Bielenberg D R and Zetter B R. (2015).

The Contribution of Angiogenesis to the Process of

Metastasis. The Cancer Journal,Vol 21,pp:267-273

Wagh VD. (2013). Propolis: A Wonder Bees Product and Its Pharmacological
Potentials. Hindawi Publishing Corporation Advances in Pharmacological Sciences,
vol 2013, p:11

M.L.F Bittencourt,et al (2015). Metabolite profiling,antioxidant and antibacterial activities of

Brazilian propolis: use of correlation and multivariate analyses to identify potential bioactive
compounds. Food research international.Vol 76, part 3,pp 449-457

Isodorov et al. (2016). Selective Behaviour of Honeybees in Acquiring European Propolis Plant

Precursors.J Chem Ecol. vol 42, pp: 475–485

Kanbur M, Eraslan G, Silici S. (2008). Antioxidant effect of propolis against exposure to

propetamphos in rats. Ecotoxicology and environment safety, vol 72 , pp;909-915

Tandean S, Japardi I, Loe L, Michael, Riawan W, July Julius. (2019). Protective Effects Of
Proposal Extract In A Rat Model Of Traumatic Brain Via Hsp70 Induction. Macedonian Journal
of Medical Science.p: 736

Prasetya D, Suparyanti E, Guntur H. (2013). Ekstrak Etanol Propolis Isolat Menurunkan Derajat
Inflamasi dan Kadar Malondialdehid pada Serum Tikus Model Sepsis. MKB, Vol 45;3, pp: 161-6

Johnson Z, Blaire Stevenson, W Andrew.Prele,M Cecilia.Fear,W Mark.wood,M Fiona. (2020).

The Role of IL-6 in Skin Fibrosis and Cutaneous Wound Healing.Biomedicine, Vol 8, p:101

Pierce F G. (1989). Platelet derived Growth Factor and Transforming Growth Factor-/
Enhance Tissue Repair Activities by Unique Mechanisms.The Journal of Cell Biology,
Volume 109, pp: 429-440

Scholz D, Cai WJ, Schaper W. (2001). Angiogenesis. Arteriogenesis, a new concept of

vascular adaptation in occlusive disease; 4(4), pp :247-57
 Chen Q,  Jin M, Yang F, Zhu J, Xiao Q,  Zhang L. (2013). Matrix Metalloproteinases:
Inflammatory Regulators of Cell Behaviors in Vascular Formation and Remodeling.
PMCID: PMC3694547.doi: 10.1155/2013/928315

Kunwar A dan Priyadarsini KI. (2011). Free radicals, oxidative stress and importance of
antioxidants in human health. Journal of Medical & Allied Sciences, 1(2), p: 53.

-Veith, A. P. et al. (2019) “Therapeutic strategies for enhancing angiogenesis in wound

healing,” Advanced drug delivery reviews, 146, p: 97–125.

- Xian D, Song , Jing; Yang, Lingyu; Xiong,Xia; Lai,Rui; Zhong, Jianqiao.(2019).

Emerging Roles of Redox-Mediated Angiogenesis and Oxidative Stress in
Dermatoses. Oxidative Medicine and Cellular Longevity 2019, pp: 242-56

- Richarz NA, Boada A, Carrascosa JM. (2017). Angiogenesis in dermatology–insights

of molecular mechanisms and latest developments. Actas dermo-sifiliograficas.
108(6), p: 515–523.

-Khan S et al. (2017). Fibroblast growth factor and vascular endothelial growth factor
play a critical role in endotheliogenesis from human adipose-derived stem cells. Journal
of vascular surgery. 65(5), p: 1483–1492.

- Pandiar D dan Shameena PM. (2014). Immunohistochemical expression of CD34 and

basic fibroblast growth factor (bFGF) in oral submucous fibrosis. Journal of oral and
maxillofacial pathology: JOMFP, 18(2), p: 155.

- Khan G J, Shakir L, Khan S, Naeem H S, Omer M O (2014). Assessment methods of

angiogenesis and present approaches for its quantification. Cancer Research Journal.
2(3): 47-62
- Mittler, R. et al. (2011). ROS signaling: the new wave?. Trends in plant science.
16(6), p: 300–309.

- Mittler R. (2017). ROS are good. Trends in plant science, 22(1), p: 11–19.

- Campos AC, Groth AK, Branco AB. (2008). Assessment and nutritional aspects of
wound healing.Graduate Program in Surgery, Federal University of Parana, Curitiba,
Brazil. Curr Opin Clin Nutr Metab Care, Vol. 11(3), pp: 281-8

- Ding Y et al. (2016). Induction of ROS overload by alantolactone prompts oxidative

DNA damage and apoptosis in colorectal cancer cells. International journal of
molecular sciences, 17(4), p: 558.

