JABATAN KEJURUTERAAN KIMIA DAN PROSES,

FAKULTI KEJURUTERAAN DAN ALAM BINA,

UNIVERSITI KEBANGSAAN MALAYSIA

INTEGRATED PROJECT FOR THIRD YEAR

CHEMICAL ENGINEERING PROGRAM
KKKR3583, KKKR3733, KKKR3723, KKKR3713

SEMESTER II, 2020/2021

COURSE LECTURERS:

KKKR3583: PROF. MADYA TS. EN. NOORHISHAM TAN KOFLI

TS. DR. AHMAD RAZI OTHMAN

KKKR3733: PROF. MADYA IR. DR. HASSIMI ABU HASSAN

PROF. MADYA TS. EN. NOORHISHAM TAN KOFLI
DR. DARMAN NORDIN
DR. MUHAMMAD ZULHAZIMAN MAT SALLEH

KKKR3723: PROF. MADYA IR DR. SHUHAIDA HARUN

IR. DR. TEOW YEIT HAAN

KKKR3713: PROF. MADYA DR. NORLIZA ABD. RAHMAN

DR. JARINAH MOHD ALI
 INTEGRATED PROJECT
KKKR3583, KKKR3733, KKKR3723, KKKR3713
Semester II, 2020-2021

Based on the product assigned for your group, prepare a report according to the given tasks in Table 1:

Table 1 Integrated Project Tasks

No. Course Tasks
1 General a) Introduction contains detail description of the chosen production method,
stoichiometric equation, properties and sources of the raw materials as well
as properties and the usage of the product produced.
b) Production Process with the overview of the process reaction and all the
process units involved from input to output with necessary stream conditions
such as temperature, pressure and material phase.
c) Process Flow Diagram (PFD) according to standard engineering drawing
symbols by applying any engineering design software i.e. MS Visio or
AutoCAD.
d) Heat and Mass Balance for the whole plant based on the PFD. Use the
demand vs supply profile to determine the feed throughput (mass flow rate)
and/or capacity of the plant
e) Economic Analysis contains demand vs supply, future marketing potential,
production capacity and other relevant information such as market price etc.
f) Environmental Issues contains waste generation, any environmental issues
such as discharge limit and relevant environmental act. Summarize the safety
issues and material handling during the production process. Material Safety
Data Sheet (MSDS) must be included in the Appendix.
g) SuperPro®/ Aspen HYSYS/ Aspen Plus/ Symmetry simulation software
to compare the mass and heat balance results with the manual calculation
and state the percentage error differences between both the manual and
simulation methods.
2 KKKR3583 Below are the required tasks for Biochemistry and Biomolecular Engineering
subject:
a) Give detail on enzyme characteristics and the appropriate E.C. code number
of the enzymes based on the standard Systematic and Nomenclature of
enzyme.
b) Which metabolic pathway that involving the selected enzyme. Explain the
enzyme main role in this metabolic pathway
c) Explain how the expression of this enzyme can be improved using
transformation technique, by describing the gene, vector and the host cells
involved.

3 KKKR3733 Below are the required tasks for Separation Process II subject:
a) Select a separation unit or units to treat a stream and determine the process
design in terms of temperature, pressure, flow rates, compositions and heat
duty and/or other related parameters.
b) Perform the mass balance on the unit and compare your results with
SuperPro®/ Aspen HYSYS/ Aspen Plus/ Symmetry simulation.

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4 KKKR3723 Below are the required tasks for Utility and Pressure Vessel Design subject:
a) Determine and explain the need of each utility and mechanism involved in the
equipment.
b) Design and estimate each utility unit in the plant using Kern Method focusing
on the thermal and hydraulic analysis.
c) Design two pressure vessels under respective internal and external pressures
according to ASME Code procedure by considering the corrosion allowance
and nominal in order to determine the wall thickness and the MAWP of the
pressure vessel.
d) Consider also the combined loading of the pressure vessel and perform the
detailed design for the vessel support and flanges, and produce a detailed
engineering drawing on the selected pressure vessels.

