

Body text list

Image copy Evaluating the problem

Take a medical history

• Carry out a physical examination
• Do a full blood count
• Ask about risk factors

NO suspected organic
pathology, NO risk factors,

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 OR as interim management
while awaiting further
investigation

IF suspected organic pathology

or risk factors present

Tests and investigations

• Carry out further blood tests
• Imaging
• Biopsy

NO organic pathology detected

Pharmaceutical treatment

IF organic pathology detected

Surgery/other treatments

Yes

Treatment failure
Development of risk factors†
Alt text HMB diagnostic pathway

Button text More information

Button link (Opens the pop-up)

Pop-up content * This pathway was developed by the HELP group, an independent panel of healthcare professionals with

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 an expert interest in HMB. The foundation and ongoing work of the HELP group is supported by Bayer AG. 

† Non-modifiable risk factors include age as well as race and genetics. Modifiable risk factors include
endogenous and exogenous hormonal factors, obesity, uterine infection and lifestyle (e.g. diet, caffeine
intake, alcohol consumption, physical activity, stress and smoking).

HELP – Heavy Menstrual Bleeding Evidence-based Learning for best Practice; HMB – heavy menstrual
bleeding
Body text (callout) The HMB diagnostic pathway may help you to decide which treatment is right for your patients

Button text Click here for a step-by-step approach on the HELP diagnostic and treatment algorithm

Button link Link to 3.4.3 Counselling on HMB Page

Abbreviations HELP – Heavy Menstrual Bleeding Evidence-based Learning for best Practice; HMB – heavy menstrual
bleeding

Module 3 – HMB treatment algorithm

Headline Find the treatment that’s right for your patient

Image title HMB treatment algorithm for individualized pharmacological therapy* †1

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Image

Image copy HMB patient seeking pregnancy

yes

Tranexamic acidb
1st line

NSAIDsc
2nd line

no

HMB patient interested in and

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 candidate for IUS

yes

Mirena®
1st line

no

HMB patient interested in and

candidate for CHCs or progestogensa

yes

Qlaira®d
1st line

Oral progestogen
(21-day)e
2nd line

no

Tranexamic acidb
1st line

NSAIDsc
2nd line

Alt text HMB treatment algorithm

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Footnote (adapted from) Adapted from Bitzer J et al. 2015.1
Button text More information
Button link (Opens the pop up)
Pop-up content * HMB can be caused by several underlying medical conditions; in clinical practice some treatments are
used despite not being specifically approved for HMB. This algorithm focuses on generally approved
treatment methods. Always refer to your local label.1

† Proposed algorithm for medical treatment of HMB in primary care. Adapted from Bitzer J et al. 2015.
These therapies are mainly suggested for women with HMB due to endometrial dysfunction (AUB-E) or
coagulopathies (AUB-C). a) Consider possible contraindication to estrogen use; b) Tranexamic acid may be
the first choice for women who do not want hormones (not a contraceptive); c) Consider if dysmenorrhea
is present (not a contraceptive); d) Only the E2V/DNG formulation had sufficient data to obtain EU and US
approval for this indication; e) Not considered a contraceptive and may be limited by tolerability. 1

AUB-C – abnormal uterine bleeding, coagulopathy; AUB-E – abnormal uterine bleeding related to
endometrial dysfunction; E2V/DNG – estradiol valerate/dienogest; HMB – heavy menstrual bleeding

1. Bitzer J, Heikinheimo O, Nelson AL et al. Obstet Gynecol Surv 2015;70(2):115–130.

Body text (callout) Medical treatment is a first-line strategy for HMB without organic pathology 1
Abbreviations CHC – combined hormonal contraceptive; HMB – heavy menstrual bleeding; IUS – intrauterine system;
NSAID – nonsteroidal anti-inflammatory drug

References 1. Bitzer J, Heikinheimo O, Nelson AL et al. Obstet Gynecol Surv 2015;70(2):115–130.

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 Module 4 – HMB treatment for SAC and LARC

Headline Different women require different treatment options for their heavy menstrual bleeding

Patient profiles – carrousel

Patient profile card 1 Name: Anabelle

Presentation: As with 1 in every 3 women, Anabelle suffers from heavy menstrual bleeding, which has a
major impact on her life (causing her to skip lectures and avoid social activities) 1,2

Image

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Alt text Woman suffering from heavy bleeding

Button text Click here to find out how Qlaira® can help women like Anabelle, who are interested in rapid and
sustained relief from heavy menstrual bleeding3
Button link [Links to “5.6 Qlaira® Product Information Page”]

References 1. Bitzer J et al. Open Access J Contraception 2013;4:21–28.

2. Hurskainen R et al. Obstetrica et Gynecol 2007;86:749–757.
3. Qlaira® Summary of Product Characteristics.

Patient profile card 2 Name: Anya

Presentation: On the approach to menopause, many women find HMB to be particularly disruptive to
their relationships and the quality of their sleep.1 Anya feels that HMB is preventing intimacy with her
partner and she feels exhausted from waking up several times during the night to change sanitary wear.

Image

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Alt text Woman suitable for Mirena

Button text Click here to find out how Mirena® can help women like Anya, who are seeking an LNG-IUS that provides
up to 5 years of efficacy in HMB2

Button link [Links to “5.2 Mirena® HMB Product Information Page”]

Abbreviations HMB – heavy menstrual bleeding; LNG-IUS – levonorgestrel-releasing intrauterine system

References 1. Brotherston J. Br J Gen Pract 2015;65(638):e630–e632.

2. Mirena® Summary of Product Characteristics.

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 Recommendations

Headline Recommendations

Thumbnail-headline Meetings and webinars [link to 2.0 “Meeting and webinars”]

*This section (topic & link) can be modified by countries’ needs
Thumbnail [Pre-defined image will be supplied]

Thumbnail-headline Training and support [link to 3.0 “Training and support”]

*This section (topic & link) can be modified by countries’ needs
Thumbnail [Pre-defined image will be supplied]

Related topics

Headline Related topics

Button text Mirena® HMB Product Information [link to 5.2 “Mirena® HMB Product Information”]
*This section (topic & link) can be modified by countries’ needs
Button text Qlaira® Product Information [link to 5.6 “Qlaira® Product Information”]
*This section (topic & link) can be modified by countries’ needs
Button text Counselling on HMB [link to 3.4.3 “Counselling on HMB”]
*This section (topic & link) can be modified by countries’ needs
Approval code PP-PF-WHC-ALL-0269-1

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 Footer

Footer [Refer to Footer section in the ‘Misc Legal’ copybook]

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