STUDENT NAME:______________________________________SECTION:_________

Activity 1: Cell Adaptation, Cell Injury & Death XWORD. HAPPY LEARNING!!!NOTE: To be
submitted today, August 18 (TUESDAY). The earlier you submit, the higher grade you get. This will
be equivalent to one Unit Test (15% of your grade). EITHER PRINT OUT, ANSWER, SCAN and
SEND BACK or DIGITALIZED ANSWERS then SEND.

Across
4 A special form of necrosis usually seen in
immune reactions involving blood
vessels. FIBRONOID
6 Cellular adaptation of non-dividing cells
such as myocardial fibers.
HYPERTROPHY
7 Pigment produced by tyrosinase-
catalyzed oxidation of tyrosine to
dihydroxyphenylalanine. MELANIN
8 Type of necrosis showing friable, white
appearance grossly and appearing as a
structureless collection of fragmented or
lysed cells and amorphous granular
Down
1 Other name for macrophages in contact
with lipid debris of necrotic cells or
abnormal forms of lipoproteins. Filled with
minute, membrane-bound vacuoles of
lipid, imparting a foamy appearance to
their cytoplasm. FOAM CELLS
2 Refers to any abnormal accumulation of
triglycerides within parenchymal cells
most often seen in the liver but can also
occur in the heart, skeletal muscle, and
kidneys. STEATOSIS
3 It is the destructive fragmentation of the
nucleus of a dying cell. KARYORRHEXIS
 debris enclosed within a distinctive
inflammatory border. CASEATION
9 Pathway of apoptosis triggered by loss of
survival signals, DNA damage and
accumulation of misfolded proteins.
Inhibited by Anti-apoptotic members of
the Bcl family. MITOCHONDRIAL
11 Reduction in the size of an organ or
tissue due to decrease in cell size and
number. ATROPHY
12 This is the first manifestation of almost all
forms of injury to cells. CELLULAR
SWELLING
13 Cell injury with loss of nuclei, cellular
fragmentation and leakage of cellular
contents. IRREVERSIBLE
14 Composed of membrane-bound vesicles
of cytosol and organelles seen in
programmed-cell death. APOPTOTIC
BODIES
15 These are chemical species with a single
unpaired electron in the outer orbital.
FREE RADICALS
19 Small clear vacuoles within the
cytoplasm, representing pinched-off
segments of the endoplasmic reticulum.
HYDROPIC CHANGE
22 Histochemical reaction used to identify
hemosiderin. PRUSSIAN BLUE TEST
25 They block free radical formation or
inactivate free radicals. ANTIOXIDANTS
27 It is the irreversible condensation of
chromatin in the nucleus of a cell
undergoing necrosis or apoptosis. It is
characterized by nuclear shrinkage and
increased basophilia. PYKNOSIS
28 Pathway of apoptosis responsible for
elimination of self-reactive lymphocytes
and damage by cytotoxic T lymphocytes.
Initiated by TNF receptors. DEATH
RECEPTOR
32 Most common exogenous pigment.
CARBON
33 Most common epithelial metaplasia is
Columnar to SQUAMOUS
34 Most common cause of cell injury in
clinical medicine. ISCHEMIA
35 It is the complete dissolution of the
chromatin of a dying cell. KARYOLYSIS
36 Presence of cholesterol-filled
4 Appearance of lipid vacuoles in the
cytoplasm. FATTY CHANGE
5 Type of necrosis of generally the lower
leg that has lost its blood supply and has
undergone coagulative necrosis involving
multiple tissue layers. GANGRENOUS
10 The most common stimulus for
hypertrophy of muscle. INCREASED
WORK LOAD
16 Cell injury with loss of microvilli, blunting,
appearance of smal amorphous densities,
ER dilation and disaggregation of
granular and fibrillar elements.
REVERSIBLE
17 Type of cell death in menopause.
APOPTOSIS
18 Type of necrosis seen in obstruction of
the blood supply of the brain parenchyma.
LICQUEFACTIVE
20 Abnormal calcium deposition occurring in
the absence of calcium metabolic
derangements is seen in what type of
calcification. DYSTROPHIC
21 Chronic production of this cytokine is
thought to be responsible for appetite
suppression and lipid depletion,
culminating in muscle atrophy and
marked muscle wasting (cachexia). TNF
23 The basal cell changes seen in reflux
esophagitis is an example of this adaptive
change. METAPLASIA
24 'Wear and Tear pigment' LIPOFUSCHIN
26 Cellular adaptation in papilloma virus
infection HYPERPLASIA
29 The type of necrosis seen in tissue injury
associated with acute pancreatitis.
ENRYMATIC FAT
30 Hemoglobin-derived granular pigment
that is golden-yellow to brown in color.
Accumulates in excess of iron.
HEMOSIDERIN
31 A form of tissue necrosis in which the
component cells are dead but the basic
tissue architecture is preserved. The
affected tissues take on a firm texture.
COAGULATIVE
 macrophages in subepithelial connective
tissue of skin or tendons. XANTHOMAS
37 Type of cell death associated with
inflammation. NECROSIS