5 KKKR3713 Below are the required tasks for Dynamic and Process Control subject:
a) Each student in all group must select ONE unit operation used in their process
and based on the chosen unit operation:

i) Explain the type of control configuration that can be applied to the unit
operation and state the reason of choosing the configuration.
ii) Develop the mathematical modelling of the unit operation to calculate
the Degree of Freedom (DOF) and state your assumptions (if any).
iii) Draw the Piping & Instrumentation Diagram (P&ID) for the unit
operation.
iv) In a Table form, summarize all the type of controllers, control
objectives, control variables, manipulated variables, control actions and
type of valve used in the control configuration. State the set points and
stream numbers accordingly.

b) Conduct a plantwide process control on your whole process and draw the
P&ID. Enclosed the diagram with your final report with proper formatting.

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Final Report:
The final report must be presented according to the Panduan Penulisan Tesis Gaya UKM, Cetakan Ketiga (2015)
format, inclusive of citation in text formatting and list of references. The report should include all the following:

1. Cover of the report (Use Template)

2. Executive Summary
3. Table of Content
4. List of Figures and Tables
5. Glossary and Nomenclature /Notations
6. Introduction: Product, physical and chemical properties, usages
7. Demand vs Supply, plant capacity estimation, future market analysis
8. Production Process description, stoichiometric equation of the process, and PFD
9. Mass and Heat Balances (manual and simulation calculation results presented in Stream and Table format)
10. Environmental Issues, safety handlings, Environmental act, waste management
11. Task required by subject 1: Biochemistry and Biomolecular Engineering (KKKR3853)
12. Task required by subject 2: Separation Process II (KKKR3733)
13. Task required by subject 3: Utility and Pressure Vessel Design (KKKR3723)
14. Task required by subject 4: Dynamic and Process Control (KKKR3713)
15. Conclusion
16. References (Must tally with the main body of the report)
17. Appendix = All Calculation steps, SuperPro®/ Aspen HYSYS/ Aspen Plus/ Symmetry simulation, MSDS sheet.

Preliminary Report Submission:

Overall IP Planning for this semester is tabulated in Table 4. One copy per group of the preliminary report I, II, III & IV
shall be submitted to the assigned lecturers.

Final Report Submision:

1. SOFTCOPY of the full integrated project report not more than 20 pages excluding the Appendices (All Calculation
steps, MSDS sheet, which can be printed in 2 pages layout or double sided).
2. VIDEO presentation with clear explanation on the project within maximum 10 minutes duration. It is important to only
highlight the key points and tasks for all subjects.
Submission date is Thursday, 17 June 2021 (Week 12) for both the report and video.

Presentation and Q&A Session:

Presentation and Q&A Session will be carried out online on Wednesday, 23 June 2021 (Week 13) via Ms Teams.
Each group is given 10 minutes for presentation and 20 minutes for Q&A.

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 Table 2 List of Groups and Project titles (Set 1 Integrated Project Semester II Academic Session 2020/2021)