- Schreml S, Szeimies RM, Prantl L, Karrer S Landthaler M, Babilas P. (2010) .

Oxygen in acute and chronic wound healing: a Review Article. British Journal of
Dermatology, pp :1-120

- Bryan N et al. (2012). Reactive oxygen species (ROS)–a family of fate deciding
molecules pivotal in constructive inflammation and wound healing. Eur Cell Mater,
24(249), p: e65.

- Kocot J, Kielcyzkowska M, Luchowska D, et al (2018). Antioxidant potential of

propolis, Bee Pollem, and Royal Jelly: Possible Medical Aplication. J.Hindawi
Oxidative Medicine and Cellular Longevity, Vol 2018.

- Kunugi H dan Mohammed Ali, A. (2019). Royal jelly and its components promote
healthy aging and longevity: from animal models to humans. International journal of
molecular sciences, 20(19), p: 4662.
- Tsikas D. (2017). Assessment of lipid peroxidation by measuring malondialdehyde
(MDA) and relatives in biological samples: Analytical and biological challenges.
Analytical biochemistry, 524, p: 13–30.

- Dunnill C. et al. (2017). Reactive oxygen species (ROS) and wound healing: the
functional role of ROS and emerging ROS‐modulating technologies for augmentation
of the healing process. International wound journal, 14(1), p: 89–96.

- Phaniendra A, Jestadi DB, Periyasamy L. (2015). Free Radicals: Properties, Sources,

Targets, and Their Implication in Various Diseases. Indian Journal of Clinical
Biochemistry, 30(1), pp. 11–26. doi: 10.1007/s12291-014-0446-0.

- Fujiwara T, et al. (2016). Extracellular superoxide dismutase deficiency impairs

wound healing in advanced age by reducing neovascularization and fibroblast
function. Experimental Dermatology, 25(3), pp. 206–211. doi: 10.1111/exd.12909.

- Kurahashi T and Fujii J. (2015). Roles of Antioxidative Enzymes in Wound Healing.

Journal of Developmental Biology, 3(2), pp. 57–70. doi: 10.3390/jdb3020057.

- Cano Sanchez, M. et al. (2018). Targeting Oxidative Stress and Mitochondrial

Dysfunction in the Treatment of Impaired Wound Healing: A Systematic Review.
Antioxidants, 7(8), p. 98. doi: 10.3390/antiox7080098.
- Nita M and Grzybowski A. (2016). The Role of the Reactive Oxygen Species and
Oxidative Stress in the Pathomechanism of the Age-Related Ocular Diseases and
Other Pathologies of the Anterior and Posterior Eye Segments in Adults. Oxidative
Medicine and Cellular Longevity, 2016, pp. 1–23. doi: 10.1155/2016/3164734.

Schieber M and Chandel N S. (2014). ROS Function in Redox Signaling and Oxidative
Stress. Current Biology, 24(10), pp. R453–R462. doi: 10.1016/j.cub.2014.03.034.

- Treiber N et al. (2012). The role of manganese superoxide dismutase in skin aging.
Dermato-Endocrinology, 4(3), pp. 232–235. doi: 10.4161/derm.21819.

- Rout-Pitt N et al. (2018). Epithelial mesenchymal transition (EMT): a universal

process in lung diseases with implications for cystic fibrosis pathophysiology.
Respiratory Research, 19(1), p. 136. doi: 10.1186/s12931-018-0834-8.

- Patel P and Chatterjee S. (2019). Peroxiredoxin6 in Endothelial Signaling.

Antioxidants, 8(3), p. 63. doi: 10.3390/antiox8030063.

Kurutas EB. (2015). The importance of antioxidants which play the role in cellular
response against oxidative/nitrosative stress: current state. Nutrition Journal, 15(1), p. 71.
doi: 10.1186/s12937-016-0186-5.
Hariharan S and Dharmaraj S. (2020). Selenium and selenoproteins: it’s role in regulation
of inflammation. Inflammopharmacology, 28(3), pp. 667–695. doi: 10.1007/s10787-020-
00690-x.

- Barku YAV. (2019). Wound Healing: Contributions from Plant Secondary Metabolite
Antioxidants, in Wound Healing - Current Perspectives. IntechOpen. doi:
10.5772/intechopen.81208.

- Koh T J and DiPietro LA. (2011). Inflammation and wound healing: the role of the
macrophage. Expert Reviews in Molecular Medicine, 13, p. e23. doi:
10.1017/S1462399411001943.
- Wang J. (2018). Neutrophils in tissue injury and repair. Cell and Tissue Research,
371(3), pp. 531–539. doi: 10.1007/s00441-017-2785-7.

- Zhao, R. et al. (2016). Inflammation in Chronic Wounds. International Journal of

Molecular Sciences, 17(12), p. 2085. doi: 10.3390/ijms17122085.

