SYSTEMIC INSULIN-DEPENDENT DIABETES PERNICIOUS ANEMIA GOODPASTURE’S DISEASE

LUPUS ERYTHEMATOSUS MELLITUS

Autoimmune Disorder Non-organ specific Pancreas Stomach Lungs & Kidneys
Female to Male ratio 10:1 5:1 - 1:4
People affected African-Americans Children (most) & Scandinavia & other Caucasian -
Adults (some) Blacks
Hispanics
Peak age of onset - 12 Y.O. 60 Y.O. (median age of dx) Young & Elderly
HLA Application HLA-DR2 HLA-DR3 - -
HLA-DR3 HLA-DR4
Antigen Ds-DNA Beta islet cells (GAD) - Anti-glomerular basement membrane
ANA Insulin (Anti-GBM)
ENA
Phospholipid

GRAVES HASHIMOTO’S RHEUMATOID MYASTHENIA SCERODERMA SJOGREN’S DISEASE

DISEASE THYROIDITIS ARTHRITIS GRAVIS
Autoimmune Thyroid Thyroid Mixture of organic specific + Tissue specific Skin/ectodermal Body’s glands
Disorder systemic symptoms (nerve & muscle) tissues (sweat, saliva, & oil)
w/ systemic effects
Female to Male ratio 8:10 20:1 3:2 4:1 3:1 10:1
People affected - - - - - -
Peak age of onset - N/A but peaks at 3rd-4th decades 40-50 Y.O. - - 45 Y.O. (primary occur)
HLA Application HLA-DR3 NO KNOWN HLA-DR4 Complex & HLA-DR3 HLA-DR3
HLA-BW35 Age-dependent (weak)
Antigen TSH receptor Thyroglobulin UNKNOWN AChR NO ANTIGEN NO ANTIGEN
Anti-Thyroid peroxidase
(TPO)/microsomal Ag