SEBACEOUS CARCINOMA OF THE RIGHT NASOLABIAL

Syeben Hietingwati1, Tri Nugraheni1, Benny Gunawan2

1
Department of pathology, Prof. Dr. W. Z. Johannes Hospital, Kupang, Indonesia
2
Department of surgery, Wirasakti Hospital, Kupang, Indonesia

Background:

Sebaceous carcinoma is a rare aggressive skin cancer derived from the epithelium of sebaceous
glands. Sebaceous carcinomas are generally divided as ocular or extraocular locations. Very few
cases of extra ocular sebaceous carcinomas have been reported till date.

Case Description:

We report a case of sebaceous carcinoma in an uncommon location, the nasolabial. A 70-year-

old male presented with a nodule of the right nasolabial, yellowish nodule were 1,5 centimeter in
diameter. On macroscopis examination revealed stratified squamous lining epithelium with
underlying tissue showing lobules or sheets of cells separated by a fibrous stroma, variable
sebaceous differentiation with foamy or vacuolated clear cells. High-power examination,
revealed prominent nucleoli, pleomorphism, hyperchromatic irregular nuclei, and mitoses.
Histological examination it was diagnosed as a well differentiated sebaceous carcinoma.

Discussion and Conclusion:

Sebaceous carcinoma is a rare and destructive malignant neoplasm The disease exhibits diverse
clinical presentations and histologic patterns, often resulting in a delay in an accurate diagnosis
as it may mimic many other cutaneous malignancies like Basal Cell Carcinoma or Squamous
Cell Carcinoma. Early, precise and prompt diagnosis is very important

Keywords: Sebaceous carcinoma, nasolabial, skin adnexa tumor