Sharma P, et al. (2012). Reactive Oxygen Species, Oxidative Damage, and Antioxidative
Defense Mechanism in Plants under Stressful Conditions. Journal of Botany, 2012, pp.
1–26. doi: 10.1155/2012/217037.

Liguori I. et al. (2018). Oxidative stress, aging, and diseases. Clinical Interventions in
Aging, Volume 13, pp. 757–772. doi: 10.2147/CIA.S158513.

Šalamon, Š. et al. (2019). Medical and Dietary Uses of N-Acetylcysteine. Antioxidants,

8(5), p. 111. doi: 10.3390/antiox8050111.
RODRIGUEZ, P. G. et al. (2008). The Role of Oxygen in Wound Healing: A Review of
the Literature. Dermatologic Surgery, 34(9), pp. 1159–1169. doi: 10.1111/j.1524-
4725.2008.34254.x.

Di Meo, S. et al. (2016). Role of ROS and RNS Sources in Physiological and
Pathological Conditions. Oxidative Medicine and Cellular Longevity, 2016, pp. 1–44.
doi: 10.1155/2016/1245049.

André-Lévigne, D. et al. (2017). Reactive Oxygen Species and NOX Enzymes Are
Emerging as Key Players in Cutaneous Wound Repair. International Journal of
Molecular Sciences, 18(10), p. 2149. doi: 10.3390/ijms18102149.

Bryan nicholas et al (2012). REACTIVE OXYGEN SPECIES (ROS) – A FAMILY OF FATE

DECIDING MOLECULES PIVOTAL IN CONSTRUCTIVE INFLAMMATION AND
WOUND HEALING. European Cells and Materials Vol. 24 (pages 249-265)

Kurutas E B. (2015). The importance of antioxidants which play the role in cellular
response against oxidative/nitrosative stress: current state. Nutrition Journal, 15(1), p. 71.
doi: 10.1186/s12937-016-0186-5.
Domínguez, R. et al. (2019) ‘A Comprehensive Review on Lipid Oxidation in Meat and
Meat Products’, Antioxidants, 8(10), p. 429. doi: 10.3390/antiox8100429.

Sarpooshi, H. R. et al. (2017) ‘Wound Healing with Vitamin C’, Translational

Biomedicine, 08(04). doi: 10.21767/2172-0479.100139.

Yarahmadi, A. et al. (2021) ‘The effect of platelet-rich plasma-fibrin glue dressing in

combination with oral vitamin E and C for treatment of non-healing diabetic foot ulcers:
a randomized, double-blind, parallel-group, clinical trial’, Expert Opinion on Biological
Therapy, 21(5), pp. 687–696. doi: 10.1080/14712598.2021.1897100.

Rayees, S. et al. (2020) ‘Macrophage TLR4 and PAR2 Signaling: Role in Regulating
Vascular Inflammatory Injury and Repair’, Frontiers in Immunology, 11. doi:
10.3389/fimmu.2020.02091.

Saha, S. et al. (2020) ‘An Overview of Nrf2 Signaling Pathway and Its Role in
Inflammation’, Molecules, 25(22), p. 5474. doi: 10.3390/molecules25225474.

Sun SC. (2017). The non-canonical NF-κB pathway in immunity and inflammation.
Nature Reviews Immunology, 17(9), pp. 545–558. doi: 10.1038/nri.2017.52.

Kim S, Östör, A. J. K. dan Nisar, M. K. (2012) “Interleukin-6 and cytochrome-P450,

reason for concern?,” Rheumatology international, 32(9), p: 2601–2604.
Fisher, D. T., Appenheimer, M. M. dan Evans, S. S. (2014) “The two faces of IL-6 in the
tumor microenvironment,” in Seminars in immunology. Elsevier, p: 38–47.

Barnes, T. C. et al. (2011) “Endothelial activation and apoptosis mediated by neutrophil-

dependent interleukin 6 trans-signalling: a novel target for systemic sclerosis?,” Annals
of the Rheumatic Diseases, 70(2), p: 366–372.

Ribatti D, Moschetta M dan Vacca A. (2014). Macrophages in multiple myeloma.

Immunology letters, 161(2), hal. 241–244.

Koyama, T. et al. (2011) “A new technique of ex vivo gene delivery of VEGF to wounds
using genetically modified skin particles promotes wound angiogenesis,” Journal of the
American College of Surgeons, 212(3), p: 340–348.
 Uciechowska-Kaczmarzyk, U. et al. (2018) “Molecular dynamics-based model of VEGF-
A and its heparin interactions,” Journal of Molecular Graphics and Modelling, 82, p:
157–166.
Venkatraman L dan Claesson-Welsh L. (2019). The Role of VEGF in Controlling
Vascular Permeability. Tumor Angiogenesis: A Key Target for Cancer Therapy, p: 33–
50.
Melincovici, C. S. et al. (2018) “Vascular endothelial growth factor (VEGF)-key factor in
normal and pathological angiogenesis,” Rom J Morphol Embryol, 59(2), p: 455–467.