Group Members Project Title

A168465 TURGA DEVI A/P GUNASEGARAN

A168551 ARUL KUMARAN A/L DORAISAMY Production of Streptomycin from
K1
A168963 MUHAMMAD NA'IM NAJMI BIN MOHAMAD SALJI Streptomyces griseus
A169346 PRASHNADEVI A/P BALAKRISHNA RAO
A167654 PUTERI MIMIE ISMA BINTI NORDIN
A169074 NUR 'IZZAH BINTI AHMAD JUANDA Production of Lovastatin from
K2
A167748 MOHAMAD AZRI BIN ISMAIL Aspergillus terreus
A167664 HUSNA BINTI AHMAD RADZUAN
A168096 ATHIRAH HASNI BINTI ANUAR
A167179 NURSYAHIRAH BINTI ZUBIR
Production of Daptomycin from S.
K3 A167599 HARIZ HAZMI BIN SAIFUL BASAR
Reseousporus
A177266 NOR ZULAIKHA AFIQAH ABD RASID
A184717 SALSABILA THANESYA PUTRI*
A168252 SAFFI IRDINA SIM BINTI WAN AZLAN SIM
A167538 NUR 'AFIAH BINTI MAZLAN
Production of Somatotropin from
K4 A168455 NUR AMANINA BINTI ROZI
Recombinant DNA E. Coli
A168510 NUR AISYAH BINTI NAZAIRI
A184722 CLARISA SAHDA VANIANDINI*
A168878 KOH WENG JIAT
A169249 SEE XING SUANG
Production Cephalosporin C from
K5 A169245 NG KHAI LI
Acremonium chrysogenum
A168884 WONG YEE LING
A184719 MICIA ZAPUTI ROHIMAH*
A168921 NUR ATHIRAH BINTI MOHD NOR
A167590 AIRISSA HANIS BINTI ADELI
Production of Botulinum Toxin type A
K6 A168957 USSHANA SAENGCHOAD A/P PERADIT
from bacteria clostridium botulinum
A168134 NORADILA BINTI KAMARULZAMAN
A184711 SAFFANAH ULFA ASFARINA*
A169349 AHMAD AMMAR BIN AHMAD NIZAM
A169316 NURFADILAH IZATY BINTI SENU Production of Erythromycin from
K7
A169229 NOR EZZATI AMIRA BINTI MUSTAPA PADZIR streptomyces erythreus
A169138 KHAIRUNNISA BINTI SHAHROL NIZAM
A168804 NURUL SHAHIRAH BINTI ABDUL KARIM
A168259 NUR SYAMIRA BINTI SAMIAN
Production of Tetracycline by
K8 A169320 NUR ZAFIRAH ALIAH BINTI BAHARUDDIN
streptomyces aureofaciens
A168196 NUR SABRINA BINTI AHAMAD NORDIN
A184721 SAZHA CHANIFA ZAHRA*
A169024 MUHAMMAD SYAZWAN BIN MOHD ROSEMANIZAR
A169345 AHMAD IKHWAN IRSYAD BIN MUHAMMAD FAKHRUZZAMAN
Production Folic acid from
K9 A168983 MUHAMMAD AFIQ BIN MOHD SHAFI
saccharomyces cerevisae
A169282 MUHAMMAD AFIQ AIZAT BIN RAMLI
A184709 RACHMAT SUGIARTO*
A168003 ENGKU AHMAD FARIZ BIN ENGKU AHMAD KHAIRUL ANUAR
A167520 MUHAMMAD ASYRAF BIN SHAFIE
Production of Penicilin from Penicilium
K10 A169159 AHMAD TAUFEQ ISMADI BIN AHMAD ZAKKI
Chrysogenum
A168739 AMIR FITRI BIN MUHAMMAD SHAFIQ POH
A184705 FARREL MUHAMMAD AKBAR*
A167692 AHMAD RADHI HADI BIN JUSOH
A169210 RHISHIKESSHAN A/L VSU DAVAN
Griseofulvin production from
K11 A169303 PAVITHIRAN A/L KRISHNAN
Penicillium griseofulvum
A184707 ACHMAD JIBRIL HARAHAP*
A184718 YUNIAR CHAIRANI PUTRI*
A169128 KASHVINWARMA A/L BASKARAN
A169309 NURUL HUSNA BINTI JAMALULLAIL
K12 A168522 NUR AZMINA HUSNA BINTI MOHD AZAM Insulin production from E. Coli
A184710 DITYA GELORA AGAMI*
A184720 NAMIRA SALSABILLA*
*Students under mobility program from ITS, Indonesia

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 Table 3 List of Groups and Project titles (Set 2 Integrated Project Semester II Academic Session 2020/2021)

