APRIL 5–8, 2018
It is argued that DHEA-S deficiency may cause adverse events by in-
creasing inflammation and endothelial dysfunction. Although there was
no relationship between DHEA-S and obstructive CAD in men and post-
menopausal women in our study, a weak correlation between DHEA-S
and hs-CRP in the group with obstructive CAD supports this view.
Topic: AJC » Treatment of
Hyperlipidemia
OP-364
Comparison of Alternative Formulas for Low Density Lipoprotein
Cholesterol Measurement with Friedewald
Formula. Ismail Biyik1, Nilgun Isiksacan2, Murat Koser3, and
Fatma Nihan Turhan Caglar2. 1Usak University, School of Medicine,
Education and Research Hospital, Usak; 2Bakirköy Dr. Sadi Konuk
Education and Research Hospital, Istanbul; 3Istanbul Mehmet Akif
Ersoy GKDC Education and Research Hospital, Istanbul.
Introduction: Low density lipoprotein cholesterol (LDL) is of great im-
portance in the pathogenesis of atherosclerotic coronary artery disease
(CAD). The measurement of LDL levels plays a role in the treatment
and follow-up of CAD. To reach the target levels of LDL recom-
mended in related international guidelines constitutes one of the
fundamentals of management of CAD, so true measurement of LDL levels
in patients with CAD is crucial. In this study, we aimed to compare dif-
ferent calculation methods of LDL with enzymatic measurement.
Methods: A total of 47779 patients were included in the study, 21432
(44.9%)men and 26347 (55.1%) women. Lipid panel measurements were
performed, total cholesterol, LDL cholesterol and HDL cholesterol
(sedimented polyethylene glycol) levels were measured by cholesterol
esterase and triglyceride levels by lipoprotein lipase. LDL measure-
ments made with enzymatic methods and LDL calculations with
Friedewald, Yungin Chen, Hatori and Anandaraja formulas were com-
pared. Statistical analyzes were performed by dividing the results into
four quarters with LDL <99 mg / dL; LDL: 100 to 123 mg / dL; LDL:
124 to 148 mg / dL; LDL > 149 mg / dL. Correlations between con-
tinuous variables showing abnormal distribution were investigated using
the Spearman Rho correlation coefficient. Correlation coefficients were
interpreted as follows; 0.90–1.00 very high relation; 0.70–0.89 high; 0.50–
0.69 medium; 0.30–0.49 low; 0.00–0.29 weak relation. Statistical
significance level was determined as 0.05.
Results: When the enzymatically measured LDL is ≤ 99 mg / dL, there
was a high level positive correlation between calculated LDL with
Friedewald, Chen and Hattori formulas; There is a moderate statisti-
cally significant correlation with LDL calculated with Anandaraja formula
(Spearman’s rho p <0,05). When the enzymatically measured LDL is
in the range of 100 to 123 mg / dL; intermediate level positive correla-
tion was found between LDL calculated with Friedewald, Chen, Hattori
formulas but there is a low statistically significant correlation between
LDL calculated with Anandaraja formula (Spearman’s rho p <0,05). When
the enzymatically measured LDL is in the range of 124–148 mg / dL;
low level positive correlation was found between calculated LDL with
Friedewald, Anandaraja, Hattori formulas but there is a moderate level
statistically significant correlation between LDL calculated with Chen
formula (Spearman’s rho p <0,05). When the enzymatically measured
LDL is ≥ 149 mg / dL, moderate level positive correlation was found
between calculated LDL with Friedewald, Chen, Anandaraja and Hattori
formulas (Spearman’s rho p <0,05).
Discussion: The cost of enzymatic direct measurement in LDL mea-
surement is high and is not widely used in biochemistry laboratories in
our country. Friedewald formula is easy to calculate and is preferred
because it does not cost extra. However, in the patients with triglycer-
ide levels above 400 mg / dL, this formula is not able to provide true
The American Journal of Cardiology® APRIL 5–8, 2018 14th INTERNATIONAL CONGRESS OF UPDATE IN CARDIOLOGY AND e105
CARDIOVASCULAR SURGERY / Oral
diagnostic and therapeutic information because the formula does not yield
real results. O
Conclusion: According to our study, Chen and Hattori formulas can
be used as an alternative to the Friedewald formula. However, it should R
be kept in mind that direct enzymatic LDL cholesterol measurement is
appropriate because it does not need for fasting and is able to provide
A
measurement by single analysis. L
Topic: AJC » Preventive Cardiology
A
B
OP-304
Comparison Rheumatic Fever (rf) and Rheumatic Heart Disease
S
(rhd) in Afghanistan and World
Wide. Asmatullah Naebkhil. Kateb Medical School -Kateb
T
University, Kabul. R
Rheumatic fever and rheumatic heart disease nowadays in Afghanistan
A
taking life of young generation of Afghanistan which in world sin world
stage Afghanistan is number one regarding incidence and turkey is number
C
4th after in ranking regarding incidence of this disease. we reached to T
appoint to organize a concerted effort of national and international agen-
cies to work to gather with strong links to support clinical and public S
health infrastructure,and advocacy and funding support from interna-
tional community to fucus on good prospect for contriving RF and RHD
over next few years.
RF and RHD recent years become mostly is a regional and need world
wide efforts tackle Rf and RH. these disease related to poverty spe-
cially countries affected by war or internal conflicts and specially affected
life of young people in third world countries we now stand at a critical
junction of RF and RHd.
This brings real opportunities to make dramatic progress in the next
few years,if we miss these opportunities these disease may reached to
an endemic point in the third world countries
Research is the base to find out the severity of the disease and inci-
dence and prevalence and we must organize a global solution to control
the spreared of RF and RHD.
With concreted efforts mixture of basic,applied and implementation
science -strong links to clinical and public health infrastructure,advocacy
and funding support from international community and same efforts as
going on to tackle Polio,Malaria and Tuberculosis. to tackle the disease
we have plan solution for the following chalnges
1-chalnge -1st
new approaches to integrating centralized control research program
2-chalange 2th
clinical trial and basics research to understand new phases -to tackle
and reduce the incidence
3-chalange 3th
To find a vaccination to prevent the disease - to identify people with
with RF in first stages -and specific research regarding effecient medical
treatment and surgical treatment before heart failure occur
Topic: AJC » Preventive Cardiology
OP-260
Butyrate Lowered Hs-crp Levels Through İnhibition of Mir-200c
Expression in Diabetic Patients. Neda Roshanravan1,
Alireza Ostadrahimi1, Naimeh mesri Alamdari2, and
Mohammad Reza Dastouri3. 1Tabriz University of Medical Sciences,
Tabriz; 2Iran University of Medical Science, Tehran; 3Ankara
University, Ankara.