Zhou, Z. et al. (2019) “Reactive oxygen species (ROS) and the calcium-(Ca2+) mediated
extrinsic and intrinsic pathways underlying BDE-47-induced apoptosis in rainbow trout
(Oncorhynchus mykiss) gonadal cells,” Science of The Total Environment, 656, p: 778–
788.
(Thronton dan Gosman, 2004; Shimizu and Kishi, 2012)belum ada dapusnya

Turissini, J. D. et al. (2019) “Major risk factors contributing to split thickness skin graft
failure,” Georgetown Medical Review, 3(1), p: 7755.
Osborn, S. L. et al. (2015) “Inosculation of blood vessels allows early perfusion and
vitality of bladder grafts—implications for bioengineered bladder wall,” Tissue
Engineering Part A, 21(11–12), hal. 1906–1915.

Knapik, A. et al. (2012) “Metalloproteinases facilitate connection of wound bed vessels

to pre-existing skin graft vasculature,” Microvascular research, 84(1), p: 16–23.

Krzyszczyk, P. et al. (2018) ‘The Role of Macrophages in Acute and Chronic Wound
Healing and Interventions to Promote Pro-wound Healing Phenotypes’, Frontiers in
Physiology, 9. doi: 10.3389/fphys.2018.00419.

Chifflet S and Hernandez J A. (2016). The Epithelial Sodium Channel and the Processes of
Wound Healing. BioMed Research International, 2016, pp. 1–14. doi: 10.1155/2016/5675047.
 Su, L.-J. et al. (2019) ‘Reactive Oxygen Species-Induced Lipid Peroxidation in
Apoptosis, Autophagy, and Ferroptosis’, Oxidative Medicine and Cellular Longevity,
2019, pp. 1–13. doi: 10.1155/2019/5080843.
Frykberg R G and Banks J. (2015). Challenges in the Treatment of Chronic Wounds.
Advances in Wound Care, 4(9), pp. 560–582. doi: 10.1089/wound.2015.0635.

Su, L.-J. et al. (2019) ‘Reactive Oxygen Species-Induced Lipid Peroxidation in

Apoptosis, Autophagy, and Ferroptosis’, Oxidative Medicine and Cellular Longevity,
2019, pp. 1–13. doi: 10.1155/2019/5080843.

Zhou, D. et al. (2018) ‘Preparation of a balsa-lysozyme eco-friendly dressing and its

effect on wound healing’, RSC Advances, 8(24), pp. 13493–13502. doi:
10.1039/C8RA02629G.

- Wang, X. et al. (2020) ‘Molecular Bases of VEGFR-2-Mediated Physiological Function

and Pathological Role’, Frontiers in Cell and Developmental Biology, 8. doi:
10.3389/fcell.2020.599281.

Albaugh V L. 2017. Proline Precursors and Collagen Synthesis: Biochemical Challenges of

Nutrient Supplementation and Wound Healing. JN the journal nutrition. Published online 2017
Oct 4. doi: 10.3945/jn.117.256404
- Tracy,lauren E et al(2016).extracellular matrix and dermal fibroblas function in the
healing wound.PMC.doi: 10.1089/wound.2014.0561. vol 5(3). P 119-136
- Sukasah CL. 2007. Penggunaan silicone gel sheet pada keloid dan jaringan parut hipertrofi.
Diunduh: 04 September 2007 dari http:/www.pdpersi.co.id/?show+detailnews
&kode=972&tbl=artikel/
- Larson,BJ et al(2011).scarring and scarless wound healing. Woodhead Publishing Series in
Biomaterials.p 77-111
- Cornara L, Biagi M, Xiao J, Burlando B. (2017). Therapeutic Properties of Bioactive
Compounds from Different Honeybee Products. Front Pharmacol. 2017 Jun
28;8:412. doi: 10.3389/fphar.2017.00412. PMID: 28701955; PMCID: PMC5487425.
- Fang Y, Li J, Ding M, Xu X, Zhang J, Jiao P, Han P, Wang J, Yao S. (2014). Ethanol
extract of propolis protects endothelial cells from oxidized low density lipoprotein-
induced injury by inhibiting lectin-like oxidized low density lipoprotein receptor-1-
mediated oxidative stress. Exp Biol Med (Maywood). 2014 Dec;239(12):1678-87.
doi: 10.1177/1535370214541911. Epub 2014 Jun 24. PMID: 24962173.