Group Members Project Title

A170080 LOW WEISHENG

A169540 TAN EE JO
Production of L- Asparaginase from
K13 A169593 CHAM ENG KWAN
Erwinia Crysanthemi
A169753 KIN MIN YING
A184712 ATHALIA SALSABILA BUDIYANTO*
A169624 KU ZHI WEI
A169367 CHEN WEI XIN
Production of Glutathione by
K14 A169497 CHAN SIN LENG
Saccharomyces Cerevisiae
A169743 LAM KAR MUN
A184706 MUHAMMAD NAUFAL BARIQUE*
A169365 WONG WHUI DHONG
A169826 TAN KIANT LEONG Production of Cobalamin from
K15
A170205 LEE JUN XIONG Streptomyces Olivaceus
A169147 UMMI DARWISYAH BINTI AZHAR
A170648 NAZATUL AZIQAH RAMLI
A170190 NUR EMYLIA EZANNA MAZLAN
Production of Polyhydroxybutyrate
K16 A169807 SITI ZULAIKHA KALET
(PHB) using Alcaligenes eutrophus
A169635 NUR AISHAH AJALI
A184715 NABILA PUTRI KURNIANTO*
A169368 NURUL FATIN NAJIHA BINTI ZAIMI
A169721 MUHAMMAD NURHAFIZUDDIN BIN BAHARUDIN
Production of Doxorubicin from
K17 A169799 MUHAMMAD AZHAM BIN ABDULLAH
Streptomyces Peucetius
A170253 NUR AISHAH FARINA BINTI ISMAIL
A184713 NADYA PRATIWI CARMADHITA*
A169481 THVYAH A/P BALA SANTARAN
A169828 SANGGAAVI A/P PANJANATHAN Production of Neomycin from
K18
A169356 HEMA DARSHINNI A/P VIJAYAKUMAR Streptomyces Fradiae
A170153 RAVEWARMAH A/L MURUGIAH
A169569 NUR ASHERIN BINTI SAYUTI
A169595 NURUL HIDAYAH BINTI HARUN
Production of Vancomycin from
K19 A169808 NURUL IZATI BINTI DULLAH
Amycolatopsis orientalis
A169610 NUR ALIANA SHAHIRAH BINTI ZAINUDDIN
A184714 MAYSANA YUMNA FANI*
A169502 YUGENTHREN KAMAYA
A170373 YUVENEISH SIVA KUMAR Production of Insulin by recombinant
K20
A169780 MANGLAMBIKAI MURUGAYAH DNA technology
A169733 ISHWARY S S RAJAN
A169708 ZUL AIDIL FITRI BIN MOHD GHAZALI
A169879 FATIHAH BINTI ZAKARIA
Production of Artemisinic acid from
K21 A169519 NURUL NABILA BINTI ABDUL RAHIM
Saccharomyces
A169466 NUR IZZATI HUSNA BINTI AHMAD NADZRI
A184716 DEVIRA FITRIA PANGGAYUH*
A169454 MUHAMAD AZRIL HISYAM BIN MOHAMMED AMIRUL FASYA
A169860 IDRIS BIN SUAHIRI
Production of Riboflavin from
K22 A169806 MUHAMMAD FAIDSYAFIQ BIN OTHMAN
Eremothecium gossypii
A169558 MUHAMMAD AFIQ BIN ZULKEFLI
A184708 RIZQY INDHIYANTO*
A170547 NURAISYAH ABDURAHIM
A169962 FARIDATUN NAJIHA BINTI MOHD JAAFAR Production of Chloramphenicol by
K23
A169794 NOR RAFIQAH BT OMAR Streptomyces venezuelae
A169840 MUHAMMAD AIMAN ZIKRY BIN NOOR ZAMRY
*Students under mobility program from ITS, Indonesia

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Figure 1 Evaluation and Assessment of Integrated Project (20-25 %)

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 Table 4 Integrated Project Planner for Semester II (2020/2021)
MINGGU/TARIKH MULA 1 2 3 4 5 6 7 CPS 8 9 10 11 12 13 14 15 16 17 18
22/ 29/ 5/ 12/ 19/ 26/ 3/ 10/ 17/ 24/ 31/ 7/6 14/ 21/ 28/ 5/ 12/7-30/7
AKTIVITI 3 3 4 4 4 4 5 5 5 5 5 6 6 6 7 (exam)
PROJEK BERSEPADU
THN III - KKKR3733, KKKR3723, KKKR3713, KKKR3743 (Penyelaras: Dr Jarinah)
Taklimat PB Tahun III, Khamis
25/3/2021
Perjumpaan pelajar-pensyarah (buku log) 29/3 – 4/6/2021
Penghantaran cadangan tajuk dan Jumaat 2/4/2021
kumpulan bagi Thn III
Penghantaran Draf Awal I (Introduction, Khamis 8/4/2021
Usage, Process Description, PFD)
Examiners:
PM Noorhisham (Set 1) &
Dr. Ahmad Razi (Set 2)
Penghantaran Draf Awal II (Economic Khamis 22/4/2021
Issues)
Examiners:
PM Ir. Dr. Hassimi/ Dr. Zulhaziman
(Set 1) &
Dr. Darman (Set 2)
Penghantaran Draf Awal III Khamis 6/5/2021
(Environmental and Safety Issues)
Examiners:
PM Dr. Norliza (Set 1) &
Dr. Jarinah (Set 2)
Penghantaran Draf Awal IV (Material Khamis 27/5/2021
and Energy Balances)
Examiner:
PM Ir. Dr. Shuhaida (Set 1) &
Ir. Dr. Teow (Set 2)
Penghantaran Laporan Akhir PB Khamis 17/6/2021
Pembentangan PB Thn III @ 8am-5pm,
Rabu 23/6/2021

Sesi Ulasan 24/6/2021

Penghantaran laporan PB yang telah Jumaat 1/7/2021
diperbaiki