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  • Taller 3 (Base)

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    LUIS RV
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    Taller 3 (base)

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    8 views4 pages

    Taller 3 (Base)

    Uploaded by

    LUIS RV
    ok

    Copyright:

    © All Rights Reserved
    Download as XLSX, PDF, TXT or read online from Scribd
    Flag for inappropriate content
    of 4

    A.

          Sistema Noradrenalina - SSF

    SSF (0.1mL) NA 10-9 M NA 10-7 M NA 10-6 M NA 10-5 M NA 10-4 M

    -- 0.4 0.7 0.9 1.1 1.1


    Contracción
    -- 0.3 0.7 0.9 1 1.1
    (N)
    -- 0.4 0.6 0.8 0.9 1

    B.      Sistema Noradrenalina - Prazosin

    Prazosin 10 -4 NA 10-9 M NA 10-7 M NA 10-6 M NA 10-5 M NA 10-4 M

    -- 0.3 0.3 0.4 0.5 0.6


    Contracción
    -- 0.3 0.5 0.5 0.6 0.6
    (N)
    -- 0.4 0.4 0.5 0.5 0.5

    C.      Sistema Noradrenalina - Terazosin

    Terazosin 10 -4 NA 10-9 M NA 10-7 M NA 10-6 M NA 10-5 M NA 10-4 M

    -- 0.3 0.3 0.5 0.5 0.5


    Contracción
    -- 0.3 0.4 0.5 0.5 0.5
    (N)
    -- 0.3 0.4 0.4 0.4 0.5

    D.      Sistema Noradrenalina - Tamsulosina

    Tamsulosina
    NA 10-9 M NA 10-7 M NA 10-6 M NA 10-5 M NA 10-4 M
    10 -4

    -- 0.2 0.3 0.4 0.4 0.4


    Contracción
    -- 0.3 0.3 0.3 0.4 0.5
    (N)
    -- 0.2 0.3 0.4 0.4 0.4

    DATOS CRUDOS

    NA
    Noradrenalin NA + NA
    NA (M) log +Tamsulosi %
    a Prazosin +Terazosin
    1.00E-09 0.37 0.33 na
    -9 34.375
    1.00E-07 -7 0.67 0.40 62.5
    1.00E-06 -6 0.87 0.47 81.25
    1.00E-05 -5 1.00 0.53 93.75
    1.00E-04 -4 1.07 100
    Agonista sin oposición Agonista + Antagonistas
    %
    NA (M) Log (NA) Contracción Prazosin Prazosin
    Contracción
    1.00E-09 -9 0.36 10-7M Contracción % 10-6M
    Log (NA) Log (NA)
    1.00E-07 -7 0.67 + (N) Contracción +
    1.00E-06 -6 0.87 NA (M) NA (M)
    1.00E-05 -5 1.00 1.00E-08 -8 0.34 1.00E-07 -7
    1.00E-04 -4 1.07 100 1.00E-07 0.52 1.00E-06
    -6 1.00E-05 0.76 1.00E-05
    1.00E-05 0.92 1.00E-04
    1.00E-03 1.05 98.1 1.00E-02

    GRÁFICA

    NA (M) + NA (M) + NA (M) +


    % % %
    NA (M) Log (NA) Prazosin10- Log (NA) Prazosin10- Log (NA) Prazosin10- Log (NA)
    Contracción Contracción Contracción
    7 6 5
    1.00E-09 -9 1.00E-08 -8 1.00E-07 -7 1.00E-06 -6
    1.00E-07 -7 1.00E-07 -7 1.00E-06 1.00E-05
    1.00E-06 -6 1.00E-05 -5 1.00E-05 1.00E-04
    1.00E-05 -5 1.00E-05 -5 1.00E-04 1.00E-03
    1.00E-04 -4 100 1.00E-03 -3 98.1 1.00E-02 93.5 1.00E-01
    Prazosin
    Contracción % 10-5M Contracción %
    Log (NA)
    (N) Contracción + (N) Contracción
    NA (M)
    0.33 1.00E-06 -6 0.35
    0.55 1.00E-05 0.52
    0.73 1.00E-04 0.68
    0.9 1.00E-03 0.88
    1 93.5 1.00E-01 1.06 99.1

    %
    Contracción

    99.1
    Regresión Shild

    dr dr - 1 log(dr-1) cc. Prazosin) Log (cc. Prazosin)


    1.00E-07 -7
    1.00E-06 -6
    1.00E-05 